{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T02:59:11Z","timestamp":1771901951021,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073733"],"award-info":[{"award-number":["82073733"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["KFJ-STS-QYZD-2021-03-002"],"award-info":[{"award-number":["KFJ-STS-QYZD-2021-03-002"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.jep.2022.115528","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T21:46:13Z","timestamp":1657575973000},"page":"115528","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Multi-target mechanisms against coronaviruses of constituents from Chinese Dagang Tea revealed by experimental and docking studies"],"prefix":"10.1016","volume":"297","author":[{"given":"Liyun","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xubing","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuda","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liyuan","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binhong","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhifang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongchang","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongfeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng-Xiang","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.jep.2022.115528_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26092654","article-title":"Olive-Derived triterpenes suppress sars COV-2 main protease: a promising scaffold for future therapeutics","volume":"26","author":"Alhadrami","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2022.115528_bib2","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.antiviral.2017.06.021","article-title":"Toward the identification of viral cap-methyltransferase inhibitors by fluorescence screening assay","volume":"144","author":"Aouadi","year":"2017","journal-title":"Antivir. Res."},{"issue":"4","key":"10.1016\/j.jep.2022.115528_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000863","article-title":"In vitro reconstitution of SARS-coronavirus mRNA cap methylation","volume":"6","author":"Bouvet","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jep.2022.115528_bib4","doi-asserted-by":"crossref","DOI":"10.1038\/s41586-021-04385-3","article-title":"Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies","author":"Cao","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.jep.2022.115528_bib5","doi-asserted-by":"crossref","DOI":"10.1038\/s41586-021-04387-1","article-title":"Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization","author":"Cele","year":"2021","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.jep.2022.115528_bib6","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.apsb.2020.10.002","article-title":"Identifying potential anti-COVID-19 pharmacological components of traditional Chinese medicine Lianhuaqingwen capsule based on human exposure and ACE2 biochromatography screening","volume":"11","author":"Chen","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jep.2022.115528_bib7","doi-asserted-by":"crossref","first-page":"105255","DOI":"10.1016\/j.phrs.2020.105255","article-title":"Naringenin is a powerful inhibitor of SARS-CoV-2 infection in vitro","volume":"163","author":"Clementi","year":"2021","journal-title":"Pharmacol. Res."},{"issue":"6","key":"10.1016\/j.jep.2022.115528_bib8","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.chom.2020.11.003","article-title":"Integrative imaging reveals SARS-CoV-2-induced reshaping of subcellular morphologies","volume":"28","author":"Cortese","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jep.2022.115528_bib9","doi-asserted-by":"crossref","DOI":"10.1038\/srep42717","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.jep.2022.115528_bib10","doi-asserted-by":"crossref","first-page":"3174","DOI":"10.1021\/acsinfecdis.0c00500","article-title":"Comparative multiplexed interactomics of SARS-CoV-2 and homologous coronavirus nonstructural proteins identifies unique and shared host-cell dependencies","volume":"6","author":"Davies","year":"2020","journal-title":"ACS Infect. Dis."},{"issue":"3","key":"10.1016\/j.jep.2022.115528_bib11","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1002\/ptr.6887","article-title":"A role for quercetin in coronavirus disease 2019 (COVID-19)","volume":"35","author":"Derosa","year":"2021","journal-title":"Phytother Res."},{"issue":"1","key":"10.1016\/j.jep.2022.115528_bib12","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/nbt.2786","article-title":"Clinical development success rates for investigational drugs","volume":"32","author":"Hay","year":"2014","journal-title":"Nat. Biotechnol."},{"issue":"2","key":"10.1016\/j.jep.2022.115528_bib13","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s13205-020-02578-7","article-title":"In silico docking analysis revealed the potential of phytochemicals present in Phyllanthus amarus and Andrographis paniculata, used in Ayurveda medicine in inhibiting SARS-CoV-2","volume":"11","author":"Hiremath","year":"2021","journal-title":"3 Biotech"},{"key":"10.1016\/j.jep.2022.115528_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2020.592289","article-title":"Supporting SARS-CoV-2 papain-like protease drug discovery: in silico methods and benchmarking","volume":"8","author":"Ibrahim","year":"2020","journal-title":"Front. Chem."},{"issue":"2","key":"10.1016\/j.jep.2022.115528_bib15","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/s13365-020-00926-0","article-title":"Neuroinvasive potential of human coronavirus OC43: case report of fatal encephalitis in an immunocompromised host","volume":"27","author":"Kasereka","year":"2021","journal-title":"J. Neurovirol."