{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T20:38:02Z","timestamp":1773952682436,"version":"3.50.1"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.jep.2022.115105","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T11:28:08Z","timestamp":1644578888000},"page":"115105","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Magnolol and honokiol target TRPC4 to regulate extracellular calcium influx and relax intestinal smooth muscle"],"prefix":"10.1016","volume":"290","author":[{"given":"Lin","family":"Niu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fukui","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9161-2173","authenticated-orcid":false,"given":"Gang","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.jep.2022.115105_bib1","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1136\/gut.2007.138982","article-title":"Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain","volume":"57","author":"Akbar","year":"2008","journal-title":"Gut"},{"issue":"31","key":"10.1016\/j.jep.2022.115105_bib2","doi-asserted-by":"crossref","first-page":"4414","DOI":"10.3748\/wjg.v25.i31.4414","article-title":"Gastrointestinal motility and absorptive disorders in patients with inflammatory bowel diseases: prevalence, diagnosis and treatment","volume":"25","author":"Barros","year":"2019","journal-title":"World J. Gastroenterol."},{"issue":"1","key":"10.1016\/j.jep.2022.115105_bib3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3748\/wjg.v20.i1.37","article-title":"Gastrointestinal motility disorders in inflammatory bowel diseases","volume":"20","author":"Bassotti","year":"2014","journal-title":"World J. Gastroenterol."},{"issue":"4","key":"10.1016\/j.jep.2022.115105_bib4","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1248\/bpb.29.790","article-title":"Inhibitory effects of magnolol on distal colon of Guinea pig in vitro","volume":"29","author":"Bian","year":"2006","journal-title":"Biol. Pharm. Bull."},{"issue":"8","key":"10.1016\/j.jep.2022.115105_bib5","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.14309\/ajg.0000000000001266","article-title":"Antispasmodics for chronic abdominal pain: analysis of North American treatment options","volume":"116","author":"Brenner","year":"2021","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.jep.2022.115105_bib6","doi-asserted-by":"crossref","first-page":"7919","DOI":"10.1038\/srep07919","article-title":"Anti-obesity and anti-hyperglycemic effects of cinnamaldehyde via altered ghrelin secretion and functional impact on food intake and gastric emptying","volume":"5","author":"Camacho","year":"2015","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.jep.2022.115105_bib7","doi-asserted-by":"crossref","DOI":"10.1172\/JCI143771","article-title":"Gastrointestinal motility disorders in neurologic disease","volume":"131","author":"Camilleri","year":"2021","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.jep.2022.115105_bib8","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s00281-016-0557-1","article-title":"TRP functions in the broncho-pulmonary system","volume":"38","author":"De Logu","year":"2016","journal-title":"Semin. Immunopathol."},{"issue":"3","key":"10.1016\/j.jep.2022.115105_bib9","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.pharmthera.2006.05.013","article-title":"Cation channels of the transient receptor potential superfamily: their role in physiological and pathophysiological processes of smooth muscle cells","volume":"112","author":"Dietrich","year":"2006","journal-title":"Pharmacol. Ther."},{"issue":"4","key":"10.1016\/j.jep.2022.115105_bib10","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ceca.2007.05.018","article-title":"Serotonin-induced activation of TRPV4-like current in rat intrapulmonary arterial smooth muscle cells","volume":"43","author":"Ducret","year":"2008","journal-title":"Cell Calcium"},{"issue":"10","key":"10.1016\/j.jep.2022.115105_bib11","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.3390\/nu10101366","article-title":"Chlorogenic acid targeting of the AKT PH domain activates AKT\/GSK3beta\/FOXO1 signaling and improves glucose metabolism","volume":"10","author":"Gao","year":"2018","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.jep.2022.115105_bib12","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1186\/s13063-021-05444-w","article-title":"The Chinese herbal formula Huoxiang Zhengqi for diarrhea-predominant irritable bowel syndrome (CHAIRS): a study protocol for a double-blinded randomized controlled trial","volume":"22","author":"Guo","year":"2021","journal-title":"Trials"},{"issue":"45","key":"10.1016\/j.jep.2022.115105_bib13","doi-asserted-by":"crossref","first-page":"7346","DOI":"10.3748\/wjg.v12.i45.7346","article-title":"Effects of huoxiangzhengqi liquid on enteric mucosal immune responses in mice with Bacillus dysenteriae and Salmonella typhimurium induced diarrhea","volume":"12","author":"He","year":"2006","journal-title":"World J. Gastroenterol."