{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T18:29:32Z","timestamp":1770229772743,"version":"3.49.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.jep.2021.114168","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T10:32:03Z","timestamp":1619605923000},"page":"114168","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["8-hydroxypinoresinol-4-O-\u03b2-D-glucoside from Valeriana officinalis L. Is a Novel Kv1.5 Channel Blocker"],"prefix":"10.1016","volume":"276","author":[{"given":"Xingxing","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueyun","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongfei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xionggang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2021.114168_bib1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/1475-2875-10-144","article-title":"Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria","volume":"10","author":"Achan","year":"2011","journal-title":"Malar. J."},{"key":"10.1016\/j.jep.2021.114168_bib2","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1002\/ptr.1027","article-title":"Effect of valepotriates (valerian extract) in generalized anxiety disorder: a randomized placebo-controlled pilot study","volume":"16","author":"Andreatini","year":"2002","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2021.114168_bib3","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.amjmed.2006.02.026","article-title":"Valerian for sleep: a systematic review and meta-analysis","volume":"119","author":"Bent","year":"2006","journal-title":"Am. J. Med."},{"key":"10.1016\/j.jep.2021.114168_bib4","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1161\/CIRCULATIONAHA.107.704890","article-title":"Atrium-selective sodium channel block as a strategy for suppression of atrial fibrillation: differences in sodium channel inactivation between atria and ventricles and the role of ranolazine","volume":"116","author":"Burashnikov","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jep.2021.114168_bib5","first-page":"947619","article-title":"Chemical components and cardiovascular activities of Valeriana spp","author":"Chen","year":"2015","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jep.2021.114168_bib6","first-page":"59","article-title":"Study on the chemical composition of essential oil from Valeriana Officinalis L","volume":"9","author":"Chen","year":"1989","journal-title":"Chem. Ind. For. Prod."},{"key":"10.1016\/j.jep.2021.114168_bib7","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0008-6363(99)00034-6","article-title":"Ionic targets for drug therapy and atrial fibrillation-induced electrical remodeling: insights from a mathematical model","volume":"42","author":"Courtemanche","year":"1999","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.jep.2021.114168_bib8","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/ptr.1002","article-title":"Effect of kava and valerian on human physiological and psychological responses to mental stress assessed under laboratory conditions","volume":"16","author":"Cropley","year":"2002","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2021.114168_bib9","article-title":"Improved functional expression of human cardiac kv1.5 channels and trafficking-defective mutants by low temperature treatment","volume":"9","author":"Ding","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.jep.2021.114168_bib10","series-title":"Study on the Drug Effect Substances and the Mechanism of Arrhythmic Effects of Valeriana Officinalis L. 2009, PhD Thesis, Hubei College of Traditional Chinese Medicine. Wuhan, China","author":"Duan","year":"2009"},{"key":"10.1016\/j.jep.2021.114168_bib11","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s00210-011-0647-5","article-title":"Atrial-selective sodium channel block by dronedarone: sufficient to terminate atrial fibrillation?","volume":"384","author":"Ehrlich","year":"2011","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"10.1016\/j.jep.2021.114168_bib12","first-page":"1259","article-title":"Effects of 8-hydroxy resin glycoside from Valeriana officinalis L.on Kv1.5 potassium channel currents","volume":"30","author":"Fang","year":"2011","journal-title":"Herald of medicine"},{"key":"10.1016\/j.jep.2021.114168_bib49","doi-asserted-by":"crossref","first-page":"1796.e1","DOI":"10.1016\/j.joms.2019.05.003","article-title":"Assessment of Valeriana officinalis l. (Valerian) for conscious sedation of patients during the extraction of impacted mandibular third molars: a randomized, split-mouth, double-blind, crossover study","volume":"77","author":"Farah","year":"2019","journal-title":"J. Oral Maxillofac. Surg."