{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T13:52:13Z","timestamp":1780408333985,"version":"3.54.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["110-2636-B-A49A-501"],"award-info":[{"award-number":["110-2636-B-A49A-501"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.jep.2021.114636","type":"journal-article","created":{"date-parts":[[2021,9,11]],"date-time":"2021-09-11T10:42:57Z","timestamp":1631356977000},"page":"114636","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Water extract of medicinal ink (WEMI) attenuates lipopolysaccharide-induced NO production of Raw264.7 cells via downregulating JAK2\/STAT3-mediated iNOS expression"],"prefix":"10.1016","volume":"282","author":[{"given":"Zhi-Hu","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huagang","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Ching","family":"Liaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Lun","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Hung","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1199-1121","authenticated-orcid":false,"given":"Tung-Yi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.jep.2021.114636_bib1","doi-asserted-by":"crossref","first-page":"6366","DOI":"10.1002\/jcp.29607","article-title":"Role of iNOS in osteoarthritis: pathological and therapeutic aspects","volume":"235","author":"Ahmad","year":"2020","journal-title":"J. Cell. Physiol."},{"issue":"20","key":"10.1016\/j.jep.2021.114636_bib2","doi-asserted-by":"crossref","first-page":"7675","DOI":"10.3390\/ijms21207675","article-title":"STAT3 differentially regulates TLR4-mediated inflammatory responses in early or late phases","volume":"21","author":"Ahuja","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2021.114636_bib3","doi-asserted-by":"crossref","first-page":"491","DOI":"10.3389\/fimmu.2014.00491","article-title":"Macrophage cytokines: involvement in immunity and infectious diseases","volume":"5","author":"Arango Duque","year":"2014","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.jep.2021.114636_bib4","doi-asserted-by":"crossref","first-page":"7204","DOI":"10.18632\/oncotarget.23208","article-title":"Inflammatory responses and inflammation-associated diseases in organs","volume":"9","author":"Chen","year":"2018","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.jep.2021.114636_bib5","first-page":"261","article-title":"Macrophages in osteoarthritis: pathophysiology and therapeutics","volume":"12","author":"Chen","year":"2020","journal-title":"Am J Transl Res"},{"issue":"4","key":"10.1016\/j.jep.2021.114636_bib6","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1007\/s00018-020-03656-y","article-title":"TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling","volume":"78","author":"Ciesielska","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.jep.2021.114636_bib7","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/med.21599","article-title":"Inducible nitric oxide synthase: regulation, structure, and inhibition","volume":"40","author":"Cinelli","year":"2020","journal-title":"Med. Res. Rev."},{"issue":"3","key":"10.1016\/j.jep.2021.114636_bib8","doi-asserted-by":"crossref","first-page":"668","DOI":"10.55563\/clinexprheumatol\/e7ayu8","article-title":"JAK\/STAT pathway and nociceptive cytokine signalling in rheumatoid arthritis and psoriatic arthritis","volume":"39","author":"Crispino","year":"2021","journal-title":"Clin. Exp. Rheumatol."},{"issue":"3","key":"10.1016\/j.jep.2021.114636_bib9","first-page":"408","article-title":"Phagocytosis and induction of nitric oxide synthase in murine macrophages","volume":"79","author":"Cunha","year":"1993","journal-title":"Immunology"},{"issue":"1","key":"10.1016\/j.jep.2021.114636_bib10","doi-asserted-by":"crossref","first-page":"360","DOI":"10.4049\/jimmunol.173.1.360","article-title":"Lipopolysaccharide-induced macrophage inflammatory response is regulated by SHIP","volume":"173","author":"Fang","year":"2004","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.jep.2021.114636_bib11","doi-asserted-by":"crossref","first-page":"84","DOI":"10.18053\/jctres.02.201603.005","article-title":"The role of TNF-\u03b1 in rheumatoid arthritis: a focus on regulatory T cells","volume":"2","author":"Farrugia","year":"2016","journal-title":"J Clin Transl Res"},{"issue":"6","key":"10.1016\/j.jep.2021.114636_bib12","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1093\/rheumatology\/36.6.651","article-title":"Immunolocalization of inducible nitric oxide synthase in synovium and cartilage in rheumatoid arthritis and osteoarthritis","volume":"36","author":"Grabowski","year":"1997","journal-title":"Br. J. Rheumatol."