{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:21:28Z","timestamp":1791390088920,"version":"4.3.3"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T00:00:00Z","timestamp":1659052800000},"content-version":"vor","delay-in-days":270,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009730","name":"Universidade Federal de Ouro Preto - Campus Morro do Cruzeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009730","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.jep.2021.114460","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T01:33:45Z","timestamp":1627263225000},"page":"114460","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Lychnophora pinaster's effects on inflammation and pain in acute gout"],"prefix":"10.1016","volume":"280","author":[{"given":"Camila Helena","family":"Barros","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3575-2272","authenticated-orcid":false,"given":"Rafaela Cunha","family":"Matosinhos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4306-586X","authenticated-orcid":false,"given":"Ana Catharina Fernandes Pereira Ferreira","family":"Bernardes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1181-3560","authenticated-orcid":false,"given":"Marcela Carolina de Paula Michel","family":"Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Pantale\u00e3o","family":"Bezerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Sachs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Dian de Oliveira Aguiar","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7533-1248","authenticated-orcid":false,"given":"D\u00eania Antunes","family":"Sa\u00fade-Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2021.114460_bib1","series-title":"Hiperuricemia y gota: El papel de la dieta","author":"\u00c1lvarez-Lario","year":"2014"},{"key":"10.1016\/j.jep.2021.114460_bib2","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/art.33355","article-title":"NLRP3 inflammasome\u2013mediated neutrophil recruitment and hypernociception depend on leukotriene B4 in a murine model of gout","volume":"64","author":"Amaral","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jep.2021.114460_bib3","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1111\/j.2042-7158.2011.01300.x","article-title":"Anti-inflammatory, analgesic and antipyretic effects of friedelin isolated from Azima tetracantha Lam. in mouse and rat models","volume":"63","author":"Antonisamy","year":"2011","journal-title":"J. Pharmacol. Pharmacother."},{"key":"10.1016\/j.jep.2021.114460_bib4","first-page":"346","article-title":"Revis\u00e3o Cr\u00edtica do tratamento medicamentoso da gota no Brasil","volume":"57","author":"Azevedo","year":"2017","journal-title":"RBR"},{"key":"10.1016\/j.jep.2021.114460_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113738","article-title":"Sesquiterpene lactones from Lychnophora species: antinociceptive, anti-inflammatory, and antioxidant pathways to treat acute gout","volume":"269","author":"Bernardes","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114460_bib6","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1021\/np400222v","article-title":"Vitexin inhibits inflammatory pain in mice by targeting TRPV1, oxidative stress, and cytokines","volume":"76","author":"Borghi","year":"2013","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2021.114460_bib7","first-page":"593","article-title":"Quercetin reduces the transcriptional activity of NF-kB in stable coronary artery disease","volume":"70","author":"Chekalina","year":"2018","journal-title":"IHJ"},{"key":"10.1016\/j.jep.2021.114460_bib8","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/(SICI)1099-1573(199611)10:7<636::AID-PTR921>3.0.CO;2-6","article-title":"In vitro screening of asteraceae plant species against Trypanosoma cruzi","volume":"10","author":"Chiari","year":"1996","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2021.114460_bib9","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1248\/bpb.29.2236","article-title":"Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid","volume":"29","author":"Dos Santos","year":"2006","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jep.2021.114460_bib10","first-page":"145","article-title":"New and improved strategies for treatment of gout","volume":"3","author":"Dubchack","year":"2010","journal-title":"Int. J. Nephrol. Renovascular Dis."