{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:37:49Z","timestamp":1792625869277,"version":"4.5.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81774014"],"award-info":[{"award-number":["81774014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.jep.2021.114784","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:31:44Z","timestamp":1635381104000},"page":"114784","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Integrating network pharmacology and non-targeted metabolomics to explore the common mechanism of Coptis Categorized Formula improving T2DM zebrafish"],"prefix":"10.1016","volume":"284","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0484-3545","authenticated-orcid":false,"given":"Tao","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingshuang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaofeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanxin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5054-1011","authenticated-orcid":false,"given":"Jianmei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.jep.2021.114784_bib1","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1007\/s00125-004-1437-0","article-title":"Abnormal p38 mitogen-activated protein kinase signalling in human and experimental diabetic nephropathy","volume":"47","author":"Adhikary","year":"2004","journal-title":"Diabetologia"},{"issue":"11","key":"10.1016\/j.jep.2021.114784_bib2","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/j.metabol.2013.07.001","article-title":"Maladaptive immune and inflammatory pathways lead to cardiovascular insulin resistance","volume":"62","author":"Aroor","year":"2013","journal-title":"Metabolism"},{"issue":"2","key":"10.1016\/j.jep.2021.114784_bib3","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrg1272","article-title":"Network biology: understanding the cell's functional organization","volume":"5","author":"Barabasi","year":"2004","journal-title":"Nat. Rev. Genet."},{"issue":"7","key":"10.1016\/j.jep.2021.114784_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0041456","article-title":"Plasma lysophosphatidylcholine levels are reduced in obesity and type 2 diabetes","volume":"7","author":"Barber","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2021.114784_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jbior.2014.11.004","article-title":"PI3K signaling in the pathogenesis of obesity: the cause and the cure","volume":"58","author":"Beretta","year":"2015","journal-title":"Adv Biol Regul"},{"issue":"11 Suppl. l","key":"10.1016\/j.jep.2021.114784_bib6","first-page":"I31","article-title":"Functional, cellular, and molecular characterization of the angiogenic response to chronic myocardial ischemia in diabetes","volume":"116","author":"Boodhwani","year":"2007","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.jep.2021.114784_bib7","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1172\/JCI13210","article-title":"Arachidonic acid as a bioactive molecule","volume":"107","author":"Brash","year":"2001","journal-title":"J. Clin. Invest."},{"issue":"R1","key":"10.1016\/j.jep.2021.114784_bib8","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1093\/hmg\/ddu123","article-title":"Branched-chain amino acid metabolism: from rare Mendelian diseases to more common disorders","volume":"23","author":"Burrage","year":"2014","journal-title":"Hum. Mol. Genet."},{"issue":"Suppl. 2","key":"10.1016\/j.jep.2021.114784_bib9","doi-asserted-by":"crossref","first-page":"S232","DOI":"10.2337\/dc09-S316","article-title":"Antioxidant anti-inflammatory treatment in type 2 diabetes","volume":"32","author":"Ceriello","year":"2009","journal-title":"Diabetes Care"},{"issue":"6","key":"10.1016\/j.jep.2021.114784_bib10","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.cmet.2016.10.002","article-title":"Adipocyte ceramides regulate subcutaneous adipose browning, inflammation, and metabolism","volume":"24","author":"Chaurasia","year":"2016","journal-title":"Cell Metabol."},{"issue":"1","key":"10.1016\/j.jep.2021.114784_bib11","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s11655-007-0041-9","article-title":"Effect of huanglian jiedu decoction ) on glucose transporter 4 expression in adipose and skeletal muscle tissues of insulin resistant rats","volume":"13","author":"Chen","year":"2007","journal-title":"Chin. J. Integr. Med."