{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T21:10:51Z","timestamp":1793826651075,"version":"4.6.1"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.jep.2021.114612","type":"journal-article","created":{"date-parts":[[2021,9,5]],"date-time":"2021-09-05T09:38:38Z","timestamp":1630834718000},"page":"114612","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Xiaoyao San attenuates hepatic steatosis through estrogen receptor \u03b1 pathway in ovariectomized ApoE\u2212\/\u2212 mice"],"prefix":"10.1016","volume":"282","author":[{"given":"Tianhui","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mian","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoping","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2021.114612_bib1","doi-asserted-by":"crossref","first-page":"112432","DOI":"10.1016\/j.jep.2019.112432","article-title":"Studies on the potential link between antidepressant effect of Xiaoyao San and its pharmacological activity of hepatoprotection based on multi-platform metabolomics","volume":"249","author":"Chen","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114612_bib2","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/1472-6882-14-206","article-title":"Identifying Chinese herbal medicine for premenstrual syndrome: implications from a nationwide database","volume":"14","author":"Chen","year":"2014","journal-title":"BMC Compl. Alternative Med."},{"issue":"10","key":"10.1016\/j.jep.2021.114612_bib3","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s000110050622","article-title":"Peroxisome proliferator-activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation","volume":"49","author":"Chinetti","year":"2000","journal-title":"Inflamm. Res."},{"issue":"1","key":"10.1016\/j.jep.2021.114612_bib4","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13000-018-0698-8","article-title":"Expression patterns of STAT3, ERK and estrogen-receptor \u03b1 are associated with development and histologic severity of hepatic steatosis: a retrospective study","volume":"13","author":"Choi","year":"2018","journal-title":"Diagn. Pathol."},{"issue":"3","key":"10.1016\/j.jep.2021.114612_bib5","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1530\/JOE-10-0462","article-title":"A selective estrogen receptor \u03b1 agonist ameliorates hepatic steatosis in the male aromatase knockout mouse","volume":"210","author":"Chow","year":"2011","journal-title":"J. Endocrinol."},{"issue":"61","key":"10.1016\/j.jep.2021.114612_bib6","first-page":"305","article-title":"Hormone replacement therapy use and the risk of stroke","volume":"4","author":"Christel","year":"2008","journal-title":"Maturitas"},{"issue":"3","key":"10.1016\/j.jep.2021.114612_bib7","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.jsbmb.2007.03.033","article-title":"Incidences of breast cancer throughout long-term hormone replacement therapy","volume":"104","author":"Cort\u00e9s-Prieto","year":"2007","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"2","key":"10.1016\/j.jep.2021.114612_bib8","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.celrep.2016.03.019","article-title":"An essential role for liver ERalpha in coupling hepatic metabolism to the reproductive cycle","volume":"15","author":"Della Torre","year":"2016","journal-title":"Cell Rep."},{"issue":"5","key":"10.1016\/j.jep.2021.114612_bib9","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1172\/JCI23621","article-title":"Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease","volume":"115","author":"Kerry","year":"2005","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.jep.2021.114612_bib10","doi-asserted-by":"crossref","DOI":"10.3892\/ijmm_00000170","article-title":"Impact of cholesterol metabolism and the LXR\u03b1-SREBP-1c pathway on nonalcoholic fatty liver disease","volume":"23","author":"Enjoji","year":"2009","journal-title":"Int. J. Mol. Med."},{"issue":"7","key":"10.1016\/j.jep.2021.114612_bib11","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.prp.2013.04.010","article-title":"Presence and extent of estrogen receptor-alpha expression in patients with simple steatosis and NASH","volume":"209","author":"Erkan","year":"2013","journal-title":"Pathol. Res. Pract."},{"issue":"3","key":"10.1016\/j.jep.2021.114612_bib12","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1590\/S0004-28032013000200032","article-title":"Nonalcoholic fatty liver disease in menopausal women","volume":"50","author":"Florentino","year":"2013","journal-title":"Arq. Gastroenterol."},{"issue":"7","key":"10.1016\/j.jep.2021.114612_bib13","first-page":"1250","article-title":"UPLC-MS fingerprint of Xiaoyao San","volume":"33","author":"Geng","year":"2013","journal-title":"Chin. J. Pharmaceut. Anal."