},{"key":"10.1016\/j.jep.2021.114460_bib11","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jep.2016.01.007","article-title":"Effects of Pimenta pseudocaryophyllus extracts on gout: anti-inflammatory activity and anti-hyperuricemic effect through xantine oxidase and uricosuric action","volume":"180","author":"Ferrari","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114460_bib12","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jep.2006.02.011","article-title":"Xanthine oxidase inibitory activity of Lychnophora species from Brazil (\u2018\u2018Arnica\u2019\u2019)","volume":"107","author":"Ferraz-Filha","year":"2006","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114460_bib13","first-page":"1","article-title":"Tabebuia roseoalba: in vivo hypouricemic and anti-inflammatory effects of its ethanolic extract and constituents","volume":"82","author":"Ferraz-Filha","year":"2016","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2021.114460_bib14","first-page":"2017","article-title":"Effects of the aqueous extract from Tabebuia roseoalba and phenolic acids on hyperuricemia and inflammation","author":"Ferraz-Filha","year":"2017","journal-title":"Evid-Based Compl. Alt. Med."},{"key":"10.1016\/j.jep.2021.114460_bib15","doi-asserted-by":"crossref","first-page":"26","DOI":"10.29327\/226760.1.1-4","article-title":"Topical anti-inflammatory effect and antinociception of Lychnophora pinaster (Brazilian Arnica) ethanolic extract","volume":"1","author":"Ferreira","year":"2019","journal-title":"Brazilian Journal of Health and Pharmacy"},{"key":"10.1016\/j.jep.2021.114460_bib16","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0014-827X(01)01111-9","article-title":"Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat","volume":"56","author":"Guardia","year":"2001","journal-title":"Farmaco"},{"key":"10.1016\/j.jep.2021.114460_bib17","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jep.2007.11.006","article-title":"Antinociceptive and antiinflammatory activities of ethanolic extracts of Lychnophora species","volume":"116","author":"Guzzo","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114460_bib18","doi-asserted-by":"crossref","first-page":"106642","DOI":"10.1016\/j.intimp.2020.106642","article-title":"Stigmasterol protects rats from collagen induced arthritis by inhibiting proinflammatory cytokines","volume":"85","author":"Khan","year":"2020","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.jep.2021.114460_bib19","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1590\/S0100-40422010001000038","article-title":"Lychnophorinae (Asteraceae): a survey of its chemical constituents and biological activities","volume":"33","author":"Keles","year":"2010","journal-title":"Quim. Nova"},{"key":"10.1016\/j.jep.2021.114460_bib20","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s12272-013-0211-6","article-title":"Caffeic acid regulates LPS-induced NF-\u03baB activation through NIK\/IKK and c-Src\/ERK signaling pathways in endothelial cells","volume":"37","author":"Kim","year":"2014","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.jep.2021.114460_bib21","doi-asserted-by":"crossref","first-page":"111","DOI":"10.5142\/JGR.2009.33.2.111","article-title":"Neuroprotective and anti-inflammatory effects of phenolic compounds in Panax ginseng CA Meyer","volume":"33","author":"Kong","year":"2009","journal-title":"J. Ginseng Res."},{"key":"10.1016\/j.jep.2021.114460_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/JAHA.113.000157","article-title":"Interacion of inflamacion, hyperuricemia, and the prevalence of hypertension among adults free off metabolic syndrome: NHANES \u2013 2009-2010","volume":"3","author":"Krishnan","year":"2014","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.jep.2021.114460_bib23","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.lfs.2016.01.001","article-title":"Lupeol inhibits LPS-induced NF-kappa B signaling in intestinal epithelial cells and macrophages and attenuates acute and chronic murine colitis","volume":"146","author":"Lee","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.jep.2021.114460_bib24","first-page":"791","article-title":"Abordagem actual da Gota","volume":"24","author":"Mediavilla","year":"2011","journal-title":"AMPHIPACIFICA"},{"key":"10.1016\/j.jep.2021.114460_bib25","article-title":"Lychnophora pinaster ethanolic extract and its chemical constituents ameliorate hyperuricemia and related inflammation","volume":"242","author":"M\u00fcller","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114460_bib27","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3831\/KPI.2017.20.003","article-title":"Treatment with rutin - a therapeutic strategy for neutrophil-mediated inflammatory and autoimmune diseases","volume":"20","author":"Nikfarjam","year":"2017","journal-title":"J. Pharmacopuncture"},{"key":"10.1016\/j.jep.2021.114460_bib28","first-page":"127","article-title":"Anti-inflammatory effects of quercetin and vitexin on activated human peripheral blood