{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T07:24:27Z","timestamp":1772609067793,"version":"3.50.1"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T00:00:00Z","timestamp":1681948800000},"content-version":"vor","delay-in-days":293,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.jep.2022.115291","type":"journal-article","created":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T05:58:02Z","timestamp":1649743082000},"page":"115291","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Stephalagine, an aporphinic alkaloid with therapeutic effects in acute gout arthritis in mice"],"prefix":"10.1016","volume":"293","author":[{"given":"Priscilla Dias","family":"Santos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6608-5738","authenticated-orcid":false,"given":"Thiago Neves","family":"Vieira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Claudia","family":"Gontijo Couto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Paulo","family":"Mesquita Luiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 Luis","family":"Lopes Saraiva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2699-9348","authenticated-orcid":false,"given":"Camila Rodrigues","family":"Borges Linhares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1292-9434","authenticated-orcid":false,"given":"Mar\u00edlia Fontes","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allisson Benatti","family":"Justino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo Rodrigues","family":"Franco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyne","family":"da Silva Brum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara Marchesan","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Dechichi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1564-9107","authenticated-orcid":false,"given":"Marcos","family":"Pivatto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veridiana","family":"de Melo Rodrigues \u00c1vila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Foued Salmen","family":"Esp\u00edndola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e1ssia Regina","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jep.2022.115291_bib2","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.pharmthera.2004.11.008","article-title":"Contribution of natural products to the discovery of the transient receptor potential (TRP) channels family and their functions","volume":"106","author":"Calixto","year":"2005","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jep.2022.115291_bib3","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"Chaplan","year":"1994","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.jep.2022.115291_bib4","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0304-3959(87)90072-8","article-title":"Ankle joint urate arthritis (AJUA) in rats: an alternative animal model of arthritis to that produced by Freund\u2019s adjuvant","volume":"28","author":"Coderre","year":"1987","journal-title":"Pain"},{"key":"10.1016\/j.jep.2022.115291_bib5","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.2174\/138161209788186308","article-title":"TRP channels and pain","volume":"15","author":"Cortright","year":"2009","journal-title":"Curr. Pharmaceut. Des."},{"key":"10.1016\/j.jep.2022.115291_bib6","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1590\/S0100-879X2004000300018","article-title":"An electronic pressure-meter nociception paw test for mice","volume":"37","author":"Cunha","year":"2004","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.jep.2022.115291_bib7","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s10787-017-0426-0","article-title":"Anti-inflammatory and antinociceptive properties of the hydroalcoholic fractions from the leaves of Annona crassiflora Mart. in mice","volume":"27","author":"da Costa Oliveira","year":"2019","journal-title":"Inflammopharmacology"},{"issue":"1","key":"10.1016\/j.jep.2022.115291_bib8","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41572-019-0115-y","article-title":"Gout","volume":"5","author":"Dalbeth","year":"2019","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.jep.2022.115291_bib9","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1016\/S0140-6736(21)00569-9","volume":"397","author":"Dalbeth","year":"2021","journal-title":"Gout. Lancet"},{"issue":"9","key":"10.1016\/j.jep.2022.115291_bib10","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1093\/rheumatology\/keh640","article-title":"Mechanisms of inflammation in gout","volume":"44","author":"Dalbeth","year":"2005","journal-title":"Rheumatology"},{"key":"10.1016\/j.jep.2022.115291_bib11","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/s41584-020-0441-1","article-title":"Global epidemiology of gout: prevalence, incidence, treatment patterns and risk factors","volume":"16","author":"Dehlin","year":"2020","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jep.2022.115291_bib12","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.molmed.2017.06.005","article-title":"Molecular pathophysiology of gout","volume":"23","author":"Desai","year":"2017","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.jep.2022.115291_bib13","article-title":"Comorbidity in gout at the time of first diagnosis: sex differences that may have implications for dosing of urate lowering therapy","volume":"20","author":"Drivelegka","year":"2018","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jep.2022.115291_bib14","doi-asserted-by":"crossref","first-page":"574","DOI":"10.3899\/jrheum.170806","article-title":"The rising incidence of gout and the increasing burden of comorbidities: a population-based study over 20 years","volume":"45","author":"Elfishawi","year":"2018","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.jep.2022.115291_bib15","first-page":"215","article-title":"Treatment options for gout","volume":"114","author":"Engel","year":"2017","journal-title":"Dtsch. Arztebl. Int."