},{"issue":"11","key":"10.1016\/j.jep.2022.115528_bib16","first-page":"696","article-title":"Natural bis-benzylisoquinoline alkaloids-tetrandrine, fangchinoline, and cepharanthine","volume":"9","author":"Kim","year":"2019","journal-title":"Inbit Human Coronavirus Infect MRC-5 Human Lung Cell."},{"issue":"1","key":"10.1016\/j.jep.2022.115528_bib17","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3109\/14756366.2012.753591","article-title":"Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds of Psoralea corylifolia","volume":"29","author":"Kim","year":"2014","journal-title":"J. Enzym. Inhib. Med. Chem."},{"issue":"20","key":"10.1016\/j.jep.2022.115528_bib18","doi-asserted-by":"crossref","first-page":"5109","DOI":"10.1093\/bioinformatics\/btaa645","article-title":"COVID-19 Docking Server: a meta server for docking small molecules, peptides and antibodies against potential targets of COVID19","volume":"36","author":"Kong","year":"2020","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jep.2022.115528_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153317","article-title":"Identification of phytochemicals as potential therapeutic agents that binds to Nsp15 protein target of coronavirus (SARS-CoV-2) that are capable of inhibiting virus replication","volume":"85","author":"Kumar","year":"2021","journal-title":"Phytomedicine"},{"issue":"Suppl. 11","key":"10.1016\/j.jep.2022.115528_bib20","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1186\/s12859-016-1169-4","article-title":"Correcting the impact of docking pose generation error on binding affinity prediction","volume":"17","author":"Li","year":"2016","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.jep.2022.115528_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2021.112984","article-title":"Natural biflavones are potent inhibitors against SARS-CoV-2 papain-like protease","volume":"193","author":"Li","year":"2022","journal-title":"Phytochemistry"},{"issue":"10224","key":"10.1016\/j.jep.2022.115528_bib22","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0140-6736(20)30251-8","article-title":"Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding","volume":"395","author":"Lu","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2022.115528_bib23","first-page":"1","article-title":"Drastic decline in sera neutralization against SARS-CoV-2 Omicron variant in Wuhan COVID-19 convalescents","author":"Ma","year":"2022","journal-title":"Emerg. Microb. Infect."},{"issue":"30","key":"10.1016\/j.jep.2022.115528_bib24","doi-asserted-by":"crossref","first-page":"9436","DOI":"10.1073\/pnas.1508686112","article-title":"Structural basis and functional analysis of the SARS coronavirus nsp14-nsp10 complex","volume":"112","author":"Ma","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jep.2022.115528_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2020.197989","article-title":"Natural product-derived phytochemicals as potential agents against coronaviruses: a review","volume":"284","author":"Mani","year":"2020","journal-title":"Virus Res."},{"key":"10.1016\/j.jep.2022.115528_bib26","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1126\/science.1085953","article-title":"The genome sequence of the SARS-associated coronavirus","volume":"300","author":"Marra","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.jep.2022.115528_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2021.105055","article-title":"Combined in silico and in vitro approaches identified the antipsychotic drug lurasidone and the antiviral drug elbasvir as SARS-CoV2 and HCoV-OC43 inhibitors","volume":"189","author":"Milani","year":"2021","journal-title":"Antivir. Res."},{"issue":"5","key":"10.1016\/j.jep.2022.115528_bib28","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1056\/NEJMc1509458","article-title":"Human coronavirus OC43 associated with fatal encephalitis","volume":"375","author":"Morfopoulou","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jep.2022.115528_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173759","article-title":"Flavonols as potential antiviral drugs targeting SARS-CoV-2 proteases (3CL(pro) and PL(pro)), spike protein, RNA-dependent RNA polymerase (RdRp) and angiotensin-converting enzyme II receptor (ACE2)","volume":"891","author":"Mouffouk","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2022.115528_bib30","article-title":"Identification of broad anti-coronavirus chemical agents for repurposing against SARS-CoV-2 and variants of concern","volume":"3","author":"Murer","year":"2022","journal-title":"Curr. Res. Virol. Sci."},{"key":"10.1016\/j.jep.2022.115528_bib31","series-title":"Human Coronavirus Infections","author":"Myint","year":"1995"},{"issue":"2","key":"10.1016\/j.jep.2022.115528_bib32","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Oleg","year":"2009","journal-title":"Comput. Chem."},{"issue":"1","key":"10.1016\/j.jep.2022.115528_bib33","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/s42003-022-03189-z","article-title":"Sulforaphane exhibits antiviral activity against pandemic SARS-CoV-2 and seasonal HCoV-OC43 coronaviruses in vitro and in mice","volume":"5","author":"Ordonez","year":"2022","journal-title":"Commun Biol."