{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T06:12:38Z","timestamp":1781071958413,"version":"3.54.1"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773858"],"award-info":[{"award-number":["81773858"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073985"],"award-info":[{"award-number":["82073985"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.jep.2022.115352","type":"journal-article","created":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T13:41:57Z","timestamp":1652967717000},"page":"115352","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Semen raphani weakened the action of ginseng under chronic fatigue condition"],"prefix":"10.1016","volume":"295","author":[{"given":"Yumeng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deqiang","family":"Dou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2022.115352_bib1","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.3390\/antiox10081246","article-title":"Diclofenac administration after physical training blunts adaptations of peripheral systems and leads to losses in exercise performance: in vivo and in silico analyses","volume":"10","author":"Barcelos","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.jep.2022.115352_bib2","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.chmed.2019.05.001","article-title":"Effects of raphani semen on anti-fatigue and pharmacokinetics of panax ginseng - sciencedirect","volume":"11","author":"Chen","year":"2019","journal-title":"Chinese Herbal Medicines"},{"key":"10.1016\/j.jep.2022.115352_bib3","volume":"vol. 9","author":"Gao","year":"2002"},{"key":"10.1016\/j.jep.2022.115352_bib4","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.dld.2018.03.016","article-title":"Exploring Bacteroidetes: metabolic key points and immunological tricks of our gut commensals","volume":"50","author":"Gibiino","year":"2018","journal-title":"Dig. Liver Dis."},{"key":"10.1016\/j.jep.2022.115352_bib5","series-title":"Research on the Metabolic Features of Middle and Long Distance Runners in Heavy Load Training Stage and the Possible Mechanism of Acupoint Stimulation Based on Metabolomics","author":"Guo","year":"2019"},{"key":"10.1016\/j.jep.2022.115352_bib6","first-page":"3066","article-title":"The anti-fatigue activities of Tuber melanosporum in a mouse model","volume":"15","author":"Jiang","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.jep.2022.115352_bib7","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s12866-017-1027-1","article-title":"Association between body mass index and Firmicutes\/Bacteroidetes ratio in an adult Ukrainian population","volume":"17","author":"Koliada","year":"2017","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.jep.2022.115352_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0120106","article-title":"Potential biomarkers of fatigue identified by plasma metabolome analysis in rats","volume":"10","author":"Kume","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2022.115352_bib9","series-title":"Quality Control of Zhuang Medicine Bawei Longzuan Granules and its Mechanisms in the Treatment of Rheumatoid Arthritis Master Dissertation","author":"Li","year":"2019"},{"key":"10.1016\/j.jep.2022.115352_bib10","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/s41598-019-56561-1","article-title":"FBA ecological guild: trio of firmicutes-bacteroidetes alliance against actinobacteria in human oral microbiome","volume":"1410","author":"Li","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2022.115352_bib11","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ijms.2018.09.036","article-title":"Studies on antagonism effect of semen raphani on panax ginseng from saponin composition and hypothalamic-pituitary-adrenal Axis regulation effect","volume":"436","author":"Li","year":"2018","journal-title":"Int. J. Mass Spectrom."},{"key":"10.1016\/j.jep.2022.115352_bib12","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jep.2016.02.031","article-title":"Urinary metabonomic study of Panax ginseng in deficiency of vital energy rat using ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry","volume":"184","author":"Lin","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.115352_bib13","series-title":"Study on the Pharmacodynamics of Characteristic Components of Honey-Processed astragalus Based on Metabolomics","author":"Liu","year":"2018"},{"key":"10.1016\/j.jep.2022.115352_bib14","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1248\/bpb.b15-00230","article-title":"Anti-fatigue effects of 20(S)-Protopanaxadiol and 20(S)-Protopanaxatriol in mice","volume":"38","author":"Oh","year":"2015","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jep.2022.115352_bib15","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/s13105-013-0256-5","article-title":"Ergogenic effect of dietary L-carnitine and fat supplementation against exercise induced physical fatigue in Wistar rats","volume":"69","author":"Pandareesh","year":"2013","journal-title":"J. Physiol. Biochem."