{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T21:10:45Z","timestamp":1793826645464,"version":"4.6.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.jep.2022.114999","type":"journal-article","created":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T11:22:59Z","timestamp":1642418579000},"page":"114999","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Xiaoyao Powder in the treatment of non-alcoholic fatty liver disease: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"288","author":[{"given":"Nian","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0926-9463","authenticated-orcid":false,"given":"Jiayao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl. 1","key":"10.1016\/j.jep.2022.114999_bib2","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/liv.14354","article-title":"New drugs for non-alcoholic steatohepatitis","volume":"40","author":"Cardoso","year":"2020","journal-title":"Liver Int."},{"issue":"1","key":"10.1016\/j.jep.2022.114999_bib3","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/hep.29367","article-title":"The diagnosis and management of non-alcoholic fatty liver disease: practice guidance from the American Association for the Study of Liver Diseases","volume":"67","author":"Chalasani","year":"2018","journal-title":"Hepatology"},{"issue":"11","key":"10.1016\/j.jep.2022.114999_bib4","first-page":"65","article-title":"Observation on the clinical effect of Xiaoyao powder in the treatment of patients with NAFLD","volume":"12","author":"Chen","year":"2019","journal-title":"Chin. J. Clin. Ration. Drug Use"},{"key":"10.1016\/j.jep.2022.114999_bib5","first-page":"1118","article-title":"Treatment of 30 cases of NAFLD with Xiaoyao powder","volume":"31","author":"Chengan","year":"2010","journal-title":"Shaanxi J. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2022.114999_bib6","first-page":"42","article-title":"Clinical effect of Danzhi Xiaoyao powder in the treatment of NAFLD","volume":"16","author":"Dan","year":"2018","journal-title":"Chin. Foreign Med. Res."},{"key":"10.1016\/j.jep.2022.114999_bib1","first-page":"177","article-title":"Guidelines for the prevention and treatment of NAFLD (updated in 2018","volume":"21","author":"Expert Committee of fatty liver disease of Chinese Physicians Association","year":"2018","journal-title":"Practical J. liver Dis."},{"key":"10.1016\/j.jep.2022.114999_bib7","first-page":"48","article-title":"Effect of Xiaoyao pill on expression of TLR4 in rats with non-alcoholic fatty liver disease of liver depression and spleen deficiency syndrome","volume":"32","author":"Fei","year":"2016","journal-title":"Shanxi J. Tradit. Chin. Med."},{"issue":"7","key":"10.1016\/j.jep.2022.114999_bib8","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies","volume":"24","author":"Friedman","year":"2018","journal-title":"Nat. Med."},{"issue":"27","key":"10.1016\/j.jep.2022.114999_bib9","first-page":"18","article-title":"Efficacy evaluation of Modified Xiaoyao Powder in the treatment of NAFLD in obese adolescents","volume":"11","author":"Haiyan","year":"2019","journal-title":"Clin. J. Chin. Med."},{"key":"10.1016\/j.jep.2022.114999_bib10","first-page":"98","article-title":"Simvastatin and DanZhi Xiaoyao powder for 81 cases of NAFLD","volume":"30","author":"Hongge","year":"2017","journal-title":"West. J. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2022.114999_bib11","first-page":"409568","article-title":"Traditional Chinese medicine zheng in the era of evidence-based medicine: a literature analysis","volume":"2012","author":"Jiang","year":"2012","journal-title":"Evid. Base Compl. Alternat. Med."},{"key":"10.1016\/j.jep.2022.114999_bib12","first-page":"399","article-title":"Effect of Shugan Jianpi Xiezhuo recipe on serum adiponectin and leptin in patients with NAFLD Zhejiang","volume":"50","author":"Jianye","year":"2015","journal-title":"J. Tradit. Chin. Med."},{"issue":"11","key":"10.1016\/j.jep.2022.114999_bib13","first-page":"5446","article-title":"Research on mechanism of Xiaoyao Pills in treating non-alcoholic fatty liver of liver depression and spleen deficiency syndrome based on serum metabolomics","volume":"34","author":"Jilong","year":"2019","journal-title":"Chin. J. Tradit. Chin. Med."},{"issue":"11","key":"10.1016\/j.jep.2022.114999_bib14","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.3748\/wjg.v23.i11.1964","article-title":"Traditional Chinese herbal extracts inducing autophagy as a novel approach in therapy of nonalcoholic fatty liver disease","volume":"23","author":"Liu","year":"2017","journal-title":"World J. Gastroenterol."},{"issue":"29","key":"10.1016\/j.jep.2022.114999_bib15","first-page":"3","article-title":"Clinical research on intervening adiponectin in NAFLD by Ganpi Xianguang theory","volume":"6","author":"Min","year":"2014","journal-title":"Clin. J. Chin. Med."