{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:52:01Z","timestamp":1789570321237,"version":"build-2803163510"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81774023"],"award-info":[{"award-number":["81774023"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.jep.2022.115195","type":"journal-article","created":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T12:32:53Z","timestamp":1647433973000},"page":"115195","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Total flavonoids of sea buckthorn (Hippophae rhamnoides L.) improve MC903-induced atopic dermatitis-like lesions"],"prefix":"10.1016","volume":"292","author":[{"given":"Yajing","family":"Gu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiufang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Decheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongquan","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2260-8506","authenticated-orcid":false,"given":"Diandong","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jep.2022.115195_bib1","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/j.1365-2222.2012.03956.x","article-title":"Induction of GITRL expression in human keratinocytes by Th2 cytokines and TNF-\u03b1: implications for atopic dermatitis","volume":"42","author":"Byrne","year":"2012","journal-title":"Clin. Exp. Allergy : J. British Soc. Aller. Clinic. Immunol."},{"key":"10.1016\/j.jep.2022.115195_bib2","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.1889","article-title":"Resveratrol ameliorates 2,4-dinitrofluorobenzene-induced atopic dermatitis-like lesions through effects on the epithelium","volume":"4","author":"Caglayan Sozmen","year":"2016","journal-title":"PeerJ"},{"key":"10.1016\/j.jep.2022.115195_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.pupt.2021.102000","article-title":"Myricetin inhibits TNF-\u03b1-induced inflammation in A549 cells via the SIRT1\/NF-\u03baB pathway","volume":"65","author":"Chen","year":"2020","journal-title":"Pulm. Pharmacol. Therapeut."},{"issue":"2","key":"10.1016\/j.jep.2022.115195_bib4","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1093\/toxsci\/kft215","article-title":"The atopic dermatitis-like symptoms induced by MC903 were alleviated in JNK1 knockout mice","volume":"136","author":"Choi","year":"2013","journal-title":"Toxicol. Sci. : Off. J. Soc. Toxicol."},{"key":"10.1016\/j.jep.2022.115195_bib5","doi-asserted-by":"crossref","first-page":"130921","DOI":"10.1016\/j.foodchem.2021.130921","article-title":"Composition of flesh lipids and oleosome yield optimization of selected sea buckthorn (Hippophae rhamnoides L.) cultivars grown in Poland","volume":"369","author":"D\u0105browski","year":"2022","journal-title":"Food Chem."},{"issue":"1","key":"10.1016\/j.jep.2022.115195_bib6","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jid.2021.05.033","article-title":"Nuclear IL-33 plays an important role in IL-31\u2012mediated downregulation of FLG, keratin 1, and keratin 10 by regulating signal transducer and activator of transcription 3 activation in human keratinocytes","volume":"142","author":"Dai","year":"2022","journal-title":"J. Invest. Dermatol."},{"issue":"17","key":"10.1016\/j.jep.2022.115195_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26175377","article-title":"Plant flavonoids: chemical characteristics and biological activity","volume":"26","author":"Dias","year":"2021","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.jep.2022.115195_bib8","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s40659-020-00316-0","article-title":"Daphnetin inhibits proliferation and inflammatory response in human HaCaT keratinocytes and ameliorates imiquimod-induced psoriasis-like skin lesion in mice","volume":"53","author":"Gao","year":"2020","journal-title":"Biol. Res."},{"issue":"5","key":"10.1016\/j.jep.2022.115195_bib9","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1159\/000489449","article-title":"The favored mechanism for coping with acute cold stress: upregulation of miR-210 in rats","volume":"46","author":"Guo","year":"2018","journal-title":"Cell. Physiol. Biochem. : Int. J. Exper. Cell. Physiol. Biochem. Pharmacol."},{"issue":"9","key":"10.1016\/j.jep.2022.115195_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18091948","article-title":"Antioxidant artemisia princeps extract enhances the expression of filaggrin and loricrin via the AHR\/OVOL1 pathway","volume":"18","author":"Hirano","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.jep.2022.115195_bib11","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1186\/s13075-021-02597-6","article-title":"Pathogenic roles and therapeutic potential of the CCL8-CCR8 axis in a murine model of IgG4-related sialadenitis","volume":"23","author":"Honda","year":"2021","journal-title":"Arthritis Res. Ther."