},{"issue":"10","key":"10.1016\/j.jep.2021.114784_bib12","doi-asserted-by":"crossref","first-page":"e111543","DOI":"10.1371\/journal.pone.0111543","article-title":"Efficacy and safety of dipeptidyl peptidase-4 inhibitors in type 2 diabetes mellitus patients with moderate to severe renal impairment: a systematic review and meta-analysis","volume":"9","author":"Cheng","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.jep.2021.114784_bib13","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1185\/03007995.2014.980886","article-title":"Evaluation of the pharmacokinetics of the DPP-4 inhibitor gemigliptin when coadministered with rosuvastatin or irbesartan to healthy subjects","volume":"31","author":"Choi","year":"2015","journal-title":"Curr. Med. Res. Opin."},{"key":"10.1016\/j.jep.2021.114784_bib14","series-title":"Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine","author":"D","year":"2006"},{"issue":"Suppl. 2","key":"10.1016\/j.jep.2021.114784_bib15","doi-asserted-by":"crossref","first-page":"S276","DOI":"10.2337\/dc11-s229","article-title":"DPP-4 inhibitors: impact on glycemic control and cardiovascular risk factors","volume":"34","author":"Dicker","year":"2011","journal-title":"Diabetes Care"},{"issue":"9","key":"10.1016\/j.jep.2021.114784_bib16","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1007\/s00125-019-4959-1","article-title":"New insights into the mechanisms of diabetic complications: role of lipids and lipid metabolism","volume":"62","author":"Eid","year":"2019","journal-title":"Diabetologia"},{"issue":"2","key":"10.1016\/j.jep.2021.114784_bib17","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/CCO.0b013e3282f5271c","article-title":"The MAPK pathway in melanoma","volume":"20","author":"Fecher","year":"2008","journal-title":"Curr. Opin. Oncol."},{"issue":"10","key":"10.1016\/j.jep.2021.114784_bib18","doi-asserted-by":"crossref","first-page":"4955","DOI":"10.1007\/s12274-018-2092-y","article-title":"Scavenging of reactive oxygen and nitrogen species with nanomaterials","volume":"11","author":"Ferreira","year":"2018","journal-title":"Nano Res"},{"issue":"7","key":"10.1016\/j.jep.2021.114784_bib19","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/eurheartj\/ehr304","article-title":"Nitric oxide synthases: regulation and function","volume":"33","author":"Forstermann","year":"2012","journal-title":"Eur. Heart J."},{"issue":"11","key":"10.1016\/j.jep.2021.114784_bib20","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1042\/CS20160823","article-title":"Kidney, heart and brain: three organs targeted by ageing and glycation","volume":"131","author":"Frimat","year":"2017","journal-title":"Clin. Sci. (Lond.)"},{"issue":"14","key":"10.1016\/j.jep.2021.114784_bib21","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.2174\/13816128113199990475","article-title":"Role of AGEs-RAGE system in cardiovascular disease","volume":"20","author":"Fukami","year":"2014","journal-title":"Curr. Pharmaceut. Des."},{"issue":"12","key":"10.1016\/j.jep.2021.114784_bib22","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1172\/JCI21625","article-title":"Increased oxidative stress in obesity and its impact on metabolic syndrome","volume":"114","author":"Furukawa","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jep.2021.114784_bib23","doi-asserted-by":"crossref","first-page":"2427301","DOI":"10.1155\/2018\/2427301","article-title":"A meta-analysis of the clinical efficacy of TCM decoctions made from formulas in the liuwei dihuang wan categorized formulas in treating diabetic nephropathy proteinuria","volume":"2018","author":"Gao","year":"2018","journal-title":"Evid Based Complement Alternat Med"},{"issue":"1","key":"10.1016\/j.jep.2021.114784_bib24","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1080\/10408363.2017.1414143","article-title":"Serum and plasma amino acids as markers of prediabetes, insulin resistance, and incident diabetes","volume":"55","author":"Gar","year":"2018","journal-title":"Crit. Rev. Clin. Lab Sci."},{"issue":"5","key":"10.1016\/j.jep.2021.114784_bib25","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.cmet.2008.08.016","article-title":"Endothelial cell-specific NF-kappaB inhibition protects mice from atherosclerosis","volume":"8","author":"Gareus","year":"2008","journal-title":"Cell Metabol."},{"issue":"9","key":"10.1016\/j.jep.2021.114784_bib26","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1161\/CIRCRESAHA.110.223545","article-title":"Oxidative stress and diabetic complications","volume":"107","author":"Giacco","year":"2010","journal-title":"Circ. Res."