{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T02:54:08Z","timestamp":1787885648326,"version":"build-2784847793"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.jep.2022.115124","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T02:40:32Z","timestamp":1645065632000},"page":"115124","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Khasianine ameliorates psoriasis-like skin inflammation and represses TNF-\u03b1\/NF-\u03baB axis mediated transactivation of IL-17A and IL-33 in keratinocytes"],"prefix":"10.1016","volume":"292","author":[{"given":"Yixi","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2022.115124_bib1","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.3389\/fimmu.2018.01549","article-title":"The interplay between Keratinocytes and immune cells in the pathogenesis of psoriasis","volume":"9","author":"Albanesi","year":"2018","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.jep.2022.115124_bib2","first-page":"1","article-title":"A review of the pharmacological aspects of Solanum nigrum Linn","volume":"6","author":"Atanu","year":"2011","journal-title":"Biotechnol. Mol. Biol. Rev."},{"key":"10.1016\/j.jep.2022.115124_bib3","series-title":"Evaluation of anti-inflammatory activity of methanolic extract of Solanum nigrum (Solanaceae)","first-page":"151","volume":"5","author":"Arunachalam","year":"2009"},{"issue":"11","key":"10.1016\/j.jep.2022.115124_bib4","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1111\/exd.12027","article-title":"IL-33 is secreted by psoriatic keratinocytes and induces pro-inflammatory cytokines via keratinocyte and mast cell activation","volume":"21","author":"Balato","year":"2012","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.jep.2022.115124_bib5","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.3389\/fimmu.2018.01682","article-title":"The IL-17 family of cytokines in psoriasis: IL-17A and beyond","volume":"9","author":"Brembilla","year":"2018","journal-title":"Front. Immunol."},{"issue":"24","key":"10.1016\/j.jep.2022.115124_bib6","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1097\/CM9.0000000000001221","article-title":"A double-blind, randomized, placebo- and positive-controlled phase III trial of 1% benvitimod cream in mild-to-moderate plaque psoriasis","volume":"133","author":"Cai","year":"2020","journal-title":"Chin Med J (Engl)"},{"issue":"1","key":"10.1016\/j.jep.2022.115124_bib7","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jid.2018.07.025","article-title":"A critical role of the IL-1beta-IL-1R signaling pathway in skin inflammation and psoriasis pathogenesis","volume":"139","author":"Cai","year":"2019","journal-title":"J. Invest. Dermatol."},{"issue":"1","key":"10.1016\/j.jep.2022.115124_bib8","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/clinchem\/45.1.7","article-title":"New insights into the role of nuclear factor-kappaB, a ubiquitous transcription factor in the initiation of diseases","volume":"45","author":"Chen","year":"1999","journal-title":"Clin. Chem."},{"issue":"1","key":"10.1016\/j.jep.2022.115124_bib9","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s12016-018-8668-1","article-title":"Psoriasis: from pathogenesis to targeted therapies","volume":"54","author":"Conrad","year":"2018","journal-title":"Clin. Rev. Allergy Immunol."},{"issue":"5","key":"10.1016\/j.jep.2022.115124_bib10","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1002\/mc.23175","article-title":"CtBP1 transactivates RAD51 and confers cisplatin resistance to breast cancer cells","volume":"59","author":"Deng","year":"2020","journal-title":"Mol. Carcinog."},{"issue":"12","key":"10.1016\/j.jep.2022.115124_bib11","first-page":"198","article-title":"Curative effect of Longkui Yinxiao Tablet combined with Liangxue Huayu decoction in the treatment of psoriasis and its influence on serum level of related factors","volume":"20","author":"Dai","year":"2018","journal-title":"J Liaoning Univ Tradit Chin Med"},{"issue":"5","key":"10.1016\/j.jep.2022.115124_bib12","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1046\/j.1523-1747.2001.01327.x","article-title":"Keratins and the keratinocyte activation cycle","volume":"116","author":"Freedberg","year":"2001","journal-title":"J. Invest. Dermatol."},{"issue":"2","key":"10.1016\/j.jep.2022.115124_bib13","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jdermsci.2012.11.002","article-title":"NF-kappaB: an essential transcription factor in psoriasis","volume":"69","author":"Goldminz","year":"2013","journal-title":"J. Dermatol. Sci."},{"issue":"6","key":"10.1016\/j.jep.2022.115124_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.26508\/lsa.202000688","article-title":"IL-36 signaling in keratinocytes controls early IL-23 production in psoriasis-like dermatitis","volume":"3","author":"Goldstein","year":"2020","journal-title":"Life Sci Alliance"},{"key":"10.1016\/j.jep.2022.115124_bib15","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.phytochem.2017.12.020","article-title":"Bioactive steroidal alkaloids from the fruits of Solanum nigrum","volume":"147","author":"Gu","year":"2018","journal-title":"Phytochemistry"},{"issue":"3","key":"10.1016\/j.jep.2022.115124_bib16","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.cell.2008.01.020","article-title":"Shared principles in NF-kappaB signaling","volume":"132","author":"Hayden","year":"2008","journal-title":"Cell"},{"issue":"20","key":"10.1016\/j.jep.2022.115124_bib17","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.142067","article-title":"Cytokinocytes: the diverse contribution of keratinocytes to immune responses in skin","volume":"5","author":"Jiang","year":"2020","journal-title":"JCI Insight"},{"issue":"3","key":"10.1016\/j.jep.2022.115124_bib18","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.4049\/jimmunol.176.3.1431","article-title":"Protein expression of TNF-alpha in psoriatic skin is regulated at a posttranscriptional level by MAPK-activated protein kinase 2","volume":"176","author":"Johansen","year":"2006","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.jep.2022.115124_bib19","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.det.2014.09.002","article-title":"The immunopathogenesis of psoriasis","volume":"33","author":"Kim","year":"2015","journal-title":"Dermatol. Clin."