},{"issue":"2","key":"10.1016\/j.jep.2021.114636_bib13","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.4049\/jimmunol.1002971","article-title":"IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3","volume":"186","author":"Greenhill","year":"2011","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.jep.2021.114636_bib14","first-page":"57","article-title":"Innate inflammation and synovial macrophages in osteoarthritis pathophysiology","volume":"37","author":"Griffin","year":"2019","journal-title":"Clin. Exp. Rheumatol."},{"issue":"1","key":"10.1016\/j.jep.2021.114636_bib15","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s13765-020-00504-2","article-title":"Anti-inflammatory effect of hispidin on LPS induced macrophage inflammation through MAPK and JAK1\/STAT3 signaling pathways","volume":"63","author":"Han","year":"2020","journal-title":"Applied Biological Chemistry"},{"issue":"10","key":"10.1016\/j.jep.2021.114636_bib16","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1016\/j.joca.2016.05.008","article-title":"Both systemic and local lipopolysaccharide (LPS) burden are associated with knee OA severity and inflammation","volume":"24","author":"Huang","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"10.1016\/j.jep.2021.114636_bib17","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.cell.2020.11.025","article-title":"Synergism of TNF-\u03b1 and IFN-\u03b3 triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes","volume":"184","author":"Karki","year":"2021","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.jep.2021.114636_bib18","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.3390\/ijms20071593","article-title":"Dehydroabietic acid suppresses inflammatory response via suppression of src-, syk-, and TAK1-mediated pathways","volume":"20","author":"Kim","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"19","key":"10.1016\/j.jep.2021.114636_bib19","doi-asserted-by":"crossref","first-page":"4736","DOI":"10.1039\/C9OB00272C","article-title":"Late-stage C-H amination of abietane diterpenoids","volume":"17","author":"Lapuh","year":"2019","journal-title":"Org. Biomol. Chem."},{"issue":"6140","key":"10.1016\/j.jep.2021.114636_bib20","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/329630a0","article-title":"Macrophage-induced angiogenesis is mediated by tumour necrosis factor-\u03b1","volume":"329","author":"Leibovich","year":"1987","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.jep.2021.114636_bib21","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.canlet.2016.03.018","article-title":"Ling Zhi-8 reduces lung cancer mobility and metastasis through disruption of focal adhesion and induction of MDM2-mediated Slug degradation","volume":"375","author":"Lin","year":"2016","journal-title":"Canc. Lett."},{"key":"10.1016\/j.jep.2021.114636_bib22","doi-asserted-by":"crossref","first-page":"153384","DOI":"10.1016\/j.phymed.2020.153384","article-title":"Functional proteomic analysis reveals that fungal immunomodulatory protein reduced expressions of heat shock proteins correlates to apoptosis in lung cancer cells","volume":"80","author":"Lin","year":"2021","journal-title":"Phytomedicine"},{"issue":"5","key":"10.1016\/j.jep.2021.114636_bib23","doi-asserted-by":"crossref","first-page":"520","DOI":"10.7150\/ijbs.8879","article-title":"Macrophage polarization in inflammatory diseases","volume":"10","author":"Liu","year":"2014","journal-title":"Int. J. Biol. Sci."},{"issue":"2","key":"10.1016\/j.jep.2021.114636_bib24","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.cyto.2008.01.006","article-title":"LPS\/TLR4 signal transduction pathway","volume":"42","author":"Lu","year":"2008","journal-title":"Cytokine"},{"key":"10.1016\/j.jep.2021.114636_bib25","doi-asserted-by":"crossref","first-page":"568756","DOI":"10.3389\/fvets.2020.568756","article-title":"Macrophage activation in the synovium of healthy and osteoarthritic equine joints","volume":"7","author":"Menarim","year":"2020","journal-title":"Front Vet Sci"},{"issue":"3","key":"10.1016\/j.jep.2021.114636_bib26","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/cei.12445","article-title":"Cytokines in immune-mediated inflammatory myopathies: cellular sources, multiple actions and therapeutic implications","volume":"178","author":"Moran","year":"2014","journal-title":"Clin. Exp. Immunol."