{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T19:23:35Z","timestamp":1769196215623,"version":"3.49.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T00:00:00Z","timestamp":1633564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.jep.2021.114700","type":"journal-article","created":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T16:29:24Z","timestamp":1632932964000},"page":"114700","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Effects of Jowiseungki-tang on high fat diet-induced obesity in mice and functional analysis on network pharmacology and metabolomics analysis"],"prefix":"10.1016","volume":"283","author":[{"given":"Xianglong","family":"Meng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingning","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junnan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An Na","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seok Yong","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenzi","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Ki","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo Won","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuosheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2021.114700_bib1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0021-9150(99)00504-3","article-title":"Relationship of dietary fat to glucose metabolism","volume":"150","author":"Lichtenstein","year":"2000","journal-title":"Atherosclerosis"},{"issue":"7","key":"10.1016\/j.jep.2021.114700_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/nu9070646","article-title":"Metabolic effects of high glycaemic index diets: a systematic review and meta-analysis of feeding studies in mice and rats","volume":"9","author":"Campbell","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.jep.2021.114700_bib3","doi-asserted-by":"crossref","first-page":"570","DOI":"10.3389\/fendo.2019.00570","article-title":"Dysregulated mitochondrial dynamics and metabolism in obesity, diabetes, and cancer","volume":"10","author":"Dai","year":"2019","journal-title":"Front. Endocrinol."},{"issue":"3","key":"10.1016\/j.jep.2021.114700_bib4","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S2213-8587(17)30236-X","article-title":"Progress and challenges in anti-obesity pharmacotherapy","volume":"6","author":"Daniel H Bessesen","year":"2018","journal-title":"The Lancet Diabetes & Endocrinology"},{"issue":"9","key":"10.1016\/j.jep.2021.114700_bib5","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1753-4887.2010.00311.x","article-title":"Impact of water intake on energy intake and weight status: a systematic review","volume":"68","author":"Daniels","year":"2010","journal-title":"Nutr. Rev."},{"issue":"2","key":"10.1016\/j.jep.2021.114700_bib7","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.diabres.2014.04.006","article-title":"Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes","volume":"105","author":"Esser","year":"2014","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"4","key":"10.1016\/j.jep.2021.114700_bib8","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1111\/j.1365-2796.2007.01852.x","article-title":"Obesity-induced inflammation: a metabolic dialogue in the language of inflammation","volume":"262","author":"Ferrante","year":"2007","journal-title":"J. Intern. Med."},{"issue":"1","key":"10.1016\/j.jep.2021.114700_bib9","doi-asserted-by":"crossref","first-page":"E93","DOI":"10.1152\/ajpendo.00198.2017","article-title":"Disruption of glucagon receptor signaling causes hyperaminoacidemia exposing a possible liver-alpha-cell axis","volume":"314","author":"Galsgaard","year":"2018","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"9","key":"10.1016\/j.jep.2021.114700_bib10","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1007\/s00125-015-3656-y","article-title":"Metabolite profiling in plasma and tissues of ob\/ob and db\/db mice identifies novel markers of obesity and type 2 diabetes","volume":"58","author":"Giesbertz","year":"2015","journal-title":"Diabetologia"},{"key":"10.1016\/j.jep.2021.114700_bib11","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ebiom.2017.10.027","article-title":"Metabolomics and gene expression analysis reveal down-regulation of the citric acid (TCA) cycle in non-diabetic CKD patients","volume":"26","author":"Hallan","year":"2017","journal-title":"EBioMedicine"},{"issue":"1","key":"10.1016\/j.jep.2021.114700_bib12","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/tox.22463","article-title":"Effects of Rhei Undulati Rhizoma on lipopolysaccharide-induced neuroinflammation in vitro and in vivo","volume":"33","author":"Hwang","year":"2018","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.jep.2021.114700_bib13","first-page":"555","article-title":"The effect of some antipolydipsia oriental prescriptions on experimental diabetic rats -Cheongsimyeonja-eum, kamijowiseunki-tang, kikukjihwang-tang","volume":"38","author":"In Ja Rhee","year":"1994","journal-title":"Yakhak Hoeji"},{"key":"10.1016\/j.jep.2021.114700_bib14","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12906-016-0997-0","article-title":"Hepatoprotective effect of licorice, the root of Glycyrrhiza uralensis Fischer, in alcohol-induced fatty liver disease","volume":"16","author":"Jung","year":"2016","journal-title":"BMC Compl. Alternative Med."