{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:20:52Z","timestamp":1793031652947,"version":"4.5.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005672","name":"Funda\u00e7\u00e3o de Apoio ao Desenvolvimento do Ensino, Ci\u00eancia e Tecnologia do Estado de Mato Grosso do Sul","doi-asserted-by":"publisher","award":["59\/300.046\/2015"],"award-info":[{"award-number":["59\/300.046\/2015"]}],"id":[{"id":"10.13039\/501100005672","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005672","name":"Funda\u00e7\u00e3o de Apoio ao Desenvolvimento do Ensino, Ci\u00eancia e Tecnologia do Estado de Mato Grosso do Sul","doi-asserted-by":"publisher","award":["71\/700.135\/2018"],"award-info":[{"award-number":["71\/700.135\/2018"]}],"id":[{"id":"10.13039\/501100005672","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["407685\/2018-9"],"award-info":[{"award-number":["407685\/2018-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["449464\/2014-8"],"award-info":[{"award-number":["449464\/2014-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.jep.2021.114568","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T11:20:13Z","timestamp":1630063213000},"page":"114568","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Cardioprotective effects of Talinum paniculatum (Jacq.) Gaertn. in doxorubicin-induced cardiotoxicity in hypertensive rats"],"prefix":"10.1016","volume":"281","author":[{"given":"Carla Ge\u00f3rgia Rodrigues Guimar\u00e3es","family":"Souto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth\u00e2nia Rosa","family":"Loren\u00e7one","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline Aparecida Macedo","family":"Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8941-6592","authenticated-orcid":false,"given":"Rhanany Alan Calloi","family":"Palozi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Vitor Moreira","family":"Rom\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0733-1975","authenticated-orcid":false,"given":"Lucas Pires","family":"Guarnier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cleide Adriane Signor","family":"Tirloni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariany Carvalho","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roosevelt Isa\u00edas Carvalho","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila Megda Jo\u00e3o Job","family":"Zago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francislaine Aparecida dos Reis","family":"L\u00edvero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emerson Luiz Botelho","family":"Louren\u00e7o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise Brentan","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3433-5098","authenticated-orcid":false,"given":"Arquimedes","family":"Gasparotto Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2021.114568_bib2","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.foodchem.2017.02.036","article-title":"Comprehensive chlorophyll composition in the main edible seaweeds","volume":"228","author":"Chen","year":"2017","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2021.114568_bib3","doi-asserted-by":"crossref","first-page":"625","DOI":"10.3904\/kjim.2016.017","article-title":"Pathophysiology and preventive strategies of anthracycline-induced cardiotoxicity","volume":"31","author":"Chung","year":"2016","journal-title":"Korean J. Intern. Med."},{"key":"10.1016\/j.jep.2021.114568_bib4","doi-asserted-by":"crossref","first-page":"2900","DOI":"10.1021\/jf026187q","article-title":"Hierarchical scheme for LCMSn identification of chlorogenic acids","volume":"51","author":"Clifford","year":"2003","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2021.114568_bib5","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1007\/s10943-018-0713-0","article-title":"Traditional plants used by remaining healers from the region of Grande Dourados, Mato Grosso do Sul, Brazil","volume":"58","author":"Coelho","year":"2019","journal-title":"J. Relig. Health"},{"key":"10.1016\/j.jep.2021.114568_bib6","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1016\/j.bbadis.2013.04.002","article-title":"Electrophysiological changes in heart failure and their implications for arrhythmogenesis","volume":"1832","author":"Coronel","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jep.2021.114568_bib7","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1590\/S0036-46652015000500005","article-title":"Chemical characterization and evaluation of antibacterial, antifungal, antimycobacterial, and cytotoxic activities of Talinum paniculatum","volume":"57","author":"Dos Reis","year":"2015","journal-title":"Rev. Inst. Med. Trop. S. Paulo"},{"issue":"4","key":"10.1016\/j.jep.2021.114568_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26041000","article-title":"Chemical profile of Launaea nudicaulis ethanolic extract and its antidiabetic effect in streptozotocin-induced rats","volume":"26","author":"El-Newary","year":"2021","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.jep.2021.114568_bib9","doi-asserted-by":"crossref","first-page":"166037","DOI":"10.1016\/j.bbadis.2020.166037","article-title":"New drug targets for hypertension: a literature review","volume":"1867","author":"Gao","year":"2021","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"key":"10.1016\/j.jep.2021.114568_bib10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ijms.2014.01.021","article-title":"Rapid characterization of chemical constituents in Saniculiphyllum guangxiense by ultra-fast liquid chromatography with diode array detection and electrospray ionization tandem mass spectrometry","volume":"361","author":"Geng","year":"2014","journal-title":"Int. J. Mass Spectrom."