{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:04:43Z","timestamp":1792670683492,"version":"4.5.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.jep.2022.115106","type":"journal-article","created":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T02:10:43Z","timestamp":1644891043000},"page":"115106","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Centella asiatica (L.) Urb. attenuates cardiac hypertrophy and improves heart function through multi-level mechanisms revealed by systems pharmacology"],"prefix":"10.1016","volume":"291","author":[{"given":"Bojiao","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqing","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuetong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangxin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8809-9137","authenticated-orcid":false,"given":"Wei","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jep.2022.115106_bib1","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S1885-5857(06)60796-2","article-title":"Cardiac hypertrophy: molecular and cellular events","volume":"59","author":"Carre\u00f1o","year":"2006","journal-title":"Revista Espa\u00f1ola de Cardiolog\u00eda (English Edition)"},{"issue":"5","key":"10.1016\/j.jep.2022.115106_bib2","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1038\/sj.cdd.4402095","article-title":"Cardiac-specific overexpression of E40K active Akt prevents pressure overload-induced heart failure in mice by increasing angiogenesis and reducing apoptosis","volume":"14","author":"Ceci","year":"2007","journal-title":"Cell Death Differ."},{"issue":"4","key":"10.1016\/j.jep.2022.115106_bib3","first-page":"137","article-title":"Activity of Centella asiatica in venous insufficiency","volume":"40","author":"Cesarone","year":"1992","journal-title":"Minerva Cardioangiol."},{"issue":"9","key":"10.1016\/j.jep.2022.115106_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11906-017-0775-5","article-title":"Herbs used for the treatment of hypertension and their mechanism of action","volume":"19","author":"Chrysant","year":"2017","journal-title":"Curr. Hypertens. Rep."},{"key":"10.1016\/j.jep.2022.115106_bib5","doi-asserted-by":"crossref","first-page":"113245","DOI":"10.1016\/j.jep.2020.113245","article-title":"Mechanisms of Fritillariae Thunbergii Flos in lung cancer treatment from a systems pharmacology perspective","volume":"264","author":"Cui","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2022.115106_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep42717","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"issue":"D1","key":"10.1016\/j.jep.2022.115106_bib7","doi-asserted-by":"crossref","first-page":"D1138","DOI":"10.1093\/nar\/gkaa891","article-title":"Comparative toxicogenomics database (CTD): update 2021","volume":"49","author":"Davis","year":"2021","journal-title":"Nucleic Acids Res."},{"issue":"17","key":"10.1016\/j.jep.2022.115106_bib8","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1161\/CIRCULATIONAHA.105.595231","article-title":"Akt1 is required for physiological cardiac growth","volume":"113","author":"DeBosch","year":"2006","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.jep.2022.115106_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1755-1536-5-15","article-title":"Cardiac fibroblasts, fibrosis and extracellular matrix remodeling in heart disease","volume":"5","author":"Fan","year":"2012","journal-title":"Fibrogenesis Tissue Repair"},{"issue":"18","key":"10.1016\/j.jep.2022.115106_bib10","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.139640","article-title":"Endothelial cell HSPA12B and yes-associated protein cooperatively regulate angiogenesis following myocardial infarction","volume":"5","author":"Fan","year":"2020","journal-title":"JCI Insight"},{"issue":"5","key":"10.1016\/j.jep.2022.115106_bib11","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.lfs.2004.09.009","article-title":"Protective effect of Centella asiatica on antioxidant tissue defense system against adriamycin induced cardiomyopathy in rats","volume":"76","author":"Gnanapragasam","year":"2004","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.jep.2022.115106_bib12","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s11010-006-9245-0","article-title":"Adriamycin induced myocardial failure in rats: protective role of Centella asiatica","volume":"294","author":"Gnanapragasam","year":"2007","journal-title":"Mol. Cell. Biochem."