{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:44:04Z","timestamp":1792651444502,"version":"4.5.0"},"reference-count":174,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.jep.2022.115075","type":"journal-article","created":{"date-parts":[[2022,2,5]],"date-time":"2022-02-05T03:16:02Z","timestamp":1644030962000},"page":"115075","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":70,"special_numbering":"C","title":["Research progress in the treatment of slow transit constipation by traditional Chinese medicine"],"prefix":"10.1016","volume":"290","author":[{"given":"LiangFeng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YanLong","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LiJie","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jep.2022.115075_bib1","first-page":"204","article-title":"Chronic severe constipation: current pathophysiological aspects, new diagnostic approaches, and therapeutic options","volume":"27","author":"Andromanakos","year":"2015","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.jep.2022.115075_bib2","series-title":"Clinical Observation of Huayu Tongbian Decoction in the Treatment of Slow Transit Constipation with Blood Stasis Type","author":"Bai","year":"2019"},{"issue":"3","key":"10.1016\/j.jep.2022.115075_bib3","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/glia.21115","article-title":"Can \u201cfunctional\u201d constipation be considered as a form of enteric neuro-gliopathy?","volume":"59","author":"Bassotti","year":"2011","journal-title":"Glia"},{"key":"10.1016\/j.jep.2022.115075_bib4","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.coph.2017.10.015","article-title":"Existing and emerging therapies for managing constipation and diarrhea","volume":"37","author":"Bharucha","year":"2017","journal-title":"Curr. Opin. Pharmacol."},{"issue":"2\u20133","key":"10.1016\/j.jep.2022.115075_bib5","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.ejphar.2008.03.008","article-title":"Health effects of quercetin: from antioxidant to nutraceutical","volume":"585","author":"Boots","year":"2008","journal-title":"Eur. J. Pharmacol."},{"issue":"34","key":"10.1016\/j.jep.2022.115075_bib6","doi-asserted-by":"crossref","first-page":"4363","DOI":"10.3748\/wjg.v16.i34.4363","article-title":"Therapy-refractory gastrointestinal motility disorder in a child with c-kit mutations","volume":"16","author":"Breuer","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jep.2022.115075_bib7","doi-asserted-by":"crossref","first-page":"170959","DOI":"10.1155\/2014\/170959","article-title":"Investigation of the chemical changes from crude and processed Paeoniae Radix Alba-Atractylodis Macrocephalae Rhizoma Herbal pair extracts by using Q exactive high-performance benchtop quadrupole-orbitrap LC-MS\/MS","author":"Cao","year":"2014","journal-title":"Evid.-based Complement Altern. Med."},{"issue":"1","key":"10.1016\/j.jep.2022.115075_bib8","doi-asserted-by":"crossref","first-page":"10322","DOI":"10.1038\/s41598-017-10835-8","article-title":"Dysbiosis contributes to chronic constipation development via regulation of serotonin transporter in the intestine","volume":"7","author":"Cao","year":"2017","journal-title":"Sci. Rep."},{"issue":"29","key":"10.1016\/j.jep.2022.115075_bib9","doi-asserted-by":"crossref","first-page":"47175","DOI":"10.18632\/oncotarget.17565","article-title":"Aquaporins 1, 3 and 8 expression in irritable bowel syndrome rats' colon via NF-\u03baB pathway","volume":"8","author":"Chao","year":"2017","journal-title":"Oncotarget"},{"issue":"11","key":"10.1016\/j.jep.2022.115075_bib10","first-page":"26","article-title":"Effects of Huayu Tongbian Decoction on slow transmit constipation mice colon in aquaporin 1 and aquaporin 3","volume":"18","author":"Chen","year":"2016","journal-title":"J. Liaoning Univ. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2022.115075_bib11","first-page":"129","article-title":"Effects of Huayu Tongbian Decoction on slow transmit constipation mice colon in substance P and vasoactive intestinal polypeptide","volume":"25","author":"Chen","year":"2017","journal-title":"Chin. J. Integr. Tradit. West. Med. Dig."},{"key":"10.1016\/j.jep.2022.115075_bib12","first-page":"12","article-title":"Rhizoma Atractylodis Macrocephalaee has effect on expression of aquaporins in the colon of model rats with slow transit constipation","volume":"51","author":"Chen","year":"2019","journal-title":"New J. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2022.115075_bib13","series-title":"Clinical Observation of Slow Transit Constipation Treated with Zhuyang Tongbian Ointment","author":"Chen","year":"2020"},{"key":"10.1016\/j.jep.2022.115075_bib14","first-page":"6331","article-title":"Aloe-Emodin induces endoplasmic reticulum stress-dependent apoptosis in colorectal cancer cells","volume":"24","author":"Cheng","year":"2018","journal-title":"Med. Sci. Mon. Int. Med. J. Exp. Clin. Res."},{"key":"10.1016\/j.jep.2022.115075_bib15","doi-asserted-by":"crossref","first-page":"695","DOI":"10.2147\/DDDT.S150284","article-title":"Hot-water extract of the branches of Hovenia dulcis Thunb. (Rhamnaceae) ameliorates low-fiber diet-induced constipation in rats","volume":"12","author":"Choi","year":"2018","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.jep.2022.115075_bib16","first-page":"532734","article-title":"Epidemiology characteristics of constipation for general population, pediatric population, and elderly population in China","author":"Chu","year":"2014","journal-title":"Gastroenterol. Res. Pract."},{"issue":"5","key":"10.1016\/j.jep.2022.115075_bib17","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s10928-019-09651-6","article-title":"A quantitative systems pharmacology model of colonic motility with applications in drug development","volume":"46","author":"Das","year":"2019","journal-title":"J. Pharmacokinet. Pharmacodyn."},{"key":"10.1016\/j.jep.2022.115075_bib18","series-title":"The Observation of the Clinical Effects of Liumotang Treatment for Slow Transit Constipation Abstract","author":"Deng","year":"2018"},{"issue":"3","key":"10.1016\/j.jep.2022.115075_bib19","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.3892\/mmr.2017.6880","article-title":"Cassiae semen: a review of its phytochemistry and pharmacology (Review)","volume":"16","author":"Dong","year":"2017","journal-title":"Mol. Med. Rep."