{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T03:24:24Z","timestamp":1790306664287,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573720"],"award-info":[{"award-number":["81573720"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974536"],"award-info":[{"award-number":["81974536"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.jep.2022.115171","type":"journal-article","created":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T11:09:12Z","timestamp":1646478552000},"page":"115171","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Screening bioactive compounds from Danggui-shaoyao-san for treating sodium retention in nephrotic syndrome using bio-affinity ultrafiltration"],"prefix":"10.1016","volume":"292","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7231-8953","authenticated-orcid":false,"given":"Mo","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianghou","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihua","family":"Xuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2752-8035","authenticated-orcid":false,"given":"Huan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2022.115171_bib1","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.016387","article-title":"Plasminogen deficiency and amiloride mitigate angiotensin II-Induced hypertension in type 1 diabetic mice suggesting effects through the epithelial sodium channel","author":"Andersen","year":"2020","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.jep.2022.115171_bib2","article-title":"Induction of nephrotic syndrome in mice by retrobulbar injection of doxorubicin and prevention of volume retention by sustained release aprotinin","volume":"135","author":"Bohnert","year":"2018","journal-title":"JoVE"},{"issue":"1","key":"10.1016\/j.jep.2022.115171_bib3","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.kint.2017.07.023","article-title":"Aprotinin prevents proteolytic epithelial sodium channel (ENaC) activation and volume retention in nephrotic syndrome","volume":"93","author":"Bohnert","year":"2018","journal-title":"Kidney Int."},{"issue":"4","key":"10.1016\/j.jep.2022.115171_bib4","doi-asserted-by":"crossref","first-page":"F480","DOI":"10.1152\/ajprenal.00199.2021","article-title":"Experimental nephrotic syndrome leads to proteolytic activation of the epithelial Na(+) channel in the mouse kidney","volume":"321","author":"Bohnert","year":"2021","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"5","key":"10.1016\/j.jep.2022.115171_bib5","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.kint.2018.12.018","article-title":"Health-related quality of life in glomerular disease","volume":"95","author":"Canetta","year":"2019","journal-title":"Kidney Int."},{"issue":"2","key":"10.1016\/j.jep.2022.115171_bib6","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1159\/000501059","article-title":"Association of urinary plasminogen-plasmin with edema and epithelial sodium channel activation in patients with nephrotic syndrome","volume":"50","author":"Chen","year":"2019","journal-title":"Am. J. Nephrol."},{"issue":"8","key":"10.1016\/j.jep.2022.115171_bib7","first-page":"17","article-title":"Dangguishaoyaosan spleen deficiency treatment of primary nephrotic syndrome of 68 cases","volume":"29","author":"Deng","year":"2015","journal-title":"J. Practical TradL. Chin. Int. Med."},{"issue":"12","key":"10.1016\/j.jep.2022.115171_bib8","doi-asserted-by":"crossref","first-page":"16191","DOI":"10.1096\/fj.202000413R","article-title":"Plasminogenuria is associated with podocyte injury, edema, and kidney dysfunction in incident glomerular disease","volume":"34","author":"Egerman","year":"2020","journal-title":"Faseb. J."},{"issue":"2","key":"10.1016\/j.jep.2022.115171_bib9","first-page":"386","article-title":"The application of Zhang Zhongjing\u2019s theory that \u201cstagnation of blood causes stagnation of body fluid\u201din nephrotic syndrome","volume":"16","author":"Fan","year":"2021","journal-title":"World J. Integrated Tradl. Western Med."},{"key":"10.1016\/j.jep.2022.115171_bib10","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jpba.2019.02.027","article-title":"Screening techniques for the identification of bioactive compounds in natural products","volume":"168","author":"Fu","year":"2019","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jep.2022.115171_bib11","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.chroma.2019.01.029","article-title":"Comprehensive screening and identification of natural inducible nitric oxide synthase inhibitors from Radix Ophiopogonis by off-line multi-hyphenated analyses","volume":"1592","author":"Guo","year":"2019","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jep.2022.115171_bib12","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.3389\/fphys.2018.01868","article-title":"Nephrotic syndrome: oedema formation and its treatment with diuretics","volume":"9","author":"Gupta","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.jep.2022.115171_bib13","first-page":"488","article-title":"Primary nephritic syndrome patients treated with combination of zhenwu decoction and danggui shaoyao decoction","volume":"35","author":"Huang","year":"2017","journal-title":"Chin. Arch. Tradit. Chin. Med."