{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T12:07:41Z","timestamp":1782821261297,"version":"3.54.5"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.jep.2021.114779","type":"journal-article","created":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T07:18:15Z","timestamp":1635319095000},"page":"114779","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Antinociceptive effects of flower extracts and the active fraction from Styrax japonicus"],"prefix":"10.1016","volume":"284","author":[{"given":"Lei","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangjun","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wencui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2021.114779_bib1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3329\/bjms.v18i2.40681","article-title":"A review on opioid dependence, mechanism and treatments used: option of treatments: modern versus alternative medicine","volume":"18","author":"Ahmad","year":"2019","journal-title":"Bangladesh J. Med. Sci."},{"key":"10.1016\/j.jep.2021.114779_bib2","first-page":"241","article-title":"Morphine-induced analgesic tolerance effect on gene expression of the NMDA receptor subunit 1 in rat striatum and prefrontal cortex","volume":"7","author":"Ahmadi","year":"2016","journal-title":"Basic Clin. Neurosci."},{"key":"10.1016\/j.jep.2021.114779_bib3","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1021\/acsomega.0c05720","article-title":"In vivo antinociceptive, muscle relaxant, sedative, and molecular docking studies of peshawaraquinone isolated from Fernandoa adenophylla (Wall. ex G. Don) Steenis","volume":"6","author":"Alhumaydhi","year":"2021","journal-title":"ACS Omega"},{"key":"10.1016\/j.jep.2021.114779_bib4","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jep.2010.09.016","article-title":"Antinociceptive activity of Quillaja saponaria Mol. Saponin extract, quillaic acid and derivatives in mice","volume":"133","author":"Arrau","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114779_bib5","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.3390\/ijms22062887","article-title":"Strategies to modulate specialized metabolism in mediterranean crops: from molecular aspects to field","volume":"22","author":"Balestrini","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2021.114779_bib6","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jep.2019.01.028","article-title":"Evaluation of polyherbal ayurvedic formulation 'Peedantak Vati' for anti-inflammatory and analgesic properties","volume":"235","author":"Balkrishna","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114779_bib7","series-title":"Emotions, Qualia, and Consciousness","first-page":"181","article-title":"The affective dimension of pain: mechanisms and implications","author":"Chapman","year":"2001"},{"key":"10.1016\/j.jep.2021.114779_bib8","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1016\/j.ijbiomac.2020.08.039","article-title":"Chamomile tea: source of a glucuronoxylan with antinociceptive, sedative and anxiolytic-like effects","volume":"164","author":"Chaves","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2021.114779_bib9","doi-asserted-by":"crossref","first-page":"112265","DOI":"10.1016\/j.jep.2019.112265","article-title":"Chemicalcomposition and evaluation of the antinociceptive, antioxidant and antimicrobial effects of essential oil from Hymenaea cangaceira (Pinto, Mansano & Azevedo) native to Brazil: a natural medicine","volume":"247","author":"de Veras","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114779_bib10","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1142\/S0192415X1550041X","article-title":"Artemisia capillaris thunberg produces sedative-hypnotic effects in mice, which are probably mediated through potentiation of the GABA(A) receptor","volume":"43","author":"dela Pena","year":"2015","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jep.2021.114779_bib11","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.biopha.2017.07.116","article-title":"In vitro schistosomicidal and antiviral activities of Arctium lappa L. (Asteraceae) against Schistosoma mansoni and herpes simplex virus-1","volume":"94","author":"Dias","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2021.114779_bib12","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.biopha.2018.08.089","article-title":"The orofacial antinociceptive effect of Kaempferol-3-O-rutinoside, isolated from the plant Ouratea fieldingiana, on adult zebrafish (Danio rerio)","volume":"107","author":"do Nascimento","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2021.114779_bib13","series-title":"Pharmacological Mechanisms and the Modulation of Pain","first-page":"325","article-title":"The potential of traditional Chinese medicine in the treatment and modulation of pain","author":"Du","year":"2016"},{"key":"10.1016\/j.jep.2021.114779_bib14","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.jep.2016.04.010","article-title":"Antinociceptive and anti-inflammatory effects of Memora nodosa and allantoin in mice","volume":"186","author":"Florentino","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114779_bib15","doi-asserted-by":"crossref","first-page":"562","DOI":"10.3389\/fphar.2017.00562","article-title":"Anti-inflammatory and analgesic effects of Polygonum orientale L. extracts","volume":"8","author":"Gou","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2021.114779_bib16","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s00210-012-0742-2","article-title":"Acute effect of essential oil of Eugenia caryophyllata on cognition and pain in mice","volume":"385","author":"Halder","year":"2012","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"10.1016\/j.jep.2021.114779_bib17","first-page":"539807","article-title":"Analgesic and anti-inflammatory activities of leaf extract of Mallotus repandus (Willd","author":"Hasan","year":"2014","journal-title":"Muell. Arg. Biomed Res. Int."