},{"issue":"2","key":"10.1016\/j.jep.2022.115075_bib20","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.nutres.2007.12.002","article-title":"Naringenin reduces tumor size and weight lost in N-methyl-N'-nitro-N-nitrosoguanidine -induced gastric carcinogenesis in rats","volume":"28","author":"Ekambaram","year":"2008","journal-title":"Nutr. Res."},{"issue":"6","key":"10.1016\/j.jep.2022.115075_bib21","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1053\/j.gastro.2009.09.002","article-title":"Enteropathogenic E coli infection inhibits intestinal serotonin transporter (SERT) function and expression","volume":"137","author":"Esmaili","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jep.2022.115075_bib22","series-title":"The Effect of Zhizhuwan on Expression of AchE 5-HT7R and Water Channel Protein in Colon Tissue of Model Mice with STC","author":"Fan","year":"2015"},{"key":"10.1016\/j.jep.2022.115075_bib23","first-page":"486","article-title":"Effects of Zhizhu Tongbian Decoction on the colon ink propelling rate, GDNF, and NOS mRNA expression in rats with slow transit constipation","volume":"32","author":"Fan","year":"2012","journal-title":"Chin. J. Integr. Tradit. West. Med."},{"issue":"14","key":"10.1016\/j.jep.2022.115075_bib24","first-page":"2140","article-title":"Pharmacological research progress of cistanches Herba","volume":"32","author":"Fang","year":"2017","journal-title":"Guangming J. Chin. Med."},{"key":"10.1016\/j.jep.2022.115075_bib25","first-page":"62","article-title":"Cathartic effect of Baishao and its effect on AQP4 and VIP in mice with constipation","volume":"36","author":"Fang","year":"2017","journal-title":"Shandong J. Tradit. Chin. Med."},{"issue":"11","key":"10.1016\/j.jep.2022.115075_bib26","first-page":"4429","article-title":"Research progress on anti-aging function of Cistanches","volume":"12","author":"Feng","year":"2021","journal-title":"J. Food Saf. Qual."},{"key":"10.1016\/j.jep.2022.115075_bib27","doi-asserted-by":"crossref","first-page":"3713","DOI":"10.2147\/OTT.S182405","article-title":"Anti-tumor effect of aloe-emodin on cervical cancer cells was associated with human papillomavirus E6\/E7 and glucose metabolism","volume":"12","author":"Gao","year":"2019","journal-title":"OncoTargets Ther."},{"key":"10.1016\/j.jep.2022.115075_bib28","first-page":"307","article-title":"Study on laxative constituents in cistanche deserticola Y. C. Ma","volume":"17","author":"Gao","year":"2015","journal-title":"Mod. Chin. Med."},{"key":"10.1016\/j.jep.2022.115075_bib29","doi-asserted-by":"crossref","first-page":"474","DOI":"10.3389\/fmicb.2019.00474","article-title":"Dose-dependent effects of Aloin on the intestinal bacterial community structure, Short Chain Fatty Acids metabolism and intestinal epithelial cell permeability","volume":"10","author":"Gokulan","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jep.2022.115075_bib30","first-page":"410","article-title":"Study of effects of Jichuan Decoction on plasma SP, ICC of intestinal tissue and intestinal motility of model rats with colon slow transit constipation","volume":"37","author":"Gu","year":"2018","journal-title":"J. Beijing Univ. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2022.115075_bib31","doi-asserted-by":"crossref","DOI":"10.1177\/1534735420953215","article-title":"A Review of therapeutic effects and the pharmacological molecular mechanisms of Chinese medicine Weifuchun in treating precancerous gastric conditions","volume":"19","author":"Gu","year":"2020","journal-title":"Integr. Cancer Ther."},{"issue":"7","key":"10.1016\/j.jep.2022.115075_bib32","doi-asserted-by":"crossref","first-page":"8276","DOI":"10.3390\/molecules17078276","article-title":"Preparative isolation and purification of four compounds from Cistanches deserticola Y.C. Ma by high-speed counter-current chromatography","volume":"17","author":"Han","year":"2012","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.jep.2022.115075_bib33","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1053\/j.gastro.2017.04.020","article-title":"Hyperglycemia increases interstitial cells of Cajal via MAPK1 and MAPK3 signaling to ETV1 and KIT, leading to rapid gastric emptying","volume":"153","author":"Hayashi","year":"2017","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.jep.2022.115075_bib34","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3949\/ccjm.84a.15141","article-title":"Chronic constipation: update on management","volume":"84","author":"Hayat","year":"2017","journal-title":"Cleve. Clin. J. Med."},{"key":"10.1016\/j.jep.2022.115075_bib35","series-title":"Clinical Research and Experimental Research on Slow Transmit Constipation of Blood-Stasis Syndrome by Huayu Tongbian Decoction Combined Acupuncture","author":"He","year":"2018"},{"key":"10.1016\/j.jep.2022.115075_bib36","first-page":"1487","article-title":"Effects of Fructus Aurantii Immaturus volatile oil on slow transit constipation in rats","volume":"28","author":"He","year":"2013","journal-title":"China J. Tradit. Chin. Med. Pharm."},{"key":"10.1016\/j.jep.2022.115075_bib37","first-page":"26","article-title":"Effect of Zhizhu Pill on slow transit constipation in rats","volume":"8","author":"He","year":"2015","journal-title":"Global Tradit. Chin. Med."},{"issue":"16","key":"10.1016\/j.jep.2022.115075_bib38","doi-asserted-by":"crossref","first-page":"9349","DOI":"10.1111\/jcmm.15586","article-title":"Astragaloside IV alleviates mouse slow transit constipation by modulating gut microbiota profile and promoting butyric acid generation","volume":"24","author":"He","year":"2020","journal-title":"J. Cell Mol. Med."},{"issue":"5","key":"10.1016\/j.jep.2022.115075_bib39","article-title":"Effects of Cassia obtusifolia L. extract on Loperamide-induced constipation in rats","volume":"31","author":"Hee","year":"2018","journal-title":"Korean J. Food Nutr."},{"issue":"5","key":"10.1016\/j.jep.2022.115075_bib40","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/sj.bjp.0706889","article-title":"Cholinergic regulation of epithelial ion transport in the mammalian intestine","volume":"149","author":"Hirota","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jep.2022.115075_bib41","series-title":"Intervention Effect of Zhuyang Tongbian Paste on STC Model Mice","author":"Hu","year":"2019"},{"key":"10.1016\/j.jep.2022.115075_bib42","first-page":"282","article-title":"Research development on pharmacology and toxicology of Cassiae Semen related to efficacy and material basis","volume":"13","author":"Huang","year":"2016","journal-title":"Chin J. Pharmacovigilance."