},{"issue":"12","key":"10.1016\/j.jep.2022.115171_bib14","doi-asserted-by":"crossref","first-page":"21254","DOI":"10.3390\/molecules201219759","article-title":"Factors influencing oral bioavailability of Thai Mango seed kernel extract and its key phenolic principles","volume":"20","author":"Jiamboonsri","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2022.115171_bib15","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jpba.2018.10.036","article-title":"Rapid identification of urokinase plasminogen activator inhibitors from Traditional Chinese Medicines based on ultrafiltration, LC-MS and in silico docking","volume":"164","author":"Li","year":"2019","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"3","key":"10.1016\/j.jep.2022.115171_bib16","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.jpba.2010.09.028","article-title":"Preparation of penta-O-galloyl-beta-D-glucose from tannic acid and plasma pharmacokinetic analyses by liquid-liquid extraction and reverse-phase HPLC","volume":"54","author":"Li","year":"2011","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"19","key":"10.1016\/j.jep.2022.115171_bib17","first-page":"9","article-title":"Protective mechanism of Danggui Shaoyaosan on podocytes of nephrotic syndrome rats based on AngII-TRPC6 pathway","volume":"27","author":"Li","year":"2021","journal-title":"Chin. J. Exp. Tradl. Med. Formulae"},{"issue":"9","key":"10.1016\/j.jep.2022.115171_bib18","doi-asserted-by":"crossref","first-page":"765","DOI":"10.2174\/138920021609151201114223","article-title":"Challenges and solutions of pharmacokinetics for efficacy and safety of traditional Chinese medicine","volume":"16","author":"Li","year":"2015","journal-title":"Curr. Drug Metabol."},{"issue":"17","key":"10.1016\/j.jep.2022.115171_bib19","first-page":"104","article-title":"Clinical analysis on Zhenwu decoction combined with Danggui Shaoyao powder in the treatment of primary nephrotic syndrome","volume":"16","author":"Liu","year":"2018","journal-title":"Chin. Med. Modern Dist. Educ. Ch."},{"issue":"10","key":"10.1016\/j.jep.2022.115171_bib20","first-page":"58","article-title":"Clinical observation on treatment of primary nephrotic syndrome with danggui Shaoyao powder and Zhuling Tang","volume":"16","author":"Liu","year":"2016","journal-title":"Practical Clin. J. Integrated Tradit. Chin. West. Med."},{"key":"10.1016\/j.jep.2022.115171_bib21","doi-asserted-by":"crossref","first-page":"112687","DOI":"10.1016\/j.jep.2020.112687","article-title":"Compound-based Chinese medicine formula: from discovery to compatibility mechanism","volume":"254","author":"Luan","year":"2020","journal-title":"J. Ethnopharmacol."},{"issue":"16","key":"10.1016\/j.jep.2022.115171_bib22","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"issue":"2","key":"10.1016\/j.jep.2022.115171_bib38","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jpba.2011.01.033","article-title":"Screening of natural compounds for ligands to PfTrxR by ultrafiltration and LC-MS based binding assay","volume":"55","author":"Munigunti","year":"2011","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jep.2022.115171_bib23","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S0254-6272(08)60013-8","article-title":"Clincal experience in TCM treatment of refractory nephrotic syndrome","volume":"28","author":"Nie","year":"2008","journal-title":"J. Tradit. Chin. Med."},{"issue":"1","key":"10.1016\/j.jep.2022.115171_bib24","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s10439-018-02145-5","article-title":"Pentagalloyl glucose and its functional role in Vascular health: biomechanics and drug-delivery characteristics","volume":"47","author":"Patnaik","year":"2019","journal-title":"Ann. Biomed. Eng."},{"issue":"4","key":"10.1016\/j.jep.2022.115171_bib25","first-page":"137","article-title":"Clinical study of modified Danggui Shaoyao San in the treatment of primary nephrotic syndrome","volume":"12","author":"Shen","year":"2014","journal-title":"Chin. Foreign Med. Res."