{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T21:18:17Z","timestamp":1792185497557,"version":"4.4.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.jep.2021.114187","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T02:20:57Z","timestamp":1620094857000},"page":"114187","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"special_numbering":"C","title":["The role and mechanism of hyperoside against myocardial infarction in mice by regulating autophagy via NLRP1 inflammation pathway"],"prefix":"10.1016","volume":"276","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1634-3684","authenticated-orcid":false,"given":"Yongkang","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingcai","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhirui","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2021.114187_bib1","first-page":"1","article-title":"The concise Guide to PHARMACOLOGY. Overview","volume":"18","author":"Alexander","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jep.2021.114187_bib2","doi-asserted-by":"crossref","DOI":"10.1007\/s11886-017-0876-4","article-title":"Adverse remodeling and reverse remodeling after myocardial infarction","author":"Bhatt","year":"2017","journal-title":"Curr. Cardiol. Rep."},{"key":"10.1016\/j.jep.2021.114187_bib3","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1016\/j.jacc.2009.08.031","article-title":"Beneficial effects of mammalian target of rapamycin inhibition on left ventricular remodeling after myocardial infarction","volume":"54","author":"Buss","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"issue":"4","key":"10.1016\/j.jep.2021.114187_bib4","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1097\/SHK.0000000000001175","article-title":"Endoplasmic reticulum stress-induced NLRP1 inflammasome activation contributes to myocardial ischemia\/reperfusion injury","volume":"51","author":"Cao","year":"2019","journal-title":"Shock"},{"issue":"1","key":"10.1016\/j.jep.2021.114187_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1142\/S0192415X05002606","article-title":"Hawthorn: potential roles in cardiovascular disease","volume":"33","author":"Chang","year":"2005","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jep.2021.114187_bib6","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1161\/CIRCULATIONAHA.113.003668","article-title":"National trends in heart failure hospitalization after acute myocardial infarction for medicare beneficiaries 1998-2010","volume":"128","author":"Chen","year":"2013","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.jep.2021.114187_bib7","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1080\/15548627.2017.1402992","article-title":"Autophagy balances inflammation in innate immunity","volume":"14","author":"Deretic","year":"2018","journal-title":"Autophagy"},{"issue":"5","key":"10.1016\/j.jep.2021.114187_bib8","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.3390\/ijms21051585","article-title":"Potential implications of quercetin and its derivatives in cardioprotection","volume":"21","author":"Ferenczyova","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2021.114187_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.yjmcc.2015.12.024","article-title":"The crossroads of inflammation, fibrosis, and arrhythmia following myocardial infarction","author":"Francis Stuart","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.jep.2021.114187_bib10","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-11777-7","article-title":"Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS\/VEGF-A axis","volume":"10","author":"Garikipati","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jep.2021.114187_bib11","doi-asserted-by":"crossref","DOI":"10.1080\/09168451.2019.1685369","article-title":"Protective effect of hyperoside on heart failure rats via attenuating myocardial apoptosis and inducing autophagy","volume":"84","author":"Guo","year":"2020","journal-title":"Biosci. Biotechnol. Biochem."},{"issue":"1","key":"10.1016\/j.jep.2021.114187_bib12","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.apjtm.2015.12.001","article-title":"Protective effect of hyperoside on cardiac ischemia reperfusion injury through inhibition of ER stress and activation of Nrf2 signaling","volume":"9","author":"Hou","year":"2016","journal-title":"Asian Pacific Journal of Tropical Medicine"},{"key":"10.1016\/j.jep.2021.114187_bib13","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1152\/ajpheart.01056.2010","article-title":"Autophagy limits acute myocardial infarction induced by permanent coronary artery occlusion","volume":"300","author":"Kanamori","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.jep.2021.114187_bib14","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1093\/cvr\/cvr073","article-title":"The role of autophagy emerging in postinfarction cardiac remodelling","volume":"91","author":"Kanamori","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.jep.2021.114187_bib15","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1038\/cdd.2015.16","article-title":"Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation","volume":"22","author":"Kaushal","year":"2015","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jep.2021.114187_bib16","article-title":"Hyperoside inhibits high-glucose-induced vascular inflammation in vitro and in vivo","volume":"37","author":"Ku","year":"2014","journal-title":"Inflammation"},{"issue":"9","key":"10.1016\/j.jep.2021.114187_bib17","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1093\/intimm\/dxq058","article-title":"Quantitative expression of RIG-like helicase, NOD-like receptor and inflammasome-related mRNAs in humans and mice","volume":"22","author":"Lech","year":"2010","journal-title":"Int. Immunol."