},{"issue":"4","key":"10.1016\/j.jep.2022.115195_bib12","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1177\/0394632017736673","article-title":"Effects of total flavonoids of sea buckthorn (Hippophae rhamnoides L.) on cytotoxicity of NK92-MI cells","volume":"30","author":"Hou","year":"2017","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"10.1016\/j.jep.2022.115195_bib13","doi-asserted-by":"crossref","first-page":"105676","DOI":"10.1016\/j.intimp.2019.105676","article-title":"Anti-inflammatory effects of quercetin in a mouse model of MC903-induced atopic dermatitis","volume":"74","author":"Hou","year":"2019","journal-title":"Int. Immunopharm."},{"issue":"2","key":"10.1016\/j.jep.2022.115195_bib14","first-page":"195","article-title":"Biological properties of sea buckthorn (Hippophae rhamnoides L.) derived products","volume":"19","author":"Ivani\u0161ov\u00e1","year":"2020","journal-title":"Acta scientiarum polonorum. Technologia alimentaria"},{"issue":"14","key":"10.1016\/j.jep.2022.115195_bib15","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.7150\/ijms.45765","article-title":"Rapamycin blocks the IL-13-induced deficiency of epidermal barrier related proteins via upregulation of miR-143 in HaCaT keratinocytes","volume":"17","author":"Jia","year":"2020","journal-title":"Int. J. Med. Sci."},{"issue":"3","key":"10.1016\/j.jep.2022.115195_bib16","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1039\/C6FO01873D","article-title":"Flavonoids from sea buckthorn inhibit the lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages through the MAPK and NF-\u03baB pathways","volume":"8","author":"Jiang","year":"2017","journal-title":"Food Funct"},{"issue":"1","key":"10.1016\/j.jep.2022.115195_bib17","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/all.14451","article-title":"Inhibition of mite-induced dermatitis, pruritus, and nerve sprouting in mice by the endothelin receptor antagonist bosentan","volume":"76","author":"Kido-Nakahara","year":"2021","journal-title":"Allergy"},{"issue":"9","key":"10.1016\/j.jep.2022.115195_bib18","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1002\/ptr.5138","article-title":"Eruca sativa and its flavonoid components, quercetin and isorhamnetin, improve skin barrier function by activation of peroxisome proliferator-activated receptor (PPAR)-\u03b1 and suppression of inflammatory cytokines","volume":"28","author":"Kim","year":"2014","journal-title":"Phytother Res. : PT"},{"issue":"1","key":"10.1016\/j.jep.2022.115195_bib19","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s13555-020-00469-6","article-title":"Real-world experience and laboratory monitoring of dupilumab in patients with moderate to severe atopic dermatitis in a tertiary centre","volume":"11","author":"Kreeshan","year":"2021","journal-title":"Dermatol. and Ther."},{"issue":"5","key":"10.1016\/j.jep.2022.115195_bib20","doi-asserted-by":"crossref","first-page":"481","DOI":"10.4062\/biomolther.2017.130","article-title":"Phloxine O, a cosmetic colorant, suppresses the expression of thymic stromal lymphopoietin and acute dermatitis symptoms in mice","volume":"26","author":"Lee","year":"2018","journal-title":"Biomol. & Therapeut."},{"issue":"8","key":"10.1016\/j.jep.2022.115195_bib21","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1111\/bph.15396","article-title":"Therapeutic effect of kaempferol on atopic dermatitis by attenuation of T cell activity via interaction with multidrug resistance-associated protein 1","volume":"178","author":"Lee","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jep.2022.115195_bib22","doi-asserted-by":"crossref","first-page":"153407","DOI":"10.1016\/j.phymed.2020.153407","article-title":"A combination of Olea europaea leaf extract and Spirodela polyrhiza extract alleviates atopic dermatitis by modulating immune balance and skin barrier function in a 1-chloro-2,4-dinitrobenzene-induced murine model","volume":"82","author":"Lee","year":"2021","journal-title":"Phytomedicine"},{"issue":"33","key":"10.1016\/j.jep.2022.115195_bib23","doi-asserted-by":"crossref","first-page":"21579","DOI":"10.1021\/acsomega.1c02593","article-title":"Molecular simulation study on the interaction between tyrosinase and flavonoids from sea buckthorn","volume":"6","author":"Li","year":"2021","journal-title":"ACS Omega"},{"key":"10.1016\/j.jep.2022.115195_bib24","doi-asserted-by":"crossref","first-page":"40040","DOI":"10.1038\/srep40040","article-title":"Weissella cibaria WIKIM28 ameliorates atopic dermatitis-like skin lesions by inducing tolerogenic dendritic cells and regulatory T cells in BALB\/c mice","volume":"7","author":"Lim","year":"2017","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.jep.2022.115195_bib25","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/bjd.19703","article-title":"Topical corticosteroids normalize both skin and systemic inflammatory markers in infant atopic dermatitis","volume":"185","author":"McAleer","year":"2021","journal-title":"Br. J. Dermatol."