{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:53:44Z","timestamp":1792518824095,"version":"4.5.0"},"reference-count":115,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.jep.2022.115024","type":"journal-article","created":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T11:52:52Z","timestamp":1643025172000},"page":"115024","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Hepatoprotective effect of Physalis divaricata in paracetamol induced hepatotoxicity: In vitro, in silico and in vivo analysis"],"prefix":"10.1016","volume":"290","author":[{"given":"Hasandeep","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9038-8082","authenticated-orcid":false,"given":"Tanveer","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrit Pal","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarabjit","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saroj","family":"Arora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balbir","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2022.115024_bib1","article-title":"In vitro ultramorphological assessment of apoptosis induced by zerumbone on (HeLa)","volume":"769568","author":"Abdel Wahab","year":"2009","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.jep.2022.115024_bib2","doi-asserted-by":"crossref","first-page":"516","DOI":"10.3923\/ijp.2017.516.528","article-title":"Hepatoprotective effect of rutin against oxidative stress of isoniazid in albino rats","volume":"13","author":"Abdel-Ghaffar","year":"2017","journal-title":"Int. J. Pharmacol."},{"key":"10.1016\/j.jep.2022.115024_bib3","series-title":"Protective Effects of Curcumin and Silymarin against Paracetamol Induced Hepatotoxicity in Adult Male Albino Rats","first-page":"143966","author":"Ahmad","year":"2019"},{"key":"10.1016\/j.jep.2022.115024_bib4","doi-asserted-by":"crossref","first-page":"143966","DOI":"10.1016\/j.gene.2019.143966","article-title":"Protective effects of curcumin and silymarin against paracetamol induced hepatotoxicity in adult male albino rats","volume":"712","author":"Ahmad","year":"2019","journal-title":"Gene"},{"issue":"4","key":"10.1016\/j.jep.2022.115024_bib5","doi-asserted-by":"crossref","first-page":"228","DOI":"10.4103\/0975-1483.104366","article-title":"Antioxidant and hepatoprotective activities of ethanolic extracts of leaves of Premna esculenta Roxb. against carbon tetrachloride-induced liver damage in rats","volume":"4","author":"Bachar","year":"2012","journal-title":"J. Young Pharm."},{"key":"10.1016\/j.jep.2022.115024_bib6","first-page":"882","article-title":"Improved method for the determination of blood glutathione","volume":"61","author":"Beutler","year":"1963","journal-title":"J. Lab. Clin. Med."},{"issue":"3","key":"10.1016\/j.jep.2022.115024_bib7","doi-asserted-by":"crossref","first-page":"606","DOI":"10.3390\/metabo3030606","article-title":"Acylcarnitine profiles in acetaminophen toxicity in the mouse: comparison to toxicity, metabolism and hepatocyte regeneration","volume":"3","author":"Bhattacharyya","year":"2013","journal-title":"Metabolites"},{"key":"10.1016\/j.jep.2022.115024_bib8","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1007\/s10495-007-0105-5","article-title":"A triterpenediol from Boswellia serrata induces apoptosis through both the intrinsic and extrinsic apoptotic pathways in human leukemia HL-60 cells","volume":"12","author":"Bhushan","year":"2007","journal-title":"Apoptosis"},{"issue":"1","key":"10.1016\/j.jep.2022.115024_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep04698","article-title":"Cell death stages in single apoptotic and necrotic cells monitored by Raman microspectroscopy","volume":"4","author":"Brauchle","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2022.115024_bib10","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.jhep.2013.03.033","article-title":"Decoding cell death signals in liver inflammation","volume":"59","author":"Brenner","year":"2013","journal-title":"J. Hepatol."},{"issue":"5","key":"10.1016\/j.jep.2022.115024_bib11","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/s00726-019-02716-3","article-title":"Comparison between the effects of selenomethionine and S-adenosylmethionine in preventing cholestasis-induced rat liver damage","volume":"51","author":"Brza\u010dki","year":"2019","journal-title":"Amino Acids"},{"key":"10.1016\/j.jep.2022.115024_bib12","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.2337\/diabetes.52.9.2296","article-title":"Pancreatic-derived factor (FAM3B), a novel islet cytokine, induces apoptosis of insulin-secreting \u03b2-Cells","volume":"52","author":"Cao","year":"2003","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.jep.2022.115024_bib13","doi-asserted-by":"crossref","first-page":"547","DOI":"10.5604\/01.3001.0012.0916","article-title":"New insights about albumin and liver disease","volume":"17","author":"Carvalho","year":"2018","journal-title":"Ann. Hepatol."