{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T13:36:33Z","timestamp":1768829793979,"version":"3.49.0"},"reference-count":115,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82004329"],"award-info":[{"award-number":["82004329"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010882","name":"Tianjin Municipal Education Commission","doi-asserted-by":"publisher","award":["2019SK025"],"award-info":[{"award-number":["2019SK025"]}],"id":[{"id":"10.13039\/501100010882","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.jep.2022.115631","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T23:17:00Z","timestamp":1660778220000},"page":"115631","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Mechanisms of Xiong-Pi-Fang in treating coronary heart disease associated with depression: A systematic pharmacology strategy and in vivo pharmacological validation"],"prefix":"10.1016","volume":"298","author":[{"given":"Fangjuan","family":"Deng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boya","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayu","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zhen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoqiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zidong","family":"Cong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wuxun","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hucheng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2022.115631_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neubiorev.2019.07.007","article-title":"Evaluation of the Wistar-Kyoto rat model of depression and the role of synaptic plasticity in depression and antidepressant response","volume":"105","author":"Aleksandrova","year":"2019","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"3","key":"10.1016\/j.jep.2022.115631_bib2","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.psyneuen.2010.03.007","article-title":"The glucocorticoid receptor: pivot of depression and of antidepressant treatment?","volume":"36","author":"Anacker","year":"2011","journal-title":"Psychoneuroendocrinology."},{"issue":"11","key":"10.1016\/j.jep.2022.115631_bib3","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1136\/jclinpath-2014-202493","article-title":"Gene of the month: interleukin 6 (IL-6)","volume":"67","author":"Ataie-Kachoie","year":"2014","journal-title":"J. Clin. Pathol."},{"issue":"1","key":"10.1016\/j.jep.2022.115631_bib4","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1017\/S2045796018000380","article-title":"Medicine-based evidence: the case of antidepressants in patients with coronary artery disease","volume":"28","author":"Barbui","year":"2019","journal-title":"Epidemiol. Psychiatr. Sci."},{"issue":"10","key":"10.1016\/j.jep.2022.115631_bib5","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1097\/HJH.0b013e32829baae7","article-title":"Sympathetic activity in major depressive disorder: identifying those at increased cardiac risk?","volume":"25","author":"Barton","year":"2007","journal-title":"J. Hypertens."},{"issue":"5","key":"10.1016\/j.jep.2022.115631_bib6","doi-asserted-by":"crossref","first-page":"e441","DOI":"10.4088\/JCP.13r08672","article-title":"Meta-analysis of selective serotonin reuptake inhibitor\u2013associated QTc prolongation","volume":"75","author":"Beach","year":"2014","journal-title":"J. Clin. Psychiatr."},{"issue":"11","key":"10.1016\/j.jep.2022.115631_bib7","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1007\/s40263-020-00763-z","article-title":"The cardiovascular effects of newer antidepressants in older adults and those with or at high risk for cardiovascular diseases","volume":"34","author":"Behlke","year":"2020","journal-title":"CNS Drugs"},{"issue":"1","key":"10.1016\/j.jep.2022.115631_bib8","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.jacc.2012.04.040","article-title":"Exercise and pharmacological treatment of depressive symptoms in patients with coronary heart disease","volume":"60","author":"Blumenthal","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jep.2022.115631_bib9","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.physrep.2005.10.009","article-title":"Complex networks: structure and dynamics","volume":"424","author":"Boccaletti","year":"2006","journal-title":"Phys. Rep."},{"issue":"5","key":"10.1016\/j.jep.2022.115631_bib10","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1111\/j.1360-0443.2010.03351.x","article-title":"Alcohol and depression","volume":"106","author":"Boden","year":"2011","journal-title":"Addiction."},{"issue":"10","key":"10.1016\/j.jep.2022.115631_bib11","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.3390\/ijms18102150","article-title":"Hypothalamic-pituitary-adrenal Axis modulation of glucocorticoids in the cardiovascular system","volume":"18","author":"Burford","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.jep.2022.115631_bib12","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0002-9149(01)01675-7","article-title":"Even minimal symptoms of depression increase mortality risk after acute myocardial infarction","volume":"88","author":"Bush","year":"2001","journal-title":"Am. J. Cardiol."