{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T05:51:03Z","timestamp":1760248263865,"version":"build-2065373602"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.jep.2021.114956","type":"journal-article","created":{"date-parts":[[2021,12,26]],"date-time":"2021-12-26T09:51:42Z","timestamp":1640512302000},"page":"114956","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Sida tuberculata: In vitro cytotoxicity and in vivo anti-inflammatory effect"],"prefix":"10.1016","volume":"287","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8474-5100","authenticated-orcid":false,"given":"Hemerson","family":"Silva da Rosa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00ed Castro","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcio Tavares","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9ia","family":"Salgueiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morgana","family":"Duarte da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele Rubert","family":"Nogueira-Librelotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiano","family":"Jesse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel Mansur","family":"Machado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu\u00eds Fl\u00e1vio","family":"Souza de Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6940-9080","authenticated-orcid":false,"given":"Vanderlei","family":"Folmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas S.L.","family":"Mendez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2021.114956_bib1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/ptr.3219","article-title":"Cryptolepine, isolated from Sida acuta, sensitizes human gastric Adenocarcinoma Cells to TRAIL-induced apoptosis","volume":"25","author":"Ahmed","year":"2011","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2021.114956_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2021.e06682","article-title":"Secondary metabolite compounds from Sida genus and their bioactivity","volume":"7","author":"Aminah","year":"2021","journal-title":"Heliyon"},{"key":"10.1016\/j.jep.2021.114956_bib3","series-title":"Biology of C Reactive Protein in Health and Disease","first-page":"67","article-title":"Inflammation and inflammatory diseases, markers, and mediators: role of CRP in some inflammatory diseases","author":"Ansar","year":"2016"},{"key":"10.1016\/j.jep.2021.114956_bib4","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jep.2021.114956_bib5","doi-asserted-by":"crossref","first-page":"100333","DOI":"10.1016\/j.hermed.2020.100333","article-title":"Determination of phytochemical composition, cytotoxicity, genotoxicity and mutagenicity of the hydroethanolic extract of Dolichandra unguis-cati L. leaves in human leukocytes","volume":"22","author":"Brondani","year":"2020","journal-title":"J. Herb. Med."},{"key":"10.1016\/j.jep.2021.114956_bib6","doi-asserted-by":"crossref","first-page":"110687","DOI":"10.1016\/j.fct.2019.110687","article-title":"Effects of Amanita muscaria extract on different in vitro neurotoxicity models at sub-cellular and cellular levels","volume":"132","author":"Burdina","year":"2019","journal-title":"Food Chem. Toxicol."},{"issue":"21","key":"10.1016\/j.jep.2021.114956_bib56","first-page":"4940","article-title":"Differences in Susceptibility to Tumor Necrosis Factor \u00c2\u00ab-inducedApoptosis amongMCF-7 Breast Cancer Cell Variants","volume":"58","author":"Burow","year":"1998","journal-title":"Canc. Res."},{"issue":"6","key":"10.1016\/j.jep.2021.114956_bib7","doi-asserted-by":"crossref","first-page":"7204","DOI":"10.18632\/oncotarget.23208","article-title":"Inflammatory responses and inflammation-associated diseases in organs","volume":"9","author":"Chen","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.jep.2021.114956_bib8","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ejphar.2018.12.004","article-title":"Progression in migraine: role of mast cells and pro-inflammatory and anti-inflammatory cytokines","volume":"844","author":"Conti","year":"2019","journal-title":"Eur. J. Pharmacol."},{"issue":"7","key":"10.1016\/j.jep.2021.114956_bib9","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1016\/j.apsb.2020.10.012","article-title":"The phytochemical, biological, and medicinal attributes of phytoecdysteroids: an updated review","volume":"11","author":"Das","year":"2021","journal-title":"Acta Pharm. Sin. B."