{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T09:28:15Z","timestamp":1768296495403,"version":"3.49.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T00:00:00Z","timestamp":1627430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.jep.2021.114449","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T04:22:59Z","timestamp":1627446179000},"page":"114449","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Babao Dan is a robust anti-tumor agent via inhibiting wnt\/\u03b2-catenin activation and cancer cell stemness"],"prefix":"10.1016","volume":"280","author":[{"given":"Xinxin","family":"Xie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinxiao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da","family":"Wo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"En","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongling","family":"Ning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weidong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7431-8156","authenticated-orcid":false,"given":"Dan-ni","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.jep.2021.114449_bib1","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1038\/nm.4409","article-title":"Cancer stem cells revisited","volume":"23","author":"Batlle","year":"2017","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.jep.2021.114449_bib2","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3727\/105221616X693639","article-title":"Novel advances in understanding of molecular pathogenesis of hepatoblastoma: a Wnt\/\u03b2-catenin perspective","volume":"17","author":"Bell","year":"2017","journal-title":"Gene Expr."},{"issue":"6","key":"10.1016\/j.jep.2021.114449_bib3","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.ccr.2008.11.002","article-title":"Hepatic stem-like phenotype and interplay of Wnt\/beta-catenin and Myc signaling in aggressive childhood liver cancer","volume":"14","author":"Cairo","year":"2008","journal-title":"Canc. Cell"},{"issue":"11","key":"10.1016\/j.jep.2021.114449_bib4","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.15252\/emmm.201707814","article-title":"Mutant CTNNB1 and histological heterogeneity define metabolic subtypes of hepatoblastoma","volume":"9","author":"Crippa","year":"2017","journal-title":"EMBO Mol. Med."},{"issue":"11","key":"10.1016\/j.jep.2021.114449_bib6","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.clinre.2011.05.010","article-title":"The Wnt\/\u03b2-catenin pathway as a therapeutic target in human hepatocellular carcinoma","volume":"35","author":"Dahmani","year":"2011","journal-title":"Clin Res Hepatol Gastroenterol"},{"issue":"15","key":"10.1016\/j.jep.2021.114449_bib7","doi-asserted-by":"crossref","first-page":"8847","DOI":"10.1073\/pnas.95.15.8847","article-title":"Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas","volume":"95","author":"de La Coste","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.jep.2021.114449_bib8","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3390\/cancers8070060","article-title":"Wnt signaling in cancer stem cell biology","volume":"8","author":"de Sousa E Melo","year":"2016","journal-title":"Cancers"},{"key":"10.1016\/j.jep.2021.114449_bib9","doi-asserted-by":"crossref","DOI":"10.1177\/0963689720912690","article-title":"Protective effects of human milk-derived exosomes on intestinal stem cells damaged by oxidative stress","volume":"29","author":"Dong","year":"2020","journal-title":"Cell Transplant."},{"issue":"6","key":"10.1016\/j.jep.2021.114449_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.26991","article-title":"A novel tissue-based \u00df-catenin gene and immunohistochemical analysis to exclude familial adenomatous polyposis among children with hepatoblastoma tumors","volume":"65","author":"Dubbink","year":"2018","journal-title":"Pediatr. Blood Canc."},{"issue":"7","key":"10.1016\/j.jep.2021.114449_bib12","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s12094-009-0380-4","article-title":"Wnt signalling and cancer stem cells","volume":"11","author":"Espada","year":"2009","journal-title":"Clin. Transl. Oncol."},{"issue":"2","key":"10.1016\/j.jep.2021.114449_bib13","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s10616-021-00454-7","article-title":"Diosgenin inhibits Wnt\/\u03b2-catenin pathway to regulate the proliferation and differentiation of MG-63 cells","volume":"73","author":"Ge","year":"2021","journal-title":"Cytotechnology"},{"issue":"8","key":"10.1016\/j.jep.2021.114449_bib14","doi-asserted-by":"crossref","first-page":"e320","DOI":"10.1097\/MPH.0b013e3182580471","article-title":"Relationship of \u03b2-catenin and postchemotherapy histopathologic changes with overall survival in patients with hepatoblastoma","volume":"34","author":"Gupta","year":"2012","journal-title":"J. Pediatr. Hematol. Oncol."},{"issue":"5","key":"10.1016\/j.jep.2021.114449_bib15","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nrc2389","article-title":"Wnt signalling and its impact on development and cancer","volume":"8","author":"Klaus","year":"2008","journal-title":"Nat. Rev. Canc."},{"issue":"5307","key":"10.1016\/j.jep.2021.114449_bib16","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1126\/science.275.5307.1784","article-title":"Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-\/- colon carcinoma","volume":"275","author":"Korinek","year":"1997","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.jep.2021.114449_bib17","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/MOP.0000000000000081","article-title":"Management of hepatoblastoma: an update","volume":"26","author":"Kremer","year":"2014","journal-title":"Curr. Opin. Pediatr."},{"issue":"50","key":"10.1016\/j.jep.2021.114449_bib18","doi-asserted-by":"crossref","first-page":"82554","DOI":"10.18632\/oncotarget.12783","article-title":"Babao Dan attenuates hepatic fibrosis by inhibiting hepatic stellate cells activation and proliferation via TLR4 signaling pathway","volume":"7","author":"Liang","year":"2016","journal-title":"Oncotarget"},{"issue":"10","key":"10.1016\/j.jep.2021.114449_bib19","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1016\/j.humpath.2009.07.003","article-title":"Hep G2 is a hepatoblastoma-derived cell line","volume":"40","author":"L\u00f3pez-Terrada","year":"2009","journal-title":"Hum. Pathol."