},{"issue":"6 Suppl. l","key":"10.1016\/j.jep.2021.114784_bib27","first-page":"S1","article-title":"Methods for insulin delivery and glucose monitoring in diabetes: summary of a comparative effectiveness review","volume":"18","author":"Golden","year":"2012","journal-title":"J. Manag. Care Pharm."},{"issue":"1","key":"10.1016\/j.jep.2021.114784_bib28","first-page":"CR35","article-title":"Concentrations of sphingosine and sphinganine in plasma of patients with Type 2 diabetes","volume":"11","author":"G\u00f3rska","year":"2005","journal-title":"Med. Sci. Mon. Int. Med. J. Exp. Clin. Res.: international medical journal of experimental and clinical research"},{"issue":"1\u20132","key":"10.1016\/j.jep.2021.114784_bib29","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.lfs.2014.04.034","article-title":"Compound K protects pancreatic islet cells against apoptosis through inhibition of the AMPK\/JNK pathway in type 2 diabetic mice and in MIN6 beta-cells","volume":"107","author":"Guan","year":"2014","journal-title":"Life Sci."},{"issue":"6","key":"10.1016\/j.jep.2021.114784_bib30","first-page":"1","article-title":"Integrating non-targeted metabolomics and toxicology networks to study the mechanism of Esculentoside A-induced hepatotoxicity in rats","volume":"35","author":"He","year":"2021","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"4","key":"10.1016\/j.jep.2021.114784_bib31","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S1096-4959(01)00408-0","article-title":"Mechanism, origin, and evolution of anoxia tolerance in animals","volume":"130","author":"Hochachka","year":"2001","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol."},{"issue":"12","key":"10.1016\/j.jep.2021.114784_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0083922","article-title":"Combining machine learning systems and multiple docking simulation packages to improve docking prediction reliability for network pharmacology","volume":"8","author":"Hsin","year":"2013","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.jep.2021.114784_bib33","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/s11655-018-3012-4","article-title":"Coptidis rhizoma-contained traditional formulae for insomnia: a potential to prevent diabetes?","volume":"24","author":"Huang","year":"2018","journal-title":"Chin. J. Integr. Med."},{"issue":"1","key":"10.1016\/j.jep.2021.114784_bib34","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/nyas.14037","article-title":"Connecting pancreatic islet lipid metabolism with insulin secretion and the development of type 2 diabetes","volume":"1461","author":"Imai","year":"2020","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"6","key":"10.1016\/j.jep.2021.114784_bib35","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1161\/01.HYP.0000069700.62727.C5","article-title":"Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease?","volume":"41","author":"Johnson","year":"2003","journal-title":"Hypertension"},{"issue":"12","key":"10.1016\/j.jep.2021.114784_bib36","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1681\/ASN.2005050572","article-title":"Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells","volume":"16","author":"Kang","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"issue":"3","key":"10.1016\/j.jep.2021.114784_bib37","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1113\/JP271274","article-title":"Effects of unsaturated fatty acids on the kinetics of voltage-gated proton channels heterologously expressed in cultured cells","volume":"594","author":"Kawanabe","year":"2016","journal-title":"J. Physiol."},{"issue":"3","key":"10.1016\/j.jep.2021.114784_bib38","doi-asserted-by":"crossref","first-page":"599","DOI":"10.2337\/diabetes.51.3.599","article-title":"Mechanism of amino acid-induced skeletal muscle insulin resistance in humans","volume":"51","author":"Krebs","year":"2002","journal-title":"Diabetes"},{"issue":"5","key":"10.1016\/j.jep.2021.114784_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20051149","article-title":"An updated review of lysophosphatidylcholine metabolism in human diseases","volume":"20","author":"Law","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2021.114784_bib40","doi-asserted-by":"crossref","DOI":"10.4149\/neo_2015_043","article-title":"The impact of Caspase-8 on non-small cell lung cancer brain metastasis in II\/III stage patient","author":"Liao","year":"2015","journal-title":"Neoplasma"},{"issue":"12","key":"10.1016\/j.jep.2021.114784_bib41","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19123999","article-title":"Caspase-3 mediated cell death in the normal development of the mammalian cerebellum","volume":"19","author":"Lossi","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.jep.2021.114784_bib42","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nrendo.2014.171","article-title":"Branched-chain amino acids in metabolic signalling and insulin resistance","volume":"10","author":"Lynch","year":"2014","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.jep.2021.114784_bib43","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ijcard.2015.08.109","article-title":"Regulation of uric acid metabolism and excretion","volume":"213","author":"Maiuolo","year":"2016","journal-title":"Int. J. Cardiol."