},{"issue":"3","key":"10.1016\/j.jep.2022.115631_bib13","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nrcardio.2016.181","article-title":"Depression and coronary heart disease","volume":"14","author":"Carney","year":"2017","journal-title":"Nat. Rev. Cardiol."},{"issue":"4","key":"10.1016\/j.jep.2022.115631_bib14","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S0022-3999(02)00311-2","article-title":"Depression as a risk factor for cardiac mortality and morbidity: a review of potential mechanisms","volume":"53","author":"Carney","year":"2002","journal-title":"J. Psychosom. Res."},{"issue":"4","key":"10.1016\/j.jep.2022.115631_bib15","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1097\/PSY.0000000000000570","article-title":"Residual symptoms after treatment for depression in patients with coronary heart disease","volume":"80","author":"Carney","year":"2018","journal-title":"Psychosom. Med."},{"issue":"3","key":"10.1016\/j.jep.2022.115631_bib16","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1097\/CRD.0b013e31820e8106","article-title":"Depression and cardiac disease: a review","volume":"19","author":"Celano","year":"2011","journal-title":"Cardiol. Rev."},{"key":"10.1016\/j.jep.2022.115631_bib17","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.jep.2017.12.011","article-title":"Network pharmacology-based strategy for predicting active ingredients and potential targets of Yangxinshi tablet for treating heart failure","volume":"219","author":"Chen","year":"2018","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.jep.2022.115631_bib18","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.nbd.2006.05.001","article-title":"IL-6 knockout mice exhibit resistance to stress-induced development of depression-like behaviors","volume":"23","author":"Chourbaji","year":"2006","journal-title":"Neurobiol. Dis."},{"issue":"3","key":"10.1016\/j.jep.2022.115631_bib19","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1097\/01.PSY.0000041624.96580.1F","article-title":"Depression and coronary heart disease in women with diabetes","volume":"65","author":"Clouse","year":"2003","journal-title":"Psychosom. Med."},{"issue":"2","key":"10.1016\/j.jep.2022.115631_bib20","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.tips.2021.11.004","article-title":"Network pharmacology: curing causal mechanisms instead of treating symptoms","volume":"43","author":"Cristian","year":"2022","journal-title":"Trends Pharmacol. Sci."},{"issue":"9","key":"10.1016\/j.jep.2022.115631_bib21","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S2215-0366(21)00034-1","article-title":"Circadian rhythm sleep\u2013wake disturbances and depression in young people: implications for prevention and early intervention","volume":"8","author":"Crouse","year":"2021","journal-title":"Lancet Psychiatr."},{"key":"10.1016\/j.jep.2022.115631_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.yfrne.2019.04.003","article-title":"Circadian regulation of depression: a role for serotonin","volume":"54","author":"Daut","year":"2019","journal-title":"Front. Neuroendocrinol."},{"issue":"13","key":"10.1016\/j.jep.2022.115631_bib23","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1017\/S0033291714000063","article-title":"Cognitive\/affective and somatic\/affective symptoms of depression in patients with heart disease and their association with cardiovascular prognosis: a meta-analysis","volume":"44","author":"de Miranda Azevedo","year":"2014","journal-title":"Psychol. Med."},{"issue":"3","key":"10.1016\/j.jep.2022.115631_bib24","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1097\/PSY.0b013e31827ac009","article-title":"Characteristics of psychological interventions that improve depression in people with coronary heart disease: a systematic review and meta-regression","volume":"75","author":"Dickens","year":"2013","journal-title":"Psychosom. Med."},{"issue":"13","key":"10.1016\/j.jep.2022.115631_bib25","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.jacc.2007.12.024","article-title":"Psychological stress and cardiovascular disease","volume":"51","author":"Dimsdale","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"issue":"2","key":"10.1016\/j.jep.2022.115631_bib26","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/nrneurol.2010.200","article-title":"Neuroplasticity in the context of motor rehabilitation after stroke","volume":"7","author":"Dimyan","year":"2011","journal-title":"Nat. Rev. Neurol."