{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:16:01Z","timestamp":1792635361409,"version":"4.5.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2019ZX09201004-002"],"award-info":[{"award-number":["2019ZX09201004-002"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai","doi-asserted-by":"publisher","award":["21ZR1460500"],"award-info":[{"award-number":["21ZR1460500"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173946"],"award-info":[{"award-number":["82173946"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.jep.2022.115164","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T02:20:00Z","timestamp":1646792400000},"page":"115164","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Swertiamarin, an active iridoid glycoside from Swertia pseudochinensis H. Hara, protects against alpha-naphthylisothiocyanate-induced cholestasis by activating the farnesoid X receptor and bile acid excretion pathway"],"prefix":"10.1016","volume":"291","author":[{"given":"Mengge","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2022.115164_bib1","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.jhep.2015.10.024","article-title":"Inhibition of intestinal bile acid absorption improves cholestatic liver and bile duct injury in a mouse model of sclerosing cholangitis","volume":"64","author":"Baghdasaryan","year":"2016","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jep.2022.115164_bib2","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1002\/hep.26225","article-title":"Free fatty acids repress small heterodimer partner (SHP) activation and adiponectin counteracts bile acid-induced liver injury in superobese patients with nonalcoholic steatohepatitis","volume":"57","author":"Bechmann","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.jep.2022.115164_bib3","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1016\/j.jhep.2015.02.023","article-title":"New paradigms in the treatment of hepatic cholestasis: from UDCA to FXR, PXR and beyond","volume":"62","author":"Beuers","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jep.2022.115164_bib4","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1002\/j.2040-4603.2013.tb00519.x","article-title":"Bile formation and secretion","volume":"3","author":"Boyer","year":"2013","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.jep.2022.115164_bib5","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jep.2015.12.033","article-title":"Geniposidic acid protected against ANIT-induced hepatotoxity and acute intrahepatic cholestasis, due to Fxr-mediated regulation of Bsep and Mrp2","volume":"179","author":"Chen","year":"2016","journal-title":"J. Ethnopharmacol."},{"issue":"4","key":"10.1016\/j.jep.2022.115164_bib6","first-page":"787","article-title":"Effect of geniposidic acid on hepato-enteric circulation in cholestasis rats through Sirt1-FXR signaling pathway","volume":"44","author":"Chen","year":"2019","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.jep.2022.115164_bib7","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.jhep.2003.11.006","article-title":"Regulation of bile acid synthesis: pathways, nuclear receptors, and mechanisms","volume":"40","author":"Chiang","year":"2004","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jep.2022.115164_bib8","series-title":"Flora Reipublicae Popularis Sinicae","year":"1988"},{"key":"10.1016\/j.jep.2022.115164_bib9","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0300-483X(01)00459-0","article-title":"Role of MRP2 and GSH in intrahepatic cycling of toxins","volume":"167","author":"Dietrich","year":"2001","journal-title":"Toxicology"},{"key":"10.1016\/j.jep.2022.115164_bib10","first-page":"772","article-title":"Research progress in potential therapeutic drugs for cholestatic liver diseases","volume":"42","author":"Ding","year":"2018","journal-title":"Prog. Pharm. Sci."},{"key":"10.1016\/j.jep.2022.115164_bib11","doi-asserted-by":"crossref","first-page":"3895","DOI":"10.1007\/s00018-018-2892-y","article-title":"The functional role of sodium taurocholate cotransporting polypeptide NTCP in the life cycle of hepatitis B, C and D viruses","volume":"75","author":"Eller","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"issue":"11","key":"10.1016\/j.jep.2022.115164_bib12","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/81137","article-title":"Metabolite profiling for plant functional genomics","volume":"18","author":"Fiehn","year":"2000","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jep.2022.115164_bib13","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1124\/dmd.113.054189","article-title":"The role of bile salt export pump gene repression in drug-induced cholestatic liver toxicity","volume":"42","author":"Garzel","year":"2014","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.jep.2022.115164_bib14","doi-asserted-by":"crossref","first-page":"3665","DOI":"10.1002\/pmic.200401031","article-title":"Current