},{"issue":"6","key":"10.1016\/j.jep.2022.115024_bib14","first-page":"496","article-title":"Hepatoprotective and antioxidant effect of Ecboliumviride (Forssk.) Alston roots against paracetamol-induced hepatotoxicity in albino wistar rats","volume":"7","author":"Cheedella","year":"2013","journal-title":"J. Pharm. Res."},{"key":"10.1016\/j.jep.2022.115024_bib15","unstructured":"ChemDraw Ultra 6.0 and Chem3D Ultra; Cambridge SoftCorporation: Cambridge, USA."},{"issue":"4","key":"10.1016\/j.jep.2022.115024_bib16","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1021\/tx800464q","article-title":"Serum metabolomics reveals irreversible inhibition of fatty acid \u03b2-oxidation through the suppression of PPAR\u03b1 activation as a contributing mechanism of acetaminophen-induced hepatotoxicity","volume":"22","author":"Chen","year":"2009","journal-title":"Chem. Res. Toxicol."},{"issue":"4","key":"10.1016\/j.jep.2022.115024_bib17","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1039\/c0np00045k","article-title":"Natural withanolides: an overview","volume":"28","author":"Chen","year":"2011","journal-title":"Nat. Prod. Rep."},{"issue":"10","key":"10.1016\/j.jep.2022.115024_bib18","doi-asserted-by":"crossref","first-page":"18352","DOI":"10.3390\/molecules201018352","article-title":"Characterization and quantification by LC-MS\/MS of the chemical components of the heating products of the flavonoids extract in pollen typhae for transformation rule exploration","volume":"20","author":"Chen","year":"2015","journal-title":"Molecules"},{"issue":"4","key":"10.1016\/j.jep.2022.115024_bib19","first-page":"477","article-title":"A phyto-pharmacological overview on Physalis minima Linn","volume":"3","author":"Chothani","year":"2012","journal-title":"Indian J. Nat. Product. Res."},{"key":"10.1016\/j.jep.2022.115024_bib20","series-title":"Fibrosis Research","first-page":"237","article-title":"Modeling liver fibrosis in rodents","author":"Constandinou","year":"2005"},{"issue":"6","key":"10.1016\/j.jep.2022.115024_bib21","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1023\/A:1020647211557","article-title":"Comparison of anthracycline-induced death of human leukemia cells: programmed cell death versus necrosis","volume":"7","author":"Dartsch","year":"2002","journal-title":"Apoptosis"},{"key":"10.1016\/j.jep.2022.115024_bib22","series-title":"Discovery Studio Modeling Environment; Release 2017","author":"Dassault Systemes Biovia","year":"2016"},{"key":"10.1016\/j.jep.2022.115024_bib23","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/353128","article-title":"Investigation of antioxidant and hepatoprotective activity of standardized Curcuma xanthorrhiza rhizome in carbon tetrachloride-induced hepatic damaged rats","author":"Devaraj","year":"2014","journal-title":"Sci. World J."},{"key":"10.1016\/j.jep.2022.115024_bib24","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.phytochem.2013.12.001","article-title":"Capsaicin production by Alternaria alternata, an endophytic fungus from Capsicum annum; LC\u2013ESI\u2013MS\/MS analysis","volume":"98","author":"Devari","year":"2014","journal-title":"Phytochemistry"},{"issue":"4","key":"10.1016\/j.jep.2022.115024_bib113","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1582-4934.2004.tb00469.x","article-title":"Dissection of the multiple mechanisms of TNF\u2010\u03b1\u2010induced apoptosis in liver injury","volume":"8","author":"Ding","year":"2004","journal-title":"J. Cell Mol. Med."},{"issue":"4","key":"10.1016\/j.jep.2022.115024_bib25","doi-asserted-by":"crossref","first-page":"993","DOI":"10.3390\/ijms20040993","article-title":"Myristica fragrans kernels prevent paracetamol-induced hepatotoxicity by inducing anti-apoptotic genes and Nrf2\/HO-1 pathway","volume":"20","author":"Dkhil","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.jep.2022.115024_bib26","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1038\/aps.2012.62","article-title":"Differential hepatoprotective mechanisms of rutin and quercetin in CCl4-intoxicated BALB\/cN mice","volume":"33","author":"Domitrovi\u0107","year":"2012","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jep.2022.115024_bib27","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.redox.2016.10.001","article-title":"Oxidative stress during acetaminophen hepatotoxicity: sources, pathophysiological role and therapeutic potential","author":"Du","year":"2016","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.jep.2022.115024_bib28","doi-asserted-by":"crossref","first-page":"92","DOI":"10.4103\/tmj.tmj_43_16","article-title":"Hepatoprotective activity of quercetin against paracetamol-induced liver toxicity in rats","volume":"45","author":"El Faras","year":"2017","journal-title":"Tanta Med. J."