{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:43:21Z","timestamp":1792194201480,"version":"4.4.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.jep.2022.115302","type":"journal-article","created":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T05:57:11Z","timestamp":1651125431000},"page":"115302","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Platycladus orientalis seed extract as a potential triple reuptake MAO inhibitor rescue depression phenotype through restoring monoamine neurotransmitters"],"prefix":"10.1016","volume":"295","author":[{"given":"Li","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufan","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peibo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jep.2022.115302_bib2","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1515\/revneuro-2015-0009","article-title":"Phytochemical constituents as future antidepressants: a comprehensive review %","volume":"26","author":"Bahramsoltani","year":"2015","journal-title":"J . Rev. Neurosci."},{"issue":"Suppl. 2","key":"10.1016\/j.jep.2022.115302_bib3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.4088\/JCP.12084su1c.04","article-title":"Neurotransmitter targeting in the treatment of depression","volume":"74","author":"Blier","year":"2013","journal-title":"J. Clin. Psychiatr."},{"issue":"4","key":"10.1016\/j.jep.2022.115302_bib4","first-page":"385","article-title":"[Mechanism of action of antidepressants and therapeutic perspectives]","volume":"57","author":"Bourin","year":"2002","journal-title":"Therapie"},{"issue":"2","key":"10.1016\/j.jep.2022.115302_bib5","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.bcp.2015.03.011","article-title":"Emerging mechanisms and treatments for depression beyond SSRIs and SNRIs","volume":"95","author":"Dale","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jep.2022.115302_bib39","doi-asserted-by":"crossref","first-page":"619","DOI":"10.4088\/JCP.v68n0420","article-title":"Preventing recurrent depression: long-term treatment for major depressive disorder","volume":"68","author":"Dunner","year":"2007","journal-title":"J. Clin. Psychiatr."},{"key":"10.1016\/j.jep.2022.115302_bib6","article-title":"An unpredictable chronic mild stress protocol for instigating depressive symptoms, behavioral changes and negative Health outcomes in rodents","volume":"106","author":"Frisbee","year":"2015","journal-title":"JoVE"},{"key":"10.1016\/j.jep.2022.115302_bib7","article-title":"Advances in the preclinical study of some flavonoids as potential antidepressant agents","author":"German-Ponciano","year":"2018","journal-title":"Sci. Tech. Rep."},{"issue":"Suppl. 4","key":"10.1016\/j.jep.2022.115302_bib8","first-page":"33","article-title":"SSRIs and SNRIs: broad spectrum of efficacy beyond major depression","volume":"60","author":"Gorman","year":"1999","journal-title":"J. Clin. Psychiatr."},{"issue":"2","key":"10.1016\/j.jep.2022.115302_bib9","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0149-7634(81)90005-1","article-title":"Acute and chronic stress effects on open field activity in the rat: implications for a model of depression","volume":"5","author":"Katz","year":"1981","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"5","key":"10.1016\/j.jep.2022.115302_bib10","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1177\/0269881114553252","article-title":"Antidepressant drug development: focus on triple monoamine reuptake inhibition","volume":"29","author":"Lane","year":"2015","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.jep.2022.115302_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112487","article-title":"Seahorse treatment improves depression-like behavior in mice exposed to CUMS through reducing inflammation\/oxidants and restoring neurotransmitter and neurotrophin function","volume":"250","author":"Li","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.115302_bib12","series-title":"Compendium of Materia Medica","author":"Li","year":"1930"},{"issue":"2","key":"10.1016\/j.jep.2022.115302_bib13","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.jep.2013.03.019","article-title":"Lifespan extension by n-butanol extract from seed of Platycladus orientalis in Caenorhabditis elegans","volume":"147","author":"Liu","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.115302_bib14","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/164_2018_172","article-title":"Selective serotonin reuptake inhibitors","volume":"250","author":"Lochmann","year":"2019","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.jep.2022.115302_bib15","doi-asserted-by":"crossref","DOI":"10.1177\/1179069518789149","article-title":"Effects of monoamines and antidepressants on astrocyte physiology: implications for monoamine hypothesis of depression","volume":"12","author":"Marathe","year":"2018","journal-title":"J. Exp. Neurosci."},{"issue":"3","key":"10.1016\/j.jep.2022.115302_bib16","doi-asserted-by":"crossref","first-page":"142","DOI":"10.4306\/pi.2008.5.3.142","article-title":"Triple reuptake inhibitors: a premise and promise","volume":"5","author":"Marks","year":"2008","journal-title":"Psychiatr. Invest."},{"key":"10.1016\/j.jep.2022.115302_bib17","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.neuroscience.2015.05.053","article-title":"Pathogenesis of depression: insights from human and rodent studies","volume":"321","author":"M\u00e9nard","year":"2016","journal-title":"Neuroscience"},{"issue":"4","key":"10.1016\/j.jep.2022.115302_bib18","doi-asserted-by":"crossref","first-page":"441","DOI":"10.2217\/pgs.12.1","article-title":"Pharmacogenetics of antidepressant drugs: current clinical practice and future directions","volume":"13","author":"Narasimhan","year":"2012","journal-title":"Pharmacogenomics"},{"issue":"11","key":"10.1016\/j.jep.2022.115302_bib19","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1248\/bpb.18.1513","article-title":"Beneficial effects of biota, a traditional Chinese herbal medicine on learning impairment induced by basal forebrain-lesion in mice","volume":"18","author":"Nishiyama","year":"1995","journal-title":"Biol. Pharm. Bull."