{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T14:46:24Z","timestamp":1789137984646,"version":"build-2803163510"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.jep.2021.114902","type":"journal-article","created":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T00:26:34Z","timestamp":1638923194000},"page":"114902","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Flavonoids and proanthocyanidins-rich fractions from Eugenia dysenterica fruits and leaves inhibit the formation of advanced glycation end-products and the activities of \u03b1-amylase and \u03b1-glucosidase"],"prefix":"10.1016","volume":"285","author":[{"given":"Allisson Benatti","family":"Justino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heitor Cappato","family":"Guerra Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Rodrigues","family":"Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0803-4411","authenticated-orcid":false,"given":"Isabela","family":"de Oliveira Cavalcante Pimentel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6616-5439","authenticated-orcid":false,"given":"Nicole Fernandes","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Lopes","family":"Saraiva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6937-1411","authenticated-orcid":false,"given":"Foued Salmen","family":"Espindola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2021.114902_bib1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.foodchem.2014.06.011","article-title":"HPLC\u2013DAD\u2013ESI-MS\/MS screening of bioactive components from Rhus coriaria L. (Sumac) fruits","volume":"166","author":"Abu-Reidah","year":"2015","journal-title":"Food Chem."},{"issue":"1","key":"10.1016\/j.jep.2021.114902_bib2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.diabres.2004.09.004","article-title":"Advanced glycation endproducts--role in pathology of diabetic complications","volume":"67","author":"Ahmed","year":"2005","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.jep.2021.114902_bib3","series-title":"Cerrado: Esp\u00e9cies Vegetais \u00dateis","author":"Almeida","year":"1998"},{"issue":"1","key":"10.1016\/j.jep.2021.114902_bib4","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1007\/s11033-020-06084-0","article-title":"A review on mechanism of inhibition of advanced glycation end products formation by plant derived polyphenolic compounds","volume":"48","author":"Anwar","year":"2021","journal-title":"Mol. Biol. Rep."},{"issue":"1","key":"10.1016\/j.jep.2021.114902_bib5","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s13205-018-1528-0","article-title":"Role of medicinal plants in the management of diabetes mellitus: a review","volume":"9","author":"Bindu","year":"2019","journal-title":"3 Biotech"},{"key":"10.1016\/j.jep.2021.114902_bib6","article-title":"Effects of abiotic factors on phenolic compounds in the Grape Berry \u2013 a review","volume":"40","author":"Blancquaert","year":"2018","journal-title":"S. Afr. J. Enol. Vitic."},{"issue":"7","key":"10.1016\/j.jep.2021.114902_bib7","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3390\/antiox8070205","article-title":"Optimization of ultrasound-assisted extraction of polyphenols from Myrtus communis L","volume":"8","author":"Bouaoudia-Madi","year":"2019","journal-title":"Pericarp. Antioxidants (Basel)"},{"issue":"4","key":"10.1016\/j.jep.2021.114902_bib8","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.foodchem.2008.04.058","article-title":"Characterization of phenolics by LC-UV\/vis, LC-MS\/MS and sugars by GC in Melicoccus bijugatus Jacq. 'Montgomery' fruits","volume":"111","author":"Bystrom","year":"2008","journal-title":"Food Chem."},{"issue":"3","key":"10.1016\/j.jep.2021.114902_bib9","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.jep.2012.03.031","article-title":"Screening of Brazilian medicinal plants for antiviral activity against rotavirus","volume":"141","author":"Cec\u00edlio","year":"2012","journal-title":"J. Ethnopharmacol."},{"issue":"864","key":"10.1016\/j.jep.2021.114902_bib10","article-title":"Extraction of flavonoids from natural sources using modern techniques","volume":"8","author":"Chaves","year":"2020","journal-title":"Front. Chem."