},{"key":"10.1016\/j.jep.2021.114956_bib10","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1007\/PL00000926","article-title":"On the distribution of phytoecdysteroids in plants, CMLS","volume":"58","author":"Dinan","year":"2001","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.jep.2021.114956_bib11","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jep.2015.10.027","article-title":"The genus Sida L. - a traditional medicine: its ethnopharmacological, phytochemical and pharmacological data for commercial exploitation in herbal drugs industry","volume":"176","author":"Dinda","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114956_bib12","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.phrs.2016.01.021","article-title":"Medicinal plants in Brazil: pharmacological studies, drug discovery,challenges and perspectives","volume":"112","author":"Dutra","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2021.114956_bib13","doi-asserted-by":"crossref","unstructured":"Ellman, G.L. Tissue sulfhydryl groups. Arch. Biochem. Biophys. 82, 70\u201377.","DOI":"10.1016\/0003-9861(59)90090-6"},{"key":"10.1016\/j.jep.2021.114956_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/0471141755.ph0504s56","article-title":"Models of Inflammation: carrageenan- or complete freund's adjuvant-induced edema and hypersensitivity in the rat","volume":"56","author":"Fehrenbacher","year":"2012","journal-title":"Curr. Protoc. Pharmacol."},{"issue":"3","key":"10.1016\/j.jep.2021.114956_bib15","doi-asserted-by":"crossref","first-page":"612","DOI":"10.3390\/molecules24030612","article-title":"Total phenols from grape leaves counteract cell proliferation and modulate apoptosis-related gene expression in MCF-7 and HepG2 human cancer cell lines","volume":"24","author":"Ferhi","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2021.114956_bib16","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s10753-007-9024-4","article-title":"A low molecular weight pro-inflammatory factor from rat spleen lymphocytes. Isolation and partial characterization","volume":"30","author":"Fran\u00e7a","year":"2007","journal-title":"Inflammation"},{"issue":"1\u20132","key":"10.1016\/j.jep.2021.114956_bib17","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0378-8741(00)00205-1","article-title":"Anti-inflammatory, analgesic activity and acute toxicity of Sida cordifolia L. (Malva-branca)","volume":"72","author":"Franzotti","year":"2000","journal-title":"J. Ethnopharmacol."},{"issue":"12","key":"10.1016\/j.jep.2021.114956_bib18","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1038\/s41591-019-0675-0","article-title":"Chronic inflammation in the etiology of disease across the life span","volume":"25","author":"Furman","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.jep.2021.114956_bib19","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nrd1383","article-title":"Inflammatory resolution: new opportunities for drug discovery","volume":"3","author":"Gilroy","year":"2004","journal-title":"Nat. Rev. Drug Discov."},{"issue":"5","key":"10.1016\/j.jep.2021.114956_bib20","first-page":"1117","article-title":"Superoxide\u2014driven oxidation of quercetin and a simple sensitive assay for determination of superoxide dismutase","volume":"19","author":"Kostyuk","year":"1989","journal-title":"Biochem. Int."},{"key":"10.1016\/j.jep.2021.114956_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.etap.2018.08.005","article-title":"Cytotoxic and genotoxic effects of antihypertensives distributed in Brazil by social programs: are they safe?","volume":"63","author":"Le\u00e3o","year":"2018","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.jep.2021.114956_bib22","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.pain.2008.04.025","article-title":"The Kyoto protocol of IASP basic pain terminology","volume":"137","author":"Loeser","year":"2008","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.jep.2021.114956_bib23","first-page":"316","article-title":"In vivo anti-inflammatory effect of aqueous and ethanolic extract of Sida rhombifolia L. Root","volume":"4","author":"Logeswari","year":"2013","journal-title":"Int. J. Pharm. Sci. Res."},{"issue":"3","key":"10.1016\/j.jep.2021.114956_bib24","doi-asserted-by":"crossref","first-page":"e14355","DOI":"10.1111\/jfpp.14355","article-title":"Improving oxidative stability of flaxseed oil with a mixture of antioxidants","volume":"44","author":"Lu","year":"2020","journal-title":"J. Food Process. Preserv."},{"key":"10.1016\/j.jep.2021.114956_bib25","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1080\/13880209.2017.1285322","article-title":"Anti-inflammatory, anti-cholinergic and cytotoxic effects of Sida rhombifolia","volume":"55","author":"Mah","year":"2017","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jep.2021.114956_bib26","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1039\/c8pp00559a","article-title":"Comparative evaluation of the hepatotoxicity, phototoxicity and photosensitizing potential of dronedarone hydrochloride and its cyclodextrin-based inclusion complexes","volume":"18","author":"Marcolino","year":"2019","journal-title":"Photochem. Photobiol. Sci."