},{"issue":"3","key":"10.1016\/j.jep.2022.115195_bib26","doi-asserted-by":"crossref","first-page":"443","DOI":"10.2332\/allergolint.13-OA-0672","article-title":"IL-33 promotes the induction and maintenance of Th2 immune responses by enhancing the function of OX40 ligand","volume":"63","author":"Murakami-Satsutani","year":"2014","journal-title":"Allergol. Int. : Off. J. Japn. Soc. Allergol."},{"key":"10.1016\/j.jep.2022.115195_bib27","article-title":"Gardenia jasminoides extract ameliorates DfE-induced atopic dermatitis in mice through restoration of barrier function and T-helper 2-mediated immune response","volume":"145","author":"Park","year":"2022","journal-title":"Biomed. & Pharmacother. = Biomedecine & pharmacotherapie"},{"key":"10.1016\/j.jep.2022.115195_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113486","article-title":"Oleic acid exhibits an expressive anti-inflammatory effect in croton oil-induced irritant contact dermatitis without the occurrence of toxicological effects in mice","volume":"267","author":"Pegoraro","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.115195_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113434","article-title":"Ethnomedicinal uses, phytochemistry and dermatological effects of Hippophae rhamnoides L.: a review","volume":"266","author":"Pundir","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.115195_bib30","doi-asserted-by":"crossref","first-page":"354250","DOI":"10.1155\/2014\/354250","article-title":"Atopic dermatitis: natural history, diagnosis, and treatment","volume":"2014","author":"Thomsen","year":"2014","journal-title":"ISRN Allergy"},{"issue":"1","key":"10.1016\/j.jep.2022.115195_bib31","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1172\/JCI9199","article-title":"T cell-mediated Fas-induced keratinocyte apoptosis plays a key pathogenetic role in eczematous dermatitis","volume":"106","author":"Trautmann","year":"2000","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.jep.2022.115195_bib32","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/bjd.16934","article-title":"Atopic dermatitis: the skin barrier and beyond","volume":"180","author":"Tsakok","year":"2019","journal-title":"Br. J. Dermatol."},{"issue":"3","key":"10.1016\/j.jep.2022.115195_bib33","doi-asserted-by":"crossref","first-page":"e13143","DOI":"10.1111\/jfbc.13143","article-title":"The role of myricetin from Rhodomyrtus tomentosa (Aiton) Hassk fruits on downregulation of Fc\u03f5RI-mediated mast cell activation","volume":"44","author":"Vo","year":"2020","journal-title":"J. Food Biochem."},{"key":"10.1016\/j.jep.2022.115195_bib34","doi-asserted-by":"crossref","first-page":"113380","DOI":"10.1016\/j.jep.2020.113380","article-title":"Network pharmacology analysis and experimental validation to explore the mechanism of sea buckthorn flavonoids on hyperlipidemia","volume":"264","author":"Xiao","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"10","key":"10.1016\/j.jep.2022.115195_bib35","doi-asserted-by":"crossref","first-page":"4556","DOI":"10.1039\/D0FO03238G","article-title":"Genistein suppresses allergic contact dermatitis through regulating the MAP2K2\/ERK pathway","volume":"12","author":"Xu","year":"2021","journal-title":"Food Funct"},{"issue":"10","key":"10.1016\/j.jep.2022.115195_bib36","doi-asserted-by":"crossref","DOI":"10.3390\/md17100586","article-title":"Anti-inflammatory and anti-aging evaluation of pigment-protein complex extracted from chlorella pyrenoidosa","volume":"17","author":"Zhang","year":"2019","journal-title":"Mar. Drugs"},{"issue":"4","key":"10.1016\/j.jep.2022.115195_bib37","doi-asserted-by":"crossref","DOI":"10.1111\/jfbc.13620","article-title":"Effect of lemon seed flavonoids on the anti-fatigue and antioxidant effects of exhausted running exercise mice","volume":"45","author":"Zhang","year":"2021","journal-title":"J. Food Biochem."},{"issue":"7","key":"10.1016\/j.jep.2022.115195_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26071946","article-title":"Protective effect of two alkaloids from Hippophae rhamnoides linn. Against doxorubicin-induced toxicity in H9c2 cardiomyoblasts","volume":"26","author":"Zhou","year":"2021","journal-title":"Molecules"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122002343?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122002343?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:23:06Z","timestamp":1759944186000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874122002343"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":38,"alternative-id":["S0378874122002343"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2022.115195","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Total flavonoids of sea buckthorn (Hippophae rhamnoides L.) improve MC903-induced atopic dermatitis-like lesions","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2022.115195","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115195"}}