{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:40:58Z","timestamp":1790692858889,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"vor","delay-in-days":250,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordination of Higher Education Personnel Improvement","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["3038751\/2017\\u20138"],"award-info":[{"award-number":["3038751\/2017\\u20138"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.jep.2021.114260","type":"journal-article","created":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T02:38:38Z","timestamp":1622255918000},"page":"114260","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Effectiveness of the polyphenols-rich Sedum dendroideum infusion on gastric ulcer healing in rats: Roles of protective endogenous factors and antioxidant and anti-inflammatory mechanisms"],"prefix":"10.1016","volume":"278","author":[{"given":"Bruna Barbosa","family":"da Luz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Maria-Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Luiz","family":"Dallazen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Fl\u00e1via","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Ederaldo","family":"Queiroz Telles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olair Carlos","family":"Beltrame","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thales Ricardo","family":"Cipriani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Fernanda","family":"de Paula Werner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2021.114260_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"[13] catalase in vitro","author":"Aebi","year":"1984","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.jep.2021.114260_bib3","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jcmgh.2018.05.003","article-title":"Reduced NGF in gastric endothelial cells is one of the main causes of impaired angiogenesis in aging gastric mucosa","volume":"6","author":"Ahluwalia","year":"2018","journal-title":"Cellular and Molecular Gastroenterology and Hepatology"},{"key":"10.1016\/j.jep.2021.114260_bib4","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.jsps.2020.06.012","article-title":"Tetramethylpyrazine ameliorates indomethacin-induced gastric ulcer in rats: impact on oxidative, inflammatory, and angiogenic machineries","volume":"28","author":"AlKreathy","year":"2020","journal-title":"Saudi Pharmaceut. J."},{"key":"10.1016\/j.jep.2021.114260_bib5","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1038\/s41385-018-0021-8","article-title":"NADPH oxidases and ROS signaling in the gastrointestinal tract","volume":"11","author":"Aviello","year":"2018","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.jep.2021.114260_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/0076-6879(88)62087-8","article-title":"Sponge implants as models","author":"Bailey","year":"1988","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.jep.2021.114260_bib7","doi-asserted-by":"crossref","DOI":"10.1152\/physrev.00040.2012","article-title":"Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases","author":"Bhattacharyya","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jep.2021.114260_bib8","doi-asserted-by":"crossref","DOI":"10.1111\/1523-1747.ep12506462","article-title":"Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker","author":"Bradley","year":"1982","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jep.2021.114260_bib9","first-page":"267","article-title":"\u00dalcera por conten\u00e7\u00e3o em ratos: a\u00e7\u00e3o protetora de extrato aquoso de b\u00e1lsamo","volume":"42","author":"Carlini","year":"1970","journal-title":"An Acad. Bras Ci\u00eancias"},{"key":"10.1016\/j.jep.2021.114260_bib10","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.jep.2014.10.042","article-title":"Antiulcer activities of the hydroethanolic extract of Sedum dendroideum Moc et Sess\u00e9 ex DC. (balsam)","volume":"158","author":"Carrasco","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114260_bib11","first-page":"65","article-title":"Gastric mucosal injury and oxidative stress. Gastrointest. Tissue oxidative stress diet","author":"Contreras-Zentella","year":"2017","journal-title":"Antioxidants"},{"key":"10.1016\/j.jep.2021.114260_bib12","doi-asserted-by":"crossref","first-page":"137","DOI":"10.2147\/JMDH.S54324","article-title":"Gastrointestinal ulcers, role of aspirin, and clinical outcomes: pathobiology, diagnosis, and treatment","volume":"7","author":"Cryer","year":"2014","journal-title":"J. Multidiscip. Healthc."},{"key":"10.1016\/j.jep.2021.114260_bib13","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jep.2018.11.019","article-title":"Chemical composition, antioxidant and gastrointestinal properties of Sedum dendroideum Moc & Sess\u00e9 ex DC leaves tea infusion","volume":"231","author":"da Luz","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114260_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2009.04.024","article-title":"Antinociceptive and anti-inflammatory kaempferol glycosides from Sedum dendroideum","author":"De Melo","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114260_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2005.06.015","article-title":"Phytochemical and pharmacological study of Sedum dendroideum leaf juice","author":"De Melo","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114260_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2018.01.015","article-title":"Gastroprotective activity of a pectic polysaccharide fraction obtained from infusion of Sedum dendroideum leaves","author":"de Oliveira","year":"2018","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2021.114260_bib17","doi-asserted-by":"crossref","first-page":"108759","DOI":"10.1016\/j.steroids.2020.108759","article-title":"Russelioside B; A pregnane glycoside for treatment of gastric ulcer via modulation of heat shock protein-70 and vascular endothelial growth factor","volume":"165","author":"El-Shiekh","year":"2021","journal-title":"Steroids"},{"key":"10.1016\/j.jep.2021.114260_bib18","doi-asserted-by":"crossref","DOI":"10.1053\/gast.2002.34156","article-title":"Interleukin 1\u03b2 polymorphisms increase risk of hypochlorhydria and atrophic gastritis and reduce risk