},{"issue":"4","key":"10.1016\/j.jep.2021.114612_bib14","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/S1665-2681(19)31616-3","article-title":"Prevalence of non alcoholic fatty liver disease in premenopausal, posmenopausal and polycystic ovary syndrome women. The role of estrogens","volume":"9","author":"Gutierrez-Grobe","year":"2010","journal-title":"Ann. Hepatol."},{"issue":"5","key":"10.1016\/j.jep.2021.114612_bib15","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1002\/hep.26951","article-title":"Estrogen receptor ligands ameliorate fatty liver through a nonclassical estrogen receptor\/Liver X receptor pathway in mice","volume":"59","author":"Han","year":"2014","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.jep.2021.114612_bib16","first-page":"620","article-title":"Study on phytoestrogenic-like effects of four kinds of Chinese medicine including Radix rehmanniae Preparata,Radix Paeoniae Alba,Radix Angelicae Sinensis,Rhizoma Chuanxiong","volume":"34","author":"Hao","year":"2009","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.jep.2021.114612_bib17","first-page":"60","article-title":"The efficacy and Safety of modified Xiaoyao San for perimenopausal syndrome (PMS): a systematic review and meta-analysis","author":"Hao","year":"2019","journal-title":"J. Biosci. Med."},{"issue":"6","key":"10.1016\/j.jep.2021.114612_bib18","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1038\/ijo.2017.50","article-title":"Hormone signaling and fatty liver in females: analysis of estrogen receptor alpha mutant mice","volume":"41","author":"Hart-Unger","year":"2017","journal-title":"Int. J. Obes."},{"issue":"3","key":"10.1016\/j.jep.2021.114612_bib19","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1073\/pnas.0405067102","article-title":"Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory element- binding protein-1 c","volume":"102","author":"Bronwyn","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jep.2021.114612_bib20","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.ejphar.2019.05.019","article-title":"Resveratrol downregulates PCSK9 expression and attenuates steatosis through estrogen receptor \u03b1-mediated pathway in L02cells","volume":"855","author":"Jing","year":"2019","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.jep.2021.114612_bib21","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s00535-013-0758-5","article-title":"Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease","volume":"48","author":"Kawano","year":"2013","journal-title":"J. Gastroenterol."},{"issue":"12","key":"10.1016\/j.jep.2021.114612_bib22","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1194\/jlr.R400010-JLR200","article-title":"PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis","volume":"45","author":"Li","year":"2004","journal-title":"J. Lipid Res."},{"issue":"29","key":"10.1016\/j.jep.2021.114612_bib23","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000016481","article-title":"Effectiveness and safety of Chinese herbal medicine Xiaoyao san for the treatment of insomnia: protocol for a systematic review and meta-analysis","volume":"98","author":"Li","year":"2019","journal-title":"Medicine"},{"issue":"4","key":"10.1016\/j.jep.2021.114612_bib24","first-page":"616","article-title":"Analysis on Xiaoyaosan in treating gynecological disease","volume":"25","author":"Li","year":"2010","journal-title":"China J. Tradit. Chin. Med. Pharm."},{"issue":"9","key":"10.1016\/j.jep.2021.114612_bib25","first-page":"826","article-title":"Effects of liver-soothing therapy on the expression of estrogen receptors mRNA in perimenopausal syndrome rats with liver qi stagnation","author":"Li","year":"2016","journal-title":"Int. J. Translat. Community Med."},{"issue":"10","key":"10.1016\/j.jep.2021.114612_bib26","first-page":"2193","article-title":"Experimental study on the estrogen-like effect of Xiaoyao San on ovariectomized mice","author":"Liu","year":"2014","journal-title":"Chin. Tradit. Patent Med."},{"issue":"8","key":"10.1016\/j.jep.2021.114612_bib27","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.2337\/diabetes.50.8.1844","article-title":"Nonalcoholic fatty liver disease: a feature of the metabolic syndrome","volume":"50","author":"Marchesini","year":"2001","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.jep.2021.114612_bib28","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0378-8741(89)90085-8","article-title":"Ethnopharmacologic investigation of ginger (Zingiber officinale)","volume":"27","author":"Mascolo","year":"1989","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.jep.2021.114612_bib29","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/GME.0000000000000500","article-title":"Surgical menopause and increased risk of nonalcoholic fatty liver disease in endometrial cancer","volume":"23","author":"Matsuo","year":"2016","journal-title":"Menopause"},{"issue":"4","key":"10.1016\/j.jep.2021.114612_bib30","doi-asserted-by":"crossref","first-page":"456","DOI":"10.5352\/JLS.2017.27.4.456","article-title":"The effects of medicinal herbs extracts on estrogen-like activities and osteoblast proliferation and differentiation","volume":"27","author":"Mihyang","year":"2017","journal-title":"J. Life Sci."