{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T06:07:40Z","timestamp":1785564460961,"version":"3.56.0"},"reference-count":140,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.jep.2021.114589","type":"journal-article","created":{"date-parts":[[2021,9,4]],"date-time":"2021-09-04T18:54:49Z","timestamp":1630781689000},"page":"114589","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"special_numbering":"C","title":["Role of medicinal plants from North Western Himalayas as an efflux pump inhibitor against MDR AcrAB-TolC Salmonella enterica serovar typhimurium: In vitro and In silico studies"],"prefix":"10.1016","volume":"282","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5954-5046","authenticated-orcid":false,"given":"Jyoti","family":"Mehta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajan","family":"Rolta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal","family":"Dev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2021.114589_bib1","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1128\/AAC.00084-08","article-title":"RamR Mutations Involved in Efflux-Mediated Multidrug Resistance in Salmonella enterica Serovar Typhimurium","volume":"52","author":"Abouzeed","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"issue":"5","key":"10.1016\/j.jep.2021.114589_bib3","doi-asserted-by":"crossref","first-page":"310","DOI":"10.4103\/0972-5229.132495","article-title":"Current concepts in combination antibiotic therapy for critically ill patients","volume":"18","author":"Ahmed","year":"2014","journal-title":"Indian J. Crit. Care Med."},{"issue":"5","key":"10.1016\/j.jep.2021.114589_bib4","doi-asserted-by":"crossref","first-page":"929","DOI":"10.4314\/tjpr.v15i5.5","article-title":"Ziziphus mauritiana leaf extract emulsion for skin rejuvenation","volume":"15","author":"Akhtar","year":"2016","journal-title":"Trop. J. Pharmaceut. Res."},{"key":"10.1016\/j.jep.2021.114589_bib5","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1093\/jac\/dky042","article-title":"Role of bacterial efflux pumps in biofilm formation","volume":"73","author":"Alav","year":"2018","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.jep.2021.114589_bib6","first-page":"512","article-title":"Potency of Barleria prionitis L. bark extracts against oral diseases causing strains of bacteria and fungi of clinical origin","volume":"3","author":"Aneja","year":"2010","journal-title":"Nucl. Sci. J."},{"key":"10.1016\/j.jep.2021.114589_bib7","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1023\/A:1025128104056","article-title":"Broad-spectrum antibacterial and anti-fungal properties of certain traditionally used Indian medicinal plants","volume":"19","author":"Aqil","year":"2003","journal-title":"World J. Microbiol. Biotechnol."},{"issue":"7","key":"10.1016\/j.jep.2021.114589_bib8","first-page":"309","article-title":"Ginger","volume":"125","author":"Awang","year":"1992","journal-title":"Can. Pharmaceut. J."},{"key":"10.1016\/j.jep.2021.114589_bib9","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1080\/14786419.2014.895729","article-title":"Efflux-pump inhibitory activity of a gallotannin from Terminalia chebula fruit against multidrug-resistant uropathogenic Escherichia coli","volume":"28","author":"Bag","year":"2014","journal-title":"Nat. Prod. Res."},{"issue":"6","key":"10.1016\/j.jep.2021.114589_bib10","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1023\/A:1025720306045","article-title":"55 kb plasmid and virulence-associated genes are positively correlated with Salmonella enteritidis pathogenicity in mice and chickens","volume":"27","author":"Bakshi","year":"2003","journal-title":"Vet. Res. Commun."},{"key":"10.1016\/j.jep.2021.114589_bib11","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/nar\/gky318","article-title":"ProTox-II: a webserver for the prediction of toxicity of chemicals","volume":"46","author":"Banerjee","year":"2018","journal-title":"Nucleic Acids Res."},{"issue":"10","key":"10.1016\/j.jep.2021.114589_bib12","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.1128\/AAC.48.10.3729-3735.2004","article-title":"AcrAB-TolC directs efflux-mediated multidrug resistance in Salmonella enterica serovar typhimurium DT104","volume":"48","author":"Baucheron","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jep.2021.114589_bib13","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3389\/fmicb.2014.00012","article-title":"Lack of efflux mediated quinolone resistance in Salmonella enterica serovars Typhi and Paratyphi A","volume":"5","author":"Baucheron","year":"2014","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jep.2021.114589_bib15","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1021\/np058057s","article-title":"Metabolites of the \u201cSmoke Tree\u201d, Dalea spinosa, potentiate antibiotic activity against multidrug-resistant Staphylococcus aureus","volume":"69","author":"Belofsky","year":"2006","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2021.114589_bib16","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2174\/157489112799829710","article-title":"Bacterial efflux pumps involved in multidrug resistance and their inhibitors: rejuvinating the antimicrobial chemotherapy","volume":"7","author":"Bhardwaj","year":"2012","journal-title":"Recent Pat. Anti-Infect. Drug Discov."