{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T23:59:24Z","timestamp":1793231964019,"version":"4.5.0"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.jep.2022.115120","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T03:40:18Z","timestamp":1645501218000},"page":"115120","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Herbo-metallic ethnomedicine \u2018Malla Sindoor\u2019 ameliorates lung inflammation in murine model of allergic asthma by modulating cytokines status and oxidative stress"],"prefix":"10.1016","volume":"292","author":[{"given":"Acharya","family":"Balkrishna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siva Kumar","family":"Solleti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoshiyar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5819-4050","authenticated-orcid":false,"given":"Rani","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9393-9807","authenticated-orcid":false,"given":"Kunal","family":"Bhattacharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8509-0882","authenticated-orcid":false,"given":"Anurag","family":"Varshney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jep.2022.115120_bib1","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1107\/S1600576715002319","article-title":"QUALX2.0: a qualitative phase analysis software using the freely available database POW-COD","volume":"48","author":"Altomare","year":"2015","journal-title":"J. Appl. Crystallogr."},{"issue":"4","key":"10.1016\/j.jep.2022.115120_bib3","doi-asserted-by":"crossref","first-page":"600","DOI":"10.3390\/biom10040600","article-title":"Application of zebrafish model in the suppression of drug-induced cardiac hypertrophy by traditional indian medicine yogendra ras","volume":"10","author":"Balkrishna","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.jep.2022.115120_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110063","article-title":"Calcio-herbal formulation, Divya-Swasari-Ras, alleviates chronic inflammation and suppresses airway remodelling in mouse model of allergic asthma by modulating pro-inflammatory cytokine response","volume":"126","author":"Balkrishna","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"3","key":"10.1016\/j.jep.2022.115120_bib5","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.jaci.2012.12.1564","article-title":"Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease","volume":"131","author":"Barnes","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"issue":"7","key":"10.1016\/j.jep.2022.115120_bib6","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/s41577-018-0006-6","article-title":"Targeting cytokines to treat asthma and chronic obstructive pulmonary disease","volume":"18","author":"Barnes","year":"2018","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.jep.2022.115120_bib7","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/0003-2697(71)90370-8","article-title":"Superoxide dismutase: improved assays and an assay applicable to acrylamide gels","volume":"44","author":"Beauchamp","year":"1971","journal-title":"Anal. Biochem."},{"issue":"3","key":"10.1016\/j.jep.2022.115120_bib8","first-page":"123","article-title":"Changes in lipid profile of rat plasma after chronic administration of mallasindura (MSL) \u2013 an ayurvedic metallic preparation","volume":"7","author":"Begum","year":"2015","journal-title":"J. Pharmaceut. Sci. Res."},{"issue":"5","key":"10.1016\/j.jep.2022.115120_bib9","first-page":"1958","article-title":"Toxicological effect of mallasindura (MSL) on liver function parameters of rat plasma after chronic administration","volume":"6","author":"Begum","year":"2015","journal-title":"Int. J. Pharmaceut. Sci. Res."},{"issue":"2","key":"10.1016\/j.jep.2022.115120_bib10","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1093\/clinchem\/45.2.301","article-title":"Arsenic speciation in human organs following fatal arsenic trioxide poisoning - a case report","volume":"45","author":"Benramdane","year":"1999","journal-title":"Clin. Chem."},{"issue":"10","key":"10.1016\/j.jep.2022.115120_bib11","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.21474\/IJAR01\/5713","article-title":"A case study on the therapeutic effect of malla sindoor and shring bhasma in the elevated absolute eosinophil count","volume":"5","author":"Bharati","year":"2017","journal-title":"Int. J. Adv. Res."