},{"key":"10.1016\/j.jep.2021.114779_bib18","doi-asserted-by":"crossref","first-page":"112699","DOI":"10.1016\/j.bbr.2020.112699","article-title":"Anti-nociceptive and antioxidant activity of betaine on formalin- and writhing tests induced pain in mice","volume":"390","author":"Hassanpour","year":"2020","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.jep.2021.114779_bib19","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s11418-008-0302-8","article-title":"Anti-inflammatory and analgesic components from \"hierba santa,'' a traditional medicine in Peru","volume":"63","author":"Kawano","year":"2009","journal-title":"J. Nat. Med."},{"key":"10.1016\/j.jep.2021.114779_bib20","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.neulet.2019.01.035","article-title":"Possible involvement of the \u03bc opioid receptor in the antinociception induced by sinomenine on formalin-induced nociceptive behavior in mice","volume":"699","author":"Komatsu","year":"2019","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jep.2021.114779_bib21","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1248\/cpb.52.1466","article-title":"Matrix metallo- proteinase-1 inhibitor from the stem bark of Styrax japonica S","volume":"52","author":"Kim","year":"2004","journal-title":"et Z. Chem. Pharm. Bull."},{"key":"10.1016\/j.jep.2021.114779_bib22","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1151\/spp021113","article-title":"The neurobiology of opioid dependence: implications for treatment","volume":"1","author":"Kosten","year":"2002","journal-title":"Sci. Pract. Perspect."},{"key":"10.1016\/j.jep.2021.114779_bib23","first-page":"369","article-title":"In vivo anti-inflammatory and antinocicep- tive activities of the extracts and chemical constituents of an endemic Turkish plant, Salsola grandis","volume":"10","author":"Kucukboyaci","year":"2016","journal-title":"Rec. Nat. Prod."},{"key":"10.1016\/j.jep.2021.114779_bib24","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s12272-010-0608-4","article-title":"Isolation of virus-cell fusion inhibitory components from the stem bark of Styrax japonica S","volume":"33","author":"Lee","year":"2010","journal-title":"et Z. Arch. Pharm. Res."},{"key":"10.1016\/j.jep.2021.114779_bib25","doi-asserted-by":"crossref","first-page":"390","DOI":"10.4062\/biomolther.2016.156","article-title":"Sedative effect of Sophora flavescens and matrine","volume":"25","author":"Lee","year":"2017","journal-title":"Biomol. Ther."},{"key":"10.1016\/j.jep.2021.114779_bib26","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.biopha.2018.04.017","article-title":"Sedative and hypnotic effects of Schisandrin B through increasing GABA\/Glu ratio and upregulating the expression of GABA(A) in mice and rats","volume":"103","author":"Li","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2021.114779_bib27","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.3389\/fphar.2019.01376","article-title":"Chemical composition, toxicity, antinociceptive, and anti-inflammatory activity of dry aqueous extract of Varronia multispicata (Cham.) Borhidi (Cordiaceae) Leaves","volume":"10","author":"Lopes","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2021.114779_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2018.03.016","article-title":"NLX-112, a highly selective 5-HT1A receptor agonist, mediates analgesia and antidepressant-like activity in rats via spinal cord and prefrontal cortex 5-HT1A receptors, respectively","volume":"1688","author":"Newman-Tancredia","year":"2018","journal-title":"Brain Res."},{"key":"10.1016\/j.jep.2021.114779_bib29","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1016\/j.biopha.2018.10.003","article-title":"Sedative and hypnotic effects of Vaccinium bracteatum Thunb. through the regulation of serotonegic and GABAA-ergic systems: involvement of 5-HT1A receptor agonistic activity","volume":"109","author":"Oh","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2021.114779_bib30","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1089\/jmf.2009.0012","article-title":"Antinociceptive effect of the extract of Morus nigra leaves in mice","volume":"12","author":"Padilha","year":"2009","journal-title":"J. Med. Food"},{"key":"10.1016\/j.jep.2021.114779_bib31","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1007\/s10787-018-0446-4","article-title":"Anti-inflammatory, anti-rheumatic and analgesic activities of 2-(5-mercapto -1,3,4-oxadiazol-2-yl)-N-propylbenzenesulphonamide (MOPBS) in rodents","volume":"26","author":"Rasheed","year":"2018","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.jep.2021.114779_bib32","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.pbb.2010.09.020","article-title":"Intraplantar injection of bergamot essential oil induces peripheral antinociception mediated by opioid mechanism","volume":"97","author":"Sakurada","year":"2011","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.jep.2021.114779_bib33","doi-asserted-by":"crossref","first-page":"111053","DOI":"10.1016\/j.fct.2019.111053","article-title":"Antinociceptive activity of the Psidium brownianum Mart ex DC. leaf essential oil in mice","volume":"135","author":"Sampaio","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jep.2021.114779_bib34","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3389\/fphar.2019.00409","article-title":"Loganin exerts sedative and hypnotic effects via modulation of the serotonergic system and GABAergic neurons","volume":"10","author":"Shi","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2021.114779_bib35","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1002\/ptr.6876","article-title":"Antinociceptive and sedative activity of Vernonia patula and predictive interactions of its phenolic compounds with the cannabinoid type 1 receptor","volume":"35","author":"Siraj","year":"2021","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2021.114779_bib36","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.2147\/JIR.S285932","article-title":"Evaluation