},{"issue":"1","key":"10.1016\/j.jep.2022.115106_bib13","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0944-7113(96)80011-0","article-title":"Quantitative determination of triterpenes in extracts and phytopreparations of Centella asiatica (L.) Urban","volume":"3","author":"G\u00fcnther","year":"1996","journal-title":"Phytomedicine"},{"issue":"12","key":"10.1016\/j.jep.2022.115106_bib14","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1055\/s-2004-835843","article-title":"Inhibitory effects of Centella asiatica water extract and asiaticoside on inducible nitric oxide synthase during gastric ulcer healing in rats","volume":"70","author":"Guo","year":"2004","journal-title":"Planta Med."},{"issue":"9S","key":"10.1016\/j.jep.2022.115106_bib15","doi-asserted-by":"crossref","first-page":"A56","DOI":"10.1016\/j.jacc.2006.07.007","article-title":"Molecular mechanisms in heart failure: focus on cardiac hypertrophy, inflammation, angiogenesis, and apoptosis","volume":"48","author":"Hilfiker-Kleiner","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"issue":"5","key":"10.1016\/j.jep.2022.115106_bib16","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1093\/bib\/bbt035","article-title":"Systems pharmacology in drug discovery and therapeutic insight for herbal medicines","volume":"15","author":"Huang","year":"2014","journal-title":"Briefings Bioinf."},{"issue":"1","key":"10.1016\/j.jep.2022.115106_bib17","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3892\/etm.2015.2871","article-title":"Asiatic acid inhibits left ventricular remodeling and improves cardiac function in a rat model of myocardial infarction","volume":"11","author":"Huo","year":"2016","journal-title":"Exp. Ther. Med."},{"issue":"1-2","key":"10.1016\/j.jep.2022.115106_bib18","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0021-9673(96)00237-3","article-title":"Determination of biologically active constituents in Centella asiatica","volume":"742","author":"Inamdar","year":"1996","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jep.2022.115106_bib19","series-title":"Centella asiatica (Linn.) Urban\u2014A Review","author":"Jamil","year":"2007"},{"issue":"1","key":"10.1016\/j.jep.2022.115106_bib20","first-page":"135","article-title":"Therapeutic efficiency of Centella asiatica (L.) Urb. An underutilized green leafy vegetable: an overview","volume":"4","author":"Joshi","year":"2013","journal-title":"Int. J. Pharma Bio Sci."},{"key":"10.1016\/j.jep.2022.115106_bib21","series-title":"The Effect of Heat Processing on Triterpene Glycosides and Antioxidant Activity of Herbal Pegaga (Centella asiatica L. Urban) Drink","author":"Kormin","year":"2005"},{"key":"10.1016\/j.jep.2022.115106_bib22","volume":"vol. 7","author":"Kutmon","year":"2018"},{"key":"10.1016\/j.jep.2022.115106_bib23","article-title":"Bailcalin protects against diabetic cardiomyopathy through Keap1\/Nrf2\/AMPK-mediated antioxidative and lipid-lowering effects","author":"Li","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jep.2022.115106_bib24","doi-asserted-by":"crossref","first-page":"113279","DOI":"10.1016\/j.jep.2020.113279","article-title":"Systems pharmacology reveals the multi-level synergetic mechanism of action of Ginkgo biloba L. leaves for cardiomyopathy treatment","volume":"264","author":"Li","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.jep.2022.115106_bib25","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1161\/CIRCRESAHA.115.303632","article-title":"Cardiac-specific YAP activation improves cardiac function and survival in an experimental murine MI model","volume":"115","author":"Lin","year":"2014","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.jep.2022.115106_bib54","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1161\/CIRCRESAHA.115.304457","article-title":"Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival","volume":"116","author":"Lin","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.jep.2022.115106_bib26","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/5902105","article-title":"Scare behavior diffusion model of health food safety based on complex network","author":"Luo","year":"2018","journal-title":"Complexity"},{"issue":"7","key":"10.1016\/j.jep.2022.115106_bib27","doi-asserted-by":"crossref","first-page":"861","DOI":"10.7150\/ijbs.14213","article-title":"Asiatic acid protects against cardiac hypertrophy through activating AMPK\u03b1 signalling pathway","volume":"12","author":"Ma","year":"2016","journal-title":"Int. J. Biol. Sci."