},{"issue":"5","key":"10.1016\/j.jep.2022.115631_bib27","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.biopsych.2009.09.033","article-title":"A meta-analysis of cytokines in major depression","volume":"67","author":"Dowlati","year":"2010","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.jep.2022.115631_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2018.02.005","article-title":"Interleukin-6 is an independent predictor of progressive atherosclerosis in the carotid artery: the Troms\u00f8 Study","volume":"271","author":"Eltoft","year":"2018","journal-title":"Atherosclerosis"},{"issue":"4","key":"10.1016\/j.jep.2022.115631_bib29","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.biopsych.2021.04.012","article-title":"Microvascular contribution to late-onset depression: mechanisms, current evidence, association with other brain diseases, and therapeutic perspectives","volume":"90","author":"Empana","year":"2021","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.jep.2022.115631_bib30","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.bbi.2019.06.015","article-title":"Markers of central inflammation in major depressive disorder: a systematic review and meta-analysis of studies examining cerebrospinal fluid, positron emission tomography and post-mortem brain tissue","volume":"81","author":"Enache","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jep.2022.115631_bib31","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.3389\/fimmu.2018.02031","article-title":"Stress and inflammation in coronary artery disease: a review psychoneuroendocrineimmunology-based","volume":"9","author":"Fioranelli","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2022.115631_bib32","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.neubiorev.2017.10.012","article-title":"Hypothalamic-pituitary-adrenal (HPA) axis functioning as predictor of antidepressant response\u2013Meta-analysis","volume":"83","author":"Fischer","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"4","key":"10.1016\/j.jep.2022.115631_bib33","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1161\/CIRCULATIONAHA.110.983023","article-title":"Deletion of cardiomyocyte mineralocorticoid receptor ameliorates adverse remodeling after myocardial infarction","volume":"123","author":"Fraccarollo","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.jep.2022.115631_bib34","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/1741-7015-11-131","article-title":"Depression as a risk factor for adverse outcomes in coronary heart disease","volume":"11","author":"Freedland","year":"2013","journal-title":"BMC Med."},{"key":"10.1016\/j.jep.2022.115631_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.vph.2020.106806","article-title":"Interleukin-6 level is a powerful predictor of long-term cardiovascular mortality in patients with acute coronary syndrome","volume":"135","author":"Gager","year":"2020","journal-title":"Vasc. Pharmacol."},{"issue":"7590","key":"10.1016\/j.jep.2022.115631_bib36","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nature16948","article-title":"Universal resilience patterns in complex networks","volume":"530","author":"Gao","year":"2016","journal-title":"Nature."},{"issue":"4","key":"10.1016\/j.jep.2022.115631_bib37","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1177\/1753944714531638","article-title":"Exploration of pharmacological interventions to prevent isoproterenol-induced myocardial infarction in experimental models","volume":"8","author":"Garg","year":"2014","journal-title":"Ther Adv Cardiovasc Dis"},{"issue":"2","key":"10.1016\/j.jep.2022.115631_bib38","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.earlhumdev.2010.11.006","article-title":"Glucocorticoid receptor-9beta polymorphism is associated with systolic blood pressure and heart growth during early childhood. The Generation R Study","volume":"87","author":"Geelhoed","year":"2011","journal-title":"Early Hum. Dev."},{"issue":"6","key":"10.1016\/j.jep.2022.115631_bib39","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1111\/j.1365-2265.2012.04439.x","article-title":"BClI polymorphism of the glucocorticoid receptor gene is associated with increased obesity, impaired glucose metabolism and dyslipidaemia in patients with Addison\u2019s disease","volume":"77","author":"Giordano","year":"2012","journal-title":"Clin. Endocrinol."},{"issue":"21","key":"10.1016\/j.jep.2022.115631_bib40","doi-asserted-by":"crossref","first-page":"8685","DOI":"10.1073\/pnas.0701361104","article-title":"The human disease network","volume":"104","author":"Goh","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.jep.2022.115631_bib41","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nm.3090","article-title":"Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression","volume":"19","author":"Golden","year":"2013","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.jep.2022.115631_bib42","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.cpr.2007.05.005","article-title":"Depression and coronary heart disease: a review of the epidemiological evidence, explanatory mechanisms and management approaches","volume":"28","author":"Goldston","year":"2008","journal-title":"Clin. Psychol. Rev."