},{"key":"10.1016\/j.jep.2021.114589_bib17","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1472-6882-11-52","article-title":"Antibacterial activity of some selected medicinal plants of Pakistan","volume":"11","author":"Bibi","year":"2011","journal-title":"BMC Compl. Alternative Med."},{"issue":"4","key":"10.1016\/j.jep.2021.114589_bib18","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00840-16","article-title":"How to measure export via bacterial multidrug resistance efflux pumps","volume":"7","author":"Blair","year":"2016","journal-title":"mBio"},{"key":"10.1016\/j.jep.2021.114589_bib19","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/nrmicro3380","article-title":"Molecular mechanisms of antibiotic resistance","volume":"13","author":"Blair","year":"2015","journal-title":"Nat. Rev. Microbiol."},{"issue":"1","key":"10.1016\/j.jep.2021.114589_bib20","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3390\/microorganisms4010014","article-title":"Bacterial multidrug efflux pumps: much more than antibiotic resistance determinants","volume":"4","author":"Blanco","year":"2016","journal-title":"Microorganisms"},{"key":"10.1016\/j.jep.2021.114589_bib21","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1111\/j.1462-5822.2005.00671.x","article-title":"The AcrAB-TolC efflux system of Salmonella enterica serovar Typhimurium plays a role in pathogenesis","volume":"8","author":"Buckley","year":"2006","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.jep.2021.114589_bib22","first-page":"57","article-title":"Developing new antimicrobial therapies: are synergistic combinations of plants extracts\/compounds with conventional antibiotics the solution?","volume":"22","author":"Cheesman","year":"2017","journal-title":"Pharmacogn. Rev."},{"key":"10.1016\/j.jep.2021.114589_bib24","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1021\/ci300367a","article-title":"AdmetSAR: a comprehensive source and free tool for assessment of chemical ADMET properties","volume":"52","author":"Cheng","year":"2012","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.jep.2021.114589_bib25","doi-asserted-by":"crossref","first-page":"705","DOI":"10.2174\/1386207319666160720101502","article-title":"Screening of natural products and derivatives for the identification of RND efflux pump inhibitors","volume":"19","author":"Choudhury","year":"2016","journal-title":"Comb. Chem. High Throughput Screen."},{"key":"10.1016\/j.jep.2021.114589_bib153","series-title":"Performance Standards for Antimicrobial Disc Suspectibility Tests","author":"CLSI","year":"1993"},{"key":"10.1016\/j.jep.2021.114589_bib154","series-title":"Performance standards for antimicrobial disk and dilution susceptibility tests for bacteria isolated from animals","author":"CLSI","year":"2013"},{"key":"10.1016\/j.jep.2021.114589_bib26","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3390\/antibiotics2010083","article-title":"Resistance to antimicrobials mediated by efflux pumps in Staphylococcus aureus","volume":"2","author":"Costa","year":"2013","journal-title":"Antibiotics"},{"key":"10.1016\/j.jep.2021.114589_bib27","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2174\/1874285801307010059","article-title":"Multidrug efflux pumps in Staphylococcus aureus: an update","volume":"7","author":"Costa","year":"2013","journal-title":"Open Microbiol. J."},{"key":"10.1016\/j.jep.2021.114589_bib147","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.3109\/13880200903382686","article-title":"In vitro additive effect of Hyptis martiusii in the resistance to aminoglycosides of methicillin-resistant Staphylococcus aureus","volume":"48","author":"Coutinho","year":"2010","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jep.2021.114589_bib148","doi-asserted-by":"crossref","first-page":"231","DOI":"10.4067\/S0718-58392011000200008","article-title":"Antifungal activity of Medicinal Plant Extracts against Phytopathogenic Fungus Alternaria Spp","volume":"7","author":"Dellavalle","year":"2011","journal-title":"Chil. J. Agric. Res."},{"key":"10.1016\/j.jep.2021.114589_bib28","doi-asserted-by":"crossref","first-page":"660","DOI":"10.3389\/fmicb.2015.00660","article-title":"Interaction of antibacterial compounds with RND efflux pumps in Pseudomonas aeruginosa","volume":"6","author":"Dreier","year":"2015","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jep.2021.114589_bib29","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/nature13205","article-title":"Structure of the AcrAB-TolC multidrug efflux pump","volume":"509","author":"Du","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jep.2021.114589_bib30","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1515\/hsz-2015-0118","article-title":"The pseudo-atomic structure of an RND-type tripartite multidrug efflux pump","volume":"396","author":"Du","year":"2015","journal-title":"Biol. Chem."