},{"key":"10.1016\/j.jep.2022.115120_bib12","series-title":"Rasendra Sara Sangraha","author":"Bhatt","year":"2010"},{"key":"10.1016\/j.jep.2022.115120_bib13","series-title":"Sidhabhesajamanimualua","author":"Bhatta","year":"2003"},{"issue":"13","key":"10.1016\/j.jep.2022.115120_bib14","doi-asserted-by":"crossref","first-page":"3967","DOI":"10.1182\/blood-2006-04-020610","article-title":"Arsenic trioxide: a promising novel therapeutic agent for lymphoproliferative and autoimmune syndromes in MRL\/lpr mice","volume":"108","author":"Bob\u00e9","year":"2006","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.jep.2022.115120_bib15","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0022-1759(90)90020-V","article-title":"Assay of the human leukocyte enzymes myeloperoxidase and eosinophil peroxidase","volume":"126","author":"Bozeman","year":"1990","journal-title":"J. Immunol. Methods"},{"issue":"3","key":"10.1016\/j.jep.2022.115120_bib16","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.anai.2009.12.006","article-title":"The traditional Chinese herbal formula ASHMI inhibits allergic lung inflammation in antigen-sensitized and antigen-challenged aged mice","volume":"104","author":"Busse","year":"2010","journal-title":"Ann. Allergy Asthma Immunol."},{"issue":"1\u20132","key":"10.1016\/j.jep.2022.115120_bib17","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3109\/15419061.2013.775257","article-title":"Role of transcription factors in the pathogenesis of asthma and COPD","volume":"20","author":"Caramori","year":"2013","journal-title":"Cell Commun. Adhes."},{"issue":"19","key":"10.1016\/j.jep.2022.115120_bib18","first-page":"2968","article-title":"Recent researches of synthetic mercury sulfide in traditional medicine system","volume":"37","author":"Chao-jun","year":"2012","journal-title":"China J. Chin. Mater. Med."},{"issue":"5","key":"10.1016\/j.jep.2022.115120_bib19","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/cmi.2010.26","article-title":"Arsenic trioxide alleviates airway hyperresponsiveness and eosinophilia in a murine model of asthma","volume":"7","author":"Chu","year":"2010","journal-title":"Cell. Mol. Immunol."},{"issue":"7","key":"10.1016\/j.jep.2022.115120_bib20","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1152\/japplphysiol.00950.2012","article-title":"Airway smooth muscle in the pathophysiology and treatment of asthma","volume":"114","author":"Doeing","year":"2013","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.jep.2022.115120_bib21","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1513\/AnnalsATS.201506-385MG","article-title":"New insights in oxidant biology in asthma","volume":"13","author":"Erzurum","year":"2016","journal-title":"Ann. Am. Thorac. Soc."},{"issue":"1","key":"10.1016\/j.jep.2022.115120_bib22","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nri3786","article-title":"Type 2 inflammation in asthma-present in most, absent in many","volume":"15","author":"Fahy","year":"2015","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.jep.2022.115120_bib23","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.lfs.2014.07.037","article-title":"Arsenic trioxide prevents rat pulmonary fibrosis via miR-98 overexpression","volume":"114","author":"Gao","year":"2014","journal-title":"Life Sci."},{"issue":"9","key":"10.1016\/j.jep.2022.115120_bib24","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1097\/TP.0000000000000735","article-title":"Arsenic trioxide induces T cell apoptosis and prolongs islet allograft survival in mice","volume":"99","author":"Gao","year":"2015","journal-title":"Transplantation"},{"key":"10.1016\/j.jep.2022.115120_bib25","series-title":"Auckland, New Zealand","article-title":"The global asthma report 2018","year":"2018"},{"issue":"2\u20133","key":"10.1016\/j.jep.2022.115120_bib26","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0009-8981(91)90067-M","article-title":"A simple method for determination of serum catalase activity and revision of reference range","volume":"196","author":"G\u00f3th","year":"1991","journal-title":"Clin. Chim. Acta"},{"issue":"1","key":"10.1016\/j.jep.2022.115120_bib27","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/cber.187901201117","article-title":"Bemerkungen zu der Abhandlung der HH. Weselsky und Benedikt \u201cUeber einige Azoverbindungen","volume":"12","author":"Griess","year":"1879","journal-title":"Ber. Dtsch. Chem. Ges."