},{"issue":"1","key":"10.1016\/j.jep.2021.114784_bib44","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1172\/JCI119126","article-title":"Glycation-dependent, reactive oxygen species-mediated suppression of the insulin gene promoter activity in HIT cells","volume":"99","author":"Matsuoka","year":"1997","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.jep.2021.114784_bib45","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nrendo.2016.169","article-title":"Sphingolipids and phospholipids in insulin resistance and related metabolic disorders","volume":"13","author":"Meikle","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"issue":"1","key":"10.1016\/j.jep.2021.114784_bib46","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1017\/S0029665100000185","article-title":"Nutrition in paediatric human immunodeficiency virus infection","volume":"59","author":"Miller","year":"2000","journal-title":"Proc. Nutr. Soc."},{"issue":"1","key":"10.1016\/j.jep.2021.114784_bib47","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/s12944-017-0540-4","article-title":"Liquid chromatography mass spectrometry-based profiling of phosphatidylcholine and phosphatidylethanolamine in the plasma and liver of acetaminophen-induced liver injured mice","volume":"16","author":"Ming","year":"2017","journal-title":"Lipids Health Dis."},{"issue":"11","key":"10.1016\/j.jep.2021.114784_bib48","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1111\/j.1463-1326.2012.01632.x","article-title":"Pancreatic beta-cell dysfunction, expression of iNOS and the effect of phosphodiesterase inhibitors in human pancreatic islets of type 2 diabetes","volume":"14","author":"Muhammed","year":"2012","journal-title":"Diabetes Obes. Metabol."},{"issue":"4","key":"10.1016\/j.jep.2021.114784_bib49","doi-asserted-by":"crossref","first-page":"4879","DOI":"10.3892\/mmr.2017.7170","article-title":"Gold nanoparticles promote osteogenic differentiation of human periodontal ligament stem cells via the p38 MAPK signaling pathway","volume":"16","author":"Niu","year":"2017","journal-title":"Mol. Med. Rep."},{"issue":"1","key":"10.1016\/j.jep.2021.114784_bib50","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3390\/biom5010194","article-title":"Advanced glycation end products and oxidative stress in type 2 diabetes mellitus","volume":"5","author":"Nowotny","year":"2015","journal-title":"Biomolecules"},{"issue":"3","key":"10.1016\/j.jep.2021.114784_bib51","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0254-6272(16)30042-5","article-title":"Retrospective study of Traditional Chinese Medicine treatment of type 2 diabetes mellitus","volume":"36","author":"Pang","year":"2016","journal-title":"J. Tradit. Chin. Med."},{"issue":"12","key":"10.1016\/j.jep.2021.114784_bib52","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nrrheum.2015.125","article-title":"Mechanisms of crystal formation in gout-a structural approach","volume":"11","author":"Pascual","year":"2015","journal-title":"Nat. Rev. Rheumatol."},{"issue":"Pt 2","key":"10.1016\/j.jep.2021.114784_bib53","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1042\/bj20021878","article-title":"Killing tumours by ceramide-induced apoptosis: a critique of available drugs","volume":"371","author":"Radin","year":"2003","journal-title":"Biochem. J."},{"issue":"7","key":"10.1016\/j.jep.2021.114784_bib54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0177738","article-title":"Biomarkers for predicting type 2 diabetes development-Can metabolomics improve on existing biomarkers?","volume":"12","author":"Savolainen","year":"2017","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.jep.2021.114784_bib55","first-page":"5447","article-title":"A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation","volume":"12","author":"Semenza","year":"1992","journal-title":"Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.jep.2021.114784_bib56","doi-asserted-by":"crossref","first-page":"76","DOI":"10.2174\/1872214810666161020154905","article-title":"The regulatory roles of mitogen-activated protein kinase (MAPK) pathways in health and diabetes: lessons learned from the pancreatic beta-cell","volume":"10","author":"Sidarala","year":"2017","journal-title":"Recent Pat. Endocr. Metab. Immune Drug Discov."