},{"key":"10.1016\/j.jep.2021.114589_bib31","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/s41579-018-0048-6","article-title":"Multidrug efflux pumps: structure, function and regulation","volume":"16","author":"Du","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.jep.2021.114589_bib32","series-title":"Medicinal Plants of China","author":"Duke","year":"1985"},{"key":"10.1016\/j.jep.2021.114589_bib33","series-title":"Handbook of Medicinal Herbs","author":"Duke","year":"2002"},{"key":"10.1016\/j.jep.2021.114589_bib34","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/cbdd.12263","article-title":"4-Hydroxy-\u03b1-tetralone and its derivative as drug resistance reversal agents in multidrug resistant Escherichia coli","volume":"3","author":"Dwivedi","year":"2014","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.jep.2021.114589_bib35","series-title":"Pharmacodynamic Basis of Herbal Medicine","author":"Ebadi","year":"2007"},{"key":"10.1016\/j.jep.2021.114589_bib36","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3389\/fmicb.2019.00337","article-title":"Essential oil, extracts, and sesquiterpenes obtained from the heartwood of pilgerodendron uviferum act as potential inhibitors of the Staphylococcus aureus NorA multidrug efflux pump","volume":"10","author":"Espinoza","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jep.2021.114589_bib37","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1055\/s-0030-1250606","article-title":"Goldenseal (Hydrastis canadensis L.) extracts synergistically enhance the antibacterial activity of berberine via efflux pump inhibition","volume":"77","author":"Ettefagh","year":"2011","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2021.114589_bib38","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ijantimicag.2007.12.010","article-title":"Quinolone resistance in the food chain","volume":"31","author":"F\u00e0brega","year":"2008","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.jep.2021.114589_bib39","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1128\/CMR.00043-12","article-title":"Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance","volume":"25","author":"Fernandez","year":"2012","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.jep.2021.114589_bib40","doi-asserted-by":"crossref","first-page":"13384","DOI":"10.3390\/molecules200713384","article-title":"Molecular docking and structure-based drug design strategies","volume":"20","author":"Ferreira","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2021.114589_bib41","series-title":"A Field Guide to Medicinal Plants","author":"Foster","year":"1990"},{"key":"10.1016\/j.jep.2021.114589_bib43","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ijantimicag.2010.10.027","article-title":"Medicinal plant extracts with efflux inhibitory activity against Gram negative bacteria","volume":"37","author":"Garvey","year":"2011","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.jep.2021.114589_bib44","doi-asserted-by":"crossref","first-page":"107275","DOI":"10.1016\/j.compbiolchem.2020.107275","article-title":"Theoretical analysis of bacterial efflux pumps inhibitors: strategies in-search of competent molecules and develop next","volume":"87","author":"Ghosh","year":"2020","journal-title":"Comput. Biol. Chem."},{"key":"10.1016\/j.jep.2021.114589_bib45","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/cbdd.12478","article-title":"Antibiotic adjuvants: diverse strategies for controlling drug-resistant pathogens","volume":"85","author":"Gill","year":"2015","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.jep.2021.114589_bib46","first-page":"8","article-title":"Natural product drug discovery in the next millennium","volume":"39","author":"Gordon","year":"2001","journal-title":"Pharm. Biol."},{"issue":"2","key":"10.1016\/j.jep.2021.114589_bib47","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ijfoodmicro.2008.12.031","article-title":"Analysis of foodborne outbreak data reported internationally for source attribution","volume":"130","author":"Greig","year":"2009","journal-title":"Int. J. Food Microbiol."},{"key":"10.1016\/j.jep.2021.114589_bib48","first-page":"1158","article-title":"Ethnobotanical uses of wild medicinal plants by guddi and gujjar. Tribes of Himachal Pradesh","volume":"13","author":"Guleria","year":"2009","journal-title":"Ethnobot Leafl"},{"key":"10.1016\/j.jep.2021.114589_bib49","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jaim.2017.05.004","article-title":"Development of botanicals to combat antibiotic resistance","volume":"8","author":"Gupta","year":"2017","journal-title":"J. Ayurveda Integr. Med."},{"key":"10.1016\/j.jep.2021.114589_bib50","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.compbiolchem.2018.06.005","article-title":"Docking techniques in pharmacology: how much promising?","volume":"76","author":"Gupta","year":"2018","journal-title":"Comput. Biol. Chem."},{"issue":"4","key":"10.1016\/j.jep.2021.114589_bib51","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0308-8146(01)00384-3","article-title":"Characterisation of antioxidative activities of various extracts of Centella asiatica (L) Urban","volume":"77","author":"Hamid","year":"2002","journal-title":"Food Chem."},{"issue":"3","key":"10.1016\/j.jep.2021.114589_bib52","first-page":"42","article-title":"Antibacterial activity of Mentha longifolia against Salmonella typhimurium","volume":"1","author":"Heydari","year":"2015","journal-title":"Advanced Herbal Medicine"},{"issue":"3","key":"10.1016\/j.jep.2021.114589_bib53","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1128\/AAC.48.3.909-917.2004","article-title":"Novel chromosomally encoded multidrug efflux transporter MdeA in Staphylococcus aureus","volume":"48","author":"Huang","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"issue":"8","key":"10.1016\/j.jep.2021.114589_bib54","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.3923\/jbs.2007.1500.1503","article-title":"Evaluation of the synergetic effect of soluble extract of green tea (Camellia sinensis) on the activity of ciprofloxacin in urinary isolated E. coli","volume":"7","author":"Jazani","year":"2007","journal-title":"J. Biol. Sci."