},{"key":"10.1016\/j.jep.2022.115075_bib43","series-title":"The Effect of Liumo Decoction on Slow Transit Constipation and its Effect on Intestinal Digestive Enzyme Activities and NOS Expression","author":"Huang","year":"2019"},{"issue":"7","key":"10.1016\/j.jep.2022.115075_bib44","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17071172","article-title":"Aquaporins in the colon as a new therapeutic target in diarrhea and constipation","volume":"17","author":"Ikarashi","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.jep.2022.115075_bib45","doi-asserted-by":"crossref","first-page":"420","DOI":"10.3109\/08923973.2014.968256","article-title":"Atractylenolide I inhibits lipopolysaccharide -induced inflammatory responses via mitogen-activated protein kinase pathways in RAW264.7 cells","volume":"36","author":"Ji","year":"2014","journal-title":"Immunopharmacol. Immunotoxicol."},{"issue":"1","key":"10.1016\/j.jep.2022.115075_bib46","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1254\/jphs.11186FP","article-title":"Echinacoside stimulates cell proliferation and prevents cell apoptosis in intestinal epithelial MODE-K cells by up-regulation of transforming growth factor-\u03b21 expression","volume":"118","author":"Jia","year":"2012","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.jep.2022.115075_bib47","doi-asserted-by":"crossref","first-page":"4249016","DOI":"10.1155\/2017\/4249016","article-title":"Yangyin Runchang decoction improves intestinal motility in mice with Atropine\/Diphenoxylate-induced slow-transit constipation","author":"Jiang","year":"2017","journal-title":"Evid.-based Complement Altern. Med."},{"key":"10.1016\/j.jep.2022.115075_bib48","series-title":"Regulatory Effects and Mechanism of Atractylenolide \u2160 on Aquaporin 3,4 of Rats with Slow Transit Constipation","author":"Jiang","year":"2017"},{"key":"10.1016\/j.jep.2022.115075_bib49","series-title":"Study on Mechanism and Therapeutic Effect of Gunrenruncahng Particles on Slow Transit Constipation Mice","author":"Jin","year":"2019"},{"key":"10.1016\/j.jep.2022.115075_bib50","doi-asserted-by":"crossref","first-page":"33793","DOI":"10.1038\/srep33793","article-title":"Receptor and transporter binding and activity profiles of albiflorin extracted from Radix paeoniae Alba","volume":"6","author":"Jin","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2022.115075_bib51","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3389\/fphar.2020.00423","article-title":"Buzhongyiqi decoction protects against Loperamide-induced constipation by regulating the Arachidonic Acid pathway in rats","volume":"11","author":"Ju","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.jep.2022.115075_bib52","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/j.1572-0241.2005.40749.x","article-title":"Tegaserod for the treatment of chronic constipation: a randomized, double-blind, placebo-controlled multinational study","volume":"100","author":"Kamm","year":"2005","journal-title":"Am. J. Gastroenterol."},{"issue":"1","key":"10.1016\/j.jep.2022.115075_bib53","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1080\/13880209.2018.1474932","article-title":"Quercetin promotes gastrointestinal motility and mucin secretion in loperamide-induced constipation of SD rats through regulation of the mAChRs downstream signal","volume":"56","author":"Kim","year":"2018","journal-title":"Pharm. Biol."},{"issue":"5","key":"10.1016\/j.jep.2022.115075_bib54","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24050896","article-title":"Laxative effect of Spicatoside A by cholinergic regulation of enteric nerve in Loperamide-induced constipation: ICR mice model","volume":"24","author":"Kim","year":"2019","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.jep.2022.115075_bib55","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jep.2013.12.055","article-title":"Rheinanthrone, a metabolite of sennoside A, triggers macrophage activation to decrease aquaporin-3 expression in the colon, causing the laxative effect of rhubarb extract","volume":"152","author":"Kon","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.115075_bib56","series-title":"Effects of Xuanfei Bushen Yangyin Decoction on P-AKT Protein, SYN Protein and NPY in Rats with Slow Transit Constipation","author":"Kong","year":"2019"},{"key":"10.1016\/j.jep.2022.115075_bib57","series-title":"Experimental Study on Xiao Fu Tong Jie Fang in Promoting Repair of Enteric Nervous System Network Structure in Slow Transit Constipation Rats","author":"Kong","year":"2019"},{"issue":"10","key":"10.1016\/j.jep.2022.115075_bib58","doi-asserted-by":"crossref","DOI":"10.3390\/nu10101562","article-title":"Effect of Cistanche Tubulosa extracts on male reproductive function in Streptozotocin(-) Nicotinamide-induced diabetic rats","volume":"10","author":"Kong","year":"2018","journal-title":"Nutrients"},{"issue":"4","key":"10.1016\/j.jep.2022.115075_bib59","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1177\/2050640616663439","article-title":"Management of chronic constipation in adults","volume":"5","author":"Krogh","year":"2017","journal-title":"United Eur. Gastroenterol. J."},{"issue":"5\u20136","key":"10.1016\/j.jep.2022.115075_bib60","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.mam.2012.03.001","article-title":"Water channel proteins in the gastrointestinal tract","volume":"33","author":"Laforenza","year":"2012","journal-title":"Mol. Aspect. Med."},{"issue":"3","key":"10.1016\/j.jep.2022.115075_bib61","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1007\/s00248-016-0809-6","article-title":"Listeria monocytogenes Inhibits serotonin transporter in human intestinal Caco-2 cells","volume":"72","author":"Latorre","year":"2016","journal-title":"Microb. Ecol."},{"issue":"33","key":"10.1016\/j.jep.2022.115075_bib62","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aau6085","article-title":"Structure and function of the immune system in the spleen","volume":"4","author":"Lewis","year":"2019","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.jep.2022.115075_bib63","first-page":"2268","article-title":"Effects of Shouhui Tongbian capsule on intestine pushing rate and colonic mucus secretion in rats with slow transit constipation","volume":"13","author":"Li","year":"2018","journal-title":"World Chin. Med."