{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:43:56Z","timestamp":1786992236269,"version":"build-2736575974"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.jep.2021.114917","type":"journal-article","created":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T12:07:19Z","timestamp":1639483639000},"page":"114917","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Ethanol supernatant extracts of Gynura procumbens could treat nanodiethylnitrosamine-induced mouse liver cancer by interfering with inflammatory factors for the tumor microenvironment"],"prefix":"10.1016","volume":"285","author":[{"given":"Ting","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Wei","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Xing","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Sang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2673-7882","authenticated-orcid":false,"given":"He-Bin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jep.2021.114917_bib1","first-page":"75","article-title":"Antihyperglycaemic and toxicological evaluations of extract and fractions of gynura procumbens leaves","volume":"25","author":"Algariri","year":"2014","journal-title":"Trop. Life Sci. Res."},{"issue":"1","key":"10.1016\/j.jep.2021.114917_bib2","first-page":"188314","article-title":"Challenges in liver cancer and possible treatment approaches. Biochimica et biophysica acta","volume":"1873","author":"Anwanwan","year":"2020","journal-title":"Reviews on cancer"},{"issue":"1","key":"10.1016\/j.jep.2021.114917_bib3","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1053\/j.gastro.2020.02.068","article-title":"Global burden of 5 major types of gastrointestinal cancer","volume":"159","author":"Arnold","year":"2020","journal-title":"Gastroenterology"},{"issue":"Suppl. 2","key":"10.1016\/j.jep.2021.114917_bib4","doi-asserted-by":"crossref","first-page":"S103","DOI":"10.1016\/S0399-8320(10)70028-2","article-title":"[Liver fibrosis in hepatitis B: a dynamic process]","volume":"34","author":"Bedossa","year":"2010","journal-title":"Gastroent\u00e9rol. Clin. Biol."},{"key":"10.1016\/j.jep.2021.114917_bib5","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/bs.enz.2016.03.003","article-title":"The many roles of PCNA in eukaryotic DNA replication","volume":"39","author":"Boehm","year":"2016","journal-title":"Enzymes"},{"issue":"13","key":"10.1016\/j.jep.2021.114917_bib6","first-page":"1122","article-title":"[Effects of glycyrrhizin on genes expression during the process of liver fibrosis]","volume":"83","author":"Cai","year":"2003","journal-title":"Zhonghua Yixue Zazhi"},{"issue":"5753","key":"10.1016\/j.jep.2021.114917_bib7","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1126\/science.1116221","article-title":"Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis","volume":"310","author":"Castellone","year":"2005","journal-title":"Science (New York, N.Y.)"},{"issue":"2","key":"10.1016\/j.jep.2021.114917_bib8","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20203982","article-title":"Correlations between glycolysis with clinical traits and immune function in bladder urothelial carcinoma","volume":"41","author":"Che","year":"2021","journal-title":"Biosci. Rep."},{"issue":"51","key":"10.1016\/j.jep.2021.114917_bib9","doi-asserted-by":"crossref","first-page":"88517","DOI":"10.18632\/oncotarget.19774","article-title":"MicroRNA deregulation in nonalcoholic steatohepatitis-associated liver carcinogenesis","volume":"8","author":"de Conti","year":"2017","journal-title":"Oncotarget"},{"issue":"6","key":"10.1016\/j.jep.2021.114917_bib10","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/jso.21522","article-title":"Comparison of conventional transarterial chemoembolization (TACE) and chemoembolization with doxorubicin drug eluting beads (DEB) for unresectable hepatocelluar carcinoma (HCC)","volume":"101","author":"Dhanasekaran","year":"2010","journal-title":"J. Surg. Oncol."},{"issue":"4","key":"10.1016\/j.jep.2021.114917_bib11","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1177\/003591577606900428","article-title":"Medical surveillance of vinyl chloride workers","volume":"69","author":"Duck","year":"1976","journal-title":"Proc. Roy. Soc. Med."},{"issue":"6","key":"10.1016\/j.jep.2021.114917_bib12","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1053\/j.gastro.2008.02.090","article-title":"Diagnosis and treatment of hepatocellular carcinoma","volume":"134","author":"El-Serag","year":"2008","journal-title":"Gastroenterology"},{"issue":"18","key":"10.1016\/j.jep.2021.114917_bib13","doi-asserted-by":"crossref","first-page":"5227","DOI":"10.7150\/thno.34273","article-title":"LncRNA PCNAP1 modulates hepatitis B virus replication and enhances tumor growth of liver cancer","volume":"9","author":"Feng","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.jep.2021.114917_bib14","series-title":"Chinese Materia Medica (Dai Medicine)","author":"Goverment","year":"2005"},{"key":"10.1016\/j.jep.2021.114917_bib15","author":"Han"},{"key":"10.1016\/j.jep.2021.114917_bib17","doi-asserted-by":"crossref","first-page":"22292","DOI":"10.1038\/srep22292","article-title":"Dietary sugar intake increases liver tumor incidence in female mice","volume":"6","author":"Healy","year":"2016","journal-title":"Sci. Rep."