{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:47:25Z","timestamp":1788385645864,"version":"build-2803163510"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFC1703904"],"award-info":[{"award-number":["2017YFC1703904"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81774007"],"award-info":[{"award-number":["81774007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82004058"],"award-info":[{"award-number":["82004058"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Department of Science and Technology of Sichuan Province","doi-asserted-by":"publisher","award":["2018JY0467"],"award-info":[{"award-number":["2018JY0467"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Department of Science and Technology of Sichuan Province","doi-asserted-by":"publisher","award":["2020YFQ0032"],"award-info":[{"award-number":["2020YFQ0032"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Department of Science and Technology of Sichuan Province","doi-asserted-by":"publisher","award":["2019 YFSY0046"],"award-info":[{"award-number":["2019 YFSY0046"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Department of Science and Technology of Sichuan Province","doi-asserted-by":"publisher","award":["21YYJC0173"],"award-info":[{"award-number":["21YYJC0173"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.jep.2021.114190","type":"journal-article","created":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T09:41:21Z","timestamp":1620294081000},"page":"114190","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Amelioration of diabetic retinopathy in db\/db mice by treatment with different proportional three active ingredients from Tibetan medicine Berberis dictyophylla F"],"prefix":"10.1016","volume":"276","author":[{"given":"Rui","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaopeng","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianrong","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianli","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2021.114190_bib1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.abb.2012.01.014","article-title":"Contribution of p38 MAPK, NF-\u03baB and glucocorticoid signaling pathways to ER stress-induced increase in retinal endothelial permeability","volume":"520","author":"Adachi","year":"2012","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.jep.2021.114190_bib2","doi-asserted-by":"crossref","first-page":"111992","DOI":"10.1016\/j.jep.2019.111992","article-title":"Amelioration of dry eye syndrome in db\/db mice with diabetes mellitus by treatment with Tibetan Medicine Formula Jikan Mingmu Drops","volume":"241","author":"Ai","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114190_bib3","first-page":"67","article-title":"Evaluation on the protection mechanism of Berberidis dictyophyllae Cortex on STZ-induced diabetic nephropathy in rats based on metabolomics","volume":"35","author":"Ai","year":"2019","journal-title":"Pharmacol. Clin. Chin. Mater. Clin. Med."},{"key":"10.1016\/j.jep.2021.114190_bib4","doi-asserted-by":"crossref","first-page":"110852","DOI":"10.1016\/j.biopha.2020.110852","article-title":"A review of traditional Chinese medicine on treatment of diabetic retinopathy and involved mechanisms","volume":"132","author":"Ai","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2021.114190_bib5","doi-asserted-by":"crossref","first-page":"108630","DOI":"10.1016\/j.diabres.2020.108630","article-title":"International diabetes federation's diabetes epidemiological guide writing group. The international diabetes federation's guide for diabetes epidemiological studies","volume":"172","author":"Aschner","year":"2020","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.jep.2021.114190_bib6","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.lfs.2015.06.017","article-title":"Possible role of endostatin in the antiangiogenic therapy of diabetic retinopathy","volume":"135","author":"Behl","year":"2015","journal-title":"Life Sci."