},{"key":"10.1016\/j.jep.2022.115291_bib16","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s10787-017-0384-6","article-title":"Arctium minus crude extract presents antinociceptive effect in a mice acute gout attack model","volume":"26","author":"Fischer","year":"2018","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.jep.2022.115291_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/ph11040105","article-title":"Evidence for transient receptor potential (TRP) channel contribution to arthritis pain and pathogenesis","volume":"11","author":"Galindo","year":"2018","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.jep.2022.115291_bib18","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1016\/j.pain.2011.03.025","article-title":"Role of TRPV1 in nociception and edema induced by monosodium urate crystals in rats","volume":"152","author":"Hoffmeister","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.jep.2022.115291_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2019.103562","article-title":"Stephalagine, an aporphine alkaloid from Annona crassiflora fruit peel, induces antinociceptive effects by TRPA1 and TRPV1 channels modulation in mice","volume":"96","author":"Justino","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.jep.2022.115291_bib20","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1007\/s10787-019-00673-7","article-title":"Protective effects of a polyphenol-enriched fraction of the fruit peel of Annona crassiflora Mart. on acute and persistent inflammatory pain","volume":"28","author":"Justino","year":"2020","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.jep.2022.115291_bib21","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1002\/acr.21772","article-title":"2012 American college of rheumatology guidelines for management of gout. part 1: systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia","volume":"64","author":"Khanna","year":"2012","journal-title":"Arthritis Care Res."},{"key":"10.1016\/j.jep.2022.115291_bib22","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/nrrheum.2015.91","article-title":"Global epidemiology of gout: prevalence, incidence and risk factors","volume":"11","author":"Kuo","year":"2015","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jep.2022.115291_bib23","doi-asserted-by":"crossref","first-page":"4073","DOI":"10.1096\/fj.11-1201ufm","article-title":"Inflammatory gout: observations over a half\u2010century","volume":"25","author":"Malawista","year":"2011","journal-title":"Faseb. J."},{"issue":"1","key":"10.1016\/j.jep.2022.115291_bib24","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/j.0105-2896.2009.00860.x","article-title":"Mechanisms of uric acid crystal-mediated autoinflammation","volume":"233","author":"Martinon","year":"2010","journal-title":"Immunol. Rev."},{"issue":"4","key":"10.1016\/j.jep.2022.115291_bib25","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s00281-013-0361-0","article-title":"Neutrophils, IL-1\u03b2, and gout: is there a link?","volume":"35","author":"Mitroulis","year":"2013","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.jep.2022.115291_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0067730","article-title":"Plant derived aporphinic alkaloid S-(+)-Dicentrine induces antinociceptive effect in both acute and chronic inflammatory pain models: evidence for a role of TRPA1 channels","volume":"8","author":"Montrucchio","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2022.115291_bib27","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.indcrop.2016.12.038","article-title":"Stephalagine, an alkaloid with pancreatic lipase inhibitory activity isolated from the fruit peel of Annona crassiflora Mart","volume":"97","author":"Pereira","year":"2017","journal-title":"Ind. Crop. Prod."},{"issue":"1","key":"10.1016\/j.jep.2022.115291_bib28","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/icb.2009.98","article-title":"Crystal-induced neutrophil activation","volume":"88","author":"Popa-Nita","year":"2010","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.jep.2022.115291_bib29","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1006\/anbo.1997.0469","article-title":"The Brazilian Cerrado vegetation and threats to its biodiversity","volume":"80","author":"Ratter","year":"1997","journal-title":"Ann. Bot."},{"key":"10.1016\/j.jep.2022.115291_bib31","first-page":"233","article-title":"Monosodium urate crystal interleukin-1\u03b2 release is dependent on Toll-like receptor 4 and transient receptor potential V1 activation","volume":"59","author":"Rossato","year":"2020","journal-title":"Rheumatol. (United Kingdom)"},{"key":"10.1016\/j.jep.2022.115291_bib32","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jtcme.2019.03.003","article-title":"In vitro and in vivo evidence of hypouricemic and anti-inflammatory activities of Maclura cochinchinensis (Lour.) Corner heartwood extract","volume":"10","author":"Sato","year":"2020","journal-title":"J. Tradit. Complement. Med."