},{"issue":"1","key":"10.1016\/j.jep.2021.114589_bib55","first-page":"43","article-title":"Ethnomedicinal uses of plant resources of the haigad watershed in kumaun Himalaya, India","volume":"4","author":"Joshi","year":"2010","journal-title":"Med. Aromat. Plant Sci. Biotechnol."},{"key":"10.1016\/j.jep.2021.114589_bib56","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1128\/AAC.44.5.1404-1406.2000","article-title":"Evidence for the existence of a multidrug efflux transporter distinct from NorA in Staphylococcus aureus","volume":"44","author":"Kaatz","year":"2000","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jep.2021.114589_bib57","doi-asserted-by":"crossref","DOI":"10.1007\/s42770-021-00492-5","article-title":"Potential of 1-(1-Napthylmethyl)-Piperazine, an efflux pump inhibitor against cadmium induced multidrug resistance in Salmonella enterica serovar Typhi as an adjunct to antibiotics","author":"Kaur","year":"2021","journal-title":"Braz. J. Microbiol."},{"issue":"1","key":"10.1016\/j.jep.2021.114589_bib58","first-page":"43","article-title":"Ethnobotanical studies on some useful herbs of Haramosh and Bugrote valleys in Gilgit, Northern areas of Pakistan","volume":"40","author":"Khan","year":"2008","journal-title":"Pakistan J. Bot."},{"key":"10.1016\/j.jep.2021.114589_bib59","doi-asserted-by":"crossref","first-page":"M41","DOI":"10.1111\/j.1750-3841.2010.01926.x","article-title":"Antimicrobial activity of plant extracts against Salmonella Typhimurium, Escherichia coli O157:H7 and Listeria monocytogenes on fresh lettuce","volume":"76","author":"Kim","year":"2011","journal-title":"J. Food Sci."},{"key":"10.1016\/j.jep.2021.114589_bib60","doi-asserted-by":"crossref","first-page":"34","DOI":"10.2174\/1874285801307010034","article-title":"Microbial efflux systems and inhibitors: approaches to drug discovery and the challenge of clinical implementation","volume":"7","author":"Kourtesi","year":"2013","journal-title":"Open Microbiol. J."},{"key":"10.1016\/j.jep.2021.114589_bib61","first-page":"797","article-title":"Multidrug efflux pumps and their inhibitors characterized by computational modeling","author":"Krishnan","year":"2016","journal-title":"Efflux Mediated Antimicrobial Resistance in Bacteria"},{"issue":"12","key":"10.1016\/j.jep.2021.114589_bib62","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.5897\/AJB2008.000-5030","article-title":"Antioxidant activity in some selected Indian medicinal plant","volume":"7","author":"Kumar","year":"2008","journal-title":"Afr. J. Biotechnol."},{"issue":"2","key":"10.1016\/j.jep.2021.114589_bib63","first-page":"95","article-title":"Medicinal potency of Momordica charantia","volume":"1","author":"Kumar","year":"2010","journal-title":"Int. J. Pharmaceut. Sci. Rev. Res."},{"key":"10.1016\/j.jep.2021.114589_bib64","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jtcme.2017.04.002","article-title":"Comparative evaluation of antimicrobial and antioxidant potential of ethanolic extract and its fractions of bark and leaves of Terminalia arjuna from north-western Himalayas, India","volume":"8","author":"Kumar","year":"2018","journal-title":"J Tradit Complement Med"},{"key":"10.1016\/j.jep.2021.114589_bib65","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s10340-009-0284-7","article-title":"Acaricidal, repellent and oviposition deterrent activities of Datura stramonium L, against adult Tetranychus urticae (Koch)","volume":"83","author":"Kumral","year":"2010","journal-title":"J. Pest. Sci."},{"key":"10.1016\/j.jep.2021.114589_bib66","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1093\/jac\/dkn178","article-title":"Plant phenolic compounds as ethidium bromide efflux inhibitors in Mycobacterium smegmatis","volume":"62","author":"Lechner","year":"2008","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.jep.2021.114589_bib67","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1128\/CMR.00117-14","article-title":"The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria","volume":"28","author":"Li","year":"2015","journal-title":"Clin. Microbiol. Rev."},{"issue":"1","key":"10.1016\/j.jep.2021.114589_bib68","first-page":"41","article-title":"An in vitro study of the effect of Centella asiatica [Indian pennywort] on enteric pathogens","volume":"36","author":"Mamtha","year":"2004","journal-title":"Indian J. Pharmacol."},{"key":"10.1016\/j.jep.2021.114589_bib69","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/S1995-7645(10)60171-X","article-title":"Synergistic anti-Staphylococcus aureus activity of amoxicillin in combination with Emblica officinalis and Nymphae odorata extracts","volume":"60","author":"Mandal","year":"2010","journal-title":"Asian Pac J Trop Dis"},{"key":"10.1016\/j.jep.2021.114589_bib70","first-page":"373","article-title":"Origins of plant derived medicines","volume":"12","author":"Maridass","year":"2008","journal-title":"Ethnobotanical Leaflets"},{"key":"10.1016\/j.jep.2021.114589_bib71","doi-asserted-by":"crossref","first-page":"72","DOI":"10.2174\/1874285801307010072","article-title":"A simple method for assessment of MDR bacteria for over-expressed efflux pumps","volume":"7","author":"Martins","year":"2013","journal-title":"Open Microbiol. J."