},{"key":"10.1016\/j.jep.2021.114190_bib7","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.phrs.2015.05.013","article-title":"Exploring the various aspects of the pathological role of vascular endothelial growth factor (VEGF) in diabetic retinopathy","volume":"99","author":"Behl","year":"2015","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2021.114190_bib8","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1038\/eye.2017.64","article-title":"Oxidative stress and diabetic retinopathy: development and treatment","volume":"31","author":"Calderon","year":"2017","journal-title":"Eye"},{"key":"10.1016\/j.jep.2021.114190_bib9","article-title":"Sustained suppression of VEGF for treatment of retinal\/choroidal vascular diseases","volume":"100921","author":"Campochiaro","year":"2020","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.jep.2021.114190_bib10","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1007\/s00125-019-4838-9","article-title":"Pancreatic kallikrein protects against diabetic retinopathy in KK Cg-A\/J and high-fat diet\/streptozotocin-induced mouse models of type 2 diabetes","volume":"62","author":"Cheng","year":"2019","journal-title":"Diabetologia"},{"key":"10.1016\/j.jep.2021.114190_bib11","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.taap.2016.12.004","article-title":"The anti-ALS drug riluzole attenuates pericyte loss in the diabetic retinopathy of streptozotocin-treated mice","volume":"315","author":"Choi","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jep.2021.114190_bib12","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1007\/s13577-019-00240-w","article-title":"Down-regulation of miR-377 suppresses high glucose and hypoxia-induced angiogenesis and inflammation in human retinal endothelial cells by direct up-regulation of target gene SIRT1","volume":"32","author":"Cui","year":"2019","journal-title":"Hum. Cell"},{"key":"10.1016\/j.jep.2021.114190_bib13","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.bbrc.2020.06.130","article-title":"Andrographolide attenuates choroidal neovascularization by inhibiting the HIF-1\u03b1\/VEGF signaling pathway","volume":"530","author":"Cui","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jep.2021.114190_bib14","first-page":"341","volume":"vol. 3","author":"Disi","year":"2012"},{"key":"10.1016\/j.jep.2021.114190_bib15","doi-asserted-by":"crossref","first-page":"104688","DOI":"10.1016\/j.phrs.2020.104688","article-title":"The Status quo and way forwards on the development of Tibetan medicine and the pharmacological research of Tibetan materia medica","volume":"155","author":"Fu","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2021.114190_bib16","doi-asserted-by":"crossref","first-page":"982","DOI":"10.3389\/fphar.2018.00982","article-title":"Magnoflorine ameliorates lipopolysaccharide-induced acute lung injury via suppressing NF-\u03baB and MAPK activation","volume":"9","author":"Guo","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2021.114190_bib17","first-page":"54","article-title":"Effects of berberine on brain edema and expression levels of HIF-1\u03b1 and VEGF in rats with cerebral hemorrhage [J]","volume":"8","author":"Guo","year":"2016","journal-title":"Chin. J. Prev. Med."},{"key":"10.1016\/j.jep.2021.114190_bib18","doi-asserted-by":"crossref","first-page":"112426","DOI":"10.1016\/j.jep.2019.112426","article-title":"Longzhibu disease and its therapeutic effects by traditional Tibetan medicine: ershi-wei Chenxiang pills","volume":"249","author":"Hou","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114190_bib19","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.2337\/db10-1160","article-title":"Retinal microglial activation and inflammation induced by amadori-glycated albumin in a rat model of diabetes","volume":"60","author":"Ibrahim","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.jep.2021.114190_bib20","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1159\/000475650","article-title":"Berbamine exerts anti-inflammatory effects via inhibition of NF-\u03baB and MAPK signaling pathways","volume":"41","author":"Jia","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.jep.2021.114190_bib21","first-page":"192","article-title":"Study on prevention and treatment of diabetic retinopathy with berberis","volume":"33","author":"Laba","year":"2014","journal-title":"China &Foreign Medical Treatment"},{"key":"10.1016\/j.jep.2021.114190_bib22","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1159\/000447826","article-title":"Curcumin attenuates retinal vascular leakage by inhibiting calcium\/calmodulin-dependent protein kinase II activity in streptozotocin-induced diabetes","volume":"39","author":"Li","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.jep.2021.114190_bib23","doi-asserted-by":"crossref","first-page":"113629","DOI":"10.1016\/j.jep.2020.113629","article-title":"Tibetan medicine Duoxuekang ameliorates hypobaric hypoxia-induced brain injury in mice by restoration of cerebrovascular