},{"key":"10.1016\/j.jep.2022.115075_bib64","first-page":"66","article-title":"Research progress on the pathogenesis about neurotransmitter change in chronic transit constipation","volume":"38","author":"Li","year":"2018","journal-title":"Chin J Coloproctology"},{"key":"10.1016\/j.jep.2022.115075_bib65","series-title":"The Effect and Machanism of Sennoside A on Promoting Intestinal Motility","author":"Li","year":"2019"},{"key":"10.1016\/j.jep.2022.115075_bib66","first-page":"1984","article-title":"Effects of Sennoside A on intestinal motility in rats with colonic slow transit constipation","volume":"13","author":"Li","year":"2018","journal-title":"World Chin. Med."},{"key":"10.1016\/j.jep.2022.115075_bib67","first-page":"102","article-title":"Study of the effects of JiaWei Jichuan Decoction on MTL, SP and VIP in elderly patients with Yang deficiency and slow transit constipation","volume":"19","author":"Li","year":"2021","journal-title":"Chin. Med. modern Distant. Edu China."},{"key":"10.1016\/j.jep.2022.115075_bib68","first-page":"126","article-title":"Clinical research of slow transit constipation based on \u201cchronic blood stasis and venation damage\u201d","volume":"21","author":"Li","year":"2019","journal-title":"J. Liaoning Univ. Tradit. Chin. Med."},{"issue":"7","key":"10.1016\/j.jep.2022.115075_bib69","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.3748\/wjg.v23.i7.1125","article-title":"Therapeutic mechanism of Yin-Chen-Hao Decoction in hepatic diseases","volume":"23","author":"Li","year":"2017","journal-title":"World J. Gastroenterol."},{"issue":"1","key":"10.1016\/j.jep.2022.115075_bib70","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/fcp.12232","article-title":"Research review on the pharmacological effects of astragaloside IV","volume":"31","author":"Li","year":"2017","journal-title":"Fundam. Clin. Pharmacol."},{"issue":"12","key":"10.1016\/j.jep.2022.115075_bib71","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph16122196","article-title":"Dissipation behavior of three fungicides during the industrial processing of Paeoniae Radix Alba and associated processing factors","volume":"16","author":"Li","year":"2019","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.jep.2022.115075_bib72","series-title":"Study on the Effect of the Expression of AQPs and Intestinal Neurotransmitter by Zengyetang in Jin Kiu Type STC Rat's Colon and Serum","author":"Li","year":"2017"},{"key":"10.1016\/j.jep.2022.115075_bib73","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3389\/fphar.2016.00041","article-title":"Herba Cistanche (Rou Cong-Rong): one of the best pharmaceutical gifts of traditional Chinese medicine","volume":"7","author":"Li","year":"2016","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2022.115075_bib74","first-page":"355","article-title":"Effect of Simo Decoction on the expressions of excitatory receptors of serotonin in slow transit colon","volume":"31","author":"Liao","year":"2013","journal-title":"Chin. Arch. Tradit. Chin. Med."},{"issue":"2","key":"10.1016\/j.jep.2022.115075_bib75","doi-asserted-by":"crossref","first-page":"G241","DOI":"10.1152\/ajpgi.90706.2008","article-title":"Roles of stem cell factor on the depletion of interstitial cells of Cajal in the colon of diabetic mice","volume":"298","author":"Lin","year":"2010","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.jep.2022.115075_bib76","series-title":"Effects of Zengye Decoction on Aquaporin of Mice with Slow Transit Constipation","author":"Liu","year":"2020"},{"key":"10.1016\/j.jep.2022.115075_bib77","first-page":"433","article-title":"Effects of Buqizengye Decoction on intestinal function, intestinal neurotransmitter and ICC in STC rats","volume":"38","author":"Liu","year":"2019","journal-title":"J. Southeast Univ., Med. Sci. Ed."},{"key":"10.1016\/j.jep.2022.115075_bib78","doi-asserted-by":"crossref","first-page":"1471824","DOI":"10.1155\/2020\/1471824","article-title":"Laxative effects of Yangyin Tongmi capsule on a model of diphenoxylate-induced constipation in mice","author":"Liu","year":"2020","journal-title":"Evid.-based Complement Altern. Med"},{"issue":"6","key":"10.1016\/j.jep.2022.115075_bib79","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1002\/fsn3.2296","article-title":"The potential of Quercetin to protect against loperamide-induced constipation in rats","volume":"9","author":"Liu","year":"2021","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.jep.2022.115075_bib80","first-page":"2145","article-title":"Effects of Semen Cassiae on colonic myoelectrical activity and AQP3 in mice","volume":"35","author":"Liu","year":"2015","journal-title":"Chin. J. Gerontol."},{"issue":"21","key":"10.1016\/j.jep.2022.115075_bib81","first-page":"2268","article-title":"Experimental study on the intestinal propulsion function of Liuwei anxiao capsule in rats with slow transit constipation","volume":"17","author":"Liu","year":"2018","journal-title":"J. Clinical. Exp. Med."},{"key":"10.1016\/j.jep.2022.115075_bib82","first-page":"5596463","article-title":"Selecting and characterizing tyrosinase ibitors from Atractylodis macrocephalae Rhizoma based on spectrum-activity relationship and molecular docking","author":"Liu","year":"2021","journal-title":"J. Anal. Methods Chem"},{"key":"10.1016\/j.jep.2022.115075_bib83","doi-asserted-by":"crossref","first-page":"598939","DOI":"10.3389\/fphar.2020.598939","article-title":"Atractylenolide-I suppresses tumorigenesis of breast cancer by inhibiting toll-like receptor 4-mediated NF-\u03baB signaling pathway","volume":"11","author":"Long","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2022.115075_bib84","first-page":"429","article-title":"Effect of Huayu Tongbian Decoction on PI3K\/Akt\/eNOS signaling pathway and vasoactive peptide in rats with slow transit constipation","volume":"44","author":"Lu","year":"2020","journal-title":"J. Shandong Univ. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2022.115075_bib85","doi-asserted-by":"crossref","first-page":"110136","DOI":"10.1016\/j.biopha.2020.110136","article-title":"Research progress in use of traditional Chinese medicine for treatment of spinal cord injury","volume":"127","author":"Lu","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2022.115075_bib86","first-page":"337","article-title":"Effects of XueXu type slow transit constipation of mice colonic smooth muscle cells on intracellular free Ca2+ concentrations and contraction on YuZhu powder","volume":"19","author":"Lu","year":"2016","journal-title":"Chin. J. Curr. Adv. Gen. Surg."