},{"key":"10.1016\/j.jep.2021.114589_bib72","doi-asserted-by":"crossref","first-page":"542","DOI":"10.3923\/pjn.2009.542.547","article-title":"Salvadora persica, Tamarix aphylla and Zizyphus mauritiana-three woody plant species mentioned in Holy Quran and Ahadith and their ethnobotanical uses in north western part (D.I. Khan) of Pakistan","volume":"8","author":"Marwat","year":"2009","journal-title":"Pakistan J. Nutr."},{"issue":"56","key":"10.1016\/j.jep.2021.114589_bib73","first-page":"218","article-title":"Extraction, isolation and characterization of lariciresinol from Zingiber officinale (ginger) rhizome extract for their efflux pump inhibitory activity on Salmonella enterica serovar typhimurium strains","volume":"40","author":"Mehta","year":"2020","journal-title":"Studies in Indian Place Names"},{"issue":"9","key":"10.1016\/j.jep.2021.114589_bib74","first-page":"2119","article-title":"Antibacterial activity and phytochemical screening of selected medicinal plants against Salmonella enterica serovar Typhimurium strains","volume":"5","author":"Mehta","year":"2016","journal-title":"IJBPAS"},{"issue":"10","key":"10.1016\/j.jep.2021.114589_bib75","first-page":"217","article-title":"Evaluation of phytochemicals and synergistic interaction between plant extracts and antibiotics for efflux pump inhibitory activity against Salmonella enterica serovar typhimurium strains","volume":"8","author":"Mehta","year":"2016","journal-title":"Int. J. Pharm. Pharmaceut. Sci."},{"key":"10.1016\/j.jep.2021.114589_bib149","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.micpath.2016.08.008","article-title":"Antibacterial and efflux pump inhibitors of thymol and carvacrol against food-borne pathogens","volume":"99","author":"Miladi","year":"2016","journal-title":"Microb. Pathog."},{"issue":"1","key":"10.1016\/j.jep.2021.114589_bib78","first-page":"1","article-title":"Ethnomedicinal and cultural uses of Ziziphus species in flora of malakand division KP, Pakistan","volume":"10","author":"Muhammad","year":"2020","journal-title":"SJSR"},{"key":"10.1016\/j.jep.2021.114589_bib79","first-page":"1","article-title":"Antimycobacterial activity of diospyrin and its derivatives against","volume":"2","author":"Mukanganyama","year":"2012","journal-title":"Mycobacterium aurum. Res. Pharm."},{"key":"10.1016\/j.jep.2021.114589_bib80","doi-asserted-by":"crossref","first-page":"4171","DOI":"10.1128\/AAC.48.11.4171-4176.2004","article-title":"Inhibition of antibiotic efflux in bacteria by the novel multidrug resistance inhibitor biricodar (VX-710) and timcodar (VX-853)","volume":"48","author":"Mullin","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jep.2021.114589_bib81","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1021\/np200906s","article-title":"Natural products as sources of new drugs over the 30 years from 1981 to 2010","volume":"75","author":"Newman","year":"2012","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2021.114589_bib82","doi-asserted-by":"crossref","first-page":"113135","DOI":"10.1016\/j.jep.2020.113135","article-title":"Synergistic potential of Citrus aurantium L. essential oil with antibiotics against Candida albicans","volume":"262","author":"Nidhi","year":"2020","journal-title":"J. Ethnopharmacol."},{"issue":"5157","key":"10.1016\/j.jep.2021.114589_bib83","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1126\/science.8153625","article-title":"Prevention of drug access to bacterial targets: permeability barriers and active efflux","volume":"264","author":"Nikaido","year":"1994","journal-title":"Science"},{"issue":"20","key":"10.1016\/j.jep.2021.114589_bib84","doi-asserted-by":"crossref","first-page":"5853","DOI":"10.1128\/jb.178.20.5853-5859.1996","article-title":"Multidrug efflux pumps of gram-negative bacteria","volume":"178","author":"Nikaido","year":"1996","journal-title":"J. Bacteriol."},{"issue":"35","key":"10.1016\/j.jep.2021.114589_bib85","doi-asserted-by":"crossref","first-page":"24245","DOI":"10.1074\/jbc.M804544200","article-title":"AcrAB multidrug efflux pump regulation in Salmonella enterica serovar Typhimurium by RamA in response to environmental signals","volume":"283","author":"Nikaido","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2021.114589_bib86","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.indcrop.2015.03.033","article-title":"Chromatographic analysis, antioxidant, anti-inflammatory, and xanthine oxidase inhibitory activities of ginger extracts and its reference compounds","volume":"70","author":"Nile","year":"2015","journal-title":"Ind. Crop. Prod."},{"key":"10.1016\/j.jep.2021.114589_bib87","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1002\/mbo3.212","article-title":"Phytochemicals increase the antibacterial activity of antibiotics by acting on a drug efflux pump","volume":"3","author":"Ohene-Agyei","year":"2014","journal-title":"Microbiology open"},{"key":"10.1016\/j.jep.2021.114589_bib88","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1754-1611-3-18","article-title":"Fluorometric determination of ethidium bromide efflux kinetics in Escherichia coli","volume":"3","author":"Paixao","year":"2009","journal-title":"J. Biol. Eng."