{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:19:40Z","timestamp":1790864380077,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP 18K11117"],"award-info":[{"award-number":["JP 18K11117"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.jep.2022.115243","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T20:43:26Z","timestamp":1648500206000},"page":"115243","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Inhibition of influenza virus replication by Apiaceae plants, with special reference to Peucedanum japonicum (Sacna) constituents"],"prefix":"10.1016","volume":"292","author":[{"given":"Ryoko","family":"Kanazawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Morimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Horio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenobu","family":"Sumitani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9701-8431","authenticated-orcid":false,"given":"Yuji","family":"Isegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2022.115243_bib1","first-page":"343","article-title":"Pharmacological activities of khellactones, compounds isolated from Peucedanum japonicum THUNB. and Peucedanum praeruptorium DUNN. Methods Find","volume":"20","author":"Aida","year":"1998","journal-title":"Exp. Clin. Pharmacol."},{"key":"10.1016\/j.jep.2022.115243_bib2","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1126\/science.1187816","article-title":"Permissive secondary mutations enable the evolution of influenza oseltamivir resistance","volume":"328","author":"Bloom","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.jep.2022.115243_bib3","doi-asserted-by":"crossref","first-page":"7268","DOI":"10.1128\/JVI.07242-12","article-title":"Enhanced mammalian transmissibility of seasonal influenza A\/H1N1 viruses encoding an oseltamivir-resistant neuraminidase","volume":"86","author":"Bouvier","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.jep.2022.115243_bib4","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/0031-9422(95)00625-7","article-title":"Coumarins and antiplatelet aggregation constituents from Formosan Peucedanum japonicum","volume":"41","author":"Chen","year":"1996","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2022.115243_bib5","doi-asserted-by":"crossref","first-page":"4655","DOI":"10.1016\/j.bmcl.2016.08.056","article-title":"Anti-adipogenic and anti-diabetic effects of cis-3\u2032,4\u2032-diisovalerylkhellactone isolated from Peucedanum japonicum Thunb leaves in vitro","volume":"26","author":"Choi","year":"2016","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.jep.2022.115243_bib6","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jep.2017.09.006","article-title":"Peucedanum japonicum extract attenuates allergic airway inflammation by inhibiting TH2 cell activation and production of pro-inflammatory mediators","volume":"211","author":"Chun","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.115243_bib7","doi-asserted-by":"crossref","first-page":"754","DOI":"10.3390\/nu10060754","article-title":"Protective effects of Peucedanum japonicum extract against osteoarthritis in an animal model using a combined systems approach for compound-target prediction","volume":"10","author":"Chun","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.jep.2022.115243_bib8","doi-asserted-by":"crossref","first-page":"6668","DOI":"10.1021\/jm5007275","article-title":"Discovery of a novel, first-in-class, orally bioavailable azaindole inhibitor (VX-787) of influenza PB2","volume":"57","author":"Clark","year":"2014","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jep.2022.115243_bib9","doi-asserted-by":"crossref","first-page":"531","DOI":"10.3390\/antiox9060531","article-title":"Isosamidin from Peucedanum japonicum roots prevents methylglyoxal-induced glucotoxicity in human umbilical vein endothelial cells via suppression of ROS-mediated Bax\/Bcl-2","volume":"9","author":"Do","year":"2020","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.jep.2022.115243_bib10","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1128\/AAC.46.4.977-981.2002","article-title":"In vitro and in vivo activities of anti-influenza virus compound T-705. Antimicrob","volume":"46","author":"Furuta","year":"2002","journal-title":"Agents Chemother"},{"key":"10.1016\/j.jep.2022.115243_bib11","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1128\/AAC.49.3.981-986.2005","article-title":"Mechanism of action of T-705 against influenza virus","volume":"49","author":"Furuta","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jep.2022.115243_bib12","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/oxfordjournals.epirev.a036250","article-title":"Serious morbidity and mortality associated with influenza epidemics","volume":"4","author":"Glezen","year":"1982","journal-title":"Epidemiol. Rev."