},{"issue":"1","key":"10.1016\/j.jep.2022.115024_bib29","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/iep.12059","article-title":"The effects of di (2\u2010ethylhexyl) phthalate on rat liver in relation to selenium status","volume":"95","author":"Erkekoglu","year":"2014","journal-title":"Int. J. Exp. Pathol."},{"issue":"1","key":"10.1016\/j.jep.2022.115024_bib30","doi-asserted-by":"crossref","first-page":"e0226185","DOI":"10.1371\/journal.pone.0226185","article-title":"In-depth hepatoprotective mechanistic study of Phyllanthus niruri: in vitro and in vivo studies and its chemical characterization","volume":"15","author":"Ezzat","year":"2020","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.jep.2022.115024_bib31","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1089\/jmf.2019.0126","article-title":"Mechanism of the hypoglycemic activity and hepatoprotective effect of the aqueous extract of Cecropia obtusifoliaBertol","volume":"23","author":"Fortis-Barrera","year":"2020","journal-title":"J. Med. Food"},{"key":"10.1016\/j.jep.2022.115024_bib32","article-title":"Review of anti-inflammatory herbal medicines","author":"Ghasemian","year":"2016","journal-title":"Adv. Pharmacol. Sci."},{"issue":"1\u20132","key":"10.1016\/j.jep.2022.115024_bib33","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.tox.2009.11.011","article-title":"Acetaminophen induced renal injury via oxidative stress and TNF-\u03b1 production: therapeutic potential of arjunolic acid","volume":"268","author":"Ghosh","year":"2010","journal-title":"Toxicology"},{"issue":"9","key":"10.1016\/j.jep.2022.115024_bib34","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1007\/s00044-010-9398-y","article-title":"PASS-assisted exploration of new therapeutic potential of natural products","volume":"20","author":"Goel","year":"2011","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.jep.2022.115024_bib35","doi-asserted-by":"crossref","first-page":"104478","DOI":"10.1016\/j.yrtph.2019.104478","article-title":"MRI-based preclinical discovery of DILI: a lesson from paracetamol-induced hepatotoxicity","volume":"108","author":"Grudzinski","year":"2019","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2022.115024_bib36","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1472-6882-11-64","article-title":"Evaluation of Abelmoschus moschatus extracts for antioxidant, free radical scavenging, antimicrobial and antiproliferative activities using in vitro assays","volume":"11","author":"Gul","year":"2011","journal-title":"BMC Compl. Alternative Med."},{"issue":"8","key":"10.1016\/j.jep.2022.115024_bib37","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1358\/mf.2002.24.8.705070","article-title":"Pyrogallol-induced hepatotoxicity in rats: a model to evaluate antioxidant hepatoprotective agents","volume":"24","author":"Gupta","year":"2002","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"issue":"5","key":"10.1016\/j.jep.2022.115024_bib38","first-page":"362","article-title":"Hepatoprotective effect of New Liv\ufb01t\u00ae, a polyherbal formulation, is mediated through its free radical scavenging activity. Phytotherapy Research","volume":"18","author":"Gupta","year":"2004","journal-title":"Int. J. Devoted Pharmacol. Toxicol. Evaluat. Nat. Product Deriv."},{"key":"10.1016\/j.jep.2022.115024_bib39","first-page":"46","article-title":"Hepatoprotective and inhibition of oxidative stress in liver of Prostechea michuacana","volume":"3","author":"Gutierrezl","year":"2009","journal-title":"Record Nat. Prod."},{"key":"10.1016\/j.jep.2022.115024_bib40","series-title":"Free Radicals in Biology and Medicine","first-page":"416","author":"Halliwell","year":"1989"},{"issue":"1","key":"10.1016\/j.jep.2022.115024_bib41","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2174\/187152809787582561","article-title":"A systematic review of the potential herbal sources of future drugs effective in oxidant-related diseases","volume":"8","author":"Hasani-Ranjbar","year":"2009","journal-title":"Inflamm. Allergy - Drug Targets"},{"key":"10.1016\/j.jep.2022.115024_bib42","series-title":"Adverse Drug Reactions","first-page":"369","article-title":"Mechanisms of acetaminophen-induced liver necrosis","author":"Hinson","year":"2010"},{"issue":"30","key":"10.1016\/j.jep.2022.115024_bib43","doi-asserted-by":"crossref","first-page":"116","DOI":"10.4103\/0973-1296.96553","article-title":"Hepatoprotective and antioxidant activity of standardized herbal extracts","volume":"8","author":"Hiraganahalli","year":"2012","journal-title":"Phcog. Mag."