function","volume":"270","author":"Li","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114190_bib24","first-page":"968","article-title":"Determination of six compounds in Berberidis Cortex and comparative study of its different species","volume":"44","author":"Li","year":"2019","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.jep.2021.114190_bib25","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.4314\/tjpr.v15i9.23","article-title":"Quality evaluation of cortex berberidis from different geographical origins by simultaneous high performance liquid chromatography combined with statistical methods","volume":"15","author":"Li","year":"2016","journal-title":"Trop. J. Pharmaceut. Res."},{"key":"10.1016\/j.jep.2021.114190_bib26","doi-asserted-by":"crossref","first-page":"122040","DOI":"10.1016\/j.jchromb.2020.122040","article-title":"A rapid method for simultaneous quantification of berberine, berbamine, magnoflorine and berberrubine in mouse serum using UPLC-MS\/MS","volume":"1142","author":"Liang","year":"2020","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"10.1016\/j.jep.2021.114190_bib27","first-page":"1281","article-title":"Effect of Tibetan medicine jikan mingmu formula on diabetic retinopathy rats and its mechanism research","volume":"37","author":"Liang","year":"2020","journal-title":"Chin. J. of Mod. Appl. Pharmacy."},{"key":"10.1016\/j.jep.2021.114190_bib28","doi-asserted-by":"crossref","first-page":"113820","DOI":"10.1016\/j.jep.2021.113820","article-title":"Tibetan medicine Ershiwuwei Lvxue Pill attenuates collagen-induced arthritis via inhibition of JAK2\/STAT3 signaling pathway","volume":"270","author":"Liu","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114190_bib29","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.jaci.2008.02.004","article-title":"Cell-specific activation profile of extracellular signal-regulated kinase 1\/2, Jun N-terminal kinase, and p38 mitogen-activated protein kinases in asthmatic airways","volume":"121","author":"Liu","year":"2008","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jep.2021.114190_bib30","first-page":"186","article-title":"Berbamine ameliorates ethanol-induced liver injury by inhibition of hepatic inflammation in mice","volume":"18","author":"Liu","year":"2020","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.jep.2021.114190_bib31","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative pcr","volume":"25","author":"Livak","year":"2002","journal-title":"Methods"},{"key":"10.1016\/j.jep.2021.114190_bib32","doi-asserted-by":"crossref","first-page":"106678","DOI":"10.1016\/j.vph.2020.106678","article-title":"Simulated hyperglycemia impairs insulin signaling in endothelial cells through a hyperosmolar mechanism","volume":"130","author":"Madonna","year":"2020","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.jep.2021.114190_bib33","doi-asserted-by":"crossref","first-page":"104299","DOI":"10.1016\/j.phrs.2019.104299","article-title":"Spermine oxidase: a promising therapeutic target for neurodegeneration in diabetic retinopathy","volume":"147","author":"Narayanan","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2021.114190_bib34","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.bbrc.2019.10.040","article-title":"Endothelial specific deletion of FOXO1 alters pericyte coverage in the developing retina","volume":"520","author":"Niimi","year":"2019","journal-title":"Biochem. Bioph. Res. Co."},{"key":"10.1016\/j.jep.2021.114190_bib35","doi-asserted-by":"crossref","first-page":"21313","DOI":"10.1096\/fj.202001740RR","article-title":"Feb. Excess adiponectin in eyes with progressive ocular vascular diseases","volume":"35","author":"Nishinaka","year":"2021","journal-title":"Faseb. J."},{"key":"10.1016\/j.jep.2021.114190_bib36","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13020-019-0284-3","article-title":"Luo Tong formula attenuates retinal inflammation in diabetic rats via inhibition of the p38MAPK\/NF-\u03baB pathway","volume":"15","author":"Pang","year":"2020","journal-title":"Chinese Medicien"},{"key":"10.1016\/j.jep.2021.114190_bib37","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.yexcr.2017.09.006","article-title":"\u03b2-arrestin-2 is involved in irisin induced glucose metabolism in type 2 diabetes via p38 MAPK signaling","volume":"360","author":"Pang","year":"2017","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.jep.2021.114190_bib38","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1159\/000331721","article-title":"Oral