},{"key":"10.1016\/j.jep.2022.115075_bib87","first-page":"1068","article-title":"Effect of Aloe on colon electrical physiology of constipation mice","volume":"33","author":"Lu","year":"2013","journal-title":"Chin. J. Gerontol"},{"issue":"4","key":"10.1016\/j.jep.2022.115075_bib88","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1136\/gut.51.4.496","article-title":"Pan-colonic decrease in interstitial cells of Cajal in patients with slow transit constipation","volume":"51","author":"Lyford","year":"2002","journal-title":"Gut"},{"key":"10.1016\/j.jep.2022.115075_bib89","article-title":"Effect of Zengye Decoction on colon AQP3 and serum NOS in slow transit constipation rats","volume":"38","author":"Ma","year":"2020","journal-title":"Chin. Arch. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2022.115075_bib90","first-page":"125","article-title":"Effect of Zengye Decoction on colonic AQP9 in slow transit constipation rats and expression changes of 5-HT in serum","volume":"38","author":"Ma","year":"2020","journal-title":"Chin. Arch. Tradit. Chin. Med."},{"issue":"14","key":"10.1016\/j.jep.2022.115075_bib91","first-page":"48","article-title":"Effect of Zhushi Runchang recipe on colonic motility in rats with slow transit constipation","volume":"25","author":"Meng","year":"2019","journal-title":"Guiding J. Tradit. Chin. Med. Pharm."},{"key":"10.1016\/j.jep.2022.115075_bib92","first-page":"489","article-title":"Mechanism research and punction of Zhushi Runchang Decoction on slow transit constipation in rats","volume":"26","author":"Meng","year":"2020","journal-title":"Chin. J. Basic Med. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2022.115075_bib93","first-page":"61","article-title":"The influence of Atractylodes macrocephala koidz on the level of NO and NOS in slow transmission constipation rats colonic mucosa","volume":"24","author":"Meng","year":"2012","journal-title":"Journal of Jiangxi University of Traditional Chinese Medicine"},{"key":"10.1016\/j.jep.2022.115075_bib94","doi-asserted-by":"crossref","first-page":"17324","DOI":"10.1038\/srep17324","article-title":"Escherichia coli Nissle 1917 enhances bioavailability of serotonin in gut tissues through modulation of synthesis and clearance","volume":"5","author":"Nzakizwanayo","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2022.115075_bib95","doi-asserted-by":"crossref","first-page":"42754","DOI":"10.1038\/srep42754","article-title":"The TNF-\u03b1 antagonist etanercept reverses age-related decreases in colonic SERT expression and faecal output in mice","volume":"7","author":"Patel","year":"2017","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.jep.2022.115075_bib96","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1055\/s-0036-1593430","article-title":"Functional disorders of constipation: paradoxical puborectalis contraction and increased perineal descent","volume":"30","author":"Payne","year":"2017","journal-title":"Clin. Colon Rectal Surg."},{"key":"10.1016\/j.jep.2022.115075_bib97","doi-asserted-by":"crossref","first-page":"110209","DOI":"10.1016\/j.pnpbp.2020.110209","article-title":"Psychological comorbidity in gastrointestinal diseases: update on the brain-gut-microbiome axis","volume":"107","author":"Person","year":"2021","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"issue":"13","key":"10.1016\/j.jep.2022.115075_bib98","first-page":"119","article-title":"Treating 56 cases of chronic constipation in elderly with jichuan jian plus the buzhong Yiqi decoction","volume":"9","author":"Qiu","year":"2017","journal-title":"Clinic. j. Chin. Med."},{"issue":"5","key":"10.1016\/j.jep.2022.115075_bib99","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0154649","article-title":"Influence of the environmental factors on the accumulation of the bioactive ingredients in Chinese Rhubarb products","volume":"11","author":"Ren","year":"2016","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.jep.2022.115075_bib100","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0254-6272(13)60189-2","article-title":"Pharmacological effects of Astragaloside IV: a literature review","volume":"33","author":"Ren","year":"2013","journal-title":"J. Tradit. Chin. Med."},{"issue":"2","key":"10.1016\/j.jep.2022.115075_bib101","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.etp.2009.03.010","article-title":"Cadmium-induced hepatotoxicity in rats and the protective effect of naringenin","volume":"62","author":"Renugadevi","year":"2010","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.jep.2022.115075_bib102","first-page":"13","article-title":"Treatment of slow transit constipation with Modified Jichuan Decoction in 50 cases","volume":"17","author":"Shen","year":"2010","journal-title":"Modern Chin. Clin. Med."},{"key":"10.1016\/j.jep.2022.115075_bib103","series-title":"Study on the Effect and Mechanism about the Extract of Raw Rhizoma Atractylodis Macrocephalae in Treating Slow Transit Constipation","author":"Shi","year":"2007"},{"issue":"3","key":"10.1016\/j.jep.2022.115075_bib104","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/apt.12571","article-title":"Systematic review with meta-analysis: highly selective 5-HT4 agonists (prucalopride, velusetrag or naronapride) in chronic constipation","volume":"39","author":"Shin","year":"2014","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.jep.2022.115075_bib105","series-title":"Effects of Yiqi Jianpi Tongbian Recipe on S-100 Protein and Serum MTL and VIP in Rats with Slow Transit Constipation","author":"Shu","year":"2019"},{"key":"10.1016\/j.jep.2022.115075_bib106","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.neuroscience.2013.02.061","article-title":"Is serotonin in enteric nerves required for distension-evoked peristalsis and propulsion of content in Guinea-pig distal colon?","volume":"240","author":"Sia","year":"2013","journal-title":"Neuroscience"},{"issue":"6","key":"10.1016\/j.jep.2022.115075_bib107","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/nmo.12092","article-title":"Clinical utility of colonic manometry in slow transit constipation","volume":"25","author":"Singh","year":"2013","journal-title":"Neuro Gastroenterol. Motil."},{"issue":"4","key":"10.1016\/j.jep.2022.115075_bib108","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/apt.14174","article-title":"Review article: dyssynergic defaecation and biofeedback therapy in the pathophysiology and management of functional constipation","volume":"46","author":"Skardoon","year":"2017","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.jep.2022.115075_bib109","series-title":"Clinical Study of Guben Runchang Ointment in Treating Slow Transit Constipation of Spleen and Kidney Yang Deficiency","author":"Sun","year":"2019"},{"key":"10.1016\/j.jep.2022.115075_bib110","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3389\/fphar.2016.00247","article-title":"A comprehensive and system review for the pharmacological mechanism of action of Rhein, an active anthraquinone ingredient","volume":"7","author":"Sun","year":"2016","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2022.115075_bib111","doi-asserted-by":"crossref","first-page":"5493192","DOI":"10.1155\/2020\/5493192","article-title":"Curative effect and mechanism of Guiren Runchang Granules on Morphine-induced slow transit constipation in mice","author":"Sun","year":"2020","journal-title":"Evid.