},{"issue":"9","key":"10.1016\/j.jep.2022.115105_bib14","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1136\/gutjnl-2016-313346","article-title":"TRPM8 polymorphisms associated with increased risk of IBS-C and IBS-M","volume":"66","author":"Henstr\u00f6m","year":"2017","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.jep.2022.115105_bib15","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ceca.2006.03.007","article-title":"A TRPC-like non-selective cation current activated by alpha 1-adrenoceptors in rat mesenteric artery smooth muscle cells","volume":"40","author":"Hill","year":"2006","journal-title":"Cell Calcium"},{"issue":"3","key":"10.1016\/j.jep.2022.115105_bib16","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.phrs.2008.11.008","article-title":"Regulation of contractile activity by magnolol in the rat isolated gastrointestinal tracts","volume":"59","author":"Jeong","year":"2009","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2022.115105_bib17","doi-asserted-by":"crossref","first-page":"108777","DOI":"10.1016\/j.biopha.2019.108777","article-title":"Suppression of TRPV1 and P2Y nociceptors by honokiol isolated from Magnolia officinalis in 3(rd) degree burn mice by inhibiting inflammatory mediators","volume":"114","author":"Khalid","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.jep.2022.115105_bib18","doi-asserted-by":"crossref","first-page":"G604","DOI":"10.1152\/ajpgi.00069.2002","article-title":"TRPC5 as a candidate for the nonselective cation channel activated by muscarinic stimulation in murine stomach","volume":"284","author":"Lee","year":"2003","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.jep.2022.115105_bib19","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/B978-0-12-813037-7.00043-1","article-title":"Systemic disorders that affect gastrointestinal motility","author":"Lee","year":"2020","journal-title":"Clinical and Basic Neurogastroenterology and Motility"},{"key":"10.1016\/j.jep.2022.115105_bib20","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jchromb.2018.06.015","article-title":"Searching for synergistic calcium antagonists and novel therapeutic regimens for coronary heart disease therapy from a Traditional Chinese Medicine, Suxiao Jiuxin Pill","volume":"1092","author":"Lei","year":"2018","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"issue":"3","key":"10.1016\/j.jep.2022.115105_bib21","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.yrtph.2007.06.005","article-title":"Evaluation of the in vitro and in vivo genotoxicity of magnolia bark extract","volume":"49","author":"Li","year":"2007","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.jep.2022.115105_bib22","volume":"vol. II","author":"Li","year":"2013"},{"issue":"3","key":"10.1016\/j.jep.2022.115105_bib23","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.yrtph.2007.06.006","article-title":"Evaluation of short-term and subchronic toxicity of magnolia bark extract in rats","volume":"49","author":"Liu","year":"2007","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.jep.2022.115105_bib24","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.jep.2019.02.041","article-title":"A review of the phytochemistry and pharmacological activities of Magnoliae officinalis cortex","volume":"236","author":"Luo","year":"2019","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2022.115105_bib25","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.immuni.2018.04.021","article-title":"TRPV4 channel signaling in macrophages promotes gastrointestinal motility via direct effects on smooth muscle cells","volume":"49","author":"Luo","year":"2018","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.jep.2022.115105_bib26","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1152\/ajplung.2001.280.5.L870","article-title":"Capacitative Ca2+ entry in agonist-induced pulmonary vasoconstriction","volume":"280","author":"Mcdaniel","year":"2001","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"issue":"6876","key":"10.1016\/j.jep.2022.115105_bib27","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/nature719","article-title":"Identification of a cold receptor reveals a general role for TRP channels in thermosensation","volume":"416","author":"Mckemy","year":"2002","journal-title":"Nature"},{"issue":"38","key":"10.1016\/j.jep.2022.115105_bib28","doi-asserted-by":"crossref","first-page":"33436","DOI":"10.1074\/jbc.M111.274167","article-title":"Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4\/C5 ion channels","volume":"286","author":"Miller","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.jep.2022.115105_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0127060","article-title":"Five hTRPA1 agonists found in indigenous Korean mint, Agastache rugosa","volume":"10","author":"Moon","year":"2015","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.jep.2022.115105_bib30","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s12195-018-0538-7","article-title":"The mechanosensitive ion channel TRPV4 is a regulator of lung development and pulmonary vasculature stabilization","volume":"11","author":"Morgan","year":"2018","journal-title":"Cell. Mol. Bioeng."