},{"issue":"12","key":"10.1016\/j.jep.2022.115528_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/v13122533","article-title":"Epigallocatechin gallate (EGCG), a green tea polyphenol, reduces coronavirus replication in a mouse model","volume":"13","author":"Park","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.jep.2022.115528_bib35","article-title":"Considerable escape of SARS-CoV-2 Omicron to antibody neutralization","author":"Planas","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.jep.2022.115528_bib36","doi-asserted-by":"crossref","first-page":"16119","DOI":"10.1073\/pnas.0805240105","article-title":"A noncovalent class of papain-like protease\/deubiquitinase inhibitors blocks SARS virus replication","volume":"105","author":"Ratia","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"4","key":"10.1016\/j.jep.2022.115528_bib37","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1016\/j.sjbs.2021.12.018","article-title":"Repurposing of phytomedicine-derived bioactive compounds with promising anti-SARS-CoV-2 potential: molecular docking, MD simulation and drug-likeness\/ADMET studies","volume":"29","author":"Rudrapal","year":"2022","journal-title":"Saudi J. Biol. Sci."},{"key":"10.1016\/j.jep.2022.115528_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104761","article-title":"Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2)","volume":"156","author":"Runfeng","year":"2020","journal-title":"Pharmacol. Res."},{"issue":"42","key":"10.1016\/j.jep.2022.115528_bib39","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abd4596","article-title":"Activity profiling and crystal structures of inhibitor-bound sars-cov-2 papain-like protease: a framework for anti-covid-19 drug design","volume":"6","author":"Rut","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jep.2022.115528_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.jviromet.2021.114317","article-title":"Improving human coronavirus OC43 (HCoV-OC43) research comparability in studies using HCoV-OC43 as a surrogate for SARS-CoV-2","volume":"299","author":"Schirtzinger","year":"2022","journal-title":"J. Virol. Methods"},{"issue":"13","key":"10.1016\/j.jep.2022.115528_bib41","doi-asserted-by":"crossref","first-page":"4582","DOI":"10.1080\/07391102.2020.1778535","article-title":"Structure-based virtual screening and molecular dynamics simulation of SARS-CoV-2 Guanine-N7 methyltransferase (nsp14) for identifying antiviral inhibitors against COVID-19","volume":"39","author":"Selvaraj","year":"2021","journal-title":"J. Biomol. Struct. Dyn."},{"issue":"2","key":"10.1016\/j.jep.2022.115528_bib42","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1080\/14786419.2017.1343327","article-title":"A new ent-kaurane diterpene derivative from the stems of Eurya chinensis R","volume":"32","author":"Song","year":"2018","journal-title":"Br. Nat Prod Res"},{"issue":"10","key":"10.1016\/j.jep.2022.115528_bib43","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1080\/10286020.2017.1373099","article-title":"Two new ent-kaurane diterpenes from the stems of Eurya chinensis","volume":"20","author":"Song","year":"2018","journal-title":"J. Asian Nat. Prod. Res."},{"issue":"89","key":"10.1016\/j.jep.2022.115528_bib44","doi-asserted-by":"crossref","first-page":"85958","DOI":"10.1039\/C6RA11994H","article-title":"Euryachins A and B, a new type of diterpenoids from Eurya chinensis with potent NO production inhibitory activity","volume":"6","author":"Song","year":"2016","journal-title":"RSC Adv."},{"issue":"3","key":"10.1016\/j.jep.2022.115528_bib45","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1080\/10286020.2016.1191474","article-title":"Anti-inflammatory and antimicrobial coumarins from the stems of Eurya chinensis","volume":"19","author":"Song","year":"2017","journal-title":"J. Asian Nat. Prod. Res."},{"issue":"9","key":"10.1016\/j.jep.2022.115528_bib46","doi-asserted-by":"crossref","first-page":"5632","DOI":"10.1021\/acs.jmedchem.0c02124","article-title":"Betulonic acid derivatives interfering with human coronavirus 229E replication via the nsp15 endoribonuclease","volume":"64","author":"Stevaert","year":"2021","journal-title":"J. Med. Chem."},{"issue":"50","key":"10.1016\/j.jep.2022.115528_bib47","doi-asserted-by":"crossref","first-page":"4087","DOI":"10.1021\/jm070295s","article-title":"Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus","author":"Wen","year":"2007","journal-title":"J. Med. Chem."},{"issue":"22","key":"10.1016\/j.jep.2022.115528_bib49","doi-asserted-by":"crossref","first-page":"11383","DOI":"10.1128\/JVI.01986-15","article-title":"The ns12.9 accessory protein of human coronavirus OC43 is a viroporin involved in virion morphogenesis and pathogenesis","volume":"89","author":"Zhang","year":"2015","journal-title":"J. Virol."},{"issue":"8","key":"10.1016\/j.jep.2022.115528_bib50","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1056\/NEJMoa2001017","article-title":"A novel coronavirus from patients with pneumonia in China, 2019","volume":"382","author":"Zhu","year":"2020","journal-title":"N. Engl. J. Med."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122005670?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122005670?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:24:07Z","timestamp":1759944247000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874122005670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":49,"alternative-id":["S0378874122005670"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2022.115528","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multi-target mechanisms against coronaviruses of constituents from Chinese Dagang Tea revealed by experimental and docking studies","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2022.115528","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"115528"}}