},{"key":"10.1016\/j.jep.2021.114902_bib11","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.foodchem.2018.08.090","article-title":"Structure-activity relationship of procyanidins on advanced glycation end products formation and corresponding mechanisms","volume":"272","author":"Chen","year":"2019","journal-title":"Food Chem."},{"issue":"8","key":"10.1016\/j.jep.2021.114902_bib12","doi-asserted-by":"crossref","first-page":"4666","DOI":"10.1021\/jf903875u","article-title":"Chemical composition and antioxidant\/antidiabetic potential of Brazilian native fruits and commercial frozen pulps","volume":"58","author":"De Souza Schmidt Goncalves","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2021.114902_bib13","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.foodres.2015.06.044","article-title":"Phenolic compounds from cagaita (Eugenia dysenterica DC.) fruit prevent body weight and fat mass gain induced by a high-fat, high-sucrose diet","volume":"77","author":"Donado-Pestana","year":"2015","journal-title":"Food Res. Int."},{"issue":"4","key":"10.1016\/j.jep.2021.114902_bib14","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.3390\/ijms11041365","article-title":"Impact of dietary polyphenols on carbohydrate metabolism","volume":"11","author":"Hanhineva","year":"2010","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2021.114902_bib15","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.3389\/fpls.2017.01772","article-title":"Editorial: plant responses to Biotic and abiotic stresses: lessons from cell signaling","volume":"8","author":"Jeandroz","year":"2017","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.jep.2021.114902_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2020.100573","article-title":"\u03b1-Glucosidase and non-enzymatic glycation inhibitory potential of Eugenia dysenterica fruit pulp extracts","volume":"35","author":"Justino","year":"2020","journal-title":"Food Biosci."},{"issue":"1","key":"10.1016\/j.jep.2021.114902_bib17","doi-asserted-by":"crossref","first-page":"19183","DOI":"10.1038\/s41598-019-55779-3","article-title":"B procyanidins of Annona crassiflora fruit peel inhibited glycation, lipid peroxidation and protein-bound carbonyls, with protective effects on glycated catalase","volume":"9","author":"Justino","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2021.114902_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2021.114387","article-title":"Antioxidant compounds of Kielmeyera coriacea Mart. with \u03b1-amylase, lipase and advanced glycation end-product inhibitory activities","volume":"206","author":"Justino","year":"2021","journal-title":"J. Pharmaceut. Biomed. Anal."},{"issue":"4","key":"10.1016\/j.jep.2021.114902_bib19","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.foodchem.2010.03.075","article-title":"In vitro inhibition of \u03b1-glucosidases and glycogen phosphorylase by catechin gallates in green tea","volume":"122","author":"Kamiyama","year":"2010","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2021.114902_bib20","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.fct.2017.04.021","article-title":"Galloylation of polyphenols alters their biological activity","volume":"105","author":"Karas","year":"2017","journal-title":"Food Chem. Toxicol. : Int. J. Publ. Br. Industr. Biol. Res. Assoc."},{"key":"10.1016\/j.jep.2021.114902_bib21","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/162750","article-title":"Chemistry and biological activities of flavonoids: an overview","volume":"2013","author":"Kumar","year":"2013","journal-title":"Sci. World J."},{"issue":"3","key":"10.1016\/j.jep.2021.114902_bib22","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3177\/jnsv.53.287","article-title":"Inhibitory activities of proanthocyanidins from Persimmon against oxidative stress and digestive enzymes related to diabetes","volume":"53","author":"Lee","year":"2007","journal-title":"J. Nutr. Sci. Vitaminol."},{"issue":"50","key":"10.1016\/j.jep.2021.114902_bib23","doi-asserted-by":"crossref","first-page":"12152","DOI":"10.1021\/jf504132x","article-title":"Quercetin inhibits advanced glycation end product formation by trapping methylglyoxal and glyoxal","volume":"62","author":"Li","year":"2014","journal-title":"J. Agric. Food Chem."