},{"key":"10.1016\/j.jep.2021.114187_bib18","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.jep.2016.07.050","article-title":"Ethnobotanical study on medicinal plants used by local Hoklos people on Hainan Island, China","volume":"194","author":"Li","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114187_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2007.12.018","article-title":"Autophagy in the pathogenesis of disease","author":"Levine","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.jep.2021.114187_bib19","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.neures.2017.08.004","article-title":"Alterations of apoptosis and autophagy in developing brain of rats with epilepsy: changes in LC3, P62, Beclin-1 and Bcl-2 levels","volume":"130","author":"Li","year":"2018","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.jep.2021.114187_bib20","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.freeradbiomed.2012.12.023","article-title":"The effect of hyperoside on the functional recovery of the ischemic\/reperfused isolated rat heart: potential involvement of the extracellular signal-regulated kinase 1\/2 signaling pathway","volume":"57","author":"Li","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jep.2021.114187_bib21","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/chromsci\/41.2.87","article-title":"Determination of flavones in Crataegus pinnatifida by capillary zone electrophoresis","volume":"41","author":"Liu","year":"2003","journal-title":"J. Chromatogr. Sci."},{"key":"10.1016\/j.jep.2021.114187_bib22","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1161\/CIRCULATIONAHA.111.041814","article-title":"Impaired autophagosome clearance contributes to cardiomyocyte death in ischemia\/reperfusion injury","volume":"125","author":"Ma","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.jep.2021.114187_bib23","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1038\/nm.3322","article-title":"Mst1 inhibits autophagy by promoting the interaction between beclin1 and Bcl-2","volume":"19","author":"Maejima","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.jep.2021.114187_bib24","doi-asserted-by":"crossref","first-page":"3094","DOI":"10.1093\/eurheartj\/ehx177","article-title":"Predictive value of telomere length on outcome following acute myocardial infarction: evidence for contrasting effects of vascular vs. blood oxidative stress","volume":"38","author":"Margaritis","year":"2017","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.jep.2021.114187_bib25","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1161\/01.RES.0000261924.76669.36","article-title":"Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and beclin 1 in mediating autophagy","volume":"100","author":"Matsui","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.jep.2021.114187_bib26","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.cmet.2012.04.004","article-title":"Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease","volume":"15","author":"Min","year":"2012","journal-title":"Cell Metabol."},{"key":"10.1016\/j.jep.2021.114187_bib27","doi-asserted-by":"crossref","DOI":"10.1161\/CIR.0000000000000152","article-title":"Heart disease and stroke statistics-2016 update A report from the American heart association","author":"Mozaffarian","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.jep.2021.114187_bib28","series-title":"Pharmacopoeia of the People's Republic of China","author":"National Pharmacopoeia Committee","year":"2015"},{"key":"10.1016\/j.jep.2021.114187_bib29","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nature10992","article-title":"Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure","volume":"485","author":"Oka","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.jep.2021.114187_bib30","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ejphar.2017.07.049","article-title":"Diosmin prevents left ventricular hypertrophy, adenosine triphosphatases dysfunction and electrolyte imbalance in experimentally induced myocardial infarcted rats","volume":"814","author":"Sabarimuthu","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2021.114187_bib31","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCULATIONAHA.109.928242","article-title":"Profound cardioprotection with chloramphenicol succinate in the swine model of myocardial ischemia-reperfusion injury","volume":"122","author":"Sala-Mercado","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.jep.2021.114187_bib32","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1016\/j.jacc.2018.02.066","article-title":"Trehalose-induced activation of autophagy improves cardiac remodeling after myocardial infarction","volume":"71","author":"Sciarretta","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jep.2021.114187_bib33","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1161\/CIRCULATIONAHA.111.078212","article-title":"Rheb is a critical regulator of autophagy during myocardial ischemia: pathophysiological implications in obesity and metabolic syndrome","volume":"125","author":"Sciarretta","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.jep.2021.114187_bib34","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1016\/j.jacc.2018.08.2186","article-title":"Renal denervation prevents heart failure progression via inhibition of the renin-angiotensin system","volume":"72","author":"Sharp","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"issue":"10","key":"10.1016\/j.jep.2021.114187_bib35","first-page":"1415","article-title":"Advances in pharmacological effects of Hyperoside on heart\/brain ischemia injury","volume":"27","author":"Shu","year":"2016","journal-title":"China Pharmacy"},{"key":"10.1016\/j.jep.2021.114187_bib37","doi-asserted-by":"crossref","DOI":"10.1038\/nrcardio.2017.161","article-title":"The NLRP3 inflammasome in acute myocardial infarction","author":"Toldo","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"issue":"6","key":"10.1016\/j.jep.2021.114187_bib38","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1016\/j.biotechadv.2018.04.002","article-title":"Vascular smooth muscle cell proliferation as a therapeutic target. Part 2: Natural products inhibiting proliferation","volume":"36","author":"Uhrin","year":"2018","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.jep.2021.114187_bib39","first-page":"828","article-title":"The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction","volume":"38","author":"Van Hout","year":"2017","journal-title":"Eur. Heart J."