-based Complement Altern. Med"},{"issue":"11","key":"10.1016\/j.jep.2022.115075_bib112","first-page":"48","article-title":"Effects of Huayu TongBian Decoction on slow transit constipation mice colon in PI3K\/AKT signaling pathway","volume":"21","author":"Sun","year":"2019","journal-title":"J. Liaoning Univ. Trad. chin. Med."},{"key":"10.1016\/j.jep.2022.115075_bib113","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.3389\/fphar.2020.01054","article-title":"Efficacy, chemical constituents, and pharmacological actions of radix paeoniae rubra and radix paeoniae alba","volume":"11","author":"Tan","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"12","key":"10.1016\/j.jep.2022.115075_bib114","first-page":"40","article-title":"Effect of Yiqi Jianpi Tongbian Decoction on PI3K\/Akt\/eNOS signaling pathway in slow transport type constipation rats","volume":"20","author":"Tang","year":"2018","journal-title":"J. Liaoning Univ. Trad. chin. Med."},{"issue":"4","key":"10.1016\/j.jep.2022.115075_bib115","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s00384-004-0679-0","article-title":"Expression of c-kit messenger ribonucleic acid and c-kit protein in sigmoid colon of patients with slow transit constipation","volume":"20","author":"Tong","year":"2005","journal-title":"Int. J. Colorectal Dis."},{"issue":"12","key":"10.1016\/j.jep.2022.115075_bib116","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1292\/jvms.11-0270","article-title":"Prokinetic effect of the 5-HT4R agonist mosapride on canine gastric motility","volume":"73","author":"Tsukamoto","year":"2011","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.jep.2022.115075_bib117","first-page":"919","article-title":"Epidemiology and management of chronic constipation in elderly patients","volume":"10","author":"Vazquez Roque","year":"2015","journal-title":"Clin. Interv. Aging"},{"key":"10.1016\/j.jep.2022.115075_bib118","first-page":"135","article-title":"Effect of Tongbiantang on PKA\/MPKA signal pathway in colon tissue of STC rat model","volume":"25","author":"Wan","year":"2019","journal-title":"Chin. J. Exp. Tradit. Med. Formulae."},{"issue":"12","key":"10.1016\/j.jep.2022.115075_bib119","first-page":"1809","article-title":"Protective effect of atractylenolide \u2160 on immunological liver injury","volume":"37","author":"Wang","year":"2012","journal-title":"China J. Chin. Mater. Med."},{"issue":"8","key":"10.1016\/j.jep.2022.115075_bib120","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1007\/s10620-015-3754-1","article-title":"Understanding the pathogenesis of slow-transit constipation: one step forward","volume":"60","author":"Wang","year":"2015","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.jep.2022.115075_bib121","first-page":"1","article-title":"Effects of Aloe emodin on colonic myoelectrical activity in slow transit constipation mice","volume":"29","author":"Wang","year":"2020","journal-title":"J. Chin. Covalescent. Med."},{"issue":"12","key":"10.1016\/j.jep.2022.115075_bib122","first-page":"23","article-title":"Study of Fuyang Tongbian Decoction on SP and ICC and expressionin intestinal tissue of mouse slow transit constipation model","volume":"6","author":"Wang","year":"2019","journal-title":"J. clin. Med."},{"key":"10.1016\/j.jep.2022.115075_bib123","article-title":"Effect of Yiqi Jianpi Tongbian recipe on ICC and SCF\/c-kit signaling pathway in colon tissue of slow transport type constipation rats","volume":"37","author":"Wang","year":"2019","journal-title":"Chin. Arch. Tradit. Chin. Med."},{"issue":"11","key":"10.1016\/j.jep.2022.115075_bib124","first-page":"15","article-title":"Influence of Shutong capsula on defecating and gastrointestinal hormones of slow transit constipation in rats","volume":"15","author":"Wang","year":"2013","journal-title":"J. Liaoning Univ. Trad. chin. Med."},{"issue":"12","key":"10.1016\/j.jep.2022.115075_bib125","first-page":"1095","article-title":"Clinical observation of Jianpi Tongbian Decoction in the treatment of slow transit constipation","volume":"41","author":"Wang","year":"2019","journal-title":"Ningxia Med. J."},{"key":"10.1016\/j.jep.2022.115075_bib126","first-page":"1909","article-title":"Mechanism of Aurantii Fructus Immaturus volatile oil in treatment of slow transit constipation based on network pharmacology","volume":"45","author":"Wang","year":"2020","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.jep.2022.115075_bib127","first-page":"970985","article-title":"Diagnosis analysis of 4 TCM patterns in suboptimal health status: a structural equation modelling approach","author":"Wang","year":"2012","journal-title":"Evid.-based Complement Altern. Med."},{"key":"10.1016\/j.jep.2022.115075_bib128","first-page":"1979","article-title":"Effects and mechanism of Baizhu Qiwu Granule on gastrointestinal function in colon slow transit constipation mice","volume":"13","author":"Wang","year":"2018","journal-title":"World Chin. Med"},{"key":"10.1016\/j.jep.2022.115075_bib129","first-page":"2824","article-title":"Effects of Zhizhu Pills on expression of PI3K and AKT in colon of mice with slow transmission and constipation of spleen deficiency syndrome","volume":"35","author":"Wang","year":"2020","journal-title":"China J. Tradit. Chin. Med. Pharm."},{"key":"10.1016\/j.jep.2022.115075_bib130","first-page":"1098","article-title":"Effect of Rhizoma Atractylodis Macrocephalae on c-kit mRNA expression in the rats of slow transit constipation","volume":"11","author":"Wang","year":"2016","journal-title":"J. World. Integrate. Trad. Western Med."},{"issue":"10","key":"10.1016\/j.jep.2022.115075_bib131","first-page":"8","article-title":"Effect of Zhizhuwan on intestinal conduction and PLC-\u03b31\/PLC-\u03b32 signaling pathway of slow transit constipation model mouse with spleen deficiency syndrome","volume":"25","author":"Wang","year":"2019","journal-title":"Chin. J. Exp. Tradit. Med. Formulae."