},{"issue":"4","key":"10.1016\/j.jep.2022.115120_bib28","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/jcb.20337","article-title":"Arsenic trioxide represses constitutive activation of NF-\u03baB and COX-2 expression in human acute myeloid leukemia, HL-60","volume":"94","author":"Han","year":"2005","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.jep.2022.115120_bib29","series-title":"Rasayoga-sagara","author":"Hariprapanna","year":"1983"},{"issue":"1","key":"10.1016\/j.jep.2022.115120_bib30","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0003-9861(68)90654-1","article-title":"Photoperoxidation in isolated chloroplasts. I. Kinetics and stoichiometry of fatty acid peroxidation","volume":"125","author":"Heath","year":"1968","journal-title":"Arch. Biochem. Biophys."},{"issue":"1","key":"10.1016\/j.jep.2022.115120_bib31","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/0003-2697(76)90326-2","article-title":"A fluorometric method for determination of oxidized and reduced glutathione in tissues","volume":"74","author":"Hissin","year":"1976","journal-title":"Anal. Biochem."},{"issue":"4","key":"10.1016\/j.jep.2022.115120_bib32","doi-asserted-by":"crossref","first-page":"268","DOI":"10.4103\/0975-9476.172383","article-title":"Preparation and characterization of mercury-based traditional herbomineral formulation: shwas kuthar rasa","volume":"6","author":"Janadri","year":"2015","journal-title":"J. Ayurveda Integr. Med."},{"issue":"3","key":"10.1016\/j.jep.2022.115120_bib33","first-page":"1","article-title":"Mercury: a review on the target organs and toxic effects","volume":"2","author":"Jeevanaraj","year":"2016","journal-title":"Asia Pac. J. Occup. Health J."},{"issue":"6","key":"10.1016\/j.jep.2022.115120_bib34","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1007\/s00204-012-0826-2","article-title":"Mercury-based traditional herbo-metallic preparations: a toxicological perspective","volume":"86","author":"Kamath","year":"2012","journal-title":"Arch. Toxicol."},{"issue":"46","key":"10.1016\/j.jep.2022.115120_bib35","doi-asserted-by":"crossref","first-page":"36062","DOI":"10.1074\/jbc.M007204200","article-title":"Inhibition of NF-\u03baB activation by arsenite through reaction with a critical cysteine in the activation loop of I\u03baB kinase","volume":"275","author":"Kapahi","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.jep.2022.115120_bib36","doi-asserted-by":"crossref","first-page":"3430","DOI":"10.1002\/art.34534","article-title":"Reactive oxygen species-mediated killing of activated fibroblasts by arsenic trioxide ameliorates fibrosis in a murine model of systemic sclerosis","volume":"64","author":"Kavian","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jep.2022.115120_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.sab.2019.01.002","article-title":"Feasibility of ion-exchange solid phase extraction inductively coupled plasma mass spectrometry for discrimination between inorganic As(III) and As(V) in phosphate-rich in vitro bioaccessible fractions of Ayurvedic formulations","volume":"153","author":"Kov\u00e1cs","year":"2019","journal-title":"Spectrochim. Acta B Atom Spectrosc."},{"issue":"3","key":"10.1016\/j.jep.2022.115120_bib38","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1385\/BTER:109:3:231","article-title":"Bhasmas: unique ayurvedic metallic\u2013herbal preparations, chemical characterization","volume":"109","author":"Kumar","year":"2006","journal-title":"Biol. Trace Elem. Res."},{"issue":"1","key":"10.1016\/j.jep.2022.115120_bib39","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s10967-006-0326-z","article-title":"Availability of essential elements in bhasmas: analysis of Ayurvedic metallic preparations by INAA","volume":"270","author":"Kumar","year":"2006","journal-title":"J. Radioanal. Nucl. Chem."},{"issue":"4","key":"10.1016\/j.jep.2022.115120_bib40","first-page":"235","article-title":"Standard manufacturing procedure of malla sindura","volume":"10","author":"Kumar","year":"2016","journal-title":"Int. J. Green Pharm."},{"issue":"1","key":"10.1016\/j.jep.2022.115120_bib41","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/ni.3049","article-title":"The immunology of asthma","volume":"16","author":"Lambrecht","year":"2015","journal-title":"Nat. Immunol."