},{"issue":"10","key":"10.1016\/j.jep.2021.114700_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0047713","article-title":"High fat diet-induced gut microbiota exacerbates inflammation and obesity in mice via the TLR4 signaling pathway","volume":"7","author":"Kim","year":"2012","journal-title":"PloS One"},{"issue":"4","key":"10.1016\/j.jep.2021.114700_bib16","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.3390\/nu5041218","article-title":"Dyslipidemia in obesity: mechanisms and potential targets","volume":"5","author":"Klop","year":"2013","journal-title":"Nutrients"},{"issue":"12","key":"10.1016\/j.jep.2021.114700_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/nu12123636","article-title":"Effects of high and low protein diets on inflammatory profiles in people with morbid obesity: a 3-week intervention study","volume":"12","author":"Koelman","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.jep.2021.114700_bib18","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12906-015-0974-z","article-title":"Protective effect of Rhei Rhizoma on reflux esophagitis in rats via Nrf2-mediated inhibition of NF-kappaB signaling pathway","volume":"16","author":"Kwon","year":"2016","journal-title":"BMC Compl. Alternative Med."},{"issue":"3","key":"10.1016\/j.jep.2021.114700_bib19","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.jep.2013.04.055","article-title":"Molecular network and chemical fragment-based characteristics of medicinal herbs with cold and hot properties from Chinese medicine","volume":"148","author":"Liang","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114700_bib20","doi-asserted-by":"crossref","first-page":"109297","DOI":"10.1016\/j.biopha.2019.109297","article-title":"Regulatory effects of the fruit extract of Lycium chinense and its active compound, betaine, on muscle differentiation and mitochondrial biogenesis in C2C12 cells","volume":"118","author":"Ma","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"12","key":"10.1016\/j.jep.2021.114700_bib21","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1177\/1535370217708188","article-title":"Butyrate reduces high-fat diet-induced metabolic alterations, hepatic steatosis and pancreatic beta cell and intestinal barrier dysfunctions in prediabetic mice","volume":"242","author":"Matheus","year":"2017","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.jep.2021.114700_bib22","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13020-020-00306-0","article-title":"Jowiseungki decoction affects diabetic nephropathy in mice through renal injury inhibition as evidenced by network pharmacology and gut microbiota analyses","volume":"15","author":"Meng","year":"2020","journal-title":"Chin. Med."},{"issue":"2","key":"10.1016\/j.jep.2021.114700_bib23","doi-asserted-by":"crossref","first-page":"93","DOI":"10.4103\/2225-4110.126635","article-title":"Anti-inflammatory and antimicrobial effects of heat-clearing Chinese herbs: a current review","volume":"4","author":"Muluye","year":"2014","journal-title":"J Tradit Complement Med"},{"key":"10.1016\/j.jep.2021.114700_bib24","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1001\/jama.2018.3060","article-title":"Trends in obesity and severe obesity prevalence in US youth and adults by sex and age, 2007-2008 to 2015-2016","volume":"319","author":"Nicholas","year":"2018","journal-title":"JAMA, J. Am. Med. Assoc."},{"key":"10.1016\/j.jep.2021.114700_bib25","doi-asserted-by":"crossref","first-page":"658913","DOI":"10.1155\/2014\/658913","article-title":"New insight into adiponectin role in obesity and obesity-related diseases","volume":"2014","author":"Nigro","year":"2014","journal-title":"BioMed Res. Int."},{"issue":"4","key":"10.1016\/j.jep.2021.114700_bib26","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.thromres.2010.11.031","article-title":"Anticoagulant and anti-platelet activity of polyphenolic-polysaccharide preparation isolated from the medicinal plant Erigeron canadensis L","volume":"127","author":"Pawlaczyk","year":"2011","journal-title":"Thromb. Res."