},{"key":"10.1016\/j.jep.2021.114589_bib89","series-title":"Economic Botany","first-page":"294","article-title":"Anita","author":"Pandey","year":"1990"},{"key":"10.1016\/j.jep.2021.114589_bib90","doi-asserted-by":"crossref","first-page":"M379","DOI":"10.1111\/j.1750-3841.2009.01287.x","article-title":"Evaluation of combined antibacterial effects of eugenol. cnnamaldehyde, thymol, carvacrol against E. coli with an improved method","volume":"74","author":"Pei","year":"2009","journal-title":"J. Food Sci."},{"key":"10.1016\/j.jep.2021.114589_bib91","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1021\/np050227d","article-title":"Polyacylated oligosaccharides from medicinal mexican morning glory species as antibacterials and inhibitors of multidrug resistance in Staphylococcus aureus","volume":"69","author":"Pereda-Miranda","year":"2006","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2021.114589_bib92","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1128\/CMR.19.2.382-402.2006","article-title":"Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria","volume":"19","author":"Piddock","year":"2006","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.jep.2021.114589_bib93","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nrmicro1464","article-title":"Multidrug-resistance efflux pumps-not just for resistance","volume":"4","author":"Piddock","year":"2006","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.jep.2021.114589_bib94","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1469-0691.2004.00763.x","article-title":"Efflux-mediated multiresistance in Gram-negative bacteria","volume":"10","author":"Poole","year":"2004","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.jep.2021.114589_bib95","series-title":"Essential Oils in Food Preservation, Flavor and Safety","first-page":"561","article-title":"Mint (Mentha spicata L.) oils A2-Preedy","author":"Prakash","year":"2016"},{"key":"10.1016\/j.jep.2021.114589_bib96","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1007\/s11101-015-9436-y","article-title":"Plant derived inhibitors of bacterial efflux pumps: an update","volume":"14","author":"Prasch","year":"2015","journal-title":"Phytochemistry Rev."},{"key":"10.1016\/j.jep.2021.114589_bib97","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.bioorg.2018.10.062","article-title":"Resistance modulatory and efflux-inhibitory activities of capsaicinoids and capsinoids","volume":"82","author":"Prasch","year":"2019","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.jep.2021.114589_bib98","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1099\/mic.0.26769-0","article-title":"Bile-salt-mediated induction of antimicrobial and bile resistance in Salmonella typhimurium","volume":"150","author":"Prouty","year":"2004","journal-title":"Microbiology"},{"key":"10.1016\/j.jep.2021.114589_bib99","volume":"vol. 4","author":"Pulliah","year":"2006"},{"issue":"2","key":"10.1016\/j.jep.2021.114589_bib100","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/jac\/dkh331","article-title":"Expression of the efflux pump genes cmeB, cmeF and the porin gene porA in multiple antibiotic- resistant Campylobacter jejuni","volume":"54","author":"Pumbwe","year":"2004","journal-title":"J. Antimicrob. Chemother."},{"issue":"1","key":"10.1016\/j.jep.2021.114589_bib101","doi-asserted-by":"crossref","first-page":"94","DOI":"10.5530\/pj.2019.1.17","article-title":"Sequential fractionation by organic solvents enhances the antioxidant and antibacterial activity of ethanolic extracts of fruits and leaves of Terminalia bellerica from north Western Himalayas, India","volume":"11","author":"Rangra","year":"2019","journal-title":"Pharmacogn J"},{"key":"10.1016\/j.jep.2021.114589_bib102","first-page":"231","article-title":"Antibacterial activities of some medicinal plants of the western region of India","volume":"31","author":"Rathish","year":"2007","journal-title":"Turk. J. Biol."},{"key":"10.1016\/j.jep.2021.114589_bib103","doi-asserted-by":"crossref","first-page":"112867","DOI":"10.1016\/j.jep.2020.112867","article-title":"Bioassay guided fractionation of rhizome extract of Rheum emodi wall as bio-availability enhancer of antibiotics against bacterial and fungal pathogens","volume":"257","author":"Rolta","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114589_bib104","article-title":"Molecular docking studies of phytocompounds of Rheum emodi Wall with proteins responsible for antibiotic resistance in bacterial and fungal pathogens: in silico approach to enhance the bio-availability of antibiotics","volume":"1\u201315","author":"Rolta","year":"2020","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.jep.2021.114589_bib105","doi-asserted-by":"crossref","first-page":"113420","DOI":"10.1016\/j.jep.2020.113420","article-title":"Combination between antibacterial and antifungal antibiotics with phytocompounds of Artemisia annua: a strategy to control drug resistance pathogens","volume":"266","author":"Rolta","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114589_bib106","first-page":"23","article-title":"Pemetrexed combination therapy in the treatment of non\u2013 small cell lung cancer","volume":"29","author":"Rosell","year":"2002","journal-title":"Semin. Oncol."