},{"issue":"4","key":"10.1016\/j.jep.2022.115120_bib42","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.immuni.2019.03.018","article-title":"The cytokines of asthma","volume":"50","author":"Lambrecht","year":"2019","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.jep.2022.115120_bib43","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.pupt.2006.10.009","article-title":"Inhaled corticosteroid prevents the thickening of airway smooth muscle in murine model of chronic asthma","volume":"21","author":"Lee","year":"2008","journal-title":"Pulm. Pharmacol. Therapeut."},{"issue":"1","key":"10.1016\/j.jep.2022.115120_bib44","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1124\/jpet.105.092874","article-title":"Arsenic trioxide induces apoptosis of human monocytes during macrophagic differentiation through nuclear factor-\u03baB-related survival pathway down-regulation","volume":"316","author":"Lemarie","year":"2006","journal-title":"J. Pharmacol. Exp. Therapeut."},{"issue":"5","key":"10.1016\/j.jep.2022.115120_bib45","first-page":"4425","article-title":"Role of CCR7 on dendritic cell-mediated immune tolerance in the airways of allergy-induced asthmatic rats","volume":"20","author":"Li","year":"2019","journal-title":"Mol. Med. Rep."},{"issue":"4","key":"10.1016\/j.jep.2022.115120_bib46","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/BF02838615","article-title":"Role of low dosage arsenic trioxide on pulmonary dendritic cells in asthmatic mice","volume":"9","author":"Lin-fu","year":"2003","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.jep.2022.115120_bib47","article-title":"Chemical compositions of metals in bhasmas and Tibetan zuotai are a major determinant of their therapeutic effects and toxicity","volume":"2019","author":"Liu","year":"2019","journal-title":"Evid. base Compl. Alternative Med."},{"issue":"2","key":"10.1016\/j.jep.2022.115120_bib48","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.taap.2012.11.008","article-title":"Inorganic arsenic impairs differentiation and functions of human dendritic cells","volume":"266","author":"Macoch","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"3","key":"10.1016\/j.jep.2022.115120_bib49","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s00210-019-01734-y","article-title":"Arsenic trioxide and curcumin attenuate cisplatin-induced renal fibrosis in rats through targeting Hedgehog signaling","volume":"393","author":"Maghmomeh","year":"2020","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"issue":"4","key":"10.1016\/j.jep.2022.115120_bib50","doi-asserted-by":"crossref","first-page":"7S","DOI":"10.1177\/0192623312438738","article-title":"International harmonization of toxicologic pathology nomenclature: an overview and review of basic principles","volume":"40","author":"Mann","year":"2012","journal-title":"Toxicol. Pathol."},{"issue":"3","key":"10.1016\/j.jep.2022.115120_bib51","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1182\/blood-2002-04-1154","article-title":"Inhibition of NF-\u03baB essentially contributes to arsenic-induced apoptosis","volume":"102","author":"Mathas","year":"2003","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.jep.2022.115120_bib52","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1111\/j.1365-2222.2005.02362.x","article-title":"Female mice are more susceptible to the development of allergic airway inflammation than male mice","volume":"35","author":"Melgert","year":"2005","journal-title":"Clin. Exp. Allergy"},{"issue":"6","key":"10.1016\/j.jep.2022.115120_bib53","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1002\/jlb.52.6.619","article-title":"A new, one-step assay on whole cell suspensions for peroxidase secretion by human neutrophils and eosinophils","volume":"52","author":"Menegazzi","year":"1992","journal-title":"J. Leukoc. Biol."},{"issue":"2","key":"10.1016\/j.jep.2022.115120_bib54","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J. Basic Clin. Pharm."},{"issue":"4\u20135","key":"10.1016\/j.jep.2022.115120_bib55","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1242\/dmm.000323","article-title":"Mouse models of allergic asthma: acute and chronic allergen challenge","volume":"1","author":"Nials","year":"2008","journal-title":"Dis. Model."