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Rep."},{"key":"10.1016\/j.jep.2021.114372_bib99","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.intimp.2011.01.018","article-title":"Costunolide stimulates the function of osteoblastic MC3T3-E1 cells","volume":"11","author":"Lee","year":"2011","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.jep.2021.114372_bib96","doi-asserted-by":"crossref","first-page":"e95530","DOI":"10.1371\/journal.pone.0095530","article-title":"growth inhibitory, bactericidal, and morphostructural effects of dehydrocostus lactone from magnolia sieboldii leaves on antibiotic-susceptible and -resistant strains of Helicobacter pylori","volume":"9","author":"Lee","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.jep.2021.114372_bib100","article-title":"\u201cEffective prescription for women,\u201d prescriptions for the use of study","author":"Li","year":"2010","journal-title":"Xinjiang medical university"},{"key":"10.1016\/j.jep.2021.114372_bib101","first-page":"901","article-title":"Chemical constituents and anti-acetylcholinesterase activities of Dolomiaea wardii","volume":"634\u2013638","author":"Li","year":"2013","journal-title":"Adv. Mater. Res."},{"key":"10.1016\/j.jep.2021.114372_bib102","first-page":"492","article-title":"Textual research on Materia Medica aucklandiae radix","volume":"43","author":"Li","year":"2020","journal-title":"J. Chin. Med. Mater."},{"issue":"109955","key":"10.1016\/j.jep.2021.114372_bib103","article-title":"Antitumor activity and mechanism of costunolide and dehydrocostus lactone: two natural sesquiterpene lactones from the Asteraceae family","volume":"125","author":"Li","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2021.114372_bib104","first-page":"82","article-title":"Study on pharmacodynamics and acute toxicity of radix aucklandiae in houpu pill","volume":"25","author":"Li","year":"2009","journal-title":"Pharmacol. Clin. Chin. Mater. 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Rep."},{"key":"10.1016\/j.jep.2021.114372_bib108","first-page":"34","article-title":"Effect of acetone extract of yunnan aucklandia lappa Decne on the models of experimental gastric ulcer rats","author":"Li","year":"2007","journal-title":"Yunnan. J. Tradit. Chin. Med. Mater. Medica"},{"key":"10.1016\/j.jep.2021.114372_bib109","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.jep.2005.01.020","article-title":"In vitro anti-Helicobacter pylori action of 30 Chinese herbal medicines used to treat ulcer diseases","volume":"98","author":"Li","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114372_bib110","first-page":"487","article-title":"Clinical study on Jiawei xianglian pill combined with Pingwei powder in the treatment of radiation enteritis","volume":"36","author":"Li","year":"2020","journal-title":"J. Pract. Tradit. Chin. 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Dig."},{"key":"10.1016\/j.jep.2021.114372_bib117","first-page":"15","article-title":"Study on introduction and cultivation of Saussurrea lappa","author":"Liu","year":"1989","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.jep.2021.114372_bib118","doi-asserted-by":"crossref","first-page":"765","DOI":"10.5114\/aoms.2018.73128","article-title":"Dehydrocostus lactone inhibits in vitro gastrinoma cancer cell growth through apoptosis induction, sub-G1 cell cycle arrest, DNA damage and loss of mitochondrial membrane potential","volume":"15","author":"Long","year":"2019","journal-title":"Arch. Med. Sci."},{"key":"10.1016\/j.jep.2021.114372_bib119","first-page":"513","article-title":"Analysis of the essential oil from Aucklandia lappa Decne.by SPME-GC-MS","volume":"31","author":"Lou","year":"2011","journal-title":"Chin. J. Pharma. 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Med."},{"key":"10.1016\/j.jep.2021.114372_bib128","first-page":"6","article-title":"The experimental research of costustoot relieves delayed-coset diarrhea caused by irinotecan","volume":"44","author":"Mu","year":"2017","journal-title":"Guangdong. Chem. Industry"},{"key":"10.1016\/j.jep.2021.114372_bib129","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1081\/IPH-120037712","article-title":"Dehydrocostus lactone enhances tumor necrosis factor-\u03b1-induced apoptosis of human leukemia HL-60 cells. Immunopharmacol","volume":"26","author":"Oh","year":"2004","journal-title":"Immunotoxicol"},{"key":"10.1016\/j.jep.2021.114372_bib130","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.intimp.2016.10.006","article-title":"Costunolide, a sesquiterpene lactone, inhibits the differentiation of pro-inflammatory CD4+ T cells through the modulation of mitogen-activated protein kinases","author":"Park","year":"2016","journal-title":"Int. Immunopharm."