},{"key":"10.1016\/j.jep.2022.115243_bib13","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1056\/NEJM198912213212502","article-title":"Emergence and apparent transmission of rimantadine-resistant influenza A virus in families","volume":"321","author":"Hayden","year":"1989","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jep.2022.115243_bib14","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1056\/NEJM199709253371302","article-title":"Efficacy and safety of the neuraminidase inhibitor zanamivir in the treatment of influenza virus infections. GG167 Influenza Study Group","volume":"337","author":"Hayden","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jep.2022.115243_bib15","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1128\/AAC.35.9.1741","article-title":"Recovery of drug-resistant influenza A virus during therapeutic use of rimantadine","volume":"35","author":"Hayden","year":"1991","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jep.2022.115243_bib16","doi-asserted-by":"crossref","first-page":"21695","DOI":"10.1038\/s41598-020-78782-5","article-title":"Acetylcholinesterase and butyrylcholinesterase inhibitory activities of khellactone coumarin derivatives isolated from Peucedanum japonicum Thurnberg","volume":"10","author":"Heo","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2022.115243_bib17","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1021\/jf0349127","article-title":"Constituents of the leaves of Peucedanum japonicum Thunb. and their biological activity","volume":"52","author":"Hisamoto","year":"2004","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2022.115243_bib18","doi-asserted-by":"crossref","first-page":"5255","DOI":"10.1021\/jf0262458","article-title":"Antioxidant compounds from the leaves of Peucedanum japonicum Thunb","volume":"51","author":"Hisamoto","year":"2003","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2022.115243_bib19","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3164\/jcbn.19-70","article-title":"Induction of a 5-lipoxygenase product by daidzein is involved in the regulation of influenza virus replication","volume":"66","author":"Horio","year":"2020","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.jep.2022.115243_bib20","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4014\/jmb.2107.07001","article-title":"Effects of 3\u2032-isovaleryl-4\u2032-senecioylkhellactone from Peucedanum japonicum Thunberg on PMA-stimulated inflammatory response in A549 human lung epithelial cells","volume":"32","author":"Hwang","year":"2022","journal-title":"J. Microbiol. Biotechnol."},{"key":"10.1016\/j.jep.2022.115243_bib21","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/S0031-9422(06)80121-4","article-title":"Coumarin glycosides from Peucedanum japonicum","volume":"35","author":"Ikeshiro","year":"1994","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2022.115243_bib22","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.antiviral.2006.01.012","article-title":"Combination chemotherapy, a potential strategy for reducing the emergence of drug-resistant influenza A variants","volume":"70","author":"Ilyushina","year":"2006","journal-title":"Antivir. Res."},{"key":"10.1016\/j.jep.2022.115243_bib23","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1177\/135965350300800301","article-title":"Safety and efficacy of nebulized zanamivir in hospitalized patients with serious influenza","volume":"8","author":"Ison","year":"2003","journal-title":"Antivir. Ther."},{"key":"10.1016\/j.jep.2022.115243_bib24","doi-asserted-by":"crossref","first-page":"6816","DOI":"10.1016\/j.bmc.2009.08.036","article-title":"Neuraminidase inhibitory activities of flavonols isolated from Rhodiola rosea roots and their in vitro anti-influenza viral activities","volume":"17","author":"Jeong","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.jep.2022.115243_bib25","series-title":"Biocontrol Agents and Secondary Metabolites: Applications and Immunization for Plant Growth and Protection","author":"Jogaiah","year":"2021"},{"key":"10.1016\/j.jep.2022.115243_bib26","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1021\/np50088a002","article-title":"An antiplatelet aggregation principle and X-ray structural analysis of cis-khellactone diester from Peucedanum japonicum","volume":"55","author":"Jong","year":"1992","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2022.115243_bib27","doi-asserted-by":"crossref","first-page":"4360","DOI":"10.1021\/jf049613b","article-title":"Polyphenol screening of pomace from red and white grape varieties (Vitis vinifera L.) by HPLC-DAD-MS\/MS","volume":"52","author":"Kammerer","year":"2004","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2022.115243_bib28","doi-asserted-by":"crossref","first-page":"410","DOI":"10.3892\/etm.2017.4480","article-title":"Peucedanum japonicum Thunb. ethanol extract suppresses RANKL-mediated osteoclastogenesis","volume":"14","author":"Kim","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.jep.2022.115243_bib29","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.antiviral.2010.08.016","article-title":"Inhibition of influenza virus replication by plant-derived isoquercetin","volume":"88","author":"Kim","year":"2010","journal-title":"Antivir. Res."},{"key":"10.1016\/j.jep.2022.115243_bib30","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1073\/pnas.0909603107","article-title":"T-705 (favipiravir) activity against lethal H5N1 influenza A viruses","volume":"107","author":"Kiso","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jep.2022.115243_bib31","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.fitote.2015.03.012","article-title":"Coriander (Coriandrum sativum L.) and its bioactive constituents","volume":"103","author":"Laribi","year":"2015","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2022.115243_bib32","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1038\/4371108a","article-title":"Avian flu: isolation of drug-resistant H5N1 virus","volume":"437","author":"Le","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.jep.2022.115243_bib33","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1080\/07388551.2017.1312275","article-title":"Advances in the research of celery, an important Apiaceae vegetable crop","volume":"38","author":"Li","year":"2018","journal-title":"Crit. Rev. Biotechnol."