},{"key":"10.1016\/j.jep.2021.114612_bib31","series-title":"Yokukansan Inhibits Morphine Tolerance and Physical Dependence in Mice: the Role of a2A-Adrenoceptor","author":"Nakagawa","year":"2012"},{"issue":"5","key":"10.1016\/j.jep.2021.114612_bib32","first-page":"603","article-title":"Impact of cholesterol metabolism and the LXR\u03b1-SREBP-1c pathway on nonalcoholic fatty liver disease","volume":"23","author":"Nakamuta","year":"2009","journal-title":"Int. J. Mol. Med."},{"issue":"2","key":"10.1016\/j.jep.2021.114612_bib33","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/sj.ijo.0801488","article-title":"Relationships between tamoxifen use, liver fat and body fat distribution in women with breast cancer","volume":"25","author":"Nguyen","year":"2001","journal-title":"Int. J. Obes. Relat. Metab. Disord. : J. Int. Assoc. Stud. Obes."},{"key":"10.1016\/j.jep.2021.114612_bib34","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jnutbio.2016.08.007","article-title":"Soy isoflavones (Glycine max) ameliorate hypertriglyceridemia and hepatic steatosis in high fat-fed ovariectomized Wistar rats (an experimental model of postmenopausal obesity)","volume":"38","author":"Panneerselvam","year":"2016","journal-title":"J. Nutr. Biochem."},{"issue":"6","key":"10.1016\/j.jep.2021.114612_bib35","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1053\/j.gastro.2007.03.055","article-title":"Abnormal lipid and glucose metabolism in obesity: implications for nonalcoholic fatty liver disease","volume":"132","author":"Parekh","year":"2007","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.jep.2021.114612_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2013.07.022","article-title":"A novel concept for detoxification: complexation between aconitine and liquiritin in a Chinese herbal formula ('Sini Tang')","volume":"149","author":"Peter","year":"2013","journal-title":"J. Ethnopharmacol."},{"issue":"12","key":"10.1016\/j.jep.2021.114612_bib37","first-page":"251","article-title":"Risk factors: HRT increases risk of ovarian cancer","volume":"5","author":"Peter","year":"2015","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"8","key":"10.1016\/j.jep.2021.114612_bib38","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1111\/j.1440-1746.2009.05934.x","article-title":"Chinese herbal medicine modified xiaoyao san for functional dyspepsia: meta-analysis of randomized controlled trials","volume":"24","author":"Qin","year":"2009","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"1\u20132","key":"10.1016\/j.jep.2021.114612_bib39","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1142\/S0192415X89000103","article-title":"Studies on herbal aphrodisiacs used in Arab system of medicine","volume":"17","author":"Qureshi","year":"1989","journal-title":"Am. J. Chin. Med."},{"issue":"7","key":"10.1016\/j.jep.2021.114612_bib40","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1055\/s-0030-1270823","article-title":"Chemical constituents and pharmacological properties of Poria cocos","volume":"77","author":"R\u00edos","year":"2011","journal-title":"Planta Med."},{"issue":"22","key":"10.1016\/j.jep.2021.114612_bib41","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1101\/gad.844900","article-title":"Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXR\u03b1 and LXR\u03b2","volume":"14","author":"Repa","year":"2000","journal-title":"Gene Dev."},{"key":"10.1016\/j.jep.2021.114612_bib42","first-page":"1","article-title":"An essential role for liver ER\u03b1 in coupling hepatic metabolism to the reproductive cycle","volume":"15","author":"Sara Torre","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.jep.2021.114612_bib43","doi-asserted-by":"crossref","first-page":"113685","DOI":"10.1016\/j.jep.2020.113685","article-title":"Medicinal Plants from the 14th edition of the Russian Pharmacopoeia, recent updates","volume":"268","author":"Shikov","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"5","key":"10.1016\/j.jep.2021.114612_bib44","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1002\/hep.26951","article-title":"Estrogen receptor ligands ameliorate