},{"issue":"15","key":"10.1016\/j.jep.2022.115075_bib132","first-page":"1685","article-title":"Effect of Rhubarb on changes of cholinergic nerves in colonic myenteric plexus for chronic slow transit constipation rat","author":"Wang","year":"2008","journal-title":"Chongqing Med"},{"issue":"1","key":"10.1016\/j.jep.2022.115075_bib133","doi-asserted-by":"crossref","first-page":"9391","DOI":"10.1038\/s41598-017-10008-7","article-title":"The adjuvant value of Herba Cistanches when used in combination with statin in murine models","volume":"7","author":"Wat","year":"2017","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.jep.2022.115075_bib134","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1111\/j.1365-2982.2008.01165.x","article-title":"Regional variation in the neurochemical coding of the myenteric plexus of the human colon and changes in patients with slow transit constipation","volume":"20","author":"Wattchow","year":"2008","journal-title":"Neuro Gastroenterol. Motil."},{"key":"10.1016\/j.jep.2022.115075_bib135","first-page":"2059","article-title":"Effect of serum-containing Anwei Decoction on promoting apoptosis of MC cells by regulating PI3K\/Akt signaling pathway","volume":"36","author":"Wei","year":"2018","journal-title":"Chin. Arch. Tradit. Chin. Med."},{"issue":"10","key":"10.1016\/j.jep.2022.115075_bib136","first-page":"2360","article-title":"From the changes of colonic ICC and AQP3 in rats with slow transit constipation to explore the mechanism of Wenyang Yiqi prescription in improving constipation","volume":"30","author":"Wu","year":"2019","journal-title":"Lishizhen Med. Mater. Med. Res."},{"key":"10.1016\/j.jep.2022.115075_bib137","first-page":"25","article-title":"Effects of Yangyin Runchang prescription on interstitial cells of Cajal of rats with slow transit constipation","volume":"16","author":"Wu","year":"2014","journal-title":"J. Liaoning Univ. Trad. chin. Med."},{"issue":"19","key":"10.1016\/j.jep.2022.115075_bib138","first-page":"1725","article-title":"Effects of Zhizhu Pills on intestinal conduction function in slow transit constipation model mice with spleen deficiency syndrome","volume":"61","author":"Xia","year":"2020","journal-title":"J. Tradit. Chin. Med."},{"issue":"21","key":"10.1016\/j.jep.2022.115075_bib139","first-page":"1923","article-title":"Effect of serum containing Zhizhuwan Decoction on proliferation and colonic interstitial cells cajal and PLC-\u03b3 signaling pathway in rats","volume":"62","author":"Xia","year":"2021","journal-title":"J. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2022.115075_bib140","doi-asserted-by":"crossref","first-page":"105056","DOI":"10.1016\/j.phrs.2020.105056","article-title":"Chinese herbal medicine for coronavirus disease 2019: a systematic review and meta-analysis","volume":"160","author":"Xiong","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2022.115075_bib141","first-page":"100","article-title":"Effects of Buzhongyiqi Decoction on vasoactive intestinal peptide in colonic tissue in slow transit constipation mice with spleen deficiency","volume":"27","author":"Xu","year":"2017","journal-title":"Chin. J. Integrated Tradit. West Med."},{"key":"10.1016\/j.jep.2022.115075_bib142","series-title":"Experimental Study of Si Jun Zi Decoction in Treatment of Slow-Transit Constipation","author":"Xu","year":"2016"},{"key":"10.1016\/j.jep.2022.115075_bib143","first-page":"22","article-title":"Effects of bitter almond on the expression of stem cell factor, c-kit, recombinant connexin 43 in old slow transit constipation rats","volume":"7","author":"Xu","year":"2020","journal-title":"Chin J. Geriatrics. Res."},{"key":"10.1016\/j.jep.2022.115075_bib144","first-page":"9372563","article-title":"Roles of Chinese medicine and gut microbiota in chronic constipation","author":"Xu","year":"2019","journal-title":"Evid.-based Complement Altern. Med."},{"key":"10.1016\/j.jep.2022.115075_bib145","series-title":"Experimental Study on Yangyin Yiqi Runchang Decotion Improving Slow Transit Constipation via Regulating Intestinal Flora","author":"Xu","year":"2020"},{"key":"10.1016\/j.jep.2022.115075_bib146","doi-asserted-by":"crossref","first-page":"6236904","DOI":"10.1155\/2017\/6236904","article-title":"Aqueous Extracts of Herba Cistanche promoted intestinal motility in Loperamide-induced constipation rats by ameliorating the interstitial cells of Cajal","author":"Yan","year":"2017","journal-title":"Evid.-based Complement Altern. Med."},{"key":"10.1016\/j.jep.2022.115075_bib147","first-page":"371","article-title":"Regulation of Yuan Xingshi's proved prescription\u201cJichuan Yanshou Ointment\u201don intestinal neurotran smitters and intestinal florain patients with functional constipation with spleen-kidney Yang deficiency","volume":"29","author":"Yang","year":"2020","journal-title":"Mod. J. Integr. Tradit. Chin. West. Med."},{"key":"10.1016\/j.jep.2022.115075_bib148","first-page":"75","article-title":"Pharmacological research progress on semen armeniacae amarum","author":"Yang","year":"2017","journal-title":"Chinese J. Traditional Veterinary. Sci."},{"key":"10.1016\/j.jep.2022.115075_bib149","first-page":"708","article-title":"Medication regularity in treatment of slow transit constipation with TCM: a data mining research","volume":"33","author":"Yang","year":"2021","journal-title":"J. Trad. Chin. Med"},{"key":"10.1016\/j.jep.2022.115075_bib150","first-page":"15","article-title":"Effect of Jichuan Decoction on aquaporin in rats with slow transit constipation","volume":"35","author":"Yang","year":"2019","journal-title":"Pharmacol. Clin. Chin. Mater. Med."},{"issue":"10","key":"10.1016\/j.jep.2022.115075_bib151","doi-asserted-by":"crossref","first-page":"e3348","DOI":"10.1371\/journal.pone.0003348","article-title":"Cellular mechanisms underlying the laxative effect of flavonol naringenin on rat constipation model","volume":"3","author":"Yang","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2022.115075_bib152","article-title":"Biofeedback therapy combined with traditional Chinese medicine prescription improves the symptoms, surface myoelectricity, and anal canal pressure of the patients with spleen deficiency constipation","volume":"830714","author":"Yao","year":"2013","journal-title":"Evid.-based Complement Altern. Med."},{"issue":"1","key":"10.1016\/j.jep.2022.115075_bib153","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jasms.2006.08.009","article-title":"Analysis of phenolic compounds in Rhubarbs using liquid chromatography coupled with electrospray ionization mass spectrometry","volume":"18","author":"Ye","year":"2007","journal-title":"J. Am. Soc. Mass Spectrom."