},{"issue":"23","key":"10.1016\/j.jep.2021.114917_bib18","doi-asserted-by":"crossref","first-page":"6745","DOI":"10.7150\/thno.34674","article-title":"Chlorogenic acid effectively treats cancers through induction of cancer cell differentiation","volume":"9","author":"Huang","year":"2019","journal-title":"Theranostics"},{"issue":"2","key":"10.1016\/j.jep.2021.114917_bib19","first-page":"713","article-title":"Multi-layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT\/\u03b2-catenin signaling activation","volume":"42","author":"Katoh","year":"2018","journal-title":"Int. J. Mol. Med."},{"issue":"4","key":"10.1016\/j.jep.2021.114917_bib20","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/cld.1014","article-title":"Histological grading and staging of chronic hepatitis","volume":"17","author":"Krishna","year":"2021","journal-title":"Clinical liver disease"},{"issue":"7","key":"10.1016\/j.jep.2021.114917_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0129743","article-title":"Deficiency of NOX1 or NOX4 prevents liver inflammation and fibrosis in mice through inhibition of hepatic stellate cell activation","volume":"10","author":"Lan","year":"2015","journal-title":"PLoS One"},{"issue":"38","key":"10.1016\/j.jep.2021.114917_bib22","doi-asserted-by":"crossref","first-page":"8460","DOI":"10.1021\/acs.jafc.5b03504","article-title":"Gynura procumbens reverses acute and chronic ethanol-induced liver steatosis through MAPK\/SREBP-1c-Dependent and -independent pathways","volume":"63","author":"Li","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2021.114917_bib48","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.3389\/fphar.2018.01487","article-title":"Lipopolysaccharide stimulated the migration of NIH3T3 cells through a positive feedback between \u03b2-Catenin and COX-2","volume":"9","author":"Li","year":"2018","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2021.114917_bib23","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1039\/c5tx00317b","article-title":"Mouse hepatic neoplasm formation induced by trace level and low frequency exposure to diethylnitrosamine through \u03b2-catenin signaling pathway","volume":"5","author":"Li","year":"2016","journal-title":"Toxicol Res (Camb)"},{"issue":"1","key":"10.1016\/j.jep.2021.114917_bib24","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1254\/jphs.11160FP","article-title":"Dragon's blood inhibits chronic inflammatory and neuropathic pain responses by blocking the synthesis and release of substance P in rats","volume":"118","author":"Li","year":"2012","journal-title":"J. Pharmacol. Sci."},{"issue":"4","key":"10.1016\/j.jep.2021.114917_bib25","doi-asserted-by":"crossref","first-page":"360","DOI":"10.3748\/wjg.v4.i4.360","article-title":"Traditional Chinese medicine for primary liver cancer","volume":"4","author":"Li","year":"1998","journal-title":"World J. Gastroenterol."},{"issue":"5","key":"10.1016\/j.jep.2021.114917_bib26","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1002\/hep.29661","article-title":"\u03b2-catenin deficiency in hepatocytes aggravates hepatocarcinogenesis driven by oncogenic \u03b2-catenin and MET","volume":"67","author":"Liang","year":"2018","journal-title":"Hepatology (Baltimore, Md"},{"issue":"11","key":"10.1016\/j.jep.2021.114917_bib27","doi-asserted-by":"crossref","first-page":"e4635","DOI":"10.1002\/bmc.4635","article-title":"Strategy for rapid screening of antioxidant and anti-inflammatory active ingredients in Gynura procumbens (Lour.) Merr. based on UHPLC-Q-TOF-MS\/MS and characteristic ion filtration","volume":"33","author":"Liu","year":"2019","journal-title":"Biomedical chromatography : BMC (Biomed. Chromatogr.)"},{"issue":"6","key":"10.1016\/j.jep.2021.114917_bib28","first-page":"741","article-title":"Electron microscopic alterations in intermediate hepatocyte-like cells in children with chronic hepatitis B: the first report in pediatric patients","volume":"22","author":"Lotowska","year":"2010","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"issue":"6","key":"10.1016\/j.jep.2021.114917_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/genes11060593","article-title":"CDK-independent and PCNA-dependent functions of p21 in DNA replication","volume":"11","author":"Mansilla","year":"2020","journal-title":"Genes"},{"issue":"5","key":"10.1016\/j.jep.2021.114917_bib30","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.apsb.2015.05.007","article-title":"HIF-1\u03b1 pathway: role, regulation and intervention for cancer therapy","volume":"5","author":"Masoud","year":"2015","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jep.2021.114917_bib31","doi-asserted-by":"crossref","first-page":"114145","DOI":"10.1016\/j.jep.2021.114145","article-title":"Traditional uses, phytochemistry, pharmacology and toxicology of the genus Gynura (Compositae): a comprehensive review","volume":"276","author":"Meng","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"14","key":"10.1016\/j.jep.2021.114917_bib32","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.2174\/1389201019666180322111800","article-title":"Caffeoylquinic acids rich versus poor fractions of gynura procumbens: their comparative antihyperlipidemic and antioxidant potential","volume":"18","author":"Murugesu","year":"2017","journal-title":"Curr. Pharmaceut. Biotechnol."