},{"key":"10.1016\/j.jep.2022.115243_bib34","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.foodchem.2016.04.111","article-title":"Antibacterial and antifungal activities of thymol: A brief review of the literature","volume":"210","author":"Marchese","year":"2016","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2022.115243_bib35","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/fsn3.2023","article-title":"Juice of Citrullus lanatus var. citroides (wild watermelon) inhibits the entry and propagation of influenza viruses in vitro and in vivo","volume":"9","author":"Morimoto","year":"2021","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.jep.2022.115243_bib36","doi-asserted-by":"crossref","first-page":"880","DOI":"10.3390\/molecules26040880","article-title":"Influenza viruses: harnessing the crucial role of the M2 ion-channel and neuraminidase toward inhibitor design","volume":"26","author":"Mtambo","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2022.115243_bib37","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1007\/s11130-019-00773-3","article-title":"Anti-influenza virus activity of adlay tea components","volume":"74","author":"Nagai","year":"2019","journal-title":"Plant Foods Hum. Nutr."},{"key":"10.1016\/j.jep.2022.115243_bib38","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1002\/jsfa.8671","article-title":"Inhibition of influenza virus replication by adlay tea","volume":"98","author":"Nagai","year":"2018","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.jep.2022.115243_bib39","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1016\/S0140-6736(00)02288-1","article-title":"Efficacy and safety of oseltamivir in treatment of acute influenza: a randomised controlled trial. Neuraminidase Inhibitor Flu Treatment Investigator Group","volume":"355","author":"Nicholson","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2022.115243_bib40","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.nut.2014.01.015","article-title":"Pteryxin: a coumarin in Peucedanum japonicum Thunb leaves exerts antiobesity activity through modulation of adipogenic gene network","volume":"30","author":"Nugara","year":"2014","journal-title":"Nutrition"},{"key":"10.1016\/j.jep.2022.115243_bib41","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1080\/09168451.2017.1417023","article-title":"Isomerization of feruloylputrescine in orange juice by light exposure","volume":"82","author":"Ogi","year":"2018","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.jep.2022.115243_bib42","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1093\/oxfordjournals.aje.a114128","article-title":"Acute respiratory disease hospitalizations as a measure of impact of epidemic influenza","volume":"122","author":"Perrotta","year":"1985","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.jep.2022.115243_bib43","doi-asserted-by":"crossref","first-page":"5386","DOI":"10.1128\/JVI.00151-12","article-title":"Efficient transmission of pandemic H1N1 influenza viruses with high-level oseltamivir resistance","volume":"86","author":"Seibert","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.jep.2022.115243_bib44","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.antiviral.2005.06.010","article-title":"Antiviral effect of catechins in green tea on influenza virus","volume":"68","author":"Song","year":"2005","journal-title":"Antivir. Res."},{"key":"10.1016\/j.jep.2022.115243_bib45","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1248\/cpb.39.1415","article-title":"Pharmacological activities of the prenylcoumarins, developed from folk usage as a medicine of Peucedanum japonicum THUNB","volume":"39","author":"Takeuchi","year":"1991","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"key":"10.1016\/j.jep.2022.115243_bib46","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s12906-017-1675-6","article-title":"Characterization and mechanisms of anti-influenza virus metabolites isolated from the Vietnamese medicinal plant Polygonum chinense","volume":"17","author":"Tran","year":"2017","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.jep.2022.115243_bib47","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1001\/jama.283.8.1016","article-title":"Efficacy and safety of the oral neuraminidase inhibitor oseltamivir in treating acute influenza: a randomized controlled trial. US Oral neuraminidase Study Group","volume":"283","author":"Treanor","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.jep.2022.115243_bib48","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.3892\/ijmm.2014.1859","article-title":"Inhibition by caffeic acid of the influenza A virus multiplication in vitro","volume":"34","author":"Utsunomiya","year":"2014","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.jep.2022.115243_bib49","first-page":"5307614","article-title":"Comparison of the antiaging and protective properties of plants from the Apiaceae family","author":"Zofia","year":"2020","journal-title":"Oxid. Med. Cell. Longev."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122002823?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122002823?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:28:03Z","timestamp":1759944483000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874122002823"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":49,"alternative-id":["S0378874122002823"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2022.115243","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of influenza virus replication by Apiaceae plants, with special reference to Peucedanum japonicum (Sacna) constituents","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2022.115243","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115243"}}