},{"key":"10.1016\/j.jep.2021.114956_bib27","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.3390\/molecules22111883","article-title":"Anti\u2010inflammatory effect of Malva sylvestris, Sida cordifolia, and Pelargonium graveolens is related to inhibition of prostanoid production","volume":"22","author":"Martins","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2021.114956_bib28","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.phymed.2016.06.009","article-title":"Antinociceptive and anti-inflammatory effect of the Scutia buxifolia Reissek stem barks extract","volume":"23","author":"Moreira","year":"2016","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2021.114956_bib29","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay to cellular growth and survival: application to proliferation and cy totoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.jep.2021.114956_bib30","first-page":"52","article-title":"Phytoecdysteroids from the stem bark of Vitex doniana and their anti-inflammatory effects","volume":"79","author":"Ochieng","year":"2013","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2021.114956_bib31","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxidation in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Ann. Biochem."},{"key":"10.1016\/j.jep.2021.114956_bib32","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1080\/0962935029000050","article-title":"Neutrophils and the calcium-binding protein MRP-14 mediate carrageenan-induced antinociception in mice","volume":"11","author":"Pagano","year":"2002","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.jep.2021.114956_bib33","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1111\/j.2042-7158.2011.01349.x","article-title":"Effects of 20-hydroxyecdysone, Leuzea carthamoides extracts, dexamethasone and their combinations on the NF-kB activation in HeLa cell","volume":"63","author":"Peschel","year":"2011","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jep.2021.114956_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2010.01.003","article-title":"In vitro cytotoxicity and antioxidant activities of five medicinal plants of Malvaceae family from Cameroon","volume":"29","author":"Pieme","year":"2010","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"4","key":"10.1016\/j.jep.2021.114956_bib35","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1177\/0964528420938379","article-title":"Acupuncture reduces peripheral and brainstem cytokines in rats subjected to lipopolysaccharide-induced inflammation","volume":"39","author":"Ramires","year":"2021","journal-title":"Acupunct. Med."},{"key":"10.1016\/j.jep.2021.114956_bib36","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.sajb.2020.04.030","article-title":"The genus Sida L. (Malvaceae): an update of its ethnomedicinal use, pharmacology and phytochemistry","volume":"132","author":"Rodrigues","year":"2020","journal-title":"South Afr. J. Bot."},{"issue":"1","key":"10.1016\/j.jep.2021.114956_bib37","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/ptr.6220","article-title":"Sida tuberculata extract reduces the nociceptive response by chemical noxious stimuli in mice: implications for mechanism of action, relation to chemical composition and molecular docking","volume":"33","author":"Rosa","year":"2019","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2021.114956_bib38","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.foodchem.2015.02.144","article-title":"Ecdysteroids in Sida tuberculata R.E. Fries (Malvaceae): chemical composition by LC-ESI-MS and selective anti-Candida krusei activity","volume":"182","author":"Rosa","year":"2015","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2021.114956_bib39","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.steroids.2018.01.014","article-title":"Extraction optimization and UHPLC method development for determination of the 20-hydroxyecdysone in Sida tuberculata leaves","volume":"132","author":"Rosa","year":"2018","journal-title":"Steroids"},{"issue":"8","key":"10.1016\/j.jep.2021.114956_bib40","article-title":"Sida tuberculata (Malvaceae): a study based on development of extractive system and in silico and in vitro properties","volume":"49","author":"Rosa","year":"2016","journal-title":"Braz. J. Med. Biol. Res."