},{"issue":"2","key":"10.1016\/j.jep.2022.115075_bib154","first-page":"649","article-title":"Naringenin induces laxative effects by upregulating the expression levels of c-Kit and SCF, as well as those of aquaporin 3 in mice with loperamide-induced constipation","volume":"41","author":"Yin","year":"2018","journal-title":"Int. J. Mol. Med."},{"issue":"1","key":"10.1016\/j.jep.2022.115075_bib155","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12858-018-0095-7","article-title":"Isolation of quercetin and mandelic acid from Aesculus indica fruit and their biological activities","volume":"19","author":"Zahoor","year":"2018","journal-title":"BMC Boichem"},{"key":"10.1016\/j.jep.2022.115075_bib156","doi-asserted-by":"crossref","first-page":"9837384","DOI":"10.1155\/2020\/9837384","article-title":"Maren pills improve constipation via regulating AQP3 and NF-\u03baB signaling pathway in slow transit constipation in vitro and in vivo","author":"Zhan","year":"2020","journal-title":"Evid.-based Complement Altern. Med"},{"key":"10.1016\/j.jep.2022.115075_bib157","series-title":"The Effects and Mechanisms of Preventing and Treating Slow Transit Constipation by Aloe","author":"Zhang","year":"2008"},{"issue":"2","key":"10.1016\/j.jep.2022.115075_bib158","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1002\/hep.23384","article-title":"Contemporary clinical research of traditional Chinese medicines for chronic hepatitis B in China: an analytical review","volume":"51","author":"Zhang","year":"2010","journal-title":"Hepatology"},{"issue":"29","key":"10.1016\/j.jep.2022.115075_bib159","first-page":"55","article-title":"Clinical observation on treating STC with the Yiqi Runchang tongfu decoction","volume":"9","author":"Zhang","year":"2017","journal-title":"Clinic. j. Chin. Med."},{"key":"10.1016\/j.jep.2022.115075_bib160","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3389\/fphar.2019.00123","article-title":"Network pharmacology databases for traditional Chinese medicine: review and assessment","volume":"10","author":"Zhang","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2022.115075_bib161","first-page":"94","article-title":"Research review on fructus aurantii immaturus","volume":"49","author":"Zhang","year":"2021","journal-title":"Acta Chin. Med. Pharmacol."},{"issue":"9","key":"10.1016\/j.jep.2022.115075_bib162","doi-asserted-by":"crossref","first-page":"4943","DOI":"10.1002\/ptr.7123","article-title":"Clinical research on traditional Chinese medicine treatment for bacterial vaginosis","volume":"35","author":"Zhao","year":"2021","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2022.115075_bib163","series-title":"Study on the Effect and Mechanism of \u201cKey Herb\u201d Compatibility in Buzhong Yiqi Decoction on Constipation Induced by Loperamide in Rats","author":"Zhao","year":"2019"},{"issue":"5","key":"10.1016\/j.jep.2022.115075_bib164","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0098061","article-title":"Chemical and genetic discrimination of Cistanches Herba based on UPLC-QTOF\/MS and DNA barcoding","volume":"9","author":"Zheng","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2022.115075_bib165","first-page":"520","article-title":"Therapeutic effect and mechanism of Shouhui Tongbian Capsules on slow transit constipation model mice","volume":"46","author":"Zheng","year":"2021","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.jep.2022.115075_bib166","series-title":"The Research of Atractylodes Macrocephala Koidz in Treating with Slow Transit Constipation","author":"Zheng","year":"2004"},{"key":"10.1016\/j.jep.2022.115075_bib167","first-page":"516","article-title":"Analysis of the orange essential oil by GC-MS and research on the prokinetic effect of it","volume":"26","author":"Zheng","year":"2015","journal-title":"Lishizhen Med. Mater. Med. Res."},{"key":"10.1016\/j.jep.2022.115075_bib168","first-page":"459","article-title":"Expression of aquaporin 3, 4, and 8 in colonic mucosa of rat models with slow transit constipation","author":"Zhi","year":"2011","journal-title":"Chin. J. Gen. Surg."},{"key":"10.1016\/j.jep.2022.115075_bib169","first-page":"2758","article-title":"Research progress on chemical constituents and pharmacological effects of Cistanche deserticola and predictive analysis of quality markers (Q-Marker)","volume":"52","author":"Zhi","year":"2021","journal-title":"Chin. Tradit. Herb. Drugs"},{"issue":"8","key":"10.1016\/j.jep.2022.115075_bib170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0160398","article-title":"Total glucosides of Paeony promote intestinal motility in slow transit constipation rats through amelioration of interstitial cells of Cajal","volume":"11","author":"Zhu","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2022.115075_bib171","series-title":"Research on the Effects of Shaoyao Gancao Decoction on Rats with Slow Transit Constipation and on Intestinal Neurotransmitters and SCF\/c-kit Signaling Pathway","author":"Zhu","year":"2014"},{"issue":"5","key":"10.1016\/j.jep.2022.115075_bib172","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/jat.1422","article-title":"Effect of astragaloside IV on the embryo-fetal development of Sprague-Dawley rats and New Zealand White rabbits","volume":"29","author":"Zhu","year":"2009","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.jep.2022.115075_bib173","series-title":"Study on Mechanism of Jiawei Zengye Decoction in the Treatment of Slow Transit Constipation in Rats","author":"Zhu","year":"2019"},{"issue":"26","key":"10.1016\/j.jep.2022.115075_bib174","first-page":"19","article-title":"Effects of Jiaweizengye Decoction on the contents of SP, MTL and GAS in serum of rats with slow transit constipation","volume":"19","author":"Zhu","year":"2019","journal-title":"World Latest Me. Info."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412200109X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412200109X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:20:35Z","timestamp":1759944035000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037887412200109X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":174,"alternative-id":["S037887412200109X"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2022.115075","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Research progress in the treatment of slow transit constipation by traditional Chinese medicine","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2022.115075","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115075"}}