},{"issue":"4","key":"10.1016\/j.jep.2021.114187_bib40","first-page":"341","article-title":"Protective effect of hyperin against myocardial ischemia and reperfusion injury","volume":"17","author":"Wang","year":"1996","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jep.2021.114187_bib41","doi-asserted-by":"crossref","first-page":"113404","DOI":"10.1016\/j.jep.2020.113404","article-title":"Autophagy as a novel insight into mechanism of Danqi pill against post-acute myocardial infarction heart failure","volume":"266","author":"Wang","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114187_bib42","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1159\/000495368","article-title":"Hyperoside protects against pressure overload-induced cardiac remodeling via the AKT signaling pathway","volume":"51","author":"Wang","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.jep.2021.114187_bib43","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1093\/cvr\/cvs216","article-title":"Impaired sonic hedgehog pathway contributes to cardiac dysfunction in type 1 diabetic mice with myocardial infarction","volume":"95","author":"Xiao","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.jep.2021.114187_bib44","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.gene.2017.07.063","article-title":"Hyperoside protects against hypoxia\/reoxygenation induced injury in cardiomyocytes by suppressing the Bnip3 expression","volume":"629","author":"Xiao","year":"2017","journal-title":"Gene"},{"issue":"4","key":"10.1016\/j.jep.2021.114187_bib45","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1253\/circj.CJ-18-1065","article-title":"Autophagy in the heart","volume":"83","author":"Yamaguchi","year":"2019","journal-title":"Circ. J."},{"key":"10.1016\/j.jep.2021.114187_bib46","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.1111\/bph.14706","article-title":"Spermidine-enhanced autophagic flux improves cardiac dysfunction following myocardial infarction by targeting the AMPK\/mTOR signalling pathway","volume":"176","author":"Yan","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jep.2021.114187_bib47","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/j.jacc.2016.05.011","volume":"68","author":"Yancy","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jep.2021.114187_bib48","doi-asserted-by":"crossref","DOI":"10.1007\/s12035-019-1638-7","article-title":"The role of neuronal NLRP1 inflammasome in Alzheimer's disease: bringing neurons into the neuroinflammation game","author":"Yap","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jep.2021.114187_bib49","first-page":"3519","article-title":"Kinetic alterations of collagen and elastic fibres and their association with cardiac function in acute myocardial infarction","volume":"17","author":"Yu","year":"2018","journal-title":"Mol. Med. Rep."},{"issue":"1","key":"10.1016\/j.jep.2021.114187_bib50","doi-asserted-by":"crossref","first-page":"138","DOI":"10.4161\/auto.8.1.18314","article-title":"Glycogen synthase kinase-3b controls autophagy during myocardial ischemia and reperfusion","volume":"8","author":"Zhai","year":"2012","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.jep.2021.114187_bib51","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1159\/000491664","article-title":"Nuclear localization leucine-rich-repeat protein 1 deficiency protects against cardiac hypertrophy by pressure overload","volume":"48","author":"Zong","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"issue":"5","key":"10.1016\/j.jep.2021.114187_bib52","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s10735-018-9789-9","article-title":"NLRP1 promotes TGF-\u03b21-induced myofibroblast differentiation in neonatal rat cardiac fibroblasts","volume":"49","author":"Zong","year":"2018","journal-title":"J. Mol. Histol."},{"key":"10.1016\/j.jep.2021.114187_bib53","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.etp.2017.04.001","article-title":"The protective effect of hyperoside on carbon tetrachloride-induced chronic liver fibrosis in mice via upregulation of Nrf2","volume":"69","author":"Zou","year":"2017","journal-title":"Exp. Toxicol. Pathol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121004141?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121004141?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:09:28Z","timestamp":1759943368000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874121004141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":53,"alternative-id":["S0378874121004141"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2021.114187","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role and mechanism of hyperoside against myocardial infarction in mice by regulating autophagy via NLRP1 inflammation pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2021.114187","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"114187"}}