},{"key":"10.1016\/j.jep.2021.114589_bib107","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.fitote.2013.07.015","article-title":"NorA efflux pump inhibitory activity of coumarins from Mesua ferrea","volume":"90","author":"Roy","year":"2013","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2021.114589_bib108","doi-asserted-by":"crossref","first-page":"4321","DOI":"10.1021\/jm701623q","article-title":"From phenothiazine to 3-Phenyl-1,4-benzothiazine derivatives as inhibitors of the Staphylococcus aureus NorA multidrug efflux pump","volume":"51","author":"Sabatini","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jep.2021.114589_bib109","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1128\/JB.00565-13","article-title":"Functional consequences of substitution mutations in MepR, a repressor of the Staphylococcus aureus mepA multidrug efflux pump gene","volume":"195","author":"Schindler","year":"2013","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.jep.2021.114589_bib110","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1517\/17460441.2012.688949","article-title":"Understanding efflux in Gram-negative bacteria: opportunities for drug discovery","volume":"7","author":"Schweizer","year":"2012","journal-title":"Expet Opin. Drug Discov."},{"issue":"4","key":"10.1016\/j.jep.2021.114589_bib111","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jpha.2019.11.002","article-title":"Plant-derived secondary metabolites as the main source of efflux pump inhibitors and methods for identification","volume":"10","author":"Seukep","year":"2019","journal-title":"J Pharm Anal"},{"issue":"3","key":"10.1016\/j.jep.2021.114589_bib112","first-page":"166","article-title":"Phytochemical, preliminary pharmacognostical and antimicrobial evaluation of combined crude aqueous extract","volume":"1","author":"Sharma","year":"2010","journal-title":"Int. J. Microbiol. Res."},{"issue":"5","key":"10.1016\/j.jep.2021.114589_bib113","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.fct.2006.11.002","article-title":"Cancer preventive properties of zinger: a brief review","volume":"45","author":"Shukla","year":"2007","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jep.2021.114589_bib114","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1007\/s10096-016-2760-3","article-title":"Typhoidal and non-typhoidal Salmonella infections in Africa","volume":"35","author":"Smith","year":"2016","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.jep.2021.114589_bib115","doi-asserted-by":"crossref","first-page":"468","DOI":"10.3390\/molecules22030468","article-title":"New roads leading to old destinations: efflux pumps as targets to reverse multidrug resistance in bacteria","volume":"22","author":"Spengler","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2021.114589_bib116","first-page":"24","article-title":"Herbs for sleep and relaxation","volume":"16","author":"Starburck","year":"2001","journal-title":"Men's Health"},{"key":"10.1016\/j.jep.2021.114589_bib117","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1073\/pnas.030540597","article-title":"Synergy in a medicinal plant: antimicrobial action of berberine potentiated 5\u2019-methoxyhydnocarpin, a multidrug pump inhibitor","volume":"97","author":"Stermitz","year":"2000","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"issue":"8","key":"10.1016\/j.jep.2021.114589_bib118","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S0305-1978(01)00025-4","article-title":"Staphylococcus aureus MDR efflux pump inhibitors from a Berberis and a Mahonia (sensu strictu) species","volume":"29","author":"Stermitz","year":"2001","journal-title":"Biochem. Systemat. Ecol."},{"key":"10.1016\/j.jep.2021.114589_bib119","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1016\/S0960-894X(03)00316-0","article-title":"Polyacylated neohesperidosides from Geranium caespitosum: bacterial multidrug resistance pump inhibitors","volume":"13","author":"Stermitz","year":"2003","journal-title":"Bioorg. Med. Chem. Lett"},{"issue":"5","key":"10.1016\/j.jep.2021.114589_bib120","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1080\/1062936X.2014.907203","article-title":"Building on a solid foundation: SAR and QSAR as a fundamental strategy to reduce animal testing","volume":"25","author":"Sullivana","year":"2014","journal-title":"SAR QSAR Environ. Res."},{"key":"10.1016\/j.jep.2021.114589_bib121","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.bbrc.2014.05.090","article-title":"Bacterial multidrug efflux pumps: mechanisms, physiology and pharmacological exploitations","volume":"453","author":"Sun","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.jep.2021.114589_bib122","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1128\/CMR.05041-11","article-title":"Combination therapy for treatment of infections with Gram-negative bacteria","volume":"25","author":"Tamma","year":"2012","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.jep.2021.114589_bib123","series-title":"Herbal Secrets of the Rainforest","article-title":"Technical data report for bitter melon (Momordica charantia)","author":"Taylor","year":"2002"},{"issue":"10","key":"10.1016\/j.jep.2021.114589_bib124","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1128\/AAC.46.10.3133-3141.2002","article-title":"Multidrug pump inhibitors uncover remarkable activity of plant antimicrobials","volume":"46","author":"Tegos","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jep.2021.114589_bib125","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.jep.2021.114589_bib126","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0378-8741(01)00409-3","article-title":"Screening of African medicinal plants for antimicrobial and enzyme inhibitory activity","volume":"80","author":"Tshibangu","year":"2001","journal-title":"J. Ethnopharmacol."