},{"key":"10.1016\/j.jep.2021.114168_bib13","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.yjmcc.2003.11.003","article-title":"Inhibition of ultra-rapid delayed rectifier K+ current by verapamil in human atrial myocytes","volume":"36","author":"Gao","year":"2004","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.jep.2021.114168_bib14","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1161\/CIRCULATIONAHA.109.894725","article-title":"Drug-induced arrhythmia","volume":"122","author":"Heist","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.jep.2021.114168_bib15","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1211\/0022357991772772","article-title":"The scientific basis for the reputed activity of valerian","volume":"51","author":"Houghton","year":"1999","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jep.2021.114168_bib16","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jacc.2014.03.022","article-title":"2014 AHA\/ACC\/HRS guideline for the management of patients with atrial fibrillation: a report of the American college of cardiology\/American heart association task force on practice guidelines and the heart rhythm society","volume":"64","author":"January","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jep.2021.114168_bib17","first-page":"40","article-title":"Effects of extract of Valeriana officinalis L. (V3d) on cardiovascular system","volume":"16","author":"Jia","year":"1999","journal-title":"J Guangxi Univ Chin Med"},{"key":"10.1016\/j.jep.2021.114168_bib18","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/ptr.1787","article-title":"Anxiolytic effects of a combination of Melissa officinalis and Valeriana officinalis during laboratory induced stress","volume":"20","author":"Kennedy","year":"2006","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2021.114168_bib19","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1126\/science.3887571","article-title":"Qinghaosu (artemisinin): an antimalarial drug from China","volume":"228","author":"Klayman","year":"1985","journal-title":"Science"},{"key":"10.1016\/j.jep.2021.114168_bib20","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1007\/s00210-002-0599-x","article-title":"Electrophysiological and antiarrhythmic effects of the novel I (Kur) channel blockers, S9947 and S20951, on left vs. right pig atrium in vivo in comparison with the I(Kr) blockers dofetilide, azimilide, d,l-sotalol and ibutilide","volume":"366","author":"Knobloch","year":"2002","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"10.1016\/j.jep.2021.114168_bib21","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0091-3057(82)90264-7","article-title":"Aqueous extract of valerian root (Valeriana officinalis L.) improves sleep quality in man","volume":"17","author":"Leathwood","year":"1982","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.jep.2021.114168_bib22","first-page":"72","article-title":"Study on the anti-arrhythmia effective substances and serum pharmacochemistry of Valeriana officinalis L","volume":"35","author":"Liu","year":"2013","journal-title":"Hubei J Tradit Chin Med"},{"key":"10.1016\/j.jep.2021.114168_bib23","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.cell.2011.08.024","article-title":"Artemisinin: discovery from the Chinese herbal garden","volume":"146","author":"Miller","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.jep.2021.114168_bib25","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/S0140-6736(06)68037-9","article-title":"Controversies in atrial fibrillation","volume":"367","author":"Nattel","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2021.114168_bib26","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/415219a","article-title":"New ideas about atrial fibrillation 50 years on","volume":"415","author":"Nattel","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.jep.2021.114168_bib27","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2478\/v10136-009-0002-z","article-title":"Biomedically relevant chemical constituents of Valeriana officinalis","volume":"8","author":"Patocka","year":"2010","journal-title":"J. Appl. Biomed."},{"key":"10.1016\/j.jep.2021.114168_bib28","first-page":"58","article-title":"Caventou, pelletier & - history of quinine","volume":"63","author":"Pai-Dhungat","year":"2015","journal-title":"J. Assoc. Phys. India"},{"key":"10.1016\/j.jep.2021.114168_bib29","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/S0140-6736(05)74775-9","article-title":"The Nobel chronicles. 1988: James whyte Black, (b 1924), gertrude elion (1918-99), and george H hitchings (1905-98)","volume":"355","author":"Raju","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2021.114168_bib30","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1093\/europace\/eun193","article-title":"Role of potassium currents in cardiac arrhythmias","volume":"10","author":"Ravens","year":"2008","journal-title":"Europace"},{"key":"10.1016\/j.jep.2021.114168_bib31","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1124\/jpet.107.127654","article-title":"Atrial antifibrillatory effects of structurally distinct IKur blockers 3-[(dimethylamino)methyl]-6-methoxy-2-methyl-4- phenylisoquinolin-1(2H)-one and 2-phenyl-1,1-dipyridin-3-yl-2-pyrrolidin-1-yl-ethanol in dogs with underlying heart failure","volume":"324","author":"Regan","year":"2008","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.jep.2021.114168_bib32","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.cpcardiol.2006.01.002","article-title":"Ablation of atrial fibrillation","volume":"31","author":"Riley","year":"2006","journal-title":"Curr. Probl. Cardiol."