{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T07:41:05Z","timestamp":1793691665559,"version":"4.5.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074032"],"award-info":[{"award-number":["82074032"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFA0708000"],"award-info":[{"award-number":["2020YFA0708000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.jep.2021.114701","type":"journal-article","created":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T17:42:02Z","timestamp":1633110122000},"page":"114701","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":83,"special_numbering":"C","title":["Xuanfei Baidu Decoction protects against macrophages induced inflammation and pulmonary fibrosis via inhibiting IL-6\/STAT3 signaling pathway"],"prefix":"10.1016","volume":"283","author":[{"given":"Yuying","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Sang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7294-9173","authenticated-orcid":false,"given":"Rui","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglin","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanhao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifeng","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3197-7936","authenticated-orcid":false,"given":"Yan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxu","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiumei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8581-5430","authenticated-orcid":false,"given":"Jian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2021.114701_bib1","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1056\/NEJMoa2007764","article-title":"Remdesivir for the treatment of covid-19 - preliminary report","volume":"383","author":"Beigel","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jep.2021.114701_bib2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.mam.2018.08.004","article-title":"Developmental pathways in the pathogenesis of lung fibrosis","volume":"65","author":"Chanda","year":"2019","journal-title":"Mol. Aspect. Med."},{"key":"10.1016\/j.jep.2021.114701_bib3","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.4049\/jimmunol.1900270","article-title":"Regulatory macrophages inhibit alternative macrophage activation and attenuate pathology associated with fibrosis","volume":"203","author":"Chandrasekaran","year":"2019","journal-title":"J. Immunol."},{"key":"10.1016\/j.jep.2021.114701_bib4","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1165\/rcmb.2015-0020TR","article-title":"Matrix metalloproteinases as therapeutic targets for idiopathic pulmonary fibrosis","volume":"53","author":"Craig","year":"2015","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.jep.2021.114701_bib5","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.phrs.2015.04.012","article-title":"Bleomycin in the setting of lung fibrosis induction: from biological mechanisms to counteractions","volume":"97","author":"Della Latta","year":"2015","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2021.114701_bib6","doi-asserted-by":"crossref","first-page":"106788","DOI":"10.1016\/j.intimp.2020.106788","article-title":"Trophoblast-derived IL-6 serves as an important factor for normal pregnancy by activating Stat3-mediated M2 macrophages polarization","volume":"90","author":"Ding","year":"2021","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.jep.2021.114701_bib7","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1080\/17435390.2018.1425501","article-title":"Macrophage polarization and activation at the interface of multi-walled carbon nanotube-induced pulmonary inflammation and fibrosis","volume":"12","author":"Dong","year":"2018","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.jep.2021.114701_bib8","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3389\/fphar.2015.00215","article-title":"Glycyrrhizic acid alleviates bleomycin-induced pulmonary fibrosis in rats","volume":"6","author":"Gao","year":"2015","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2021.114701_bib9","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.rmed.2018.12.015","article-title":"Inflammation and immunity in IPF pathogenesis and treatment","volume":"147","author":"Heukels","year":"2019","journal-title":"Respir. Med."