},{"issue":"5","key":"10.1016\/j.jep.2021.114589_bib127","first-page":"707","article-title":"Phytochemical Screening of Pistacia chinensis var integerrima","volume":"7","author":"Uddin","year":"2011","journal-title":"Middle East J. Sci. Res."},{"issue":"2","key":"10.1016\/j.jep.2021.114589_bib129","first-page":"277","article-title":"Synergistic and efflux pump inhibitory activity of plant extracts and antibiotics on staphylococcus aureus strains","volume":"9","author":"Urmila","year":"2016","journal-title":"Asian J. Pharmaceut. Clin. Res."},{"issue":"8","key":"10.1016\/j.jep.2021.114589_bib130","first-page":"1965","article-title":"Synergism between natural products and fluoroquinolones against staphylococcus aureus strains","volume":"5","author":"Urmila","year":"2016","journal-title":"IJBPAS"},{"issue":"4","key":"10.1016\/j.jep.2021.114589_bib131","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1590\/S1517-83822007000400024","article-title":"Antibacterial activity of medicinal plant extracts","volume":"38","author":"Ushimaru","year":"2007","journal-title":"Braz. J. Microbiol."},{"issue":"3","key":"10.1016\/j.jep.2021.114589_bib132","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1080\/21513732.2013.823113","article-title":"Traditional and indigenous uses of medicinal plants by local residents in Himachal Pradesh, North Western Himalaya, India","volume":"9","author":"Vidyarthi","year":"2013","journal-title":"Int J biodivers sci ecosyst serv manag"},{"issue":"4","key":"10.1016\/j.jep.2021.114589_bib134","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00968-17","article-title":"Lack of AcrB efflux function confers loss of virulence on Salmonella enterica serovar Typhimurium","volume":"8","author":"Wang-Kan","year":"2017","journal-title":"mBio"},{"key":"10.1016\/j.jep.2021.114589_bib136","doi-asserted-by":"crossref","first-page":"4276","DOI":"10.1128\/JB.00363-09","article-title":"The global consequence of disruption of the AcrAB-TolC efflux pump in Salmonella enterica includes reduced expression of SPI-1 and other attributes required to infect the host","volume":"191","author":"Webber","year":"2009","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.jep.2021.114589_bib139","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.tim.2016.06.009","article-title":"Antibiotic adjuvants: rescuing antibiotics from resistance","volume":"24","author":"Wright","year":"2016","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.jep.2021.114589_bib140","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-36025-8","article-title":"Crystal structure of the multidrug resistance regulator RamR complexed with bile acids","volume":"9","author":"Yamasaki","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2021.114589_bib141","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1093\/bioinformatics\/bty707","article-title":"AdmetSAR 2.0: web-service for prediction and optimization of chemical ADMET properties","volume":"35","author":"Yang","year":"2019","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jep.2021.114589_bib142","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/jmr.2266","article-title":"Latest developments in molecular docking: 2010\u20132011 in review","volume":"26","author":"Yuriev","year":"2013","journal-title":"J. Mol. Recogn."},{"key":"10.1016\/j.jep.2021.114589_bib143","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2174\/157489109787236256","article-title":"Inhibitors of multidrug resistant efflux systems in bacteria","volume":"4","author":"Zechini","year":"2009","journal-title":"Recent Pat. Anti-Infect. Drug Discov."},{"issue":"2","key":"10.1016\/j.jep.2021.114589_bib144","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1046\/j.1365-2958.2000.01926.x","article-title":"Multidrug resistance mechanisms: drug efflux across two membranes","volume":"37","author":"Zgurskaya","year":"2000","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.jep.2021.114589_bib145","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1021\/acsinfecdis.5b00097","article-title":"Permeability barrier of Gram-negative cell envelopes and approaches to bypass it","volume":"1","author":"Zgurskaya","year":"2015","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.jep.2021.114589_bib146","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.biomaterials.2016.06.018","article-title":"Edible ginger-derived nanoparticles: a novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer","volume":"101","author":"Zhang","year":"2016","journal-title":"Biomaterials"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121008187?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121008187?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:21:53Z","timestamp":1759944113000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874121008187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":140,"alternative-id":["S0378874121008187"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2021.114589","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of medicinal plants from North Western Himalayas as an efflux pump inhibitor against MDR AcrAB-TolC Salmonella enterica serovar typhimurium: In vitro and In silico studies","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2021.114589","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114589"}}