},{"issue":"13","key":"10.1016\/j.jep.2022.115631_bib43","doi-asserted-by":"crossref","first-page":"6809","DOI":"10.3390\/ijms22136809","article-title":"Melatonin in early nutrition: long-term effects on cardiovascular system","volume":"22","author":"Gombert","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.jep.2022.115631_bib44","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1159\/000486794","article-title":"Antidepressant use by class: association with major adverse cardiac events in patients with coronary artery disease","volume":"87","author":"Grace","year":"2018","journal-title":"Psychother. Psychosom."},{"issue":"3","key":"10.1016\/j.jep.2022.115631_bib45","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1134\/S0006297917030014","article-title":"Molecular mechanisms of neuroplasticity: an expanding universe","volume":"82","author":"Gulyaeva","year":"2017","journal-title":"Biochemistry (Mosc.)"},{"key":"10.1016\/j.jep.2022.115631_bib46","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.bbi.2015.06.001","article-title":"Cumulative meta-analysis of interleukins 6 and 1\u03b2, tumour necrosis factor \u03b1 and C-reactive protein in patients with major depressive disorder","volume":"49","author":"Haapakoski","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jep.2022.115631_bib47","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ijcard.2017.05.093","article-title":"Hemodynamic, catecholamine, vasomotor and vascular responses: determinants of myocardial ischemia during mental stress","volume":"243","author":"Hammadah","year":"2017","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.jep.2022.115631_bib48","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJMra043430","article-title":"Inflammation, atherosclerosis, and coronary artery disease","volume":"352","author":"Hansson","year":"2005","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.jep.2022.115631_bib49","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/ddr.21214","article-title":"Network pharmacology: a Rosetta Stone for traditional Chinese medicine","volume":"75","author":"Hao","year":"2014","journal-title":"Drug Dev. Res."},{"issue":"3","key":"10.1016\/j.jep.2022.115631_bib50","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/CRD.0000000000000021","article-title":"Inflammation and atherosclerosis: a review of the role of interleukin-6 in the development of atherosclerosis and the potential for targeted drug therapy","volume":"22","author":"Hartman","year":"2014","journal-title":"Cardiol. Rev."},{"issue":"10","key":"10.1016\/j.jep.2022.115631_bib51","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.005077","article-title":"Inflammatory biomarkers interleukin\u20106 and C\u2010reactive protein and outcomes in stable coronary heart disease: experiences from the STABILITY (stabilization of atherosclerotic plaque by initiation of darapladib therapy) trial","volume":"6","author":"Held","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.jep.2022.115631_bib52","doi-asserted-by":"crossref","DOI":"10.1177\/2045125320980573","article-title":"Protracted withdrawal syndrome after stopping antidepressants: a descriptive quantitative analysis of consumer narratives from a large internet forum","volume":"10","author":"Hengartner","year":"2020","journal-title":"Ther Adv Psychopharmacol"},{"issue":"2","key":"10.1016\/j.jep.2022.115631_bib53","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1017\/S1461145711000368","article-title":"Subchronic treatment with aldosterone induces depression-like behaviours and gene expression changes relevant to major depressive disorder","volume":"15","author":"Hlavacova","year":"2012","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2022.115631_bib54","first-page":"508","article-title":"Kai-Xin-San suppresses matrix metalloproteinases and myocardial apoptosis in rats with myocardial infarction and depression","volume":"21","author":"Hu","year":"2020","journal-title":"Mol. Med. Rep."},{"issue":"10","key":"10.1016\/j.jep.2022.115631_bib55","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1161\/01.ATV.19.10.2364","article-title":"Interleukin-6 exacerbates early atherosclerosis in mice","volume":"19","author":"Huber","year":"1999","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"10","key":"10.1016\/j.jep.2022.115631_bib56","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1096\/fj.04-3099fje","article-title":"STAT3 is a potential modulator of HIF\u20101\u2010mediated VEGF expression in human renal carcinoma cells","volume":"19","author":"Jung","year":"2005","journal-title":"Faseb. J."