},{"issue":"41254","key":"10.1016\/j.jep.2021.114372_bib132","article-title":"Costunolide and dehydrocostuslactone combination treatment inhibit breast cancer by inducing cell cycle arrest and apoptosis through c-Myc\/p53 and AKT\/14-3-3 pathway","volume":"7","author":"Peng","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2021.114372_bib133","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1002\/ptr.5155","article-title":"In vitro and in silico evaluation of NF-\u03baB targeted costunolide action on estrogen receptor-negative breast cancer cells-A comparison with normal breast cells","volume":"28","author":"Pitchai","year":"2014","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2021.114372_bib134","first-page":"269","article-title":"Effects of Radix Vladimiriae and paper-roast products on gastric empty and intestinal propulsive function of mice. West. China","volume":"25","author":"Qu","year":"2010","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.jep.2021.114372_bib135","first-page":"1442","article-title":"Experimental study on anti-inflammatory and analgesic effects of Radix Vladimiriae raw and baked. Lishizhen","volume":"21","author":"Qu","year":"2010","journal-title":"Med. Mater. Medica. Res."},{"key":"10.1016\/j.jep.2021.114372_bib136","doi-asserted-by":"crossref","first-page":"328","DOI":"10.3390\/12030328","article-title":"Acylated flavone glycosides from the roots of saussurea lappa and their antifungal activity","volume":"12","author":"Rao","year":"2007","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2021.114372_bib137","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.3390\/molecules18021418","article-title":"Induction of apoptosis by costunolide in bladder cancer cells is mediated through ROS generation and mitochondrial dysfunction","volume":"18","author":"Rasul","year":"2013","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2021.114372_bib138","first-page":"1079","article-title":"Costunolide inhibits proinflammatory cytokines and iNOS in activated murine BV2 microglia","volume":"1","author":"Rayan","year":"2011","journal-title":"Front. Biosci."},{"key":"10.1016\/j.jep.2021.114372_bib139","doi-asserted-by":"crossref","first-page":"615","DOI":"10.2174\/138955710791383992","article-title":"Bioactivity of sesquiterpenes: compounds that protect from alcohol-induced gastric mucosal lesions and oxidative damage","volume":"10","author":"Repetto","year":"2010","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.jep.2021.114372_bib140","doi-asserted-by":"crossref","first-page":"4015","DOI":"10.1016\/j.bmcl.2008.06.008","article-title":"A new sesquiterpene lactone from the roots of Saussurea lappa: structure\u2013anticancer activity study. Bioorg","volume":"18","author":"Robinson","year":"2008","journal-title":"Med. Chem. Lett."},{"key":"10.1016\/j.jep.2021.114372_bib141","first-page":"65","article-title":"Xiangsha weiling pills berberine trimethoprim treatment of chronic ulcerative colitis 80 case","volume":"23","author":"Rong","year":"2009","journal-title":"J. Pract. Tradit. Chin. Intern. 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Res."},{"key":"10.1016\/j.jep.2021.114372_bib147","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1016\/0031-9422(92)83317-R","article-title":"A biologicial active guaianolide from saussurea lappa","volume":"31","author":"Singh","year":"1992","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2021.114372_bib148","article-title":"Phytoconstituents from saussurea lappa roots","volume":"35","author":"Singh","year":"2004","journal-title":"ChemInform"},{"key":"10.1016\/j.jep.2021.114372_bib150","first-page":"399","article-title":"The protective effect of dehydrocostus lactone on liver injury in laboratory rats. World. Chin","volume":"10","author":"Sun","year":"2015","journal-title":"Med. Times"},{"key":"10.1016\/j.jep.2021.114372_bib149","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1021\/np030147e","article-title":"Cytotoxic sesquiterpene lactones from the root of saussurea lappa","volume":"66","author":"Sun","year":"2003","journal-title":"J. Nat. 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Archives. Tradit. Chin. Med"},{"key":"10.1016\/j.jep.2021.114372_bib156","first-page":"44","article-title":"Comparative studies of volatile constituents in ordinary powder and micronized powder of Aucklandia lappa Dence","volume":"25","author":"Tang","year":"2013","journal-title":"Strait. Pharma. J."},{"key":"10.1016\/j.jep.2021.114372_bib157","first-page":"2180","article-title":"Inhibitory effects of sesquiterpenes from Common Aucklandia Root on proliferation of five kinds cultured cancer cells in vitro","volume":"25","author":"Tang","year":"2010","journal-title":"Chin. J. Tradit. Chin. Med. 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