},{"key":"10.1016\/j.jep.2022.115352_bib16","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1139\/apnm-2013-0546","article-title":"Metabolomics of salivary fatigue markers in soccer players after consecutive games","volume":"39","author":"Ra","year":"2014","journal-title":"Appl. Physiol. Nutr. Metabol."},{"key":"10.1016\/j.jep.2022.115352_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115113","article-title":"The correlations of adverse effect and tonifying effect of ginseng medicines","volume":"291","author":"Ran","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.115352_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12275-018-7318-x","article-title":"Taxonomic hierarchy of the phylum Firmicutes and novel Firmicutes species originated from various environments in Korea","volume":"56","author":"Seong","year":"2018","journal-title":"J. Microbiol."},{"key":"10.1016\/j.jep.2022.115352_bib19","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1042\/BCJ20160510","article-title":"Introduction to the human gut microbiota","volume":"474","author":"Thursby","year":"2017","journal-title":"Biochem. J."},{"key":"10.1016\/j.jep.2022.115352_bib20","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.toxlet.2013.12.017","article-title":"Metabonomic analysis of quercetin against the toxicity of chronic exposure to low-level dichlorvos in rats via ultra-performance liquid chromatography-mass spectrometry","volume":"225","author":"Wang","year":"2014","journal-title":"Toxicology letters"},{"key":"10.1016\/j.jep.2022.115352_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112822","article-title":"Application of RRLC-QTOF-MS-based metabonomics and UPE for investigating Spleen-Qi deficiency syndrome with Panax ginseng treatment","volume":"256","author":"Wang","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.115352_bib22","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.3390\/genes11101167","article-title":"Regulatory effect of methylation of the porcine aqp3 gene promoter region on its expression level and porcine epidemic diarrhea virus resistance","volume":"10","author":"Wu","year":"2020","journal-title":"Genes"},{"key":"10.1016\/j.jep.2022.115352_bib23","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jchromb.2016.06.044","article-title":"Serum metabonomics study of anti-depressive effect of Xiao-Chai-Hu-Tang on rat model of chronic unpredictable mild stress","volume":"1029\u20131030","author":"Xiong","year":"2016","journal-title":"Journal of chromatography. B, Analytical technologies in the biomedical and life sciences"},{"key":"10.1016\/j.jep.2022.115352_bib24","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jep.2016.06.024","article-title":"The ginseng's fireness is associated with the lowering activity of liver Na (+)-K (+)-ATPase","volume":"190","author":"Xu","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.115352_bib25","doi-asserted-by":"crossref","DOI":"10.1080\/16546628.2017.1334485","article-title":"Anti-fatigue effects of dietary nucleotides in mice","volume":"61","author":"Xu","year":"2017","journal-title":"Food Nutr. Res."},{"key":"10.1016\/j.jep.2022.115352_bib26","doi-asserted-by":"crossref","first-page":"4548","DOI":"10.1002\/jsfa.8322","article-title":"Anti-fatigue activity of sea cucumber peptides prepared from Stichopus japonicus in an endurance swimming rat model","volume":"97","author":"Ye","year":"2017","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.jep.2022.115352_bib27","first-page":"559","article-title":"Study on the variation of chemical constituents during combination of ginseng with trogopteroum feces and semen raphani by high performance liquid chromatography-mass spectrometry","volume":"35","author":"Zhang","year":"2007","journal-title":"Chin. J. Anal. Chem."},{"key":"10.1016\/j.jep.2022.115352_bib28","doi-asserted-by":"crossref","first-page":"7755","DOI":"10.1039\/C9FO01182J","article-title":"Anti-fatigue effect of anwulignan via the NRF2 and PGC-1\u03b1 signaling pathway in mice","volume":"10","author":"Zhang","year":"2019","journal-title":"Food Funct."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122003919?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122003919?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:23:19Z","timestamp":1759944199000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874122003919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":28,"alternative-id":["S0378874122003919"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2022.115352","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Semen raphani weakened the action of ginseng under chronic fatigue condition","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2022.115352","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115352"}}