},{"key":"10.1016\/j.jep.2022.115024_bib44","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0076-6879(95)52023-6","article-title":"Thioredoxin and thioredoxin reductase","volume":"252","author":"Holmgren","year":"1995","journal-title":"Methods Enzymol."},{"issue":"1","key":"10.1016\/j.jep.2022.115024_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13002-015-0019-1","article-title":"Ethnobotanical study on medicinal plants used by Maonan people in China","volume":"11","author":"Hong","year":"2015","journal-title":"J. Ethnobiol. Ethnomed."},{"issue":"1","key":"10.1016\/j.jep.2022.115024_bib46","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jep.2008.07.042","article-title":"Antioxidative and hepatoprotective effect of CGX, an herbal medicine, against toxic acute injury in mice","volume":"120","author":"Hu","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.115024_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jphotobiol.2016.03.027","article-title":"Hepatoprotective effect of grape seed oil against carbon tetrachloride induced oxidative stress in liver of \u03b3-irradiated rat","volume":"160","author":"Ismail","year":"2016","journal-title":"J. Photochem. Photobiol. B Biol."},{"issue":"1","key":"10.1016\/j.jep.2022.115024_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40816-019-0112-4","article-title":"Hepatoprotective and antioxidant activity of Ipomoea staphylina Linn","volume":"5","author":"Jeyadevi","year":"2019","journal-title":"Clin. Phytoscience"},{"issue":"3","key":"10.1016\/j.jep.2022.115024_bib49","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/embor.2009.12","article-title":"Natural products and drug discovery: can thousands of years of ancient medical knowledge lead us to new and powerful drug combinations in the fight against cancer and dementia?","volume":"10","author":"Ji","year":"2009","journal-title":"EMBO Rep."},{"issue":"1","key":"10.1016\/j.jep.2022.115024_bib50","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jtcme.2017.04.010","article-title":"Antioxidant and hepatoprotective effects of Capparis spinosa L. fractions and Quercetin on tert-butyl hydroperoxide-induced acute liver damage in mice","volume":"8","author":"Kalantari","year":"2018","journal-title":"J. Tradit., Complementary Med."},{"issue":"1","key":"10.1016\/j.jep.2022.115024_bib51","doi-asserted-by":"crossref","first-page":"31","DOI":"10.5487\/TR.2018.34.1.031","article-title":"Antioxidant and skin anti-aging effects of marigold methanol extract","volume":"34","author":"Kang","year":"2018","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.jep.2022.115024_bib52","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/0277-5379(91)90142-Z","article-title":"Comparison of the sulforhodamine B protein and tetrazolium (MTT) assays for in vitro chemosensitivity testing","author":"Keepers","year":"1991","journal-title":"Eur. J. Cancer Clin. Oncol."},{"issue":"1","key":"10.1016\/j.jep.2022.115024_bib115","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3109\/10408449309104073","article-title":"Free radicals as mediators of tissue injury and disease","volume":"23","author":"Kehrer","year":"1993","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.jep.2022.115024_bib53","series-title":"Preliminary Phytochemical Screening in Practical Pharmacognosy","first-page":"1156","author":"Khandelwal","year":"2004"},{"issue":"1","key":"10.1016\/j.jep.2022.115024_bib54","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s12906-017-1594-6","article-title":"Promotion of HepG2 cell apoptosis by flower of Allium atroviolaceum and the mechanism of action","volume":"17","author":"Khazaei","year":"2017","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.jep.2022.115024_bib55","series-title":"\u201cZinc,\u201din Modern Nutrition in Health and Disease, 10thEdn","first-page":"271","author":"King","year":"2006"},{"issue":"11","key":"10.1016\/j.jep.2022.115024_bib56","doi-asserted-by":"crossref","first-page":"6823","DOI":"10.3168\/jds.2014-8556","article-title":"Effect of commercial or depurinized milk diet on plasma advanced oxidation protein products, cardiovascular markers, and bone marrow CD34+ stem cell potential in rat experimental hyperuricemia","volume":"97","author":"Kocic","year":"2014","journal-title":"J. Dairy Sci."