},{"issue":"16","key":"10.1016\/j.jep.2021.114449_bib21","doi-asserted-by":"crossref","first-page":"4515","DOI":"10.1158\/0008-5472.CAN-13-3275","article-title":"\u03b2-catenin activation in a novel liver progenitor cell type is sufficient to cause hepatocellular carcinoma and hepatoblastoma","volume":"74","author":"Mokkapati","year":"2014","journal-title":"Canc. Res."},{"issue":"7","key":"10.1016\/j.jep.2021.114449_bib22","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1053\/j.gastro.2015.02.056","article-title":"\u03b2-Catenin signaling and roles in liver homeostasis, injury, and Tumorigenesis","volume":"148","author":"Monga","year":"2015","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.jep.2021.114449_bib23","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1245\/s10434-013-3430-7","article-title":"EpCAM-targeted therapy for human hepatocellular carcinoma","volume":"21","author":"Ogawa","year":"2014","journal-title":"Ann. Surg Oncol."},{"issue":"2","key":"10.1016\/j.jep.2021.114449_bib24","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/s41575-018-0075-9","article-title":"Wnt-\u03b2-catenin signalling in liver development, health and disease","volume":"16","author":"Perugorria","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"7035","key":"10.1016\/j.jep.2021.114449_bib25","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/nature03319","article-title":"Wnt signalling in stem cells and cancer","volume":"434","author":"Reya","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.jep.2021.114449_bib26","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1146\/annurev-pathol-020117-044010","article-title":"Wnt\/\u03b2-Catenin signaling in liver development, homeostasis, and pathobiology","volume":"13","author":"Russell","year":"2018","journal-title":"Annu. Rev. Pathol."},{"issue":"9","key":"10.1016\/j.jep.2021.114449_bib27","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20192466","article-title":"Wnt\/\u03b2-catenin signaling as a useful therapeutic target in hepatoblastoma","volume":"39","author":"Sha","year":"2019","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.jep.2021.114449_bib28","doi-asserted-by":"crossref","first-page":"584330","DOI":"10.3389\/fonc.2020.584330","article-title":"BaBao dan suppresses tumor growth of pancreatic cancer through modulating transcriptional reprogramming of cancer-related genes","volume":"10","author":"Song","year":"2020","journal-title":"Front Oncol"},{"issue":"11","key":"10.1016\/j.jep.2021.114449_bib29","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1002\/mnfr.201300155","article-title":"The dietary terpene lupeol targets colorectal cancer cells with constitutively active Wnt\/\u03b2-catenin signaling","volume":"57","author":"Tarapore","year":"2013","journal-title":"Mol. Nutr. Food Res."},{"issue":"10","key":"10.1016\/j.jep.2021.114449_bib30","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1093\/carcin\/bgq169","article-title":"Specific targeting of Wnt\/\u03b2-catenin signaling in human melanoma cells by a dietary triterpene lupeol","volume":"31","author":"Tarapore","year":"2010","journal-title":"Carcinogenesis"},{"issue":"2","key":"10.1016\/j.jep.2021.114449_bib31","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jhep.2009.10.026","article-title":"EpCAM, a new marker for cancer stem cells in hepatocellular carcinoma","volume":"52","author":"Terris","year":"2010","journal-title":"J. Hepatol."},{"issue":"8","key":"10.1016\/j.jep.2021.114449_bib32","first-page":"5272","article-title":"Babaodan inhibits cell growth by inducing autophagy through the PI3K\/AKT\/mTOR pathway and enhances antitumor effects of cisplatin in NSCLC cells","volume":"11","author":"Wang","year":"2019","journal-title":"Am J Transl Res"},{"key":"10.1016\/j.jep.2021.114449_bib33","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.biopha.2018.04.019","article-title":"Beneficial health effects of lupenone triterpene: a review","volume":"103","author":"Xu","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"22","key":"10.1016\/j.jep.2021.114449_bib34","doi-asserted-by":"crossref","first-page":"10831","DOI":"10.1158\/0008-5472.CAN-07-0908","article-title":"Activation of hepatic stem cell marker EpCAM by Wnt-beta-catenin signaling in hepatocellular carcinoma","volume":"67","author":"Yamashita","year":"2007","journal-title":"Canc. Res."},{"key":"10.1016\/j.jep.2021.114449_bib35","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13578-019-0343-6","article-title":"Babao Dan attenuates acute ethanol-induced liver injury via Nrf2 activation and autophagy","volume":"9","author":"Yu","year":"2019","journal-title":"Cell Biosci."},{"issue":"10","key":"10.1016\/j.jep.2021.114449_bib37","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/nrd2137","article-title":"Tumour-initiating cells: challenges and opportunities for anticancer drug discovery","volume":"8","author":"Zhou","year":"2009","journal-title":"Nat. Rev. Drug Discov."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121006784?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121006784?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:15:35Z","timestamp":1759943735000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874121006784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":33,"alternative-id":["S0378874121006784"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2021.114449","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Babao Dan is a robust anti-tumor agent via inhibiting wnt\/\u03b2-catenin activation and cancer cell stemness","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2021.114449","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"114449"}}