{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T14:28:17Z","timestamp":1783002497755,"version":"3.54.5"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473317"],"award-info":[{"award-number":["81473317"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973471"],"award-info":[{"award-number":["81973471"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.jep.2021.114678","type":"journal-article","created":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T11:15:46Z","timestamp":1632395746000},"page":"114678","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Investigation of the effective components inhibited macrophage foam cell formation in Ophiopogonis Radix"],"prefix":"10.1016","volume":"283","author":[{"given":"YuShan","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9324-559X","authenticated-orcid":false,"given":"Shanquan","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juntao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puyang","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BoYang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2021.114678_bib1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1126\/science.3513311","article-title":"A receptor-mediated pathway for cholesterol homeostasis","volume":"232","author":"Brown","year":"1986","journal-title":"Science"},{"key":"10.1016\/j.jep.2021.114678_bib2","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1096\/fj.10-173377","article-title":"Carbamylated low-density lipoprotein induces oxidative stress and accelerated senescence in human endothelial progenitor cells","volume":"25","author":"Carracedo","year":"2011","journal-title":"Faseb. J."},{"key":"10.1016\/j.jep.2021.114678_bib3","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jep.2016.01.037","article-title":"Ophiopogon japonicus-A phytochemical, ethnomedicinal and pharmacological review","volume":"181","author":"Chen","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114678_bib4","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ijcard.2016.12.164","article-title":"How do macrophages sense modified low-density lipoproteins?","volume":"230","author":"Chistiakov","year":"2017","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.jep.2021.114678_bib5","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.cardiores.2007.03.010","article-title":"CD36 and macrophages in atherosclerosis","volume":"75","author":"Collot-Teixeira","year":"2007","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.jep.2021.114678_bib6","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.vph.2005.06.004","article-title":"Inhibitory effects of ethanol extract from Radix Ophiopogon japonicus on venous thrombosis linked with its endothelium-protective and anti-adhesive activities","volume":"43","author":"Kou","year":"2005","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.jep.2021.114678_bib7","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.jpba.2006.01.014","article-title":"Live cell extraction and HPLC-MS analysis for predicting bioactive components of traditional Chinese medicines","volume":"41","author":"Li","year":"2006","journal-title":"J. Pharmaceut. Biomed. Anal."},{"key":"10.1016\/j.jep.2021.114678_bib8","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00011-013-0667-3","article-title":"OxLDL-induced IL-1 beta secretion promoting foam cell formation was mainly via CD36 mediated ROS production leading to NLRP3 inflammasome activation","volume":"63","author":"Liu","year":"2014","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.jep.2021.114678_bib9","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1161\/CIRCULATIONAHA.109.876839","article-title":"Erythropoietin suppresses the formation of macrophage foam cells: role of liver X receptor alpha","volume":"121","author":"Lu","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.jep.2021.114678_bib10","article-title":"An overview of systematic reviews of shenmai injection for healthcare, evidence-based complement","volume":"840650","author":"Lu","year":"2014","journal-title":"Alternat. Med.: eCAM"},{"key":"10.1016\/j.jep.2021.114678_bib11","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jpba.2016.11.025","article-title":"Comparison of the chemical consituents and immunomodulatory activity of ophiopogonis radix from two different producing areas","volume":"134","author":"Lu","year":"2017","journal-title":"J. Pharmaceut. Biomed. Anal."},{"key":"10.1016\/j.jep.2021.114678_bib12","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1124\/mol.112.078915","article-title":"Cholesterol-lowering drugs inhibit lectin-like oxidized low-density lipoprotein-1 receptor function by membrane raft disruption","volume":"82","author":"Matarazzo","year":"2012","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.jep.2021.114678_bib13","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.plipres.2011.04.002","article-title":"Cytokines, macrophage lipid metabolism and foam cells: implications for cardiovascular disease therapy","volume":"50","author":"McLaren","year":"2011","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.jep.2021.114678_bib14","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nri3520","article-title":"Macrophages in atherosclerosis: a dynamic balance","volume":"13","author":"Moore","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jep.2021.114678_bib15","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.cell.2011.04.005","article-title":"Macrophages in the pathogenesis of atherosclerosis","volume":"145","author":"Moore","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.jep.2021.114678_bib16","doi-asserted-by":"crossref","first-page":"e99","DOI":"10.1038\/emm.2014.38","article-title":"CD36, a scavenger receptor implicated in atherosclerosis","volume":"46","author":"Park","year":"2014","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.jep.2021.114678_bib17","doi-asserted-by":"crossref","DOI":"10.3791\/1488","article-title":"Isolation of mouse peritoneal cavity cells","author":"Ray","year":"2010","journal-title":"JoVE"},{"key":"10.1016\/j.jep.2021.114678_bib18","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1007\/s11033-011-1062-1","article-title":"N-acetyl cysteine suppresses the foam cell formation that is induced by oxidized low density lipoprotein via regulation of gene expression","volume":"39","author":"Sung","year":"2012","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.jep.2021.114678_bib20","doi-asserted-by":"crossref","first-page":"121817","DOI":"10.1016\/j.jchromb.2019.121817","article-title":"Screening and identification of potential active components in Ophiopogonis Radix against atherosclerosis by biospecific cell extraction","volume":"1133","author":"Tian","year":"2019","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.jep.2021.114678_bib21","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s12944-019-1046-z","article-title":"Several circulating miRNAs related to hyperlipidemia and atherosclerotic cardiovascular diseases","volume":"18","author":"Xu","year":"2019","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.jep.2021.114678_bib22","article-title":"Macrophage miR-34a is a key regulator of cholesterol efflux and atherosclerosis","author":"Xu","year":"2019","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jep.2021.114678_bib23","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1080\/09540100701284693","article-title":"The inhibitory effects of isoflavonoids and resveratrol on oxdized low-density lipoprotein uptake in macrophage cell line J774.1","volume":"18","author":"Yamaki","year":"2007","journal-title":"Food Agric. Immunol."},{"key":"10.1016\/j.jep.2021.114678_bib24","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.jpba.2007.01.003","article-title":"Macrophage biospecific extraction and high performance liquid chromatography for hypothesis of immunological active components in Cordyceps sinensis","volume":"44","author":"Yu","year":"2007","journal-title":"J. Pharmaceut. Biomed. Anal."},{"key":"10.1016\/j.jep.2021.114678_bib25","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.cca.2013.06.006","article-title":"Foam cells in atherosclerosis","volume":"424","author":"Yu","year":"2013","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.jep.2021.114678_bib26","first-page":"2496","article-title":"Pharmacological activities and possible mechanism of effective components in Ophiopogonis radix","volume":"22","author":"Yuan","year":"2013","journal-title":"Chin. J. N. Drugs"},{"key":"10.1016\/j.jep.2021.114678_bib27","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1034\/j.1600-0463.2002.100604.x","article-title":"Activation of the p38 MAP kinase pathway is required for foam cell formation from macrophages exposed to oxidized LDL","volume":"110","author":"Zhao","year":"2002","journal-title":"APMIS"},{"key":"10.1016\/j.jep.2021.114678_bib28","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jpba.2013.01.003","article-title":"Macrophage biospecific extraction and HPLC-ESI-MSn analysis for screening immunological active components in Smilacis Glabrae Rhizoma","volume":"77","author":"Zheng","year":"2013","journal-title":"J. Pharmaceut. Biomed. Anal."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121009077?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121009077?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:17:30Z","timestamp":1759943850000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874121009077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":27,"alternative-id":["S0378874121009077"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2021.114678","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigation of the effective components inhibited macrophage foam cell formation in Ophiopogonis Radix","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2021.114678","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114678"}}