two-dimensional electrophoresis technology for proteomics","volume":"4","author":"Gorg","year":"2004","journal-title":"Proteomics"},{"key":"10.1016\/j.jep.2022.115164_bib15","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1053\/j.gastro.2014.12.005","article-title":"Efficacy of obeticholic acid in patients with primary biliary cirrhosis and inadequate response to ursodeoxycholic acid","volume":"148","author":"Hirschfield","year":"2015","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.jep.2022.115164_bib16","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jep.2010.04.019","article-title":"Antioxidant and hepatoprotective effect of swertiamarin from Enicostemma axillare against D-galactosamine induced acute liver damage in rats","volume":"30","author":"Jaishree","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.115164_bib17","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1002\/1522-2683(20001001)21:16<3369::AID-ELPS3369>3.0.CO;2-7","article-title":"Proteomics meets cell biology: the establishment of subcellular proteomes","volume":"21","author":"Jung","year":"2000","journal-title":"Electrophoresis"},{"key":"10.1016\/j.jep.2022.115164_bib18","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1124\/pr.113.008201","article-title":"Bile acid signaling in metabolic disease and drug therapy","volume":"66","author":"Li","year":"2014","journal-title":"Pharmacol. Rev."},{"issue":"3","key":"10.1016\/j.jep.2022.115164_bib19","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1248\/bpb.28.534","article-title":"Hepatoprotective activity of the constituents in Swertia pseudochinensis","volume":"28","author":"Li","year":"2005","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jep.2022.115164_bib20","doi-asserted-by":"crossref","first-page":"115248","DOI":"10.1016\/j.taap.2020.115248","article-title":"Picroside II alleviates liver injury induced by alpha-naphthylisothiocyanate through AMPK-FXR pathway","volume":"408","author":"Li","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jep.2022.115164_bib21","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.jpba.2019.04.009","article-title":"A systemic combined nontargeted and targeted LC-MS based metabolomic strategy of plasma and liver on pathology exploration of alpha-naphthylisothiocyanate induced cholestatic liver injury in mice","volume":"171","author":"Lin","year":"2019","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jep.2022.115164_bib22","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1159\/000484626","article-title":"iTRAQ-based proteomic analysis of neonatal kidney from offspring of protein restricted rats reveals abnormalities in intraflagellar transport proteins","volume":"44","author":"Liu","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.jep.2022.115164_bib23","first-page":"2","article-title":"Consensus on the diagnosis and treatment of cholestasis liver diseases","volume":"19","author":"Lu","year":"2015","journal-title":"J. Prac. Hepatol."},{"key":"10.1016\/j.jep.2022.115164_bib24","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.biochi.2019.07.027","article-title":"Improved hepatic MRP2\/ABCC2 transport activity in LPS-induced cholestasis by aquaporin-1 gene transfer","volume":"165","author":"Marrone","year":"2019","journal-title":"Biochimie"},{"key":"10.1016\/j.jep.2022.115164_bib25","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1002\/hep.21819","article-title":"Insights in the regulation of cholesterol 7alpha-hydroxylase gene reveal a target for modulating bile acid synthesis","volume":"46","author":"Mitro","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jep.2022.115164_bib26","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1016\/j.bmcl.2018.04.002","article-title":"Structure-activity relationship study of a series of caspase inhibitors containing gamma-amino acid moiety for treatment of cholestatic liver disease","volume":"28","author":"Mou","year":"2018","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.jep.2022.115164_bib27","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.cbpa.2013.07.015","article-title":"Postprandial response and tissue distribution of the bile acid synthesis-related genes, cyp7a1, cyp8b1 and shp, in rainbow trout Oncorhynchus mykiss","volume":"166","author":"Murashita","year":"2013","journal-title":"Comp. Biochem. Physiol. Mol. Integr. Physiol."