},{"issue":"8","key":"10.1016\/j.jep.2021.114902_bib24","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1016\/j.peptides.2010.05.003","article-title":"Identification of E. dysenterica laxative peptide: a novel strategy in the treatment of chronic constipation and irritable bowel syndrome","volume":"31","author":"Lima","year":"2010","journal-title":"Peptides"},{"key":"10.1016\/j.jep.2021.114902_bib25","series-title":"Vivo Effects of Cagaita (Eugenia Dysenterica, DC.) Leaf Extracts on Diarrhea Treatment","author":"Lima","year":"2011"},{"issue":"10","key":"10.1016\/j.jep.2021.114902_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/molecules21101374","article-title":"An overview of plant phenolic compounds and their importance in human nutrition and management of type 2 diabetes","volume":"21","author":"Lin","year":"2016","journal-title":"Molecules"},{"issue":"10","key":"10.1016\/j.jep.2021.114902_bib27","doi-asserted-by":"crossref","first-page":"5675","DOI":"10.1021\/cr900302x","article-title":"Chemical methods to evaluate antioxidant ability","volume":"110","author":"Liu","year":"2010","journal-title":"Chem. Rev."},{"issue":"24","key":"10.1016\/j.jep.2021.114902_bib28","doi-asserted-by":"crossref","first-page":"7251","DOI":"10.1021\/jf040203x","article-title":"Characterization of cigarette tobacco by direct electrospray ionization-ion trap mass spectrometry (ESI-ITMS) analysis of the aqueous extract--a novel and simple approach","volume":"52","author":"Ng","year":"2004","journal-title":"J. Agric. Food Chem."},{"issue":"1","key":"10.1016\/j.jep.2021.114902_bib29","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3390\/biom5010194","article-title":"Advanced glycation end products and oxidative stress in type 2 diabetes mellitus","volume":"5","author":"Nowotny","year":"2015","journal-title":"Biomolecules"},{"issue":"6","key":"10.1016\/j.jep.2021.114902_bib30","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1021\/jf073065v","article-title":"Cinnamon bark proanthocyanidins as reactive carbonyl scavengers to prevent the formation of advanced glycation endproducts","volume":"56","author":"Peng","year":"2008","journal-title":"J. Agric. Food Chem."},{"issue":"5","key":"10.1016\/j.jep.2021.114902_bib31","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1248\/bpb.b13-00514","article-title":"The gastroprotective effects of Eugenia dysenterica (Myrtaceae) leaf extract: the possible role of condensed tannins","volume":"37","author":"Prado","year":"2014","journal-title":"Biol. Pharmaceut. Bull."},{"issue":"1","key":"10.1016\/j.jep.2021.114902_bib32","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1080\/14756366.2017.1368503","article-title":"\u03b1-Glucosidase inhibition by flavonoids: an in vitro and in silico structure-activity relationship study","volume":"32","author":"Proen\u00e7a","year":"2017","journal-title":"J. Enzym. Inhib. Med. Chem."},{"issue":"5","key":"10.1016\/j.jep.2021.114902_bib33","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1039\/C7FO00220C","article-title":"Differential \u03b1-amylase\/\u03b1-glucosidase inhibitory activities of plant-derived phenolic compounds: a virtual screening perspective for the treatment of obesity and diabetes","volume":"8","author":"Rasouli","year":"2017","journal-title":"Food Funct."},{"issue":"2","key":"10.1016\/j.jep.2021.114902_bib34","doi-asserted-by":"crossref","first-page":"3309","DOI":"10.3390\/molecules20023309","article-title":"Prevention of protein glycation by natural compounds","volume":"20","author":"Sadowska-Bartosz","year":"2015","journal-title":"Molecules"},{"issue":"7","key":"10.1016\/j.jep.2021.114902_bib35","doi-asserted-by":"crossref","first-page":"8402","DOI":"10.3390\/molecules18078402","article-title":"Characterization of flavonoids and phenolic acids in Myrcia bella Cambess. using FIA-ESI-IT-MS(n) and HPLC-PAD-ESI-IT-MS combined with NMR","volume":"18","author":"Saldanha","year":"2013","journal-title":"Molecules"},{"issue":"12","key":"10.1016\/j.jep.2021.114902_bib36","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1021\/tx700190s","article-title":"Tea polyphenol (\u2212)-Epigallocatechin-3-Gallate: a new trapping agent of reactive dicarbonyl species","volume":"20","author":"Sang","year":"2007","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.jep.2021.114902_bib37","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/8386065","article-title":"Antioxidant and antidiabetic effects of flavonoids: a structure-activity relationship based study","volume":"2017","author":"Sarian","year":"2017","journal-title":"BioMed Res. Int."