},{"issue":"1","key":"10.1016\/j.jep.2022.115024_bib57","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1002\/cld.148","article-title":"Role of special stains in diagnostic liver pathology","volume":"2","author":"Krishna","year":"2013","journal-title":"Clin. Liver Dis."},{"key":"10.1016\/j.jep.2022.115024_bib58","series-title":"LeadIT Version 2.3.2","author":"LeadIT","year":"2017"},{"issue":"22","key":"10.1016\/j.jep.2022.115024_bib59","doi-asserted-by":"crossref","first-page":"6490","DOI":"10.1021\/jf020388c","article-title":"Antioxidant property of an ethanol extract of the stem of Opuntia ficus-indica var. saboten","volume":"50","author":"Lee","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2022.115024_bib60","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1002\/9781119436812.ch55","article-title":"Oxidative stress and inflammation in the liver","author":"Lemasters","year":"2020","journal-title":"Liver: Biol. Pathobiol."},{"key":"10.1016\/j.jep.2022.115024_bib61","article-title":"The Hepatoprotective effect of HaoqinQingdan decoction against liver injury induced by a chemotherapeutic drug cyclophosphamide","author":"Li","year":"2015","journal-title":"Evid. base Compl. Alternative Med."},{"issue":"2","key":"10.1016\/j.jep.2022.115024_bib62","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1111\/j.1523-1755.2005.67115.x","article-title":"Role of Bcl-xL in paracetamol-induced tubular epithelial cell death","volume":"67","author":"Lorz","year":"2005","journal-title":"Kidney Int."},{"issue":"1\u20132","key":"10.1016\/j.jep.2022.115024_bib63","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cccn.2004.12.012","article-title":"Oxidative stress and antioxidant status in patients with alcoholic liver disease","volume":"355","author":"Masalkar","year":"2005","journal-title":"Clin. Chim. Acta"},{"issue":"3","key":"10.1016\/j.jep.2022.115024_bib64","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.etp.2010.08.002","article-title":"Hepatoprotective role and antioxidant capacity of selenium on arsenic-induced liver injury in rats","volume":"64","author":"Messarah","year":"2012","journal-title":"Exp. Toxicol. Pathol."},{"issue":"4","key":"10.1016\/j.jep.2022.115024_bib65","first-page":"79","article-title":"Therapeutic activities and phytochemistry of Physalis species based on traditional and modern medicine","volume":"6","author":"Mirzaee","year":"2019","journal-title":"Res. J. Pharmacogn."},{"issue":"12","key":"10.1016\/j.jep.2022.115024_bib66","doi-asserted-by":"crossref","first-page":"6523","DOI":"10.1021\/acsomega.9b04189","article-title":"Hepatoprotective and antioxidant capacity of Mallotusrepandus ethyl acetate stem extract against D-galactosamine-induced hepatotoxicity in rats","volume":"5","author":"Mondal","year":"2020","journal-title":"ACS Omega"},{"issue":"63","key":"10.1016\/j.jep.2022.115024_bib67","first-page":"1","article-title":"Hepatoprotective and antioxidant effect of stem barks extracts: methanolic and aqueous of Pseudocedrelakotschyi (Meliaceae) on paracetamol-induced hepatic damage in rats","volume":"7","author":"Nchouwet","year":"2017","journal-title":"Asian J. Biomed. Pharmaceut. Sci."},{"issue":"10","key":"10.1016\/j.jep.2022.115024_bib68","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.3109\/10715762.2010.498478","article-title":"Pathological aspects of lipid peroxidation","volume":"44","author":"Negre-Salvayre","year":"2010","journal-title":"Free Radic. Res."},{"issue":"2","key":"10.1016\/j.jep.2022.115024_bib69","first-page":"131","article-title":"Germination and emergence characteristics of annual ground cherry (Physalis divaricata)","volume":"9","author":"Nosratti","year":"2016","journal-title":"Jordan J. Biol. Sci."},{"key":"10.1016\/j.jep.2022.115024_bib70","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1023\/A:1003851821487","article-title":"Expression of TNF-alpha and immunohistochemical distribution of hepatic macrophage surface markers in carbon tetrachloride-induced chronic liver injury in rats","volume":"31","author":"Orfila","year":"1999","journal-title":"Histochem. J."},{"issue":"3","key":"10.1016\/j.jep.2022.115024_bib71","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.tox.2007.11.021","article-title":"The current state of serum biomarkers of hepatotoxicity","volume":"245","author":"Ozer","year":"2008","journal-title":"Toxicology"},{"issue":"5","key":"10.1016\/j.jep.2022.115024_bib72","first-page":"164","article-title":"Herbal drugs\u2013an approach for the treatment of liver disorders","volume":"6","author":"Pandey","year":"2019","journal-title":"Int. J. Pharmacogn."