},{"key":"10.1016\/j.jep.2021.114701_bib10","doi-asserted-by":"crossref","first-page":"104939","DOI":"10.1016\/j.phrs.2020.104939","article-title":"Review on the potential action mechanisms of Chinese medicines in treating Coronavirus Disease 2019 (COVID-19)","volume":"158","author":"Huang","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2021.114701_bib11","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1016\/S0140-6736(11)60052-4","article-title":"Idiopathic pulmonary fibrosis","volume":"378","author":"King","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2021.114701_bib12","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/978-1-60761-987-1_18","article-title":"Cytoscape: software for visualization and analysis of biological networks","volume":"696","author":"Kohl","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jep.2021.114701_bib13","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/d41586-020-01824-5","article-title":"Coronavirus breakthrough: dexamethasone is first drug shown to save lives","volume":"582","author":"Ledford","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jep.2021.114701_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/1535370215597194","article-title":"Epithelial-mesenchymal transition: an emerging target in tissue fibrosis","volume":"241","author":"Li","year":"2016","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.jep.2021.114701_bib15","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.taap.2019.01.011","article-title":"Macrophage-secreted TSLP and MMP9 promote bleomycin-induced pulmonary fibrosis","volume":"366","author":"Li","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jep.2021.114701_bib16","article-title":"The therapeutic efficacy of Xuanfei Baidu Formula combined with conventional drug in the treatment of coronavirus disease 2019: a protocol for systematic review and meta-analysis","volume":"100","author":"Li","year":"2021","journal-title":"Medicine (Baltim.)"},{"key":"10.1016\/j.jep.2021.114701_bib17","doi-asserted-by":"crossref","first-page":"27610","DOI":"10.1038\/srep27610","article-title":"Salvianolic acid B attenuates experimental pulmonary fibrosis through inhibition of the TGF-\u03b2 signaling pathway","volume":"6","author":"Liu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2021.114701_bib18","doi-asserted-by":"crossref","first-page":"21146","DOI":"10.1038\/srep21146","article-title":"BATMAN-TCM: a bioinformatics analysis tool for molecular mechANism of traditional Chinese medicine","volume":"6","author":"Liu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2021.114701_bib19","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.immuni.2019.06.014","article-title":"Targeting degradation of the transcription factor C\/EBPbeta reduces lung fibrosis by restoring activity of the ubiquitin-editing enzyme A20 in macrophages","volume":"51","author":"Liu","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.jep.2021.114701_bib20","doi-asserted-by":"crossref","first-page":"104896","DOI":"10.1016\/j.phrs.2020.104896","article-title":"Efficacy and safety of integrated traditional Chinese and western medicine for corona virus disease 2019 (COVID-19): a systematic review and meta-analysis","volume":"158","author":"Liu","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2021.114701_bib21","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3892\/etm.2020.9190","article-title":"Polydatin prevents bleomycin-induced pulmonary fibrosis by inhibiting the TGF-\u03b2\/Smad\/ERK signaling pathway","volume":"20","author":"Liu","year":"2020","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.jep.2021.114701_bib22","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.bcp.2018.05.007","article-title":"Quercetin ameliorates kidney injury and fibrosis by modulating M1\/M2 macrophage polarization","volume":"154","author":"Lu","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jep.2021.114701_bib23","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13020-020-00317-x","article-title":"Treatment efficacy analysis of traditional Chinese medicine for novel coronavirus pneumonia (COVID-19): an empirical study from Wuhan, Hubei Province, China","volume":"15","author":"Luo","year":"2020","journal-title":"Chin. Med."},{"key":"10.1016\/j.jep.2021.114701_bib24","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01229-2019","article-title":"Dysregulated balance of lung macrophage populations in idiopathic pulmonary fibrosis revealed by single-cell RNA seq: an unstable \"menage-a-trois","volume":"54","author":"Mari","year":"2019","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.jep.2021.114701_bib25","doi-asserted-by":"crossref","first-page":"17074","DOI":"10.1038\/nrdp.2017.74","article-title":"Idiopathic pulmonary fibrosis","volume":"3","author":"Martinez","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.jep.2021.114701_bib26","doi-asserted-by":"crossref","first-page":"114913","DOI":"10.1016\/j.taap.2020.114913","article-title":"Honokiol: a polyphenol neolignan ameliorates pulmonary fibrosis by inhibiting TGF-beta\/Smad signaling, matrix proteins and IL-6\/CD44\/STAT3 axis both in vitro and in vivo","volume":"391","author":"Pulivendala","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jep.2021.114701_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/7947596","article-title":"Elevation of IL-6 and IL-33 levels in serum associated with lung fibrosis and skeletal muscle wasting in a bleomycin-induced lung injury mouse model","author":"Shieh","year":"2019","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.jep.2021.114701_bib28","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1002\/cpbi.5","article-title":"The GeneCards suite: from gene data mining to disease genome sequence analyses","volume":"54","author":"Stelzer","year":"2016","journal-title":"Curr. Protoc. Bioinformatics."