},{"issue":"7216","key":"10.1016\/j.jep.2022.115164_bib28","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1038\/4551054a","article-title":"Systems biology - metabonomics","volume":"455","author":"Nicholson","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.jep.2022.115164_bib29","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.tox.2007.11.021","article-title":"The current state of serum biomarkers of hepatotoxicity","volume":"245","author":"Ozer","year":"2008","journal-title":"Toxicology"},{"key":"10.1016\/j.jep.2022.115164_bib30","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nrm3314","article-title":"Innovation: metabolomics: the apogee of the omics trilogy","volume":"13","author":"Patti","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jep.2022.115164_bib31","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1053\/jhep.2002.36088","article-title":"Ursodeoxycholic acid in cholestatic liver disease: mechanisms of action and therapeutic use revisited","volume":"36","author":"Paumgartner","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.jep.2022.115164_bib32","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1111\/jgh.13738","article-title":"Diagnostic considerations for cholestatic liver disease","volume":"32","author":"Pollock","year":"2017","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jep.2022.115164_bib33","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1002\/hep.510290603","article-title":"Ten-year survival in ursodeoxycholic acid-treated patients with primary biliary cirrhosis","volume":"29","author":"Poupon","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.jep.2022.115164_bib34","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s00011-014-0717-5","article-title":"Swertiamarin ameliorates inflammation and osteoclastogenesis intermediates in IL-1\u03b2 induced rat fibroblast-like synoviocytes","volume":"63","author":"Saravanan","year":"2014","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.jep.2022.115164_bib35","first-page":"71","article-title":"Hepatoprotective and cholagogic effects and mechanisms of Hugan Tablet on ANIT-induced cholestasis in rats","volume":"34","author":"Shi","year":"2020","journal-title":"Acad. J. Shanghai Univ. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2022.115164_bib36","doi-asserted-by":"crossref","first-page":"S237","DOI":"10.2337\/dc09-S355","article-title":"Bile acids and metabolic regulation: mechanisms and clinical responses to bile acid sequestration","volume":"32","author":"Staels","year":"2009","journal-title":"Diabetes Care"},{"issue":"7","key":"10.1016\/j.jep.2022.115164_bib37","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1002\/ptr.2738","article-title":"Assessment of systemic interaction between swertia chirata extract and its bioactive constituents in rabbits","volume":"23","author":"Suryawanshi","year":"2009","journal-title":"Phytother Res."},{"issue":"7","key":"10.1016\/j.jep.2022.115164_bib38","doi-asserted-by":"crossref","first-page":"885","DOI":"10.2116\/analsci.17.885","article-title":"Analysis of swertiamarin in Swertia herb and preparations containing this crude drug by capillary electrophoresis","volume":"17","author":"Takei","year":"2001","journal-title":"Anal. Sci."},{"key":"10.1016\/j.jep.2022.115164_bib39","doi-asserted-by":"crossref","first-page":"470","DOI":"10.3762\/bjoc.14.33","article-title":"Latest development in the synthesis of ursodeoxycholic acid (UDCA): a critical review","volume":"14","author":"Tonin","year":"2018","journal-title":"Beilstein J. Org. Chem."},{"key":"10.1016\/j.jep.2022.115164_bib40","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1152\/physrev.00027.2002","article-title":"Bile salt transporters: molecular characterization, function, and regulation","volume":"83","author":"Trauner","year":"2003","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jep.2022.115164_bib41","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s11418-009-0350-8","article-title":"Antihyperlipidaemic activity of swertiamarin, a secoiridoid glycoside in poloxamer-407-induced hyperlipidaemic rats","volume":"63","author":"Vaidya","year":"2009","journal-title":"J. Nat. Med."},{"key":"10.1016\/j.jep.2022.115164_bib42","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1002\/ptr.3708","article-title":"Beneficial effects of swertiamarin on dyslipidaemia in streptozotocin-induced type 2 diabetic rats","volume":"26","author":"Vaidya","year":"2012","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2022.115164_bib43","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.jhep.2009.05.012","article-title":"New molecular insights into the mechanisms of cholestasis","volume":"51","author":"Wagner","year":"2009","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jep.2022.115164_bib45","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1038\/aps.2014.119","article-title":"Resveratrol effectively attenuates alpha-naphthyl-isothiocyanate-induced acute cholestasis and liver injury through choleretic and anti-inflammatory mechanisms","volume":"35","author":"Wang","year":"2014","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jep.2022.115164_bib46","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jep.2016.12.022","article-title":"Geniposide