},{"issue":"5","key":"10.1016\/j.jep.2021.114902_bib38","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/ajcn\/79.5.727","article-title":"Polyphenols: food sources and bioavailability","volume":"79","author":"Scalbert","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jep.2021.114902_bib39","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1590\/S1517-83822002000300012","article-title":"Antifungal properties of Brazilian Cerrado plants","volume":"33","author":"Souza","year":"2002","journal-title":"Braz. J. Microbiol."},{"issue":"11","key":"10.1016\/j.jep.2021.114902_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0048589","article-title":"Plants from Brazilian cerrado with potent tyrosinase inhibitory activity","volume":"7","author":"Souza","year":"2012","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.jep.2021.114902_bib41","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1055\/s-0031-1280404","article-title":"Inhibitory activity of alpha-amylase and alpha-glucosidase by plant extracts from the Brazilian cerrado","volume":"78","author":"Souza","year":"2012","journal-title":"Planta Med."},{"issue":"3","key":"10.1016\/j.jep.2021.114902_bib42","doi-asserted-by":"crossref","first-page":"679","DOI":"10.3390\/12030679","article-title":"Screening non-colored phenolics in red wines using liquid chromatography\/ultraviolet and mass spectrometry\/mass spectrometry libraries","volume":"12","author":"Sun","year":"2007","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.jep.2021.114902_bib43","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.3390\/molecules18032803","article-title":"Characterization of proanthocyanidins from Parkia biglobosa (Jacq.) G. Don. (Fabaceae) by flow injection analysis-electrospray ionization ion trap tandem mass spectrometry and liquid chromatography\/electrospray ionization mass spectrometry","volume":"18","author":"Tala","year":"2013","journal-title":"Molecules"},{"issue":"9","key":"10.1016\/j.jep.2021.114902_bib44","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1016\/j.foodres.2011.05.022","article-title":"Phytochemicals from berries and grapes inhibited the formation of advanced glycation end\u2010products by scavenging reactive carbonyls","volume":"44","author":"Wang","year":"2011","journal-title":"Food Res. Int."},{"issue":"10","key":"10.1016\/j.jep.2021.114902_bib45","doi-asserted-by":"crossref","first-page":"16039","DOI":"10.3390\/molecules191016039","article-title":"Characterization and quantification of the compounds of the ethanolic extract from Caesalpinia ferrea stem bark and evaluation of their mutagenic activity","volume":"19","author":"Wyrepkowski","year":"2014","journal-title":"Molecules"},{"issue":"36","key":"10.1016\/j.jep.2021.114902_bib46","doi-asserted-by":"crossref","first-page":"8924","DOI":"10.1021\/jf301147n","article-title":"Inhibition of \u03b1-amylase and \u03b1-glucosidase activity by tea and Grape seed extracts and their constituent catechins","volume":"60","author":"Yilmazer-Musa","year":"2012","journal-title":"J. Agric. Food Chem."},{"issue":"6","key":"10.1016\/j.jep.2021.114902_bib47","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1021\/jf104640k","article-title":"Antioxidant activity and phenolic compositions of lentil (Lens culinaris var. Morton) extract and its fractions","volume":"59","author":"Zou","year":"2011","journal-title":"J. Agric. Food Chem."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121011326?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121011326?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:16:29Z","timestamp":1759943789000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874121011326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":47,"alternative-id":["S0378874121011326"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2021.114902","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Flavonoids and proanthocyanidins-rich fractions from Eugenia dysenterica fruits and leaves inhibit the formation of advanced glycation end-products and the activities of \u03b1-amylase and \u03b1-glucosidase","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2021.114902","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114902"}}