},{"key":"10.1016\/j.jep.2021.114568_bib11","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.jep.2009.01.021","article-title":"Natriuretic and diuretic effects of Tropaeolum majus (Tropaeolaceae) in rats","volume":"122","author":"Gasparotto Junior","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114568_bib12","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.jep.2010.12.026","article-title":"Antihypertensive effects of isoquercitrin and extracts from Tropaeolum majus L.: evidence for the inhibition of angiotensin converting enzyme","volume":"134","author":"Gasparotto Junior","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114568_bib13","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.ejphar.2016.08.006","article-title":"Nitric oxide and Kir6.1 potassium channel mediate isoquercitrin-induced endothelium-dependent and independent vasodilation in the mesenteric arterial bed of rats","volume":"788","author":"Gasparotto Junior","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2021.114568_bib14","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1084\/jem.59.3.347","article-title":"Studies on experimental hypertension: I. The production of persistent elevation of systolic blood pressure by means of renal ischemia","volume":"59","author":"Goldblatt","year":"1934","journal-title":"J. Exp. Med."},{"issue":"11","key":"10.1016\/j.jep.2021.114568_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/biom9110664","article-title":"Development of a predictive model to induce atherogenesis and hepato-renal impairment in female rats","volume":"9","author":"Guarnier","year":"2019","journal-title":"Biomolecules"},{"issue":"4","key":"10.1016\/j.jep.2021.114568_bib16","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.ecl.2019.08.007","article-title":"Renovascular hypertension","volume":"48","author":"Herrmann","year":"2019","journal-title":"Endocrinol Metab. Clin. N. Am."},{"key":"10.1016\/j.jep.2021.114568_bib17","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.jpba.2019.06.011","article-title":"Rapid profiling of alkaloid analogues in Sinomenii Caulis by an integrated characterization strategy and quantitative analysis","volume":"174","author":"Jiang","year":"2019","journal-title":"J. Pharmaceut. Biomed. Anal."},{"key":"10.1016\/j.jep.2021.114568_bib18","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.2174\/092986706776360860","article-title":"Antidiabetic agents from medicinal plants","volume":"13","author":"Jung","year":"2006","journal-title":"Curr. Med. Chem."},{"issue":"12","key":"10.1016\/j.jep.2021.114568_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/molecules21121614","article-title":"Screening for triterpenoid saponins in plants using hyphenated analytical platforms","volume":"21","author":"Khakimov","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2021.114568_bib20","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1161\/CIRCRESAHA.113.300218","article-title":"Emerging paradigms in cardiomyopathies associated with cancer therapies","volume":"113","author":"Ky","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.jep.2021.114568_bib21","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1161\/CIRCULATIONAHA.115.017443","article-title":"Doxorubicin blocks cardiomyocyte autophagic flux by inhibiting lysosome acidification","volume":"133","author":"Li","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.jep.2021.114568_bib22","doi-asserted-by":"crossref","first-page":"857","DOI":"10.3390\/molecules23040857","article-title":"Chloroplast genome of the folk medicine and vegetable plant Talinum paniculatum (Jacq.) Gaertn: gene organization, comparative and phylogenetic analysis","volume":"23","author":"Liu","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2021.114568_bib23","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.yjmcc.2018.11.019","article-title":"Progression of excitation-contraction coupling defects in doxorubicin cardiotoxicity","volume":"126","author":"Llach","year":"2019","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.jep.2021.114568_bib24","series-title":"Techniques of Flavonoid Identification","first-page":"36","article-title":"Ultraviolet-visible absorption spectroscopy","author":"Markham","year":"1982"},{"key":"10.1016\/j.jep.2021.114568_bib25","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jpba.2012.09.014","article-title":"LC-ESI-MS quali-quantitative determination of phenolic constituents in different parts of wild and cultivated Astragalus gombiformis","volume":"72","author":"Montoro","year":"2013","journal-title":"J. Pharmaceut. Biomed. Anal."},{"key":"10.1016\/j.jep.2021.114568_bib26","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.yjmcc.2012.03.006","article-title":"Doxorubicin-induced cardiomyopathy: from molecular mechanisms to therapeutic strategies","volume":"52","author":"Octavia","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.jep.2021.114568_bib27","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jep.2009.07.015","article-title":"Ta'ta', Huayani: perception of leishmaniasis and evaluation of medicinal plants used by the Chayahuita in Peru. Part II","volume":"126","author":"Odonne","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114568_bib28","doi-asserted-by":"crossref","first-page":"112916","DOI":"10.1016\/j.jep.2020.112916","article-title":"From general toxicology to DNA disruption: a safety assessment of Plinia cauliflora (Mart.)","volume":"258","author":"Palozi","year":"2020","journal-title":"Kausel. J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114568_bib29","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jep.2005.06.006","article-title":"Ethnopharmacology and drug discovery","volume":"100","author":"Patwardhan","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114568_bib30","first-page":"1","article-title":"Antioxidant capacity determination in plants and plant-derived products: a review","author":"Pisoschi","year":"2016","journal-title":"Oxid. Med. Cell Longev."