},{"key":"10.1016\/j.jep.2022.115105_bib31","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/j.biopha.2018.12.145","article-title":"Effect of N-methyltyramine on the regulation of adrenergic receptors via enzymatic epinephrine synthesis for the treatment of gastrointestinal disorders","volume":"111","author":"Ni","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2022.115105_bib32","doi-asserted-by":"crossref","first-page":"114524","DOI":"10.1016\/j.jep.2021.114524","article-title":"The rich pharmacological activities of Magnolia officinalis and secondary effects based on significant intestinal contributions","volume":"281","author":"Niu","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2022.115105_bib33","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00424-015-1704-6","article-title":"Effect of hypoxia on TRPV1 and TRPV4 channels in rat pulmonary arterial smooth muscle cells","volume":"468","author":"Parpaite","year":"2016","journal-title":"Pfl\u00fcgers Archiv"},{"issue":"13","key":"10.1016\/j.jep.2022.115105_bib34","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1007\/s40265-020-01362-4","article-title":"Functional dyspepsia: diagnostic and therapeutic approaches","volume":"80","author":"Sayuk","year":"2020","journal-title":"Drugs"},{"issue":"21","key":"10.1016\/j.jep.2022.115105_bib35","article-title":"Greater overlap of Rome IV disorders of gut-brain interactions leads to increased disease severity and poorer quality of life","volume":"S1542\u20133565","author":"Sperber","year":"2021","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"4","key":"10.1016\/j.jep.2022.115105_bib36","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1053\/j.gastro.2009.06.046","article-title":"Deletion of TRPC4 and TRPC6 in mice impairs smooth muscle contraction and intestinal motility in vivo","volume":"137","author":"Tsvilovskyy","year":"2009","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.jep.2022.115105_bib37","doi-asserted-by":"crossref","first-page":"S-488","DOI":"10.1016\/S0016-5085(21)01873-4","article-title":"Sleep disorders are associated with a lower quality of life in functional dyspesia","volume":"160","author":"Wuestenberghs","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jep.2022.115105_bib38","series-title":"Airway Smooth Muscle Cells","first-page":"35","article-title":"Transient receptor potential and orai channels in airway smooth muscle cells, calcium signaling","author":"Xiao","year":"2014"},{"issue":"5","key":"10.1016\/j.jep.2022.115105_bib39","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/nn1692","article-title":"Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels","volume":"9","author":"Xu","year":"2006","journal-title":"Nat. Neurosci."},{"issue":"3","key":"10.1016\/j.jep.2022.115105_bib40","doi-asserted-by":"crossref","first-page":"H157","DOI":"10.1152\/ajpheart.00457.2014","article-title":"Role of TRP channels in the cardiovascular system","volume":"308","author":"Yue","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"14","key":"10.1016\/j.jep.2022.115105_bib41","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.phymed.2013.07.008","article-title":"Magnolol inhibits colonic motility through down-regulation of voltage-sensitive L-type Ca2+ channels of colonic smooth muscle cells in rats","volume":"20","author":"Zhang","year":"2013","journal-title":"Phytomedicine"},{"issue":"28","key":"10.1016\/j.jep.2022.115105_bib42","doi-asserted-by":"crossref","first-page":"4414","DOI":"10.3748\/wjg.v11.i28.4414","article-title":"Effects of magnolol and honokiol derived from traditional Chinese herbal remedies on gastrointestinal movement","volume":"11","author":"Zhang","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jep.2022.115105_bib43","series-title":"Shang Han Lun","author":"Zhang","year":"2013"},{"key":"10.1016\/j.jep.2022.115105_bib44","series-title":"Jin Gui Yao Lue","author":"Zhang","year":"1997"},{"key":"10.1016\/j.jep.2022.115105_bib45","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jchromb.2016.12.012","article-title":"Comparison and evaluation of antimuscarinic and anti-inflammatory effects of five Bulbus fritillariae species based on UPLC-Q\/TOF integrated dual-luciferase reporter assay, PCA and ANN analysis","volume":"1041\u20131042","author":"Zhou","year":"2017","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412200143X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037887412200143X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:20:49Z","timestamp":1759944049000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037887412200143X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":45,"alternative-id":["S037887412200143X"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2022.115105","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Magnolol and honokiol target TRPC4 to regulate extracellular calcium influx and relax intestinal smooth muscle","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2022.115105","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115105"}}