},{"key":"10.1016\/j.jep.2021.114701_bib29","doi-asserted-by":"crossref","first-page":"D362","DOI":"10.1093\/nar\/gkw937","article-title":"The STRING database in 2017: quality-controlled protein-protein association networks, made broadly accessible","volume":"45","author":"Szklarczyk","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jep.2021.114701_bib30","doi-asserted-by":"crossref","first-page":"959","DOI":"10.2217\/imt-2016-0020","article-title":"Immunotherapeutic implications of IL-6 blockade for cytokine storm","volume":"8","author":"Tanaka","year":"2016","journal-title":"Immunotherapy"},{"key":"10.1016\/j.jep.2021.114701_bib31","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3389\/fmed.2017.00118","article-title":"Exploring animal models that resemble idiopathic pulmonary fibrosis","volume":"4","author":"Tashiro","year":"2017","journal-title":"Front. Med."},{"key":"10.1016\/j.jep.2021.114701_bib32","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41577-020-0311-8","article-title":"The trinity of COVID-19: immunity, inflammation and intervention","volume":"20","author":"Tay","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jep.2021.114701_bib33","series-title":"treatment Effective on over 90% of COVID-19 Patients on Mainland","author":"TCM","year":"2020"},{"key":"10.1016\/j.jep.2021.114701_bib34","first-page":"1361","article-title":"The molecular mechanism of Xuanfei Baidu Formula in the treatment of COVID-19 antiviral effect based on network pharmacology and molecular docking","volume":"26","author":"Wang","year":"2020","journal-title":"Journal of Hainan Medical University"},{"key":"10.1016\/j.jep.2021.114701_bib35","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1165\/rcmb.2018-0328OC","article-title":"STAT3 regulates the onset of oxidant-induced senescence in lung fibroblasts","volume":"61","author":"Waters","year":"2019","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.jep.2021.114701_bib36","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1097\/SHK.0000000000000309","article-title":"Inhibition effect of glycyrrhizin in lipopolysaccharide-induced high-mobility group box 1 releasing and expression from RAW264.7 cells","volume":"43","author":"Wu","year":"2015","journal-title":"Shock"},{"key":"10.1016\/j.jep.2021.114701_bib37","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.immuni.2016.02.015","article-title":"Macrophages in tissue repair, regeneration, and fibrosis","volume":"44","author":"Wynn","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.jep.2021.114701_bib38","doi-asserted-by":"crossref","first-page":"100489","DOI":"10.1016\/j.imr.2020.100489","article-title":"Efficacy of herbal medicine (Xuanfei Baidu decoction) combined with conventional drug in treating COVID-19:A pilot randomized clinical trial","volume":"9","author":"Xiong","year":"2020","journal-title":"Integr Med Res"},{"key":"10.1016\/j.jep.2021.114701_bib39","doi-asserted-by":"crossref","first-page":"10970","DOI":"10.1073\/pnas.2005615117","article-title":"Effective treatment of severe COVID-19 patients with tocilizumab","volume":"117","author":"Xu","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jep.2021.114701_bib40","doi-asserted-by":"crossref","first-page":"9419","DOI":"10.1002\/jcb.27259","article-title":"IL-6\/STAT3 pathway intermediates M1\/M2 macrophage polarization during the development of hepatocellular carcinoma","volume":"119","author":"Yin","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.jep.2021.114701_bib41","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1002\/jmv.26634","article-title":"Discharge may not be the end of treatment: pay attention to pulmonary fibrosis caused by severe COVID-19","volume":"93","author":"Zhang","year":"2021","journal-title":"J. Med. Virol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121009302?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121009302?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:12:22Z","timestamp":1759943542000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874121009302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":41,"alternative-id":["S0378874121009302"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2021.114701","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Xuanfei Baidu Decoction protects against macrophages induced inflammation and pulmonary fibrosis via inhibiting IL-6\/STAT3 signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2021.114701","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"114701"}}