},{"key":"10.1016\/j.jep.2022.115024_bib73","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.etp.2011.11.005","article-title":"Effect of extracts from Phyllanthus watsonii Airy Shaw on cell apoptosis in cultured human breast cancer MCF-7 cells","volume":"65","author":"Ramasamy","year":"2013","journal-title":"Exp. Toxicol. Pathol."},{"issue":"5","key":"10.1016\/j.jep.2022.115024_bib74","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/ptr.1866","article-title":"Plants and animals utilized as medicines in the Ja\u00fa National Park (JNP), Brazilian Amazon","volume":"20","author":"Rodrigues","year":"2006","journal-title":"Phytother Res."},{"issue":"18","key":"10.1016\/j.jep.2022.115024_bib75","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1056\/NEJMoa0907929","article-title":"Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis","volume":"362","author":"Sanyal","year":"2010","journal-title":"N. Engl. J. Med."},{"issue":"7","key":"10.1016\/j.jep.2022.115024_bib76","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1177\/0748233712462445","article-title":"Effect of selenium on methimazole-induced liver damage and oxidative stress in adult rats and their offspring","volume":"30","author":"Sefi","year":"2014","journal-title":"Toxicol. Ind. Health"},{"issue":"1","key":"10.1016\/j.jep.2022.115024_bib77","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1146\/annurev.nu.05.070185.002053","article-title":"Mechanisms and consequences of lipid peroxidation in biological systems","volume":"5","author":"Sevanian","year":"1985","journal-title":"Annu. Rev. Nutr."},{"issue":"1","key":"10.1016\/j.jep.2022.115024_bib78","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jep.2012.06.034","article-title":"The treatment of jaundice with medicinal plants in indigenous communities of the Sub-Himalayan region of Uttarakhand, India","volume":"143","author":"Sharma","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.115024_bib79","series-title":"Book: Functional Foods, Nutraceuticals and Natural Products","article-title":"Pleiotropic effects of bioactive phytochemicals (Polyphenols and terpenes)","author":"Shehzad","year":"2018"},{"issue":"1","key":"10.1016\/j.jep.2022.115024_bib80","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-36475-0","article-title":"Cytostatic and anti-tumor potential of Ajwa date pulp against human hepatocellular carcinoma HepG2 cells","volume":"9","author":"Siddiqui","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.jep.2022.115024_bib81","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1080\/1028415X.2019.1587247","article-title":"Anti-depressant like effects of quercetin 4'-O-glucoside from Allium cepa via regulation of brain oxidative stress and monoamine levels in mice subjected to unpredictable chronic mild stress","volume":"24","author":"Singh","year":"2021","journal-title":"Nutr. Neurosci."},{"issue":"2","key":"10.1016\/j.jep.2022.115024_bib82","first-page":"1","article-title":"Ocimum kilimandscharicum Guerke: phytochemical and pharmacological aspects; A review","volume":"3","author":"Singh","year":"2014","journal-title":"J. Pharmacogn. Phytochem."},{"key":"10.1016\/j.jep.2022.115024_bib83","first-page":"1142","article-title":"Activity guided isolation of anti-inflammatory compound\/fraction from root of Ricinus communis Linn","volume":"5","author":"Singh","year":"2013","journal-title":"Int. J. PharmTech Res."},{"issue":"4","key":"10.1016\/j.jep.2022.115024_bib84","doi-asserted-by":"crossref","first-page":"229","DOI":"10.4103\/0973-8258.74130","article-title":"Withanolides: phytoconstituents with significant pharmacological activities","volume":"4","author":"Singh","year":"2010","journal-title":"Int. J. Green Pharm."},{"issue":"7","key":"10.1016\/j.jep.2022.115024_bib85","doi-asserted-by":"crossref","first-page":"11673","DOI":"10.1021\/acsomega.9b01109","article-title":"Monocarbonyl curcumin-based molecular hybrids as potent antibacterial agents","volume":"4","author":"Singh","year":"2019","journal-title":"ACS Omega"},{"key":"10.1016\/j.jep.2022.115024_bib87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuro.2015.04.007","article-title":"Neuroprotective effect of Allium cepa L. in aluminium chloride induced neurotoxicity","volume":"49","author":"Singh","year":"2015","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.jep.2022.115024_bib88","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ejphar.2016.05.019","article-title":"Adjuvant indoleamine 2, 3-dioxygenase