},{"key":"10.1016\/j.jep.2021.114168_bib33","first-page":"220","article-title":"Macedo T. Synaptosomal GABA release as influenced by valerian root extract-involvement of the GABA carrier","volume":"327","author":"Santos","year":"1994","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"10.1016\/j.jep.2021.114168_bib34","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1021\/np010464q","article-title":"Lignans isolated from valerian: identification and characterization of a new olivil derivative with partial agonistic activity at A(1) adenosine receptors","volume":"65","author":"Schumacher","year":"2002","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2021.114168_bib35","doi-asserted-by":"crossref","first-page":"113685","DOI":"10.1016\/j.jep.2020.113685","article-title":"Medicinal plants from the 14th edition of the Russian Pharmacopoeia, recent updates","volume":"268","author":"Shikov","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114168_bib36","series-title":"The Newly Revised Materia Medica","author":"Su","year":"1959"},{"key":"10.1016\/j.jep.2021.114168_bib37","series-title":"European Union Herbal Monograph on Valeriana Officinalis L., Radix","author":"The Committee on Herbal Medicinal Products of European Medicines Agency","year":"2016"},{"key":"10.1016\/j.jep.2021.114168_bib38","series-title":"The European Pharmacopoeia","author":"The Council of Europe and The European Pharmacopoeia Commission","year":"1983"},{"key":"10.1016\/j.jep.2021.114168_bib39","series-title":"The Chinese Pharmacopoeia","author":"The Pharmacopoeia Commission","year":"1977"},{"key":"10.1016\/j.jep.2021.114168_bib41","series-title":"The United States Pharmacopoeia. Easton, Pa., the United States","author":"The United States Pharmacopoeial Convention","year":"1920"},{"key":"10.1016\/j.jep.2021.114168_bib42","series-title":"Artemisia Annua and Artemisinin Medications","author":"Tu","year":"2009"},{"key":"10.1016\/j.jep.2021.114168_bib43","first-page":"CD005049","article-title":"Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation","volume":"9","author":"Valembois","year":"2019","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.jep.2021.114168_bib44","doi-asserted-by":"crossref","first-page":"235","DOI":"10.2459\/JCM.0b013e328358554b","article-title":"Risk factors for atrial fibrillation recurrence: a literature review","volume":"15","author":"Vizzardi","year":"2014","journal-title":"J. Cardiovasc. Med."},{"key":"10.1016\/j.jep.2021.114168_bib45","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1161\/01.RES.73.6.1061","article-title":"Sustained depolarization-induced outward current in human atrial myocytes: evidence for a novel delayed rectifier K+ current similar to Kv1.5 cloned channels currents","volume":"73","author":"Wang","year":"1993","journal-title":"Circ. Res."},{"key":"10.1016\/j.jep.2021.114168_bib46","first-page":"191","article-title":"Effect of extracts of Valeriana officinalis L. on cardiac arrhythmias","volume":"29","author":"Wen","year":"2009","journal-title":"Chin Hosp Pharm J"},{"key":"10.1016\/j.jep.2021.114168_bib47","first-page":"63","article-title":"Clinical research on Xiedanxintai Tablet in treating angina caused by coronary heart disease","volume":"27","author":"Wu","year":"2008","journal-title":"J Tianjin Univ of Trad Chin Med"},{"key":"10.1016\/j.jep.2021.114168_bib48","first-page":"540","article-title":"Clincial studies on the treatment of coronary heart disease with Valeriana officinalis L","volume":"9","author":"Yang","year":"1994","journal-title":"Chin. J. Integrated Tradit. West Med."}],"updated-by":[{"DOI":"10.1016\/j.jep.2021.114442","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:00:00Z","timestamp":1635379200000}}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121003950?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121003950?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,2,12]],"date-time":"2023-02-12T17:20:53Z","timestamp":1676222453000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874121003950"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":47,"alternative-id":["S0378874121003950"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2021.114168","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.jep.2021.114442","asserted-by":"object"}]},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"8-hydroxypinoresinol-4-O-\u03b2-D-glucoside from Valeriana officinalis L. Is a Novel Kv1.5 Channel Blocker","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2021.114168","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114168"}}