},{"issue":"4","key":"10.1016\/j.jep.2021.114568_bib31","doi-asserted-by":"crossref","first-page":"133","DOI":"10.14715\/cmb\/2020.66.4.18","article-title":"Potassium channels on smooth muscle as a molecular target for plant-derived Resveratrol","volume":"66","author":"Rajkovic","year":"2020","journal-title":"Cell. Mol. Biol. (Noisy-Le-Grand)"},{"key":"10.1016\/j.jep.2021.114568_bib32","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ejphar.2017.10.043","article-title":"Molecular mechanism of doxorubicin-induced cardiomyopathy - an update","volume":"818","author":"Renu","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2021.114568_bib33","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1161\/01.HYP.7.2.244","article-title":"An improved fluorometric assay of rat serum and plasma converting enzyme","volume":"7","author":"Santos","year":"1985","journal-title":"Hypertension"},{"key":"10.1016\/j.jep.2021.114568_bib34","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s11120-018-00611-8","article-title":"Spectral signatures of five hydroxymethyl chlorophyll a derivatives chemically derived from chlorophyll b or chlorophyll f","volume":"140","author":"Sawicki","year":"2019","journal-title":"Photosynth. Res."},{"key":"10.1016\/j.jep.2021.114568_bib35","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/0006-291X(89)91067-X","article-title":"Enzymatic formation of nitrogen oxides from L-arginine in bovine brain cytosol","volume":"165","author":"Schmidt","year":"1989","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jep.2021.114568_bib36","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/s42003-018-0162-z","article-title":"Doxorubicin induces caspase-mediated proteolysis of KV7","volume":"1","author":"Strigli","year":"2018","journal-title":"Commun. Biol."},{"issue":"6","key":"10.1016\/j.jep.2021.114568_bib37","first-page":"2311","article-title":"Review: medicinal plants combating against hypertension: a green antihypertensive approach","volume":"30","author":"Sultana","year":"2017","journal-title":"Pak. J. Pharm. Sci."},{"key":"10.1016\/j.jep.2021.114568_bib38","first-page":"478","article-title":"Talinum paniculatum (Jacq.) Gaertn: a medicinal plant with potential estrogenic activity in ovariectomized rats","volume":"5","author":"Thanamool","year":"2013","journal-title":"Int. J. Pharm. Pharmaceut. Sci."},{"issue":"1","key":"10.1016\/j.jep.2021.114568_bib39","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1177\/0960327120945756","article-title":"Effects of Talinum paniculatum (Jacq.) Gaertn. leaf extract on general toxicity and pubertal development of rats","volume":"40","author":"Tolouei","year":"2021","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.jep.2021.114568_bib40","doi-asserted-by":"crossref","first-page":"111873","DOI":"10.1016\/j.jep.2019.111873","article-title":"Ethnopharmacological approaches for Talinum paniculatum (Jacq.) Gaertn. - exploring the cardiorenal effects of the Brazilian Cerrado","volume":"238","author":"Tolouei","year":"2019","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.jep.2021.114568_bib42","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3810\/pgm.2009.05.2007","article-title":"Beta-blockers in the treatment of hypertension: are there clinically relevant differences?","volume":"121","author":"Weir","year":"2009","journal-title":"Postgrad. Med."},{"issue":"10","key":"10.1016\/j.jep.2021.114568_bib43","first-page":"1953","volume":"36","author":"Williams","year":"2018","journal-title":"Eur. Heart J."},{"issue":"6","key":"10.1016\/j.jep.2021.114568_bib44","doi-asserted-by":"crossref","first-page":"100041","DOI":"10.1016\/j.ijchy.2020.100041","article-title":"Position statement of the Interamerican Society of Cardiology (IASC) on the current guidelines for the prevention, diagnosis, and treatment of arterial hypertension 2017\u20132020","volume":"15","author":"Wyss","year":"2020","journal-title":"Int. J. Cardiol. Hypertens."},{"key":"10.1016\/j.jep.2021.114568_bib45","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3389\/fphys.2014.00094","article-title":"Effects of curcumin on ion channels and transporters","volume":"5","author":"Zhang","year":"2014","journal-title":"Front. Physiol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121007972?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121007972?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,27]],"date-time":"2025-07-27T10:21:06Z","timestamp":1753611666000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874121007972"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":43,"alternative-id":["S0378874121007972"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2021.114568","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardioprotective effects of Talinum paniculatum (Jacq.) Gaertn. in doxorubicin-induced cardiotoxicity in hypertensive rats","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2021.114568","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114568"}}