},{"issue":"7","key":"10.1016\/j.jep.2021.114784_bib57","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.2337\/db11-1378","article-title":"Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men","volume":"61","author":"Stancakova","year":"2012","journal-title":"Diabetes"},{"issue":"10","key":"10.1016\/j.jep.2021.114784_bib58","doi-asserted-by":"crossref","first-page":"973","DOI":"10.2174\/138161208784139693","article-title":"Possible involvement of advanced glycation end-products (AGEs) in the pathogenesis of Alzheimer's disease","volume":"14","author":"Takeuchi","year":"2008","journal-title":"Curr. Pharmaceut. Des."},{"key":"10.1016\/j.jep.2021.114784_bib59","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jare.2017.11.004","article-title":"Arachidonic acid: physiological roles and potential health benefits - a review","volume":"11","author":"Tallima","year":"2018","journal-title":"J. Adv. Res."},{"issue":"9","key":"10.1016\/j.jep.2021.114784_bib60","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18091988","article-title":"The future challenge of reactive oxygen species (ROS) in hypertension: from bench to bed side","volume":"18","author":"Togliatto","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.jep.2021.114784_bib61","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2174\/157016112798829760","article-title":"The role of nitric oxide on endothelial function","volume":"10","author":"Tousoulis","year":"2012","journal-title":"Curr. Vasc. Pharmacol."},{"issue":"4","key":"10.1016\/j.jep.2021.114784_bib62","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nm.2307","article-title":"Metabolite profiles and the risk of developing diabetes","volume":"17","author":"Wang","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.jep.2021.114784_bib63","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.cbi.2017.06.011","article-title":"Metabolomics highlights pharmacological bioactivity and biochemical mechanism of traditional Chinese medicine","volume":"273","author":"Wang","year":"2017","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jep.2021.114784_bib64","doi-asserted-by":"crossref","first-page":"109914","DOI":"10.1016\/j.biopha.2020.109914","article-title":"Composite probiotics alleviate type 2 diabetes by regulating intestinal microbiota and inducing GLP-1 secretion in db\/db mice","volume":"125","author":"Wang","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"3","key":"10.1016\/j.jep.2021.114784_bib65","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/ismej.2014.177","article-title":"Structural modulation of gut microbiota during alleviation of type 2 diabetes with a Chinese herbal formula","volume":"9","author":"Xu","year":"2015","journal-title":"ISME J."},{"issue":"6","key":"10.1016\/j.jep.2021.114784_bib66","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1097\/HJH.0b013e328337da1d","article-title":"Oxidative stress with an activation of the renin\u2013angiotensin system in human vascular endothelial cells as a novel mechanism of uric acid-induced endothelial dysfunction","volume":"28","author":"Yu","year":"2010","journal-title":"J. Hypertens."},{"issue":"5","key":"10.1016\/j.jep.2021.114784_bib67","first-page":"615","article-title":"Hypolipidemic effect of the Chinese polyherbal Huanglian Jiedu decoction in type 2 diabetic rats and its possible mechanism","volume":"21","author":"Zhang","year":"2014","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412101014X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412101014X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:16:59Z","timestamp":1759943819000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037887412101014X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":67,"alternative-id":["S037887412101014X"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2021.114784","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrating network pharmacology and non-targeted metabolomics to explore the common mechanism of Coptis Categorized Formula improving T2DM zebrafish","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2021.114784","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"114784"}}