fatty liver through a nonclassical estrogen receptor\/Liver X receptor pathway in mice","volume":"59","author":"Song\u2010iee Han","year":"2014","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.jep.2021.114612_bib45","doi-asserted-by":"crossref","first-page":"191","DOI":"10.2217\/17455057.5.2.191","article-title":"Nonalcoholic fatty liver disease in women","volume":"5","author":"Suzuki","year":"2009","journal-title":"Womens Health (Lond)"},{"issue":"6","key":"10.1016\/j.jep.2021.114612_bib46","article-title":"Identification of licopyranocoumarin and glycyrurol from herbal medicines as neuroprotective compounds for Parkinson's disease","volume":"9","author":"Takahiro","year":"2014","journal-title":"PloS One"},{"issue":"7","key":"10.1016\/j.jep.2021.114612_bib47","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1210\/en.2011-1980","article-title":"Molecular mechanisms of estrogen receptors' suppression of lipogenesis in pancreatic beta-cells","volume":"153","author":"Tiano","year":"2012","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.jep.2021.114612_bib48","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jhep.2015.02.029","article-title":"Hepatic estrogen receptor alpha improves hepatosteatosis through upregulation of small heterodimer partner","volume":"63","author":"Wang","year":"2015","journal-title":"J. Hepatol."},{"issue":"11","key":"10.1016\/j.jep.2021.114612_bib49","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1002\/ptr.6161","article-title":"Paeoniflorin protects against liver ischemia\/reperfusion injury in mice via inhibiting HMGB1-TLR4 signaling pathway","volume":"32","author":"Xie","year":"2018","journal-title":"Phytother Res.: PTR"},{"key":"10.1016\/j.jep.2021.114612_bib50","doi-asserted-by":"crossref","first-page":"152849","DOI":"10.1016\/j.phymed.2019.152849","article-title":"Efficacy and safety of Chinese herbal medicine Xiao Yao San in hypertension: a systematic review and meta-analysis","volume":"61","author":"Xiong","year":"2019","journal-title":"Phytomedicine : Int. J. Phytother. Phytopharm."},{"key":"10.1016\/j.jep.2021.114612_bib51","article-title":"Integrative lipidomic and transcriptomic study unravels the therapeutic effects of saikosaponins A and D on non-alcoholic fatty liver disease","volume":"11","author":"Xl","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"issue":"1","key":"10.1016\/j.jep.2021.114612_bib52","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jep.2014.04.011","article-title":"Hugan Qingzhi medication ameliorates hepatic steatosis by activating AMPK and PPARalpha pathways in L02 cells and HepG2 cells","volume":"154","author":"Yin","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114612_bib53","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3389\/fphar.2020.00284","article-title":"An integrated pharmacology-based analysis for antidepressant mechanism of Chinese herbal formula Xiao-Yao-san","volume":"11","author":"Yuan","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"8","key":"10.1016\/j.jep.2021.114612_bib54","first-page":"1576","article-title":"Pharmacodynamic and pharmacokinetic study on reducing enzyme by Xiaoyao Powder used for liver-injured rats in vivo","volume":"42","author":"Zhang","year":"2011","journal-title":"Chin. Tradit. Herb. Drugs"},{"issue":"6","key":"10.1016\/j.jep.2021.114612_bib55","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1016\/j.jhep.2015.07.037","article-title":"Upregulation of miR-125b by estrogen protects against non-alcoholic fatty liver in female mice","volume":"63","author":"Zhang","year":"2015","journal-title":"J. Hepatol."},{"issue":"2","key":"10.1016\/j.jep.2021.114612_bib56","doi-asserted-by":"crossref","first-page":"424","DOI":"10.2337\/db11-1718","article-title":"Estrogen treatment after ovariectomy protects against fatty liver and may improve pathway-selective insulin resistance","volume":"62","author":"Zhu","year":"2013","journal-title":"Diabetes"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121008412?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121008412?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:12:36Z","timestamp":1759943556000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874121008412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":56,"alternative-id":["S0378874121008412"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2021.114612","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Xiaoyao San attenuates hepatic steatosis through estrogen receptor \u03b1 pathway in ovariectomized ApoE\u2212\/\u2212 mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2021.114612","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114612"}}