},{"key":"10.1016\/j.jep.2022.115124_bib20","doi-asserted-by":"crossref","first-page":"467541","DOI":"10.1155\/2014\/467541","article-title":"Serum levels of TNF-alpha, IL-12\/23p40, and IL-17 in plaque psoriasis and their correlation with disease severity","volume":"2014","author":"Kyriakou","year":"2014","journal-title":"J Immunol Res"},{"issue":"3","key":"10.1016\/j.jep.2022.115124_bib21","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/path.4786","article-title":"Macrophage-mediated psoriasis can be suppressed by regulatory T lymphocytes","volume":"240","author":"Leite Dantas","year":"2016","journal-title":"J. Pathol."},{"issue":"52","key":"10.1016\/j.jep.2022.115124_bib22","doi-asserted-by":"crossref","first-page":"19057","DOI":"10.1073\/pnas.0509736102","article-title":"Increase in TNF-alpha and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a)","volume":"102","author":"Lowes","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"30","key":"10.1016\/j.jep.2022.115124_bib23","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abb6049","article-title":"Treatment of psoriasis with NFKBIZ siRNA using topical ionic liquid formulations","volume":"6","author":"Mandal","year":"2020","journal-title":"Sci. Adv."},{"issue":"9","key":"10.1016\/j.jep.2022.115124_bib24","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1016\/0031-9422(80)83026-3","article-title":"Steroidal alkaloids from Solanum khasian um: application of 13C NMR spectroscopy to their structural elucidation","volume":"19","author":"Mahato","year":"1980","journal-title":"Phytochemistry"},{"issue":"6891","key":"10.1016\/j.jep.2022.115124_bib25","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/nature00820","article-title":"TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2","volume":"417","author":"Pasparakis","year":"2002","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.jep.2022.115124_bib26","first-page":"28","article-title":"New and emerging topical therapies for psoriasis and atopic dermatitis","volume":"12","author":"Psomadakis","year":"2019","journal-title":"J Clin Aesthet Dermatol"},{"issue":"2","key":"10.1016\/j.jep.2022.115124_bib27","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.immuni.2007.05.024","article-title":"Crosstalk between keratinocytes and adaptive immune cells in an IkappaBalpha protein-mediated inflammatory disease of the skin","volume":"27","author":"Rebholz","year":"2007","journal-title":"Immunity"},{"issue":"38","key":"10.1016\/j.jep.2022.115124_bib28","doi-asserted-by":"crossref","first-page":"36916","DOI":"10.1074\/jbc.M301598200","article-title":"Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway","volume":"278","author":"Sakurai","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.jep.2022.115124_bib29","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1016\/j.jid.2017.05.004","article-title":"Tapinarof is a natural AhR agonist that resolves skin inflammation in mice and humans","volume":"137","author":"Smith","year":"2017","journal-title":"J. Invest. Dermatol."},{"issue":"8","key":"10.1016\/j.jep.2022.115124_bib30","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1172\/JCI27179","article-title":"Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation","volume":"116","author":"Stratis","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jep.2022.115124_bib31","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.jconrel.2021.08.039","article-title":"TNFalpha siRNA delivery by nanoparticles and photochemical internalization for psoriasis topical therapy","volume":"338","author":"Suzuki","year":"2021","journal-title":"J. Contr. Release"},{"issue":"1","key":"10.1016\/j.jep.2022.115124_bib32","first-page":"24","article-title":"Observation on the efficacy of Longkui Yinxiao Tablet in the treatment of plaque psoriasis","volume":"27","author":"Zhang","year":"2011","journal-title":"China J Leprosy Skin Diseases"},{"issue":"6","key":"10.1016\/j.jep.2022.115124_bib33","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.jaci.2010.03.018","article-title":"Identification of TNF-related apoptosis-inducing ligand and other molecules that distinguish inflammatory from resident dendritic cells in patients with psoriasis","volume":"125","author":"Zaba","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"issue":"3","key":"10.1016\/j.jep.2022.115124_bib34","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.jid.2020.07.027","article-title":"An autocrine circuit of IL-33 in Keratinocytes is involved in the progression of psoriasis","volume":"141","author":"Zeng","year":"2021","journal-title":"J. Invest. Dermatol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122001623?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122001623?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:23:20Z","timestamp":1759944200000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874122001623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":34,"alternative-id":["S0378874122001623"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2022.115124","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Khasianine ameliorates psoriasis-like skin inflammation and represses TNF-\u03b1\/NF-\u03baB axis mediated transactivation of IL-17A and IL-33 in keratinocytes","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2022.115124","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"115124"}}