carnosine supplementation prevents vascular damage in experimental diabetic retinopathy","volume":"28","author":"Pfister","year":"2011","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.jep.2021.114190_bib39","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.bcp.2018.09.016","article-title":"Computational systems biology approach to identify novel pharmacological targets for diabetic retinopathy","volume":"158","author":"Platania","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jep.2021.114190_bib40","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.diabet.2019.04.002","article-title":"Diabetic retinopathy, a vascular and inflammatory disease: therapeutic implications","volume":"45","author":"Semeraro","year":"2019","journal-title":"Diabetes Metab."},{"key":"10.1016\/j.jep.2021.114190_bib41","doi-asserted-by":"crossref","first-page":"113514","DOI":"10.1016\/j.jep.2020.113514","article-title":"Ethyl acetate extract of Tibetan medicine Rhamnella gilgitica ameliorated type II collagen-induced arthritis in rats via regulating JAK-STAT signaling pathway","volume":"267","author":"Su","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114190_bib42","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1177\/1534735413513635","article-title":"Suppression of vascular endothelial growth factor via inactivation of eukaryotic elongation factor 2 by alkaloids in Coptidis rhizome in hepatocellular carcinoma","volume":"13","author":"Tan","year":"2014","journal-title":"Integr. Canc. Ther."},{"key":"10.1016\/j.jep.2021.114190_bib43","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00125-018-4797-6","article-title":"lncRNA H19 prevents endothelial-mesenchymal transition in diabetic retinopathy","volume":"62","author":"Thomas","year":"2019","journal-title":"Diabetologia"},{"key":"10.1016\/j.jep.2021.114190_bib44","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/1476-4598-8-81","article-title":"Suppression of growth, migration and invasion of highly-metastatic human breast cancer cells by berbamine and its molecular mechanisms of action","volume":"8","author":"Wang","year":"2009","journal-title":"Mol. Canc."},{"key":"10.1016\/j.jep.2021.114190_bib45","doi-asserted-by":"crossref","first-page":"110822","DOI":"10.1016\/j.biopha.2020.110822","article-title":"Potential applications of microfluidics based blood brain barrier (BBB)-on-chips for in vitro drug development","volume":"132","author":"Wang","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2021.114190_bib46","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.trac.2019.05.043","article-title":"Microfluidic chip and its application in autophagy detection","volume":"117","author":"Wang","year":"2019","journal-title":"Trac. Trends Anal. Chem."},{"key":"10.1016\/j.jep.2021.114190_bib47","doi-asserted-by":"crossref","first-page":"111801","DOI":"10.1016\/j.jep.2019.03.028","article-title":"Rhodiola crenulata attenuates apoptosis and mitochondrial energy metabolism disorder in rats with hypobaric hypoxia-induced brain injury by regulating the HIF-1\u03b1\/microRNA 210\/ISCU1\/2(COX10) signaling pathway","volume":"241","author":"Wang","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114190_bib48","first-page":"1584","article-title":"Isolation and identification of chemical constituents from branches and leaves of berberis kansuensis","volume":"23","author":"Xu","year":"2012","journal-title":"China Pharmacy"},{"key":"10.1016\/j.jep.2021.114190_bib49","doi-asserted-by":"crossref","first-page":"113995","DOI":"10.1016\/j.jep.2021.113995","article-title":"Berberis kansuensis extract alleviates type 2 diabetes in rats by regulating gut microbiota composition","volume":"273","author":"Xu","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114190_bib50","doi-asserted-by":"crossref","first-page":"104632","DOI":"10.1016\/j.phrs.2020.104632","article-title":"Magnoflorine: a review of its pharmacology, pharmacokinetics and toxicity","volume":"152","author":"Xu","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2021.114190_bib51","first-page":"2852","article-title":"Determination of 6 components in Tibetan medicine Berberis Cortex with quantitative analysis of multi-components by single marker","volume":"29","author":"Xu","year":"2020","journal-title":"Chinese Journal of New Drugs"},{"key":"10.1016\/j.jep.2021.114190_bib52","doi-asserted-by":"crossref","first-page":"110984","DOI":"10.1016\/j.biopha.2020.110984","article-title":"Therapeutic effect of berberine on metabolic