},{"issue":"6","key":"10.1016\/j.jep.2022.115106_bib28","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.3390\/nu12061618","article-title":"Intra-articular route for the system of molecules 14G1862 from centella asiatica: pain relieving and protective effects in a rat model of osteoarthritis","volume":"12","author":"Micheli","year":"2020","journal-title":"Nutrients"},{"issue":"14","key":"10.1016\/j.jep.2022.115106_bib29","doi-asserted-by":"crossref","first-page":"8151","DOI":"10.1111\/jcmm.15474","article-title":"Hinokiflavone induces apoptosis via activating mitochondrial ROS\/JNK\/caspase pathway and inhibiting NF\u2010\u03baB activity in hepatocellular carcinoma","volume":"24","author":"Mu","year":"2020","journal-title":"J. Cell Mol. Med."},{"issue":"3","key":"10.1016\/j.jep.2022.115106_bib30","doi-asserted-by":"crossref","first-page":"265a","DOI":"10.1016\/j.bpj.2018.11.1439","article-title":"The role of GSK3B mislocalization in arrythmogenic cardiomyopathy","volume":"116","author":"Ng","year":"2019","journal-title":"Biophys. J."},{"issue":"2","key":"10.1016\/j.jep.2022.115106_bib31","first-page":"62","article-title":"Comparative antioxidant and anti-inflammatory activity of different extracts of Centella asiatica (L.) Urban and its active compounds, asiaticoside and madecassoside","volume":"7","author":"Nurlaily","year":"2012","journal-title":"Med. Health"},{"key":"10.1016\/j.jep.2022.115106_bib32","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/946259","article-title":"Centella asiatica (L.) Urban: from traditional medicine to modern medicine with neuroprotective potential","author":"Orhan","year":"2012","journal-title":"Evid. Based Complement. Alternat. Med."},{"issue":"1","key":"10.1016\/j.jep.2022.115106_bib33","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.redox.2013.01.009","article-title":"Imbalance of mitochondrial-nuclear cross talk in isocyanate mediated pulmonary endothelial cell dysfunction","volume":"1","author":"Panwar","year":"2013","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.jep.2022.115106_bib34","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jep.2004.03.025","article-title":"Cardioprotective activity of Hydrocotyle asiatica L. in ischemia-reperfusion induced myocardial infarction in rats","volume":"93","author":"Pragada","year":"2004","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.jep.2022.115106_bib35","article-title":"Role of Centella asiatica on cerebral post-ischemic reperfusion and long-term hypoperfusion in rats","volume":"3","author":"Raghavendra","year":"2009","journal-title":"Int. J. Green Pharm.(IJGP)"},{"issue":"16","key":"10.1016\/j.jep.2022.115106_bib36","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1055\/a-1008-6138","article-title":"Cardiovascular protective effects of Centella asiatica and its triterpenes: a review","volume":"85","author":"Razali","year":"2019","journal-title":"Planta Med."},{"issue":"1","key":"10.1016\/j.jep.2022.115106_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1758-2946-6-13","article-title":"TCMSP: a database of systems pharmacology for drug discovery from herbal medicines","volume":"6","author":"Ru","year":"2014","journal-title":"J. Cheminf."},{"issue":"6","key":"10.1016\/j.jep.2022.115106_bib38","doi-asserted-by":"crossref","first-page":"931","DOI":"10.3390\/antiox10060931","article-title":"Oxidative stress as A mechanism for functional alterations in cardiac hypertrophy and heart failure","volume":"10","author":"Shah","year":"2021","journal-title":"Antioxidants"},{"issue":"9792","key":"10.1016\/j.jep.2022.115106_bib39","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/S0140-6736(11)60894-5","article-title":"In search of new therapeutic targets and strategies for heart failure: recent advances in basic science","volume":"378","author":"Shah","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2022.115106_bib40","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.yjmcc.2016.06.001","article-title":"Physiological and pathological cardiac hypertrophy","volume":"97","author":"Shimizu","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"1","key":"10.1016\/j.jep.2022.115106_bib41","doi-asserted-by":"crossref","first-page":"12","DOI":"10.2174\/1871527318666191111105508","article-title":"Madecassic acid reduces fast transient potassium channels and promotes neurite elongation in hippocampal CA1 