},{"key":"10.1016\/j.jep.2022.115120_bib56","first-page":"509","article-title":"Assessing the role of ayurvedic \u201cBhasms\u201d as ethno-nanomedicine in the metal based nanomedicine patent regime","volume":"16","author":"Paul","year":"2011","journal-title":"J. Intellect. Property Rights"},{"issue":"4073","key":"10.1016\/j.jep.2022.115120_bib57","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1126\/science.179.4073.588","article-title":"Selenium: biochemical role as a component of glatathione peroxidase","volume":"179","author":"Rotruck","year":"1973","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.jep.2022.115120_bib58","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1097\/WOX.0b013e318232389e","article-title":"Oxidative stress in asthma","volume":"4","author":"Sahiner","year":"2011","journal-title":"World Allergy Org. J."},{"issue":"3","key":"10.1016\/j.jep.2022.115120_bib59","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.coph.2013.03.013","article-title":"Cytokine targets in airway inflammation","volume":"13","author":"Schuijs","year":"2013","journal-title":"Curr. Opin. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2022.115120_bib60","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1080\/01926230252824761","article-title":"Qualitative and quantitative analysis of nonneoplastic lesions in toxicology studies","volume":"30","author":"Shackelford","year":"2002","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.jep.2022.115120_bib61","series-title":"Ayurveda Sar Sangrah","author":"Sharma","year":"2009"},{"issue":"9","key":"10.1016\/j.jep.2022.115120_bib62","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1182\/blood.V89.9.3354","article-title":"Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients","volume":"89","author":"Shen","year":"1997","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.jep.2022.115120_bib63","first-page":"1246","article-title":"Evaluation of anti histaminic activity of malla sindoora in Guinea pigs","volume":"6","author":"Shruthan","year":"2018","journal-title":"Int. Ayurvedic Med. J."},{"issue":"4","key":"10.1016\/j.jep.2022.115120_bib64","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1177\/1753425910371668","article-title":"Arsenic trioxide reduces 2,4,6-trinitrobenzene sulfonic acid-induced murine colitis via nuclear factor-\u03baB down-regulation and caspase-3 activation","volume":"17","author":"Singer","year":"2011","journal-title":"Innate Immun."},{"issue":"1","key":"10.1016\/j.jep.2022.115120_bib65","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1006\/exnr.1998.6969","article-title":"Evidence that oxidative stress is associated with the pathophysiology of inherited hydrocephalus in the H-Tx rat model","volume":"155","author":"Socci","year":"1999","journal-title":"Exp. Neurol."},{"issue":"3","key":"10.1016\/j.jep.2022.115120_bib66","doi-asserted-by":"crossref","first-page":"L293","DOI":"10.1152\/ajplung.00287.2014","article-title":"Airway epithelial cell PPAR\u03b3 modulates cigarette smoke-induced chemokine expression and emphysema susceptibility in mice","volume":"309","author":"Solleti","year":"2015","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"issue":"7","key":"10.1016\/j.jep.2022.115120_bib67","first-page":"2615","article-title":"Serpine2 deficiency results in lung lymphocyte accumulation and bronchus-associated lymphoid tissue formation","volume":"30","author":"Solleti","year":"2016","journal-title":"FASEB (Fed. Am. Soc. Exp. Biol.) J."},{"issue":"2","key":"10.1016\/j.jep.2022.115120_bib68","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0003-2697(83)90019-2","article-title":"Assay method for myeloperoxidase in human polymorphonuclear leukocytes","volume":"132","author":"Suzuki","year":"1983","journal-title":"Anal. Biochem."},{"issue":"5","key":"10.1016\/j.jep.2022.115120_bib69","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/resp.12078","article-title":"Gender difference in allergic airway remodelling and immunoglobulin production in mouse model of asthma","volume":"18","author":"Takeda","year":"2013","journal-title":"Respirology"},{"issue":"2","key":"10.1016\/j.jep.2022.115120_bib70","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1093\/toxsci\/kfh132","article-title":"Micromolar concentrations of sodium arsenite induce cyclooxygenase-2 expression and stimulate p42\/44 mitogen-activated protein kinase phosphorylation in normal human epidermal keratinocytes","volume":"79","author":"Trouba","year":"2004","journal-title":"Toxicol. Sci."