},{"issue":"2","key":"10.1016\/j.jep.2022.115631_bib57","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s00213-006-0555-4","article-title":"Different responses to dexamethasone and prednisolone in the same depressed patients","volume":"189","author":"Juruena","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"issue":"10","key":"10.1016\/j.jep.2022.115631_bib58","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/S0046-8177(87)80220-4","article-title":"Neovascularization and coronary atherosclerotic plaque: cinematographic localization and quantitative histologic analysis","volume":"18","author":"Kamat","year":"1987","journal-title":"Hum. Pathol."},{"issue":"5","key":"10.1016\/j.jep.2022.115631_bib59","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1097\/01.psy.0000233237.79085.57","article-title":"Course of depressive symptoms after myocardial infarction and cardiac prognosis: a latent class Analysis","volume":"68","author":"Kaptein","year":"2006","journal-title":"Psychosom. Med."},{"issue":"2","key":"10.1016\/j.jep.2022.115631_bib60","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/0006-8993(86)91355-7","article-title":"Female rats are more vulnerable than males in an animal model of depression: the possible role of serotonin","volume":"382","author":"Kennett","year":"1986","journal-title":"Brain Res."},{"issue":"7","key":"10.1016\/j.jep.2022.115631_bib61","doi-asserted-by":"crossref","first-page":"3659","DOI":"10.1038\/s41380-020-0857-7","article-title":"Correction: shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort","volume":"26","author":"Khandaker","year":"2021","journal-title":"Mol. Psychiatr."},{"issue":"10","key":"10.1016\/j.jep.2022.115631_bib62","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1002\/stem.511","article-title":"Differential regulation of proliferation and differentiation in neural precursor cells by the jak pathway","volume":"28","author":"Kim","year":"2010","journal-title":"Stem Cell."},{"issue":"5082","key":"10.1016\/j.jep.2022.115631_bib63","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1126\/science.1411569","article-title":"Interleukin-6 and its receptor: a paradigm for cytokines","volume":"258","author":"Kishimoto","year":"1992","journal-title":"Science."},{"issue":"37","key":"10.1016\/j.jep.2022.115631_bib64","doi-asserted-by":"crossref","first-page":"34573","DOI":"10.1074\/jbc.M205059200","article-title":"Macrophage foam cell formation with native low density lipoprotein","volume":"277","author":"Kruth","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.jep.2022.115631_bib65","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1055\/s-2002-35401","article-title":"Systematic review of prospective cohort studies of psychosocial factors in the etiology and prognosis of coronary heart disease","volume":"2","author":"Kuper","year":"2002","journal-title":"Semin. Vasc. Med."},{"issue":"3","key":"10.1016\/j.jep.2022.115631_bib66","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1600-0447.2009.01463.x","article-title":"Serum adiponectin and resistin levels in major depressive disorder","volume":"121","author":"Lehto","year":"2010","journal-title":"Acta Psychiatr. Scand."},{"issue":"9","key":"10.1016\/j.jep.2022.115631_bib67","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1161\/hc0902.104707","article-title":"Five-year risk of cardiac mortality in relation to initial severity and one-year changes in depression symptoms after myocardial infarction","volume":"105","author":"Lesp\u00e9rance","year":"2002","journal-title":"Circulation."},{"issue":"12","key":"10.1016\/j.jep.2022.115631_bib68","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1161\/CIR.0000000000000019","article-title":"Depression as a risk factor for poor prognosis among patients with acute coronary syndrome: systematic review and recommendations: a scientific statement from the American heart association","volume":"129","author":"Lichtman","year":"2014","journal-title":"Circulation."},{"key":"10.1016\/j.jep.2022.115631_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111552","article-title":"Hesperetin modulates the Sirt1\/Nrf2 signaling pathway in counteracting myocardial ischemia through suppression of oxidative stress, inflammation, and apoptosis","volume":"139","author":"Liu","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2022.115631_bib70","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.trsl.2021.01.007","article-title":"Mechanism of IL-6-related spontaneous atrial fibrillation after coronary artery grafting surgery: IL-6 knockout mouse study and human observation","volume":"233","author":"Liu","year":"2021","journal-title":"Transl. Res."},{"issue":"4","key":"10.1016\/j.jep.2022.115631_bib71","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods."},{"issue":"1","key":"10.1016\/j.jep.2022.115631_bib72","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s11655-019-3064-0","article-title":"Network pharmacology in research of Chinese medicine formula: methodology, application and prospective","volume":"26","author":"Luo","year":"2020","journal-title":"Chin. J. Integr. Med."},{"issue":"3","key":"10.1016\/j.jep.2022.115631_bib73","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1001\/archgenpsychiatry.2010.2","article-title":"Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies","volume":"67","author":"Luppino","year":"2010","journal-title":"Arch. Gen. Psychiatr."},{"issue":"6801","key":"10.1016\/j.jep.2022.115631_bib74","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/35025203","article-title":"Atherosclerosis","volume":"407","author":"Lusis","year":"2000","journal-title":"Nature."},{"issue":"1","key":"10.1016\/j.jep.2022.115631_bib75","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0165-1781(93)90027-E","article-title":"Relationships between interleukin-6 activity, acute phase proteins, and function of the hypothalamic-pituitary-adrenal axis in severe depression","volume":"49","author":"Maes","year":"1993","journal-title":"Psychiatr. Res."},{"issue":"8","key":"10.1016\/j.jep.2022.115631_bib76","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1001\/archinte.166.8.876","article-title":"Depressive symptoms after acute myocardial infarction: evidence for highest rates in younger women","volume":"166","author":"Mallik","year":"2006","journal-title":"Arch. Intern. Med."},{"issue":"3","key":"10.1016\/j.jep.2022.115631_bib77","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.jpsychires.2012.11.002","article-title":"Glucocorticoid and mineralocorticoid receptor expression in the human hippocampus in major depressive disorder","volume":"47","author":"Medina","year":"2013","journal-title":"J. Psychiatr. Res."},{"issue":"12","key":"10.1016\/j.jep.2022.115631_bib78","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.2337\/dc08-0985","article-title":"Depression and type 2 diabetes over the lifespan: a meta-analysis","volume":"31","author":"Mezuk","year":"2008","journal-title":"Diabetes Care"},{"issue":"1","key":"10.1016\/j.jep.2022.115631_bib79","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nri.2015.5","article-title":"The role of inflammation in depression: from evolutionary imperative to modern treatment target","volume":"16","author":"Miller","year":"2016","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.jep.2022.115631_bib80","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-30487-6","article-title":"IL-1\u03b2, IL-6, TNF- \u03b1 and CRP in elderly patients with depression or Alzheimer\u2019s disease: systematic review and meta-analysis","volume":"8","author":"Ng","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2022.115631_bib81","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3389\/fendo.2017.00070","article-title":"Stress-related and circadian secretion and target tissue actions of glucocorticoids: impact on health","volume":"8","author":"Nicolaides","year":"2017","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.jep.2022.115631_bib82","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bbi.2015.02.002","article-title":"Insufficient glucocorticoid signaling and elevated inflammation in coronary heart disease patients with comorbid depression","volume":"48","author":"Nikkheslat","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jep.2022.115631_bib83","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1017\/S0033291719004082","article-title":"Time-dependent cognitive and somatic symptoms of depression as predictors of new cardiac-related events in at-risk patients: the UPBEAT-UK cohort","volume":"51","author":"Norton","year":"2021","journal-title":"Psychol. Med."},{"issue":"42","key":"10.1016\/j.jep.2022.115631_bib84","doi-asserted-by":"crossref","first-page":"17035","DOI":"10.1073\/pnas.1302546110","article-title":"Essential role of stress hormone signaling in cardiomyocytes for the prevention of heart disease","volume":"110","author":"Oakley","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"5","key":"10.1016\/j.jep.2022.115631_bib85","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0006-3223(00)01088-X","article-title":"Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment","volume":"49","author":"Pariante","year":"2001","journal-title":"Biol. Psychiatr."},{"issue":"8","key":"10.1016\/j.jep.2022.115631_bib86","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/j.febslet.2008.02.011","article-title":"Network medicine","volume":"582","author":"Pawson","year":"2008","journal-title":"FEBS Lett."},{"issue":"10","key":"10.1016\/j.jep.2022.115631_bib87","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1177\/2047487314543075","article-title":"Psychosocial aspects in cardiac rehabilitation: from theory to practice. A position paper from the cardiac rehabilitation section of the European association of cardiovascular prevention and rehabilitation of the European society of cardiology","volume":"22","author":"Pogosova","year":"2015","journal-title":"Eur J Prev Cardiol."