neurons","volume":"19","author":"Siddiqui","year":"2020","journal-title":"CNS Neurol. Disord. - Drug Targets"},{"issue":"suppl_1","key":"10.1016\/j.jep.2022.115106_bib42","first-page":"D561","article-title":"The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored","volume":"39","author":"Szklarczyk","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jep.2022.115106_bib43","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.jep.2015.10.040","article-title":"Network pharmacology-based prediction of the active ingredients and potential targets of Mahuang Fuzi Xixin decoction for application to allergic rhinitis","volume":"176","author":"Tang","year":"2015","journal-title":"J. Ethnopharmacol."},{"issue":"10","key":"10.1016\/j.jep.2022.115106_bib44","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1172\/JCI27643.","article-title":"Transcription factor MITF regulates cardiac growth and hypertrophy","volume":"116","author":"Tshori","year":"2006","journal-title":"J. Clin. Invest."},{"issue":"11","key":"10.1016\/j.jep.2022.115106_bib45","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/s41569-018-0063-3","article-title":"The Hippo pathway in the heart: pivotal roles in development, disease, and regeneration","volume":"15","author":"Wang","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.jep.2022.115106_bib46","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jff.2018.02.030","article-title":"Deciphering the multicomponent synergy mechanism from a systems pharmacology perspective: application to Gualou Xiebai decoction for coronary heart disease","volume":"47","author":"Yang","year":"2018","journal-title":"J. Funct.Foods"},{"issue":"5","key":"10.1016\/j.jep.2022.115106_bib47","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1021\/acschembio.6b00762","article-title":"Systematic investigation of Ginkgo biloba leaves for treating cardio-cerebrovascular diseases in an animal model","volume":"12","author":"Yang","year":"2017","journal-title":"ACS Chem. Biol."},{"issue":"6","key":"10.1016\/j.jep.2022.115106_bib48","doi-asserted-by":"crossref","first-page":"C508","DOI":"10.1152\/ajpcell.00248.2012","article-title":"Exendin-4 attenuates high glucose-induced cardiomyocyte apoptosis via inhibition of endoplasmic reticulum stress and activation of SERCA2a","volume":"304","author":"Younce","year":"2013","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"5","key":"10.1016\/j.jep.2022.115106_bib49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0037608","article-title":"A systematic prediction of multiple drug-target interactions from chemical, genomic, and pharmacological data","volume":"7","author":"Yu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2022.115106_bib50","doi-asserted-by":"crossref","first-page":"392","DOI":"10.3389\/fphar.2016.00392","article-title":"Hydrogen (H2) inhibits isoproterenol-induced cardiac hypertrophy via antioxidative pathways","volume":"7","author":"Zhang","year":"2016","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2022.115106_bib51","first-page":"1","article-title":"Large-scale direct targeting for drug repositioning and discovery","volume":"5","author":"Zheng","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2022.115106_bib52","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ejps.2016.05.018","article-title":"A novel systems pharmacology platform to dissect action mechanisms of traditional Chinese medicines for bovine viral diarrhea disease","volume":"94","author":"Zheng","year":"2016","journal-title":"Eur. J. Pharmaceut. Sci."},{"issue":"1","key":"10.1016\/j.jep.2022.115106_bib53","first-page":"1","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat. Commun."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122001441?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122001441?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:25:41Z","timestamp":1759944341000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874122001441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":54,"alternative-id":["S0378874122001441"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2022.115106","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Centella asiatica (L.) Urb. attenuates cardiac hypertrophy and improves heart function through multi-level mechanisms revealed by systems pharmacology","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2022.115106","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115106"}}