},{"key":"10.1016\/j.jep.2022.115291_bib33","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1136\/annrheumdis-2011-200711","article-title":"Cytokine levels in human synovial fluid during the different stages of acute gout: role of transforming growth factor \u03b21 in the resolution phase","volume":"71","author":"Scanu","year":"2012","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jep.2022.115291_bib34","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1080\/14740338.2017.1284199","article-title":"The safety of treatment options available for gout","volume":"16","author":"Schlesinger","year":"2017","journal-title":"Expet Opin. Drug Saf."},{"key":"10.1016\/j.jep.2022.115291_bib35","doi-asserted-by":"crossref","DOI":"10.1007\/s11926-013-0398-z","article-title":"Anti-interleukin-1 therapy in the management of gout","volume":"16","author":"Schlesinger","year":"2014","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.jep.2022.115291_bib36","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jep.2012.10.054","article-title":"The antinociceptive and anti-inflammatory effects of the crude extract of Jatropha isabellei in a rat gout model","volume":"145","author":"Silva","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.115291_bib37","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nrrheum.2017.155","article-title":"Inflammation in gout: mechanisms and therapeutic targets","volume":"13","author":"So","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"issue":"2","key":"10.1016\/j.jep.2022.115291_bib38","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/BOR.0000000000000691","article-title":"Comorbidities in gout and hyperuricemia: causality or epiphenomena?","volume":"32","author":"Sumpter","year":"2020","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.jep.2022.115291_bib39","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1002\/acr.22585","article-title":"Study for updated gout classification criteria: identification of features to classify gout","volume":"67","author":"Taylor","year":"2015","journal-title":"Arthritis Care Res."},{"key":"10.1016\/j.jep.2022.115291_bib40","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/j.1476-5381.1991.tb12484.x","article-title":"Dicentrine, a natural vascular \u03b11\u2010adrenoceptor antagonist, isolated from Lindera megaphylla","volume":"104","author":"Teng","year":"1991","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jep.2022.115291_bib41","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.freeradbiomed.2014.04.021","article-title":"TRPA1 receptor stimulation by hydrogen peroxide is critical to trigger hyperalgesia and inflammation in a model of acute gout","volume":"72","author":"Trevisan","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jep.2022.115291_bib42","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1021\/np070564h","article-title":"Vasorelaxing alkaloids and flavonoids from Cassytha filiformis","volume":"71","author":"Tsai","year":"2008","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2022.115291_bib43","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1053\/j.ajkd.2017.01.055","article-title":"Management of gout and hyperuricemia in CKD","volume":"70","author":"Vargas-Santos","year":"2017","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.jep.2022.115291_bib44","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1590\/S1519-69842008000100020","article-title":"Assessment of the mutagenic, antimutagenic and cytotoxic activities of ethanolic extract of araticum (Annona crassiflora Mart. 1841) by micronucleus test in mice","volume":"68","author":"Vilar","year":"2008","journal-title":"Braz. J. Biol."},{"key":"10.1016\/j.jep.2022.115291_bib45","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1002\/phar.1788","article-title":"Gouty arthritis: a review of acute management and prevention","volume":"36","author":"Wilson","year":"2016","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.jep.2022.115291_bib46","article-title":"Antinociceptive effects of dehydrocorydaline in mouse models of inflammatory pain involve the opioid receptor and inflammatory cytokines","volume":"6","author":"Yin","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2022.115291_bib47","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.expneurol.2012.08.023","article-title":"Mitotoxicity and bortezomib-induced chronic painful peripheral neuropathy","volume":"238","author":"Zheng","year":"2012","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jep.2022.115291_bib48","series-title":"Ethical Guidelines for Investigations of Experimental Pain in Conscious Animals","author":"Zimmermann","year":"1983"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122003300?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122003300?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T16:42:09Z","timestamp":1740069729000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874122003300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":46,"alternative-id":["S0378874122003300"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2022.115291","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stephalagine, an aporphinic alkaloid with therapeutic effects in acute gout arthritis in mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2022.115291","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"115291"}}