},{"issue":"5604","key":"10.1016\/j.jep.2022.115631_bib88","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/266730a0","article-title":"Depression: a new animal model sensitive to antidepressant treatments","volume":"266","author":"Porsolt","year":"1977","journal-title":"Nature."},{"issue":"7","key":"10.1016\/j.jep.2022.115631_bib89","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nrrheum.2017.83","article-title":"The role of IL-6 in host defence against infections: immunobiology and clinical implications","volume":"13","author":"Rose-John","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"issue":"16","key":"10.1016\/j.jep.2022.115631_bib90","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1161\/01.CIR.99.16.2192","article-title":"Impact of psychological factors on the pathogenesis of cardiovascular disease and implications for therapy","volume":"99","author":"Rozanski","year":"1999","journal-title":"Circulation."},{"issue":"2","key":"10.1016\/j.jep.2022.115631_bib91","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.neuron.2012.01.003","article-title":"JAK\/STAT: the enigma within the mystery of NMDAR-LTD","volume":"73","author":"Sacktor","year":"2012","journal-title":"Neuron."},{"issue":"2","key":"10.1016\/j.jep.2022.115631_bib92","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1124\/jpet.300.3.729","article-title":"Role of inflammatory mediators in thrombogenesis","volume":"300","author":"Shebuski","year":"2002","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.jep.2022.115631_bib93","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1749-6632.2012.06633.x","article-title":"Glucocorticoid regulation of inflammation and its functional correlates: from HPA axis to glucocorticoid receptor dysfunction: glucocorticoid resistance in inflammatory disease","volume":"1261","author":"Silverman","year":"2012","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"1","key":"10.1016\/j.jep.2022.115631_bib94","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/path.2518","article-title":"Novel concepts in atherogenesis: angiogenesis and hypoxia in atherosclerosis","volume":"218","author":"Sluimer","year":"2009","journal-title":"J. Pathol."},{"key":"10.1016\/j.jep.2022.115631_bib95","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1001\/jamacardio.2021.3079","article-title":"Interleukin 6 and cardiovascular outcomes in patients with chronic kidney disease and chronic coronary syndrome","volume":"6(12)","author":"Batra","year":"2021","journal-title":"JAMA Cardiol."},{"issue":"6","key":"10.1016\/j.jep.2022.115631_bib96","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/nrcardio.2012.45","article-title":"Stress and cardiovascular disease","volume":"9","author":"Steptoe","year":"2012","journal-title":"Nat. Rev. Cardiol."},{"issue":"1","key":"10.1016\/j.jep.2022.115631_bib97","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1525-1497.2005.00269.x","article-title":"Prevalence of depression in survivors of acute myocardial infarction: review of the evidence","volume":"21","author":"Thombs","year":"2006","journal-title":"J. Gen. Intern. Med."},{"issue":"6","key":"10.1016\/j.jep.2022.115631_bib98","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1172\/JCI80590","article-title":"Role of the circadian system in cardiovascular disease","volume":"128","author":"Thosar","year":"2018","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.jep.2022.115631_bib99","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.jpsychores.2014.10.001","article-title":"The anxious heart in whose mind? A systematic review and meta-regression of factors associated with anxiety disorder diagnosis, treatment and morbidity risk in coronary heart disease","volume":"77","author":"Tully","year":"2014","journal-title":"J. Psychosom. Res."},{"issue":"1","key":"10.1016\/j.jep.2022.115631_bib100","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/s41569-020-0431-7","article-title":"Ageing and atherosclerosis: vascular intrinsic and extrinsic factors and potential role of IL-6","volume":"18","author":"Tyrrell","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"issue":"6","key":"10.1016\/j.jep.2022.115631_bib101","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/gps.1723","article-title":"Depression and the risk for cardiovascular diseases: systematic review and meta analysis","volume":"22","author":"Van der Kooy","year":"2007","journal-title":"Int. J. Geriatr. Psychiatr."