},{"issue":"10","key":"10.1016\/j.jep.2022.115120_bib71","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0185579","article-title":"Inhibition of early T cell cytokine production by arsenic trioxide occurs independently of Nrf2","volume":"12","author":"VanDenBerg","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2022.115120_bib72","series-title":"Respiratory Diseases in Women","article-title":"Differences between males and females in the natural history of asthma and COPD","author":"Watson","year":"2003"},{"key":"10.1016\/j.jep.2022.115120_bib73","series-title":"Concise International Chemical Assessment Document 50: Elemental Mercury and Inorganic Mercury Compounds: Human Health Aspects","year":"2003"},{"key":"10.1016\/j.jep.2022.115120_bib74","series-title":"Preventing Disease through Healthy Environments Exposure to Mercury: A Major Public Health Concern","year":"2007"},{"key":"10.1016\/j.jep.2022.115120_bib75","series-title":"Preventing Disease through Healthy Environments: Exposure to Arsenic: a Major Public Health Concern","year":"2010"},{"issue":"8","key":"10.1016\/j.jep.2022.115120_bib76","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.18520\/cs\/v114\/i08\/1650-1655","article-title":"Is mercury really toxic? The way forward for its judicious medicinal applications based on the therapeutic doctrines of Ayurveda","volume":"114","author":"Yadav","year":"2018","journal-title":"Curr. Sci."},{"issue":"2","key":"10.1016\/j.jep.2022.115120_bib77","doi-asserted-by":"crossref","first-page":"196","DOI":"10.21053\/ceo.2019.00094","article-title":"Antiallergic effect of hizikia fusiformis in an ovalbumin-induced allergic rhinitis mouse model","volume":"12","author":"Zhang","year":"2019","journal-title":"Clin. Exp. Otorhinolaryngol."},{"issue":"3","key":"10.1016\/j.jep.2022.115120_bib78","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/s41419-018-0446-8","article-title":"Immunosuppressive effect of arsenic trioxide on islet xenotransplantation prolongs xenograft survival in mice article","volume":"9","author":"Zhao","year":"2018","journal-title":"Cell Death Dis."},{"issue":"21","key":"10.1016\/j.jep.2022.115120_bib79","doi-asserted-by":"crossref","first-page":"7653","DOI":"10.1073\/pnas.0502825102","article-title":"Systems analysis of transcriptome and proteome in retinoic acid\/arsenic trioxide-induced cell differentiation apoptosis of promyelocytic leukemia","volume":"102","author":"Zheng","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"1","key":"10.1016\/j.jep.2022.115120_bib80","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/1465-9921-7-146","article-title":"Arsenic trioxide, a potent inhibitor of NF-\u03baB, abrogates allergen-induced airway hyperresponsiveness and inflammation","volume":"7","author":"Zhou","year":"2006","journal-title":"Respir. Res."},{"issue":"439","key":"10.1016\/j.jep.2022.115120_bib81","article-title":"Inhibition of nuclear factor \u03baB overexpression by arsenic trioxide contributes to apoptosis of pulmonary eosinophils in asthmatic Guinea-pigs","volume":"25","author":"Zhou Lf","year":"2002","journal-title":"Zhonghua Jiehe He Huxi Zazhi"},{"issue":"4","key":"10.1016\/j.jep.2022.115120_bib82","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1067\/mai.2000.109432","article-title":"Alternative medicine for allergy and asthma","volume":"106","author":"Ziment","year":"2000","journal-title":"J. Allergy Clin. Immunol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122001581?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122001581?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:25:46Z","timestamp":1759944346000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874122001581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":81,"alternative-id":["S0378874122001581"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2022.115120","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Herbo-metallic ethnomedicine \u2018Malla Sindoor\u2019 ameliorates lung inflammation in murine model of allergic asthma by modulating cytokines status and oxidative stress","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2022.115120","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115120"}}