enzyme inhibition for comprehensive management of epilepsy and comorbid depression","volume":"784","author":"Singh","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2022.115024_bib86","doi-asserted-by":"crossref","first-page":"112399","DOI":"10.1016\/j.jep.2019.112399","article-title":"Ameliorative potential of Argyreia speciosa against CCI-induced neuropathic pain in rats: biochemical and histopathological studies","volume":"249","author":"Singh","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.115024_bib89","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1111\/epi.16715","article-title":"Neocortical injury\u2013induced status epilepticus","volume":"61","author":"Singh","year":"2020","journal-title":"Epilepsia"},{"key":"10.1016\/j.jep.2022.115024_bib90","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.neuint.2016.12.023","article-title":"Adjuvant quercetin therapy for combined treatment of epilepsy and comorbid depression","volume":"104","author":"Singh","year":"2017","journal-title":"Neurochem. Int."},{"issue":"19","key":"10.1016\/j.jep.2022.115024_bib114","doi-asserted-by":"crossref","first-page":"4694","DOI":"10.3390\/ijms20194694","article-title":"Beneficial and deleterious effects of female sex hormones, oral contraceptives, and phytoestrogens by immunomodulation on the liver","volume":"20","author":"Soria-Jasso","year":"2019","journal-title":"International J. Mol. Sci."},{"key":"10.1016\/j.jep.2022.115024_bib91","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.foodchem.2018.09.040","article-title":"In vitro antioxidant activity of Kyoho grape extracts in DPPH and ABTS assays: estimation methods for EC50 using advanced statistical programs","volume":"275","author":"Sridhar","year":"2019","journal-title":"Food Chem."},{"issue":"4","key":"10.1016\/j.jep.2022.115024_bib92","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.dld.2006.11.004","article-title":"Herbal medicine in the treatment of liver diseases","volume":"39","author":"Stickel","year":"2007","journal-title":"Dig. Liver Dis."},{"issue":"2","key":"10.1016\/j.jep.2022.115024_bib93","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/S0925-4439(00)00098-3","article-title":"Evaluation of oxidative stress during apoptosis and necrosis caused by carbon tetrachloride in rat liver","volume":"1535","author":"Sun","year":"2001","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"issue":"1","key":"10.1016\/j.jep.2022.115024_bib94","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12906-018-2097-9","article-title":"Poly herbal formulation with anti-elastase and anti-oxidant properties for skin anti-aging","volume":"18","author":"Sundaram","year":"2018","journal-title":"BMC Compl. Alternative Med."},{"issue":"6","key":"10.1016\/j.jep.2022.115024_bib95","doi-asserted-by":"crossref","first-page":"804","DOI":"10.3390\/foods9060804","article-title":"Potential hepatoprotective activity of super critical carbon dioxide olive leaf extracts against CCl4-induced liver damage","volume":"9","author":"Taamalli","year":"2020","journal-title":"Foods"},{"issue":"1","key":"10.1016\/j.jep.2022.115024_bib96","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00418-007-0356-9","article-title":"Morphological and cytochemical determination of cell death by apoptosis","volume":"129","author":"Taatjes","year":"2008","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.jep.2022.115024_bib97","doi-asserted-by":"crossref","first-page":"518","DOI":"10.3389\/fphar.2017.00518","article-title":"Ethnopharmacological approaches for therapy of jaundice: Part I","volume":"8","author":"Tewari","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2022.115024_bib98","first-page":"1","article-title":"A review on potential footprints of ferulic acid for treatment of neurological disorders","author":"Thapliyal","year":"2021","journal-title":"Neurochem. Res."},{"issue":"3","key":"10.1016\/j.jep.2022.115024_bib99","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.cbi.2009.11.028","article-title":"Pyrogallol-mediated toxicity and natural antioxidants: triumphs and pitfalls of preclinical findings and their translational limitations","volume":"183","author":"Upadhyay","year":"2010","journal-title":"Chem. Biol. Interact."},{"issue":"1\u20133","key":"10.1016\/j.jep.2022.115024_bib100","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.ejphar.2007.03.004","article-title":"Effect of silymarin on pyrogallol-and rifampicin-induced hepatotoxicity in mouse","volume":"565","author":"Upadhyay","year":"2007","journal-title":"Eur. J. Pharmacol."