neutrophils","volume":"20","author":"Nikfarjam","year":"2017","journal-title":"J. Pharmacopuncture"},{"key":"10.1016\/j.jep.2021.114460_bib29","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/(SICI)1099-1573(199606)10:4<292::AID-PTR834>3.0.CO;2-O","article-title":"Trypanocidal sesquiterpenes from Lychnophora species","volume":"10","author":"Oliveira","year":"1996","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2021.114460_bib30","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.reuma.2010.09.002","article-title":"Gota: pasado, presente y futuro","volume":"7","author":"P\u00e9rez-Ruiz","year":"2011","journal-title":"Reumatol. Cl\u00ednica"},{"key":"10.1016\/j.jep.2021.114460_bib31","first-page":"102","article-title":"Levantamento etnobot\u00e2nico de plantas medicinais do dom\u00ednio cerrado na regi\u00e3o do Alto Rio Grande - Minas Gerais","volume":"25","author":"Rodrigues","year":"2001","journal-title":"Cienc. E Agrotecnol"},{"key":"10.1016\/j.jep.2021.114460_bib32","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1093\/jn\/137.5.1208","article-title":"Quercetin inhibits TNF-induced NF-kB transcription factor recruitment to proinflammatory gene promoters in murine intestinal epithelial cells","volume":"137","author":"Ruiz","year":"2007","journal-title":"J. Nutr."},{"key":"10.1016\/j.jep.2021.114460_bib33","doi-asserted-by":"crossref","DOI":"10.5380\/rmu.v3i1.46382","article-title":"Gota: uma revis\u00e3o","author":"Santos","year":"2016","journal-title":"Ver. Med. UFPR"},{"key":"10.1016\/j.jep.2021.114460_bib34","first-page":"90","article-title":"Constituents from the aerial parts of Lychnophora trichocarpha","volume":"69","author":"Sa\u00fade","year":"1998","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2021.114460_bib35","doi-asserted-by":"crossref","first-page":"5950","DOI":"10.1039\/C8FO01286E","article-title":"Anti-inflammatory effects of cinnamon extract and identification of active compounds influencing the TLR2 and TLR4 signaling pathways","volume":"9","author":"Schink","year":"2018","journal-title":"Food Funct"},{"key":"10.1016\/j.jep.2021.114460_bib36","series-title":"Revis\u00e3o taxonomica de Lychnophora Mart. (Vernoniaeae: Compositae)","author":"Semir","year":"1991"},{"key":"10.1016\/j.jep.2021.114460_bib37","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1078\/0940-2993-00260","article-title":"Anti-inflammatory effect of rutin on rat paw oedema, and on neutrophils chemotaxis and degranulation","volume":"54","author":"Selloum","year":"2003","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.jep.2021.114460_bib38","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.medcli.2016.10.019","article-title":"Diagn\u00f3stico y tratamiento de la gota","volume":"148","author":"Sivera","year":"2016","journal-title":"Med. Clin."},{"key":"10.1016\/j.jep.2021.114460_bib39","series-title":"Caracteriza\u00e7\u00e3o da diversidade gen\u00e9tica e composi\u00e7\u00e3o qu\u00edmica de Lychnophora pinaster Mart. Tese (Doutorado) - Curso de Ci\u00eancias Agron\u00f4micas, Universidade Estadual Paulista \"J\u00falio de Mesquita Filho","author":"Silva","year":"2016"},{"key":"10.1016\/j.jep.2021.114460_bib40","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1590\/S0102-695X2005000400006","article-title":"Biological activity of the aqueous extract of Lychnophora pinaster Mart","volume":"15","author":"Silveira","year":"2005","journal-title":"Rev. Bras. Farmacog."},{"key":"10.1016\/j.jep.2021.114460_bib41","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1159\/000451027","article-title":"Rutin attenuates oxidative stress and proinflammatory cytokine level in adjuvant induced rheumatoid arthritis via inhibition of NF-\u03baB","volume":"100","author":"Sun","year":"2017","journal-title":"Pharmacol"},{"key":"10.1016\/j.jep.2021.114460_bib42","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.pharmthera.2006.04.001","article-title":"Hypernociceptive role of cytokines and chemokines: targets for analgesic drug development?","volume":"112","author":"Verri","year":"2006","journal-title":"Pharmacol. Ther."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121006899?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121006899?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:14:27Z","timestamp":1759943667000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874121006899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":41,"alternative-id":["S0378874121006899"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2021.114460","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lychnophora pinaster's effects on inflammation and pain in acute gout","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2021.114460","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"114460"}}