},{"key":"10.1016\/j.jep.2022.114999_bib16","first-page":"35","article-title":"Observation on the therapeutic effect of Danzhi Xiaoyao powder in the treatment of NAFLD","volume":"38","author":"Ping","year":"2017","journal-title":"Yunnan J. Tradit. Chin. Med. Mater. Med."},{"issue":"22","key":"10.1016\/j.jep.2022.114999_bib17","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1001\/jama.2015.5370","article-title":"Nonalcoholic fatty liver disease: a systematic review","volume":"313","author":"Rinella","year":"2015","journal-title":"JAMA"},{"issue":"12","key":"10.1016\/j.jep.2022.114999_bib18","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1001\/jama.2020.2298","article-title":"Nonalcoholic steatohepatitis: a review","volume":"323","author":"Sheka","year":"2020","journal-title":"JAMA, J. Am. Med. Assoc."},{"issue":"3","key":"10.1016\/j.jep.2022.114999_bib19","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s00535-017-1415-1","article-title":"Current and future pharmacological therapies for NAFLD\/NASH","volume":"53","author":"Sumida","year":"2018","journal-title":"J. Gastroenterol."},{"issue":"2","key":"10.1016\/j.jep.2022.114999_bib20","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jhep.2017.11.013","article-title":"Non-invasive assessment of non-alcoholic fatty liver disease: clinical prediction rules and blood-based biomarkers","volume":"68","author":"Vilar-Gomez","year":"2018","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jep.2022.114999_bib21","first-page":"193","article-title":"Treatment of 58 cases of NAFLD with modified Xiaoyao powder","author":"Wen","year":"2008","journal-title":"J. Snake"},{"issue":"14","key":"10.1016\/j.jep.2022.114999_bib22","first-page":"2213","article-title":"Clinical observation of Xiaoyao powder combined with simvastatin in the treatment of NAFLD","volume":"34","author":"Wen","year":"2019","journal-title":"Guangming J. Chin. Med."},{"issue":"8","key":"10.1016\/j.jep.2022.114999_bib23","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/s41575-018-0014-9","article-title":"Noninvasive biomarkers in NAFLD and NASH - current progress and future promise","volume":"15","author":"Wong","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jep.2022.114999_bib24","first-page":"154","article-title":"Effects of Xiaoyao Powder on Hepatic steatosis and ER Stress\/SREBP1\/lipid metabolism pathway in rats","volume":"18","author":"Xin","year":"2012","journal-title":"Chin. J. Basic Med. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2022.114999_bib25","first-page":"861","article-title":"Clinical observation of Danzhi Xiaoyao Pills combined with rosuvastatin in treatment of NAFLD","volume":"33","author":"Xudong","year":"2018","journal-title":"Drugs & Clinic"},{"issue":"17","key":"10.1016\/j.jep.2022.114999_bib26","first-page":"108","article-title":"Effect of Xiaoyao powder on TLR-4\/TRIF signal transduction pathway in rats of non-alcoholic fatty hepatitis with liver-Qi stagnation and spleen deficiency syndrome","volume":"24","author":"Yang","year":"2018","journal-title":"Chin. J. Exp. Formulas"},{"key":"10.1016\/j.jep.2022.114999_bib27","series-title":"A Study on the Therapeutic Effect of Xiaoyao Powder Combined with Reduced Glutathione in the Treatment of NAFLD","author":"Yue","year":"2019"},{"key":"10.1016\/j.jep.2022.114999_bib28","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s13020-020-00302-4","article-title":"Translating traditional herbal formulas into modern drugs: a network-based analysis of Xiaoyao decoction","volume":"15","author":"Zhang","year":"2020","journal-title":"Chin. Med."},{"key":"10.1016\/j.jep.2022.114999_bib29","first-page":"3631","article-title":"Clinical application and modern research progress of Xiaoyao powder and its addition and subtraction in the treatment of liver diseases","volume":"32","author":"Zhi","year":"2017","journal-title":"Chin. J. Tradit. Chin. Med."},{"issue":"5","key":"10.1016\/j.jep.2022.114999_bib30","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1002\/hep.31150","article-title":"Epidemiological features of NAFLD from 1999 to 2018 in China","volume":"71","author":"Zhou","year":"2020","journal-title":"Hepatology"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122000332?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122000332?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:18:50Z","timestamp":1759943930000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874122000332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":30,"alternative-id":["S0378874122000332"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2022.114999","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Xiaoyao Powder in the treatment of non-alcoholic fatty liver disease: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2022.114999","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114999"}}