},{"key":"10.1016\/j.jep.2022.115171_bib26","doi-asserted-by":"crossref","first-page":"114562","DOI":"10.1016\/j.jep.2021.114562","article-title":"Danggui-Shaoyao-San improves cognitive impairment through inhibiting O-GlcNAc-modification of estrogen alpha receptor in female db\/db mice","volume":"281","author":"Shi","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"14","key":"10.1016\/j.jep.2022.115171_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24142671","article-title":"Screening and evaluation of xanthine oxidase inhibitors from gnetum parvifolium in China","volume":"24","author":"Tang","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2022.115171_bib28","doi-asserted-by":"crossref","first-page":"113020","DOI":"10.1016\/j.jep.2020.113020","article-title":"Evaluation of the mechanism of Danggui-Shaoyao-San in regulating the metabolome of nephrotic syndrome based on urinary metabonomics and bioinformatics approaches","volume":"261","author":"Wang","year":"2020","journal-title":"J. Ethnopharmacol."},{"issue":"4","key":"10.1016\/j.jep.2022.115171_bib29","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/bmc.3586","article-title":"The difference between blood-associated and water-associated herbs of Danggui-Shaoyao San in theory of TCM, based on serum pharmacochemistry","volume":"30","author":"Wang","year":"2016","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.jep.2022.115171_bib30","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.jpba.2016.09.021","article-title":"Pharmaceutical applications of affinity-ultrafiltration mass spectrometry: recent advances and future prospects","volume":"131","author":"Wei","year":"2016","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jep.2022.115171_bib31","doi-asserted-by":"crossref","first-page":"103981","DOI":"10.1016\/j.jprot.2020.103981","article-title":"Proteasuria in nephrotic syndrome-quantification and proteomic profiling","volume":"230","author":"Worn","year":"2021","journal-title":"J. Proteonomics"},{"key":"10.1016\/j.jep.2022.115171_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153284","article-title":"Characterization of spirostanol glycosides and furostanol glycosides from anemarrhenae rhizoma as dual targeted inhibitors of 5-lipoxygenase and Cyclooxygenase-2 by employing a combination of affinity ultrafiltration and HPLC\/MS","volume":"77","author":"Xie","year":"2020","journal-title":"Phytomedicine"},{"issue":"13","key":"10.1016\/j.jep.2022.115171_bib33","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.phymed.2011.05.002","article-title":"Anti-depression effects of Danggui-Shaoyao-San, a fixed combination of Traditional Chinese Medicine, on depression model in mice and rats","volume":"18","author":"Xu","year":"2011","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2022.115171_bib34","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s13020-020-00376-0","article-title":"Characterization of thrombin\/factor Xa inhibitors in Rhizoma Chuanxiong through UPLC-MS-based multivariate statistical analysis","volume":"15","author":"Yang","year":"2020","journal-title":"Chin. Med."},{"key":"10.1016\/j.jep.2022.115171_bib35","first-page":"2985270","article-title":"Danggui Shaoyao San ameliorates renal fibrosis via regulation of hypoxia and autophagy","author":"Zhang","year":"2019","journal-title":"Evid. Based Compl. Alternat. Med."},{"key":"10.1016\/j.jep.2022.115171_bib36","first-page":"1","article-title":"Professor shi Zhensheng's experience in treating nephropathy with Danggui Shaoyao San","volume":"9","author":"Zhao","year":"1995","journal-title":"J. New Chin. Med."},{"issue":"13","key":"10.1016\/j.jep.2022.115171_bib37","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.1111\/bph.15038","article-title":"Plasmin improves blood-gas barrier function in oedematous lungs by cleaving epithelial sodium channels","volume":"177","author":"Zhao","year":"2020","journal-title":"Br. J. Pharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122002094?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122002094?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:23:51Z","timestamp":1759944231000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874122002094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":38,"alternative-id":["S0378874122002094"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2022.115171","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Screening bioactive compounds from Danggui-shaoyao-san for treating sodium retention in nephrotic syndrome using bio-affinity ultrafiltration","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2022.115171","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115171"}}