of duodenal ulcer recurrence in Japan","author":"Furuta","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jep.2021.114260_bib19","author":"Gottschald"},{"key":"10.1016\/j.jep.2021.114260_bib20","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2008.05.030","article-title":"Gastric mucosal defense and cytoprotection: bench to bedside","author":"Laine","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jep.2021.114260_bib21","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0140-6736(16)32404-7","article-title":"Peptic ulcer disease","volume":"390","author":"Lanas","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2021.114260_bib22","article-title":"Kaempferol protects ethanol-induced gastric ulcers in mice via pro-inflammatory cytokines and NO","author":"Li","year":"2018","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1016\/j.jep.2021.114260_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/0304-4165(85)90147-3","article-title":"Cobalt(II) ion as a promoter of hydroxyl radical and possible \u201ccrypto-hydroxyl\u201d radical formation under physiological conditions. Differential effects of hydroxyl radical scavengers","author":"Moorhouse","year":"1985","journal-title":"BBA - Gen. Subj."},{"key":"10.1016\/j.jep.2021.114260_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2007.07.004","article-title":"Influence of tetrahydrocurcumin on erythrocyte membrane bound enzymes and antioxidant status in experimental type 2 diabetic rats","author":"Murugan","year":"2007","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114260_bib25","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J. Basic Clin. Pharm."},{"key":"10.1016\/j.jep.2021.114260_bib26","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1248\/bpb.28.1321","article-title":"An overview of acetic acid ulcer models--the history and state of the art of peptic ulcer research","volume":"28","author":"Okabe","year":"2005","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jep.2021.114260_bib27","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/BF02235252","article-title":"A method for experimental, penetrating gastric and duodenal ulcers in rats","volume":"16","author":"Okabe","year":"1971","journal-title":"Am. J. Dig. Dis."},{"key":"10.1016\/j.jep.2021.114260_bib28","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1080\/09168451.2017.1398068","article-title":"Development and application of oxidative stress biomarkers","volume":"82","author":"Osawa","year":"2018","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.jep.2021.114260_bib29","doi-asserted-by":"crossref","DOI":"10.1002\/ptr.4835","article-title":"Antiulcer effect of bark extract of Tabebuia avellanedae: activation of cell proliferation in gastric mucosa during the healing process","author":"Pereira","year":"2013","journal-title":"Phyther. Res."},{"key":"10.1016\/j.jep.2021.114260_bib30","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/abbs\/gmz140","article-title":"In vivo acute toxicity and anti-gastric evaluation of a novel dichloro Schiff base: bax and HSP70 alteration","volume":"52","author":"Saremi","year":"2020","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1016\/j.jep.2021.114260_bib31","doi-asserted-by":"crossref","DOI":"10.2174\/1381612824666180629111227","article-title":"Roles of cyclooxygenase, prostaglandin E2 and EP receptors in mucosal protection and ulcer healing in the gastrointestinal tract","author":"Takeuchi","year":"2018","journal-title":"Curr. Pharmaceut. Des."},{"key":"10.1016\/j.jep.2021.114260_bib32","doi-asserted-by":"crossref","DOI":"10.2165\/11634850-000000000-00000","article-title":"Therapeutic management of recurrent peptic ulcer disease","author":"Tang","year":"2012","journal-title":"Drugs"},{"key":"10.1016\/j.jep.2021.114260_bib33","doi-asserted-by":"crossref","DOI":"10.1111\/jgh.12734","article-title":"Angiogenesis in gastric mucosa: an important component of gastric erosion and ulcer healing and its impairment in aging","author":"Tarnawski","year":"2014","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jep.2021.114260_bib34","series-title":"Guide, Guide for the Care and Use of Laboratory Animals","author":"The National Research Council","year":"2011"},{"key":"10.1016\/j.jep.2021.114260_bib35","first-page":"391","article-title":"Involvement of heat shock proteins in the healing of acetic acid-induced gastric ulcers in rats","volume":"52","author":"Tsukimi","year":"2001","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.jep.2021.114260_bib36","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2017.04.047","article-title":"Complications of proton pump inhibitor therapy","author":"Vaezi","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jep.2021.114260_bib37","doi-asserted-by":"crossref","DOI":"10.1163\/156856002321544765","article-title":"Mechanisms of peptic ulcer recurrence: role of inflammation","author":"Watanabe","year":"2002","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.jep.2021.114260_bib38","article-title":"Tumor vascularity: a histological measure of angiogenesis and hypoxia","author":"West","year":"2001","journal-title":"Canc. Res."},{"key":"10.1016\/j.jep.2021.114260_bib39","doi-asserted-by":"crossref","DOI":"10.1155\/2006\/175217","article-title":"The association of Helicobacter pylori infection and nonsteroidal anti-inflammatory drugs in peptic ulcer disease","author":"Zapata-Colindres","year":"2006","journal-title":"Can. J. Gastroenterol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121004876?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121004876?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:42:27Z","timestamp":1777570947000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874121004876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":38,"alternative-id":["S0378874121004876"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2021.114260","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effectiveness of the polyphenols-rich Sedum dendroideum infusion on gastric ulcer healing in rats: Roles of protective endogenous factors and antioxidant and anti-inflammatory mechanisms","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2021.114260","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"114260"}}