diseases: both pharmacological data and clinical evidence","volume":"133","author":"Xu","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2021.114190_bib53","doi-asserted-by":"crossref","first-page":"113510","DOI":"10.1016\/j.jep.2020.113510","article-title":"Magnoflorine prevent the skeletal muscle atrophy via Akt\/mTOR\/FoxO signal pathway and increase slow-MyHC production in streptozotocin-induced diabetic rats","volume":"267","author":"Yadav","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114190_bib54","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1080\/10739680490503375","article-title":"Retinal endothelial angiogenic activity: effects of hypoxia and glial [Muller] cells","volume":"11","author":"Yafai","year":"2004","journal-title":"Microcirculation"},{"key":"10.1016\/j.jep.2021.114190_bib55","first-page":"1584","volume":"42","author":"Yan","year":"2019","journal-title":"J. Chin. Med. Mater."},{"key":"10.1016\/j.jep.2021.114190_bib56","first-page":"171","volume":"vol. 2","author":"Yangjin","year":"2019"},{"key":"10.1016\/j.jep.2021.114190_bib57","first-page":"181","article-title":"Effect of Tibetan medicine berberis cortex on expressions of PKC-\u03b2, VEGF, HIF-1\u03b1 in retina of diabetic rats","volume":"16","author":"Yue","year":"2014","journal-title":"Modernization of Traditional Chinese Medicine And Materia Medica-World Science And Technology"},{"key":"10.1016\/j.jep.2021.114190_bib58","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1182\/blood-2006-07-037952","article-title":"Orientation of endothelial cell division is regulated by VEGF signaling during blood vessel formation","volume":"109","author":"Zeng","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.jep.2021.114190_bib59","first-page":"4227","article-title":"Berberine protects against diabetic retinopathy by inhibiting cell apoptosis via deactivation of the NF-\u03baB signaling pathway","volume":"22","author":"Zhai","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jep.2021.114190_bib60","first-page":"1","article-title":"CPSF1 mediates retinal vascular dysfunction in diabetes mellitus via the MAPK\/ERK pathway","volume":"18","author":"Zhang","year":"2020","journal-title":"Arch. Physiol. Biochem."},{"key":"10.1016\/j.jep.2021.114190_bib61","doi-asserted-by":"crossref","first-page":"165794","DOI":"10.1016\/j.bbadis.2020.165794","article-title":"Identification of proliferative diabetic retinopathy-associated genes on the protein-protein interaction network by using heat diffusion algorithm","volume":"1866","author":"Zhang","year":"2020","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"key":"10.1016\/j.jep.2021.114190_bib62","first-page":"71","article-title":"Comparison of the contents of alkaloids in Berberis L. of Gansu from different parts and seasons","volume":"35","author":"Zheng","year":"2009","journal-title":"J. Lanzhou Univ."},{"key":"10.1016\/j.jep.2021.114190_bib63","first-page":"116","article-title":"Effect of water extract from cortex of berberis dictyophylla on retinopathy in spontaneous type 2 diabetic db\/db mice (\u2161)","volume":"22","author":"Zhou","year":"2016","journal-title":"Chin. J. Exp. Tradit. Med. Form."},{"key":"10.1016\/j.jep.2021.114190_bib64","first-page":"171","article-title":"Tibetan medicine understanding of diabetic retinopathy and new drug discovery strategy","author":"Zhou","year":"2017","journal-title":"Lishizhen Med. Mater. Med. Res."},{"key":"10.1016\/j.jep.2021.114190_bib65","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/s10456-018-9619-4","article-title":"Prion protein is essential for diabetic retinopathy-associated neovascularization","volume":"21","author":"Zhu","year":"2018","journal-title":"Angiogenesis"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121004177?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121004177?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T09:51:11Z","timestamp":1778752271000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874121004177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":65,"alternative-id":["S0378874121004177"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2021.114190","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amelioration of diabetic retinopathy in db\/db mice by treatment with different proportional three active ingredients from Tibetan medicine Berberis dictyophylla F","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2021.114190","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114190"}}