},{"issue":"6","key":"10.1016\/j.jep.2022.115302_bib20","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/ptr.2650060602","article-title":"Biota (Po\u2010Tzu\u2010Jen), a traditional Chinese medicine, ameliorates the memory acquisition disorder induced by amygdala lesion in mice","volume":"6","author":"Nishiyama","year":"1992","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2022.115302_bib21","unstructured":"Peng, M. D. Y. Ti Ren Hui Bian, Fu Feng Xiang."},{"issue":"1","key":"10.1016\/j.jep.2022.115302_bib22","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s00441-018-2978-8","article-title":"Monoaminergic system and depression","volume":"377","author":"Perez-Caballero","year":"2019","journal-title":"Cell Tissue Res."},{"issue":"5963","key":"10.1016\/j.jep.2022.115302_bib24","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1126\/science.1183090","article-title":"Zebrafish behavioral profiling links drugs to biological targets and rest\/wake regulation","volume":"327","author":"Rihel","year":"2010","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.jep.2022.115302_bib25","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1517\/13543776.2014.859676","article-title":"Triple reuptake inhibitors: a patent review (2006 - 2012)","volume":"24","author":"Shao","year":"2014","journal-title":"Expert Opin. Ther. Pat."},{"issue":"17","key":"10.1016\/j.jep.2022.115302_bib26","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.4155\/fmc.15.134","article-title":"Triple reuptake inhibitors as potential next-generation antidepressants: a new hope?","volume":"7","author":"Sharma","year":"2015","journal-title":"Future Med. Chem."},{"issue":"2","key":"10.1016\/j.jep.2022.115302_bib27","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/ptr.6237","article-title":"L-theanine ameliorate depressive-like behavior in a chronic unpredictable mild stress rat model via modulating the monoamine levels in limbic-cortical-striatal-pallidal-thalamic-circuit related brain regions","volume":"33","author":"Shen","year":"2019","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2022.115302_bib28","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/9724371","article-title":"The link between depression and chronic pain: neural mechanisms in the brain","volume":"2017","author":"Sheng","year":"2017","journal-title":"Neural Plast."},{"issue":"2","key":"10.1016\/j.jep.2022.115302_bib29","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2174\/187152707780363285","article-title":"Triple reuptake inhibitors (\"broad spectrum\" antidepressants)","volume":"6","author":"Skolnick","year":"2007","journal-title":"CNS Neurol. Disord. - Drug Targets"},{"issue":"6","key":"10.1016\/j.jep.2022.115302_bib30","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1021\/acs.jmedchem.6b01827","article-title":"Triple reuptake inhibitors as potential therapeutics for depression and other disorders: design paradigm and developmental challenges","volume":"61","author":"Subbaiah","year":"2018","journal-title":"J. Med. Chem."},{"issue":"5","key":"10.1016\/j.jep.2022.115302_bib31","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.cellsig.2004.12.007","article-title":"Mechanisms of action of antidepressants: from neurotransmitter systems to signaling pathways","volume":"17","author":"Taylor","year":"2005","journal-title":"Cell. Signal."},{"key":"10.1016\/j.jep.2022.115302_bib32","series-title":"Shen Nong Ben Cao Jing, Peking\uff1aChina Press of Traditional Chinese Medicine","author":"Teng","year":"2015"},{"key":"10.1016\/j.jep.2022.115302_bib33","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jep.2017.04.009","article-title":"Involvement of serotonergic, noradrenergic and dopaminergic systems in the antidepressant-like effect of ginsenoside Rb1, a major active ingredient of Panax ginseng C.A. Meyer.\"","volume":"204","author":"Wang","year":"2017","journal-title":"J. Ethnopharmacol."},{"issue":"12","key":"10.1016\/j.jep.2022.115302_bib34","first-page":"916","article-title":"Evaluation of neuroactive effects of ethanol extract of Schisandra chinensis, Schisandrin, and Schisandrin B and determination of underlying mechanisms by zebrafish behavioral profiling","volume":"16","author":"Wang","year":"2018","journal-title":"Chin. J. Nat. Med."},{"issue":"3","key":"10.1016\/j.jep.2022.115302_bib35","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/BF00187257","article-title":"Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant","volume":"93","author":"Willner","year":"1987","journal-title":"Psychopharmacology (Berl)"},{"issue":"1","key":"10.1016\/j.jep.2022.115302_bib36","doi-asserted-by":"crossref","first-page":"S83","DOI":"10.1186\/1744-859X-5-S1-S83","article-title":"Selective serotonin reuptake inhibitor use associates with apathy among depressed elderly: a case-control study","volume":"5","author":"Wongpakaran","year":"2006","journal-title":"Ann. Gen. Psychiatr."},{"key":"10.1016\/j.jep.2022.115302_bib37","series-title":"Ben Shi Fang","author":"Xu","year":"1959"},{"key":"10.1016\/j.jep.2022.115302_bib38","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3389\/fnagi.2020.00207","article-title":"Modulation of the a\u03b2-peptide-aggregation pathway by active compounds from Platycladus orientalis seed extract in alzheimer's disease models","volume":"12","author":"Yan","year":"2020","journal-title":"Front. Aging Neurosci."}],"updated-by":[{"DOI":"10.1016\/j.jep.2023.116821","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000}}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122003415?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122003415?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T10:58:18Z","timestamp":1695293898000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874122003415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":37,"alternative-id":["S0378874122003415"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2022.115302","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.jep.2023.116821","asserted-by":"object"}]},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Platycladus orientalis seed extract as a potential triple reuptake MAO inhibitor rescue depression phenotype through restoring monoamine neurotransmitters","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2022.115302","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"115302"}}