},{"key":"10.1016\/j.jep.2021.114700_bib27","article-title":"Targeted metabolomics","volume":"30","author":"Roberts","year":"2012","journal-title":"Curr Protoc Mol Biol Chapter"},{"issue":"6","key":"10.1016\/j.jep.2021.114700_bib28","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.3945\/ajcn.116.137414","article-title":"The role of obesity in the relation between total water intake and urine osmolality in US adults, 2009-2012","volume":"104","author":"Rosinger","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"issue":"1","key":"10.1016\/j.jep.2021.114700_bib29","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.celrep.2016.12.028","article-title":"Interplay between obesity-induced inflammation and cGMP signaling in white adipose tissue","volume":"18","author":"Sanyal","year":"2017","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.jep.2021.114700_bib30","first-page":"135","article-title":"Obesity pharmacotherapy","volume":"102","author":"Saunders","year":"2018","journal-title":"Med. Clin."},{"key":"10.1016\/j.jep.2021.114700_bib31","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1038\/oby.2007.342","article-title":"Effect of obesity on high\u2010density lipoprotein metabolism","volume":"15","author":"Shirya Rashid","year":"2007","journal-title":"Obesity"},{"issue":"4","key":"10.1016\/j.jep.2021.114700_bib32","doi-asserted-by":"crossref","first-page":"352","DOI":"10.4162\/nrp.2014.8.4.352","article-title":"Anti-inflammatory effect of methanol extract from Erigeron Canadensis L. may be involved with upregulation of heme oxygenase-1 expression and suppression of NFkappaB and MAPKs activation in macrophages","volume":"8","author":"Sung","year":"2014","journal-title":"Nutr Res Pract"},{"key":"10.1016\/j.jep.2021.114700_bib33","first-page":"153","article-title":"The constituents of licorice (Glycyrrhiza uralensis) differentially suppress nitric oxide production in interleukin-1 beta-treated hepatocytes","volume":"2","author":"Tanemoto","year":"2015","journal-title":"Biochem Biophys Rep"},{"key":"10.1016\/j.jep.2021.114700_bib35","series-title":"Obesity and Overweight. Fact Sheets","author":"WHO","year":"2021"},{"issue":"7","key":"10.1016\/j.jep.2021.114700_bib36","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2019-029426","article-title":"Lorcaserin for prevention and remission of type 2 diabetes mellitus in people with overweight or obesity: protocol for a systematic review and meta-analysis","volume":"9","author":"Zeng","year":"2019","journal-title":"BMJ Open"},{"key":"10.1016\/j.jep.2021.114700_bib37","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1038\/srep01476","article-title":"Dietary obesity-induced Egr-1 in adipocytes facilitates energy storage via suppression of FOXC2","volume":"3","author":"Zhang","year":"2013","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.jep.2021.114700_bib38","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1038\/s41598-017-03039-7","article-title":"TCM-Mesh: the database and analytical system for network pharmacology analysis for TCM preparations","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2021.114700_bib39","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3389\/fphar.2019.00123","article-title":"Network pharmacology databases for traditional Chinese medicine: review and assessment","volume":"10","author":"Zhang","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"47","key":"10.1016\/j.jep.2021.114700_bib40","doi-asserted-by":"crossref","first-page":"82621","DOI":"10.18632\/oncotarget.19734","article-title":"Lingguizhugan decoction improves non-alcoholic fatty liver disease by altering insulin resistance and lipid metabolism related genes: a whole trancriptome study by RNA-Seq","volume":"8","author":"Zhu","year":"2017","journal-title":"Oncotarget"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121009296?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121009296?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:18:35Z","timestamp":1759943915000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874121009296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":38,"alternative-id":["S0378874121009296"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2021.114700","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of Jowiseungki-tang on high fat diet-induced obesity in mice and functional analysis on network pharmacology and metabolomics analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2021.114700","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"114700"}}