},{"issue":"6","key":"10.1016\/j.jep.2022.115631_bib102","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1097\/MOL.0b013e3283587543","article-title":"Novel anti-inflammatory strategies in atherosclerosis","volume":"23","author":"van der Valk","year":"2012","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.jep.2022.115631_bib103","article-title":"Psychosocial stress and cardiovascular risk - current opinion","author":"von","year":"2012","journal-title":"Swiss Med. Wkly."},{"issue":"1","key":"10.1016\/j.jep.2022.115631_bib104","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s11655-015-2110-9","article-title":"Systematic review on randomized controlled trials of coronary heart disease complicated with depression treated with Chinese herbal medicines","volume":"22","author":"Wang","year":"2016","journal-title":"Chin. J. Integr. Med."},{"issue":"1","key":"10.1016\/j.jep.2022.115631_bib105","first-page":"1","article-title":"TCM network pharmacology: a new trend towards combining computational, experimental and clinical approaches","volume":"19","author":"Wang","year":"2021","journal-title":"Chin. J. Nat. Med."},{"issue":"2","key":"10.1016\/j.jep.2022.115631_bib106","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.112.000068","article-title":"Association of anxiety and depression with all\u2010cause mortality in individuals with coronary heart disease","volume":"2","author":"Watkins","year":"2013","journal-title":"J. Am. Heart Assoc."},{"issue":"1","key":"10.1016\/j.jep.2022.115631_bib107","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1210\/en.2017-00728","article-title":"Glucocorticoid signaling in health and disease: insights from tissue-specific GR knockout mice","volume":"159","author":"Whirledge","year":"2018","journal-title":"Endocrinology"},{"issue":"20","key":"10.1016\/j.jep.2022.115631_bib108","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1001\/jama.2008.711","article-title":"Depressive symptoms, health behaviors, and risk of cardiovascular events in patients with coronary heart disease","volume":"300","author":"Whooley","year":"2008","journal-title":"JAMA."},{"issue":"4","key":"10.1016\/j.jep.2022.115631_bib109","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1097\/PSY.0000000000000689","article-title":"Platelet serotonin signaling in patients with cardiovascular disease and comorbid depression","volume":"81","author":"Williams","year":"2019","journal-title":"Psychosom. Med."},{"issue":"3","key":"10.1016\/j.jep.2022.115631_bib110","doi-asserted-by":"crossref","DOI":"10.1016\/j.cpcardiol.2019.03.002","article-title":"New insights into the comorbidity of coronary heart disease and depression","volume":"46","author":"Wu","year":"2021","journal-title":"Curr. Probl. Cardiol."},{"issue":"8","key":"10.1016\/j.jep.2022.115631_bib111","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s11655-019-2702-x","article-title":"Oral Chinese herbal medicine for depressive disorder in patients after percutaneous coronary intervention: a systematic review and meta-analysis","volume":"26","author":"Xue","year":"2020","journal-title":"Chin. J. Integr. Med."},{"issue":"143","key":"10.1016\/j.jep.2022.115631_bib112","first-page":"e58276","article-title":"Evaluating the anti-depression effect of xiaoyaosan on chronically-stressed mice","author":"Yan","year":"2019","journal-title":"J Vis Exp."},{"issue":"15","key":"10.1016\/j.jep.2022.115631_bib113","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1017\/S0033291718000090","article-title":"Association between increased serum interleukin-6 levels and sustained attention deficits in patients with major depressive disorder","volume":"48","author":"Ye","year":"2018","journal-title":"Psychol. Med."},{"issue":"10","key":"10.1016\/j.jep.2022.115631_bib114","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1007\/s10072-020-04381-x","article-title":"Mendelian randomization study to evaluate the effects of interleukin-6 signaling on four neurodegenerative diseases","volume":"41","author":"Zhang","year":"2020","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.jep.2022.115631_bib115","article-title":"An integrative pharmacology-based strategy to uncover the mechanism of xiong-pi-fang in treating coronary heart disease with depression","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Pharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122006705?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122006705?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:34:34Z","timestamp":1759944874000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874122006705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":115,"alternative-id":["S0378874122006705"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2022.115631","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanisms of Xiong-Pi-Fang in treating coronary heart disease associated with depression: A systematic pharmacology strategy and in vivo pharmacological validation","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2022.115631","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115631"}}