},{"issue":"11","key":"10.1016\/j.jep.2021.114636_bib27","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1093\/intimm\/dxy054","article-title":"Macrophages in inflammation, repair and regeneration","volume":"30","author":"Oishi","year":"2018","journal-title":"Int. Immunol."},{"issue":"10","key":"10.1016\/j.jep.2021.114636_bib28","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1111\/febs.14801","article-title":"IL-35 ameliorates collagen-induced arthritis by promoting TNF-\u03b1-induced apoptosis of synovial fibroblasts and stimulating M2 macrophages polarization","volume":"286","author":"Peng","year":"2019","journal-title":"FEBS J."},{"key":"10.1016\/j.jep.2021.114636_bib29","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.ijbiomac.2020.03.066","article-title":"Fucoidan increased the sensitivity to gefitinib in lung cancer cells correlates with reduction of TGFbeta-mediated Slug expression","volume":"153","author":"Qiu","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2021.114636_bib30","doi-asserted-by":"crossref","first-page":"444","DOI":"10.3389\/fimmu.2018.00444","article-title":"Tumor necrosis factor \u03b1 and regulatory T cells in oncoimmunology","volume":"9","author":"Salomon","year":"2018","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.jep.2021.114636_bib31","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1084\/jem.165.6.1688","article-title":"Lipopolysaccharide induces recurrence of arthritis in rat joints previously injured by peptidoglycan-polysaccharide","volume":"165","author":"Stimpson","year":"1987","journal-title":"J. Exp. Med."},{"issue":"8","key":"10.1016\/j.jep.2021.114636_bib32","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3390\/s30800276","article-title":"Measurement of nitric oxide production in biological systems by using griess reaction assay","volume":"3","author":"Sun","year":"2003","journal-title":"Sensors"},{"issue":"22","key":"10.1016\/j.jep.2021.114636_bib33","doi-asserted-by":"crossref","first-page":"4695","DOI":"10.1039\/b914981c","article-title":"Synthesis, photolysis studies and in vitro photorelease of caged TRPV1 agonists and antagonists","volume":"7","author":"Van Ryssen","year":"2009","journal-title":"Org. Biomol. Chem."},{"issue":"2","key":"10.1016\/j.jep.2021.114636_bib34","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201600474","article-title":"Nonivamide, a capsaicin analogue, exhibits anti-inflammatory properties in peripheral blood mononuclear cells and U-937 macrophages","volume":"61","author":"Walker","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"issue":"Suppl. 1","key":"10.1016\/j.jep.2021.114636_bib35","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1590\/S0074-02762005000900002","article-title":"Nitric oxide as a regulator of inflammatory processes","volume":"100","author":"Wallace","year":"2005","journal-title":"Mem. Inst. Oswaldo Cruz"},{"issue":"10","key":"10.1016\/j.jep.2021.114636_bib36","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1093\/rheumatology\/keaa248","article-title":"A roadmap to target interleukin-6 in osteoarthritis","volume":"59","author":"Wiegertjes","year":"2020","journal-title":"Rheumatology"},{"issue":"3","key":"10.1016\/j.jep.2021.114636_bib37","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.immuni.2016.02.015","article-title":"Macrophages in tissue repair, regeneration, and fibrosis","volume":"44","author":"Wynn","year":"2016","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.jep.2021.114636_bib38","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/BF03401781","article-title":"Inducible nitric oxide synthase and inflammatory diseases","volume":"6","author":"Zamora","year":"2000","journal-title":"Mol Med"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121008655?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121008655?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:12:27Z","timestamp":1778692347000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874121008655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":38,"alternative-id":["S0378874121008655"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2021.114636","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Water extract of medicinal ink (WEMI) attenuates lipopolysaccharide-induced NO production of Raw264.7 cells via downregulating JAK2\/STAT3-mediated iNOS expression","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2021.114636","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114636"}}