},{"issue":"1","key":"10.1016\/j.jep.2021.114917_bib33","first-page":"99","article-title":"Antiproliferative effect of gynura procumbens (lour.) Merr. Leaves etanolic extract on 7,12-dimethylbenz(a)antracene induced male rat liver","volume":"2","author":"Nisa","year":"2012","journal-title":"Adv. Pharmaceut. Bull."},{"key":"10.1016\/j.jep.2021.114917_bib34","author":"Ogrodnik"},{"issue":"42","key":"10.1016\/j.jep.2021.114917_bib35","doi-asserted-by":"crossref","first-page":"12150","DOI":"10.3748\/wjg.v21.i42.12150","article-title":"Oncogenic role of p21 in hepatocarcinogenesis suggests a new treatment strategy","volume":"21","author":"Ohkoshi","year":"2015","journal-title":"World J. Gastroenterol."},{"issue":"8","key":"10.1016\/j.jep.2021.114917_bib36","first-page":"1075","article-title":"Liver fibrosis: a dynamic and potentially reversible process","volume":"25","author":"Povero","year":"2010","journal-title":"Histol. Histopathol."},{"issue":"8","key":"10.1016\/j.jep.2021.114917_bib37","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1089\/acm.2016.0100","article-title":"The efficacy of gynura pseudochina dc. var. hispida thv. Ointment in treating chronic plaque psoriasis: a randomized controlled trial","volume":"22","author":"Rerknimitr","year":"2016","journal-title":"J. Alternative Compl. Med."},{"issue":"9","key":"10.1016\/j.jep.2021.114917_bib38","doi-asserted-by":"crossref","first-page":"3664","DOI":"10.1172\/JCI67230","article-title":"HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations","volume":"123","author":"Semenza","year":"2013","journal-title":"J. Clin. Invest."},{"issue":"45","key":"10.1016\/j.jep.2021.114917_bib39","doi-asserted-by":"crossref","first-page":"9933","DOI":"10.3748\/wjg.v22.i45.9933","article-title":"Reprogramming of glucose metabolism in hepatocellular carcinoma: progress and prospects","volume":"22","author":"Shang","year":"2016","journal-title":"World J. Gastroenterol."},{"issue":"3","key":"10.1016\/j.jep.2021.114917_bib40","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1080\/01635581.2015.1004591","article-title":"Natural grape extracts regulate colon cancer cells malignancy","volume":"67","author":"Signorelli","year":"2015","journal-title":"Nutr. Cancer"},{"issue":"2","key":"10.1016\/j.jep.2021.114917_bib41","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0002-9440(10)64554-3","article-title":"The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages","volume":"157","author":"Talks","year":"2000","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jep.2021.114917_bib42","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3389\/fphar.2016.00052","article-title":"Gynura procumbens: an overview of the biological activities","volume":"7","author":"Tan","year":"2016","journal-title":"Front. Pharmacol."},{"issue":"7","key":"10.1016\/j.jep.2021.114917_bib43","first-page":"787","article-title":"[Liver cancer]. Rinsho byori","volume":"64","author":"Yamashita","year":"2016","journal-title":"Jpn. J. Clin. Pathol."},{"key":"10.1016\/j.jep.2021.114917_bib44","author":"Yang"},{"key":"10.1016\/j.jep.2021.114917_bib45","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.cca.2020.03.024","article-title":"COX-2 in liver fibrosis","volume":"506","author":"Yang","year":"2020","journal-title":"Clinica chimica acta; international journal of clinical chemistry"},{"issue":"2","key":"10.1016\/j.jep.2021.114917_bib46","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.nano.2016.09.017","article-title":"The dark side of \"the force\" - lipid nanoparticles enhance the oncogenesis of diethylnitrosamine and result in liver cancer in mice","volume":"13","author":"Zhang","year":"2017","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"issue":"1","key":"10.1016\/j.jep.2021.114917_bib47","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s13045-020-00990-3","article-title":"Targeting the Wnt\/\u03b2-catenin signaling pathway in cancer","volume":"13","author":"Zhang","year":"2020","journal-title":"J. Hematol. Oncol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121011478?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121011478?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:18:06Z","timestamp":1759943886000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874121011478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":47,"alternative-id":["S0378874121011478"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2021.114917","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ethanol supernatant extracts of Gynura procumbens could treat nanodiethylnitrosamine-induced mouse liver cancer by interfering with inflammatory factors for the tumor microenvironment","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2021.114917","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114917"}}