of analgesic and anti-inflammatory potential of 80% methanol leaf extract of Otostegia integrifolia Benth (Lamiaceae)","volume":"13","author":"Tesfaye","year":"2020","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.jep.2021.114779_bib37","doi-asserted-by":"crossref","first-page":"125766","DOI":"10.1016\/j.foodchem.2019.125766","article-title":"UPLC-PDA-Q\/TOF-MS profiling of phenolic and carotenoid compounds and their influence on anticholinergic potential for AChE and BuChE inhibition and on-line antioxidant activity of selected Hippopha rhamnoides L. cultivars","volume":"309","author":"Tkacz","year":"2020","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2021.114779_bib38","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jff.2018.06.028","article-title":"Potential health advantages of Periploca laevigata: preliminary phytochemical analysis and evaluation of in vitro antioxidant capacity and assessment of hepatoprotective, anti-inflammatory and analgesic effects","volume":"48","author":"Tlili","year":"2018","journal-title":"J. Funct. Food."},{"key":"10.1016\/j.jep.2021.114779_bib39","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jaap.2010.02.005","article-title":"Investigation on catalytic pyrolysis of pine sawdust: catalyst screening by Py-GC-MIP-AED","volume":"88","author":"Torri","year":"2010","journal-title":"J. Anal. Appl. Pyrolysis"},{"key":"10.1016\/j.jep.2021.114779_bib40","series-title":"Compilation of National Chinese Herbal Medicine","author":"Wang","year":"2014"},{"key":"10.1016\/j.jep.2021.114779_bib41","first-page":"437","article-title":"Progress on active analgesic components and mechanisms of commonly used traditional Chinese medicines: a comprehensive review","volume":"21","author":"Wang","year":"2018","journal-title":"J. Pharm. Pharmaceut. Sci."},{"key":"10.1016\/j.jep.2021.114779_bib42","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.jep.2013.12.003","article-title":"Antinociceptive and anti-inflammatory activities of extract and two isolated flavonoids of Carthamus tinctorius L","volume":"151","author":"Wang","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114779_bib43","first-page":"2153","article-title":"Determination of six constituents in vitamin C Yinqiao tablets by LC-MS\/MS","volume":"35","author":"Yang","year":"2013","journal-title":"Chin. Tradit. Pat. Med."},{"key":"10.1016\/j.jep.2021.114779_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00702-007-0808-3","article-title":"Both endogenous and exogenous ACh plays antinociceptive role in the hippocampus CA1 of rats","volume":"115","author":"Yang","year":"2008","journal-title":"J. Neural. Transm."},{"key":"10.1016\/j.jep.2021.114779_bib45","doi-asserted-by":"crossref","first-page":"126568","DOI":"10.1016\/j.foodchem.2020.126568","article-title":"Characterization of chemical composition and prebiotic effect of a dietary medicinal plant Penthorum Chinense Pursh","volume":"319","author":"Yin","year":"2020","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2021.114779_bib46","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1248\/cpb.48.1093","article-title":"Antisweet natural products. XV. Structures of jegosaponins A-D from Styrax japonica SIEB","volume":"48","author":"Yoshikawa","year":"2000","journal-title":"et ZUCC. Chem. Pharm. Bull."},{"key":"10.1016\/j.jep.2021.114779_bib47","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1248\/bpb.30.139","article-title":"Styraxoside A isolated from the stem bark of Styrax japonica inhibits lipopolysaccharide-induced expression of inducible nitric oxide synthase and cyclooxygenase-2 in RAW 264.7 cells by suppressing nuclear factor-kappa B activation","volume":"30","author":"Yun","year":"2007","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jep.2021.114779_bib48","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1111\/jphp.13346","article-title":"Characterization of lignans in forsythiae fructus and their metabolites in rats by ultra-performance liquid chromatography coupled time-of\u2010flight mass spectrometry","volume":"72","author":"Zhang","year":"2020","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jep.2021.114779_bib49","first-page":"4320","article-title":"Review for sedative and hypnotic mechanism of sedative traditional Chinese medicine and relative active components on neurotransmitters","volume":"41","author":"Zhang","year":"2016","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.jep.2021.114779_bib50","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1016\/j.phymed.2016.10.017","article-title":"The anxiolytic effect of essential oil of Cananga odorata exposure on mice and determination of its major active constituents","volume":"23","author":"Zhang","year":"2016","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2021.114779_bib51","doi-asserted-by":"crossref","first-page":"418","DOI":"10.3389\/fnmol.2018.00418","article-title":"Glutamate, glutamine and GABA levels in rat brain measured using MRS, HPLC and NMR methods in study of two models of autism","volume":"11","author":"Zieminska","year":"2018","journal-title":"Front. Mol. Neurosci."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121010096?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121010096?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:13:58Z","timestamp":1759943638000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874121010096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":51,"alternative-id":["S0378874121010096"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2021.114779","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antinociceptive effects of flower extracts and the active fraction from Styrax japonicus","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2021.114779","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114779"}}