},{"issue":"21","key":"10.1016\/j.jep.2021.114956_bib41","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jep.2013.03.070","article-title":"The influence of Bauhinia forficata Link subsp. pruinosa tea on lipid peroxidation and non-protein SH groups in human erythrocytes exposed to high glucose concentrations","volume":"148","author":"Salgueiro","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114956_bib42","first-page":"9","article-title":"Effects of Bauhinia forficata tea on oxidative stress and liver damage in diabetic mice","author":"Salgueiro","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jep.2021.114956_bib43","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202100041","article-title":"Polyphenolic composition and in vitro antihypertensive and anti-Inflammatory effects of Cuphea lindmaniana and Cuphea urbaniana","volume":"18","author":"Santos","year":"2021","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.jep.2021.114956_bib55","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0165-1161(75)90058-8","article-title":"The micronucleus Test","volume":"31","author":"Schmid","year":"1975","journal-title":"Mutation Res."},{"key":"10.1016\/j.jep.2021.114956_bib44","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.bpa.2003.12.002","article-title":"Mechanisms of the inflammatory response","volume":"18","author":"Sherwood","year":"2004","journal-title":"Best Pract. Res. Clin. Anaesthesiol."},{"key":"10.1016\/j.jep.2021.114956_bib45","first-page":"9","article-title":"Involvement of interleukin-10 in the anti-inflammatory effect of sanyinjiao (SP6) acupuncture in a mouse model of peritonitis","author":"Silva","year":"2011","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"10.1016\/j.jep.2021.114956_bib46","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.procbio.2021.03.028","article-title":"New perspectives into the chemical characterization of Sida acuta Burm. f. extracts with respect to its anti-cancer, antioxidant and enzyme inhibitory effects","volume":"105","author":"Uysal","year":"2021","journal-title":"Process Biochem."},{"key":"10.1016\/j.jep.2021.114956_bib47","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1590\/S0100-40422007000500046","article-title":"Reactive oxygen and nitrogen species, antioxidants and markers of oxidative damage in human blood: main analytical methods for their determination","volume":"30","author":"Vasconcelos","year":"2007","journal-title":"Quim. Nova"},{"key":"10.1016\/j.jep.2021.114956_bib48","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1002\/rcm.3625","article-title":"Structural characterization and identification of ecdysteroids from Sida rhombifolia L. in positive electrospray ionization by tandem mass spectrometry","volume":"22","author":"Wang","year":"2008","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.jep.2021.114956_bib49","doi-asserted-by":"crossref","first-page":"3742","DOI":"10.1172\/JCI45178","article-title":"What is this thing called pain?","volume":"120","author":"Woolf","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jep.2021.114956_bib50","doi-asserted-by":"crossref","first-page":"112277","DOI":"10.1016\/j.jep.2019.112277","article-title":"Sida tuberculata reduces oxidative stress and pain caused by the knee osteoarthritis","volume":"248","author":"Yamada","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2021.114956_bib51","article-title":"Photobiomodulation and Sida tuberculata combination declines the inflammation's markers in knee-induced osteoarthritis","author":"Yamada","year":"2021","journal-title":"Laser Med. Sci."},{"issue":"3","key":"10.1016\/j.jep.2021.114956_bib54","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/ddr.21170","article-title":"\u03b2-Ecdysterone Suppresses Interleukin-1\u03b2-Induced Apoptosis and Inflammation in Rat Chondrocytes via Inhibition of NF-\u03baB Signaling Pathway","volume":"75","author":"Zhang","year":"2014","journal-title":"Drug. Dev. Res."},{"issue":"8","key":"10.1016\/j.jep.2021.114956_bib52","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1080\/10408398.2016.1251390","article-title":"Anti-inflammatory effects of phytochemicals from fruits, vegetables, and food legumes: a review","volume":"58","author":"Zhu","year":"2018","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.jep.2021.114956_bib53","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals","volume":"16","author":"Zimmermann","year":"1983","journal-title":"Pain"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121011867?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874121011867?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:15:35Z","timestamp":1759943735000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874121011867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":56,"alternative-id":["S0378874121011867"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2021.114956","relation":{},"ISSN":["0378-8741"],"issn-type":[{"type":"print","value":"0378-8741"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sida tuberculata: In vitro cytotoxicity and in vivo anti-inflammatory effect","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2021.114956","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114956"}}