},{"issue":"1\u20133","key":"10.1016\/j.jep.2022.115024_bib101","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.ejphar.2008.08.019","article-title":"Resveratrol modulates pyrogallol-induced changes in hepatic toxicity markers, xenobiotic metabolizing enzymes and oxidative stress","volume":"596","author":"Upadhyay","year":"2008","journal-title":"Eur. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.jep.2022.115024_bib102","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1016\/j.fct.2010.03.041","article-title":"Involvement of multiple molecular events in pyrogallol-induced hepatotoxicity and silymarin-mediated protection: evidence from gene expression profiles","volume":"48","author":"Upadhyay","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jep.2022.115024_bib103","first-page":"163","article-title":"Evaluation of hepatoprotective activity of the fruits of Coccinia grandis Linn","volume":"1","author":"Vadivu","year":"2008","journal-title":"Int. J. Health Res."},{"issue":"18","key":"10.1016\/j.jep.2022.115024_bib104","doi-asserted-by":"crossref","first-page":"4511","DOI":"10.3390\/ijms20184511","article-title":"Mechanism of action of the tumor vessel targeting agent NGR-hTNF: role of both NGR peptide and hTNF in cell binding and signaling","volume":"20","author":"Valentinis","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"712","key":"10.1016\/j.jep.2022.115024_bib105","first-page":"107","article-title":"A taxonomic study of the genus Physalis in North America north of Mexico","volume":"60","author":"Waterfall","year":"1958","journal-title":"Rhodora"},{"issue":"1","key":"10.1016\/j.jep.2022.115024_bib106","first-page":"43","article-title":"Mouse models of liver fibrosis","volume":"45","author":"Weiler-Normann","year":"2007","journal-title":"Zeitschriftf\u00fcrGastroenterologie"},{"issue":"5","key":"10.1016\/j.jep.2022.115024_bib107","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.4049\/jimmunol.161.5.2524","article-title":"Advanced oxidation protein products as novel mediators of inflammation and monocyte activation in chronic renal failure","volume":"161","author":"Witko-Sarsat","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.jep.2022.115024_bib108","first-page":"4263","article-title":"Docking prediction for tumor necrosis factor-\u03b1 and five herbal inhibitors","volume":"2","author":"Wua","year":"2010","journal-title":"Int. J. Eng. Sci. Technol."},{"issue":"5","key":"10.1016\/j.jep.2022.115024_bib109","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1124\/dmd.116.069419","article-title":"Glycyrrhizin protects against acetaminophen-induced acute liver injury via alleviating tumor necrosis factor \u03b1\u2013mediated apoptosis","volume":"44","author":"Yan","year":"2016","journal-title":"Drug Metabol. Dispos."},{"issue":"1","key":"10.1016\/j.jep.2022.115024_bib110","doi-asserted-by":"crossref","first-page":"39","DOI":"10.2174\/1872213X12666180115153635","article-title":"Anti-inflammatory drugs and herbs with special emphasis on herbal medicines for countering inflammatory diseases and disorders-a review","volume":"12","author":"Yatoo","year":"2018","journal-title":"Recent Pat. Inflamm. Allergy Drug Discov."},{"issue":"11","key":"10.1016\/j.jep.2022.115024_bib111","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.1016\/j.fct.2010.08.034","article-title":"Potential protective effects of quercetin and curcumin on paracetamol-induced histological changes, oxidative stress, impaired liver and kidney functions and haematotoxicity in rat","volume":"48","author":"Yousef","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jep.2022.115024_bib112","doi-asserted-by":"crossref","first-page":"110S","DOI":"10.1097\/01.alc.0000189288.30358.4b","article-title":"Oxidative stress and signal transduction pathways in alcoholic liver disease","volume":"29","author":"Zima","year":"2005","journal-title":"Alcohol Clin. Exp. Res."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122000587?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122000587?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:23:37Z","timestamp":1759944217000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874122000587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":115,"alternative-id":["S0378874122000587"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2022.115024","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatoprotective effect of Physalis divaricata in paracetamol induced hepatotoxicity: In vitro, in silico and in vivo analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2022.115024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115024"}}