{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T21:26:29Z","timestamp":1788989189169,"version":"build-2803163510"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012175","name":"Zhejiang Administration Bureau of Traditional Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012175","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004863","name":"Zhejiang Chinese Medical University","doi-asserted-by":"publisher","award":["2018ZG35"],"award-info":[{"award-number":["2018ZG35"]}],"id":[{"id":"10.13039\/501100004863","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.jep.2022.115213","type":"journal-article","created":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T03:11:28Z","timestamp":1647832288000},"page":"115213","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Smilax glabra Roxb. flavonoids protect against pathological cardiac hypertrophy by inhibiting the Raf\/MEK\/ERK pathway: In vivo and in vitro studies"],"prefix":"10.1016","volume":"292","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6602-4820","authenticated-orcid":false,"given":"Danting","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangfeng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanchun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jue","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueqin","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaowei","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dejun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2022.115213_bib1","author":"Bernardo"},{"key":"10.1016\/j.jep.2022.115213_bib2","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jep.2015.04.026","article-title":"Medicinal effect and its JP2\/RyR2-based mechanism of Smilax glabra flavonoids on angiotensin II-induced hypertrophy model of cardiomyocytes","volume":"169","author":"Cai","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.115213_bib3","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1080\/13880209.2020.1723648","article-title":"Aqueous extract attenuates isoproterenol-induced cardiac hypertrophy through the ERK signalling pathway","volume":"58","author":"Cao","year":"2020","journal-title":"Pharmaceut. Biol."},{"key":"10.1016\/j.jep.2022.115213_bib4","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s11010-017-3020-2","article-title":"Sestrin 2 attenuates neonatal rat cardiomyocyte hypertrophy induced by phenylephrine via inhibiting ERK1\/2","volume":"433","author":"Dong","year":"2017","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.jep.2022.115213_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20092164","article-title":"ERK: a key player in the pathophysiology of cardiac hypertrophy","volume":"20","author":"Gallo","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2022.115213_bib6","doi-asserted-by":"crossref","first-page":"28092","DOI":"10.1074\/jbc.270.47.28092","article-title":"The mitogen-activated protein kinase kinase MEK1 stimulates a pattern of gene expression typical of the hypertrophic phenotype in rat ventricular cardiomyocytes","volume":"270","author":"Gillespie-Brown","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2022.115213_bib7","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3109\/1061186X.2015.1113540","article-title":"Smilax glabra Roxb targets Akt(p-Thr308) and inhibits Akt-mediated signaling pathways in SGC7901 cells","volume":"24","author":"Hao","year":"2016","journal-title":"J. Drug Target."},{"key":"10.1016\/j.jep.2022.115213_bib8","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1142\/S0192415X18500143","article-title":"Ethnomedicine, phytochemistry and pharmacology of Smilax glabra: an important traditional Chinese medicine","volume":"46","author":"Hua","year":"2018","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jep.2022.115213_bib9","doi-asserted-by":"crossref","first-page":"111777","DOI":"10.1016\/j.jep.2019.03.004","article-title":"The anti-hyperuricemic effect of four astilbin stereoisomers in Smilax glabra on hyperuricemic mice","volume":"238","author":"Huang","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.115213_bib10","doi-asserted-by":"crossref","DOI":"10.1111\/apha.13272","article-title":"Renal denervation attenuates pressure overload-induced cardiac remodelling in rats with biphasic regulation of autophagy","volume":"226","author":"Huo","year":"2019","journal-title":"Acta Physiol."},{"key":"10.1016\/j.jep.2022.115213_bib11","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1111\/jcmm.16182","article-title":"The protective effect of isosteviol sodium on cardiac function and myocardial remodelling in transverse aortic constriction rat","volume":"25","author":"Ke","year":"2021","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.jep.2022.115213_bib12","doi-asserted-by":"crossref","first-page":"H1635","DOI":"10.1152\/ajpheart.2000.279.4.H1635","article-title":"Significance of ERK cascade compared with JAK\/STAT and PI3-K pathway in gp130-mediated cardiac hypertrophy","volume":"279","author":"Kodama","year":"2000","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.jep.2022.115213_bib13","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1016\/j.biocel.2009.08.002","article-title":"Cardiac hypertrophy: targeting Raf\/MEK\/ERK1\/2-signaling","volume":"41","author":"Lorenz","year":"2009","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.jep.2022.115213_bib14","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00395-020-0779-1","article-title":"Triad3A attenuates pathological cardiac hypertrophy involving the augmentation of ubiquitination-mediated degradation of TLR4 and TLR9","volume":"115","author":"Lu","year":"2020","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.jep.2022.115213_bib15","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1002\/jcb.27668","article-title":"Total flavonoids from Smilax glabra Roxb blocks epithelial-mesenchymal transition and inhibits renal interstitial fibrosis by targeting miR-21\/PTEN signaling","volume":"120","author":"Luo","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.jep.2022.115213_bib16","doi-asserted-by":"crossref","first-page":"112660","DOI":"10.1016\/j.jep.2020.112660","article-title":"Songling Xuemaikang Capsule inhibits isoproterenol-induced cardiac hypertrophy via CaMKII\u03b4 and ERK1\/2 pathways","volume":"253","author":"Qi","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.115213_bib17","first-page":"516","article-title":"Smilax quality and its pharmacological research","volume":"29","author":"Sha","year":"2006","journal-title":"Zhong Yao Cai"},{"key":"10.1016\/j.jep.2022.115213_bib18","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.jep.2013.08.009","article-title":"Modulation effect of Smilax glabra flavonoids on ryanodine receptor mediated intracellular Ca2+ release in cardiomyoblast cells","volume":"150","author":"Shou","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.115213_bib19","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1007\/s00204-015-1477-x","article-title":"Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets","volume":"89","author":"Tham","year":"2015","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.jep.2022.115213_bib20","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1002\/ehf2.12555","article-title":"Highlights in heart failure","volume":"6","author":"Tomasoni","year":"2019","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.jep.2022.115213_bib21","doi-asserted-by":"crossref","first-page":"110438","DOI":"10.1016\/j.biopha.2020.110438","article-title":"\u03b2-adrenergic activation may promote myosin light chain kinase degradation through calpain in pressure overload-induced cardiac hypertrophy: \u03b2-adrenergic activation results in MLCK degradation","volume":"129","author":"Wang","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2022.115213_bib22","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13020-025-01295-8","article-title":"The effect and mechanism of Smilax on renal hypertensive rats","volume":"21","author":"Wang","year":"2011","journal-title":"Chin. J. Comp. Med."},{"key":"10.1016\/j.jep.2022.115213_bib23","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1080\/10641963.2020.1833022","article-title":"Renal sympathetic denervation attenuates left ventricle hypertrophy in spontaneously hypertensive rats by suppressing the Raf\/MEK\/ERK signaling pathway","volume":"43","author":"Xiao","year":"2021","journal-title":"Clin. Exp. Hypertens."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122002525?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122002525?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:43:34Z","timestamp":1777571014000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874122002525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":23,"alternative-id":["S0378874122002525"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2022.115213","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Smilax glabra Roxb. flavonoids protect against pathological cardiac hypertrophy by inhibiting the Raf\/MEK\/ERK pathway: In vivo and in vitro studies","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2022.115213","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115213"}}