attenuates ANIT-induced cholestasis through regulation of transporters and enzymes involved in bile acids homeostasis in rats","volume":"196","author":"Wang","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.115164_bib47","doi-asserted-by":"crossref","first-page":"113816","DOI":"10.1016\/j.jep.2021.113816","article-title":"Network pharmacology-based mechanism prediction and pharmacological validation of Xiaoyan Lidan formula on attenuating alpha-naphthylisothiocyanate induced cholestatic hepatic injury in rats","volume":"24","author":"Wang","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.115164_bib48","doi-asserted-by":"crossref","first-page":"458","DOI":"10.3389\/fphar.2018.00458","article-title":"Metabolomic assessment of acute cholestatic injuries induced by thioacetamide and by bile duct ligation, and the protective effects of huang-lian-jie-du-decoction","volume":"9","author":"Wei","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2022.115164_bib49","doi-asserted-by":"crossref","first-page":"153257","DOI":"10.1016\/j.phymed.2020.153257","article-title":"Ethyl acetate extract of herpetospermum pedunculosum alleviates alpha-naphthylisothiocyanate-induced cholestasis by activating the farnesoid x receptor and suppressing oxidative stress and inflammation in rats","volume":"76","author":"Wei","year":"2020","journal-title":"Phytomedicine"},{"issue":"5","key":"10.1016\/j.jep.2022.115164_bib50","first-page":"876","article-title":"Content determination of swertiamarin and gentiopicroside in Swertia mileensis T. N. Ho et W. L. Shih and its cut crude drug","volume":"29","author":"Xiao","year":"2009","journal-title":"Chin. J. Pharm. Anal."},{"key":"10.1016\/j.jep.2022.115164_bib51","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jep.2017.07.031","article-title":"Analyzing the hepatoprotective effect of the Swertia cincta Burkill extract against ANIT-induced cholestasis in rats by modulating the expression of transporters and metabolic enzymes","volume":"209","author":"Xu","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.115164_bib52","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.mam.2008.08.003","article-title":"Glutathione in liver diseases and hepatotoxicity","volume":"30","author":"Yuan","year":"2009","journal-title":"Mol. Aspect. Med."},{"issue":"1","key":"10.1016\/j.jep.2022.115164_bib53","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s11418-005-0014-2","article-title":"Gastroprotective effects of bitter principles isolated from gentian root and swertia herb on experimentally-induced gastric lesions in rats","volume":"60","author":"Yujiro","year":"2006","journal-title":"J. Nat. Med."},{"key":"10.1016\/j.jep.2022.115164_bib54","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.bbadis.2010.10.006","article-title":"Role of nuclear receptor SHP in metabolism and cancer","volume":"1812","author":"Zhang","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jep.2022.115164_bib55","doi-asserted-by":"crossref","first-page":"8143","DOI":"10.1007\/s00216-013-7061-4","article-title":"Recent advances in metabolomics in neurological disease, and future perspectives","volume":"405","author":"Zhang","year":"2013","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jep.2022.115164_bib56","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.taap.2016.06.019","article-title":"Dioscin protects against ANIT-induced cholestasis via regulating Oatps, Mrp2 and Bsep expression in rats","volume":"305","author":"Zhang","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jep.2022.115164_bib57","doi-asserted-by":"crossref","first-page":"112966","DOI":"10.1016\/j.jpba.2019.112966","article-title":"Xiaoyan lidan formula ameliorates alpha-naphthylisothiocyanate-induced intrahepatic cholestatic liver injury in rats as revealed by non-targeted and targeted metabolomics","volume":"179","author":"Zhang","year":"2020","journal-title":"J. Pharm. Biomed. Anal."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122002021?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122002021?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:25:16Z","timestamp":1759944316000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874122002021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":56,"alternative-id":["S0378874122002021"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2022.115164","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Swertiamarin, an active iridoid glycoside from Swertia pseudochinensis H. Hara, protects against alpha-naphthylisothiocyanate-induced cholestasis by activating the farnesoid X receptor and bile acid excretion pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2022.115164","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115164"}}