{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:37:42Z","timestamp":1788961062883,"version":"build-2803163510"},"reference-count":102,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.jep.2022.115650","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T02:20:11Z","timestamp":1660789211000},"page":"115650","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":77,"special_numbering":"C","title":["A comprehensive review on ethnopharmacological, phytochemical, pharmacological and toxicological evaluation, and quality control of Pinellia ternata (Thunb.) Breit."],"prefix":"10.1016","volume":"298","author":[{"given":"Jing","family":"Bai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbo","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengtao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.jep.2022.115650_bib1","first-page":"1059","article-title":"Comparision of expectorant and antitussive actions between pinellia tubers from different areas of production","volume":"20","author":"Bai","year":"2004","journal-title":"Chin. Pharmacol. Bull."},{"issue":"1","key":"10.1016\/j.jep.2022.115650_bib2","first-page":"17","article-title":"Research progress on the medicinal plant Pinellia","volume":"26","author":"Cai","year":"2004","journal-title":"Foreign Med. Sci."},{"issue":"4","key":"10.1016\/j.jep.2022.115650_bib3","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S0031-9422(03)00421-7","article-title":"Pinelloside, an antimicrobial cerebroside from Pinellia ternata","volume":"64","author":"Chen","year":"2003","journal-title":"Phytochemistry"},{"issue":"2","key":"10.1016\/j.jep.2022.115650_bib4","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jchromb.2006.05.028","article-title":"Characterization and quantification of eight water-soluble constituents in tubers of Pinellia ternata and in tea granules from the Chinese multiherb remedy Xiaochaihu-tang","volume":"843","author":"Chen","year":"2006","journal-title":"J. Chromatogr. B"},{"issue":"5","key":"10.1016\/j.jep.2022.115650_bib5","first-page":"919","article-title":"Combination of fingerprint and chemometrics for identification of four processed products of Pinelliae Rhizoma based on nucleosides and nucleobases","volume":"41","author":"Chen","year":"2021","journal-title":"Chin. J. Pharm. Anal."},{"issue":"2","key":"10.1016\/j.jep.2022.115650_bib6","first-page":"44","article-title":"Identification of Pinellia ternata and Rhizoma Pinelliae with thin layer chromatography","volume":"14","author":"Chen","year":"2018","journal-title":"Asia-Pacific Tradit. Med."},{"issue":"24","key":"10.1016\/j.jep.2022.115650_bib7","first-page":"7428","article-title":"Effect of multi-material and multi-process processing on chemical composition of Pinellia ternata based on UPLC-Q-TOF-MS\/MS","volume":"52","author":"Cui","year":"2021","journal-title":"Chin. Tradit. Herb. Drugs"},{"issue":"1","key":"10.1016\/j.jep.2022.115650_bib8","first-page":"52","article-title":"Extraction process of ginger Pinellia and its anti-proliferative and proapoptotic activities on human gastric cancer SGC7901 cells","volume":"27","author":"Cui","year":"2016","journal-title":"Biomed. Res-India"},{"issue":"4","key":"10.1016\/j.jep.2022.115650_bib9","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1007\/s11418-020-01425-6","article-title":"The acrid raphides in tuberous root of Pinellia ternata have lipophilic character and are specifically denatured by ginger extract","volume":"74","author":"Fueki","year":"2020","journal-title":"J. Nat. Med."},{"issue":"3","key":"10.1016\/j.jep.2022.115650_bib10","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1007\/s11418-021-01501-5","article-title":"Correction to: the acrid raphides in tuberous root of Pinellia ternata have lipophilic character and are specifically denatured by ginger extract","volume":"75","author":"Fueki","year":"2021","journal-title":"J. Nat. Med."},{"issue":"4","key":"10.1016\/j.jep.2022.115650_bib11","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1080\/11263504.2013.852633","article-title":"Influence of outbreak of macroalgal blooms on phosphorus release from the sediments in Swan Lake Wetland, China","volume":"147","author":"Gao","year":"2013","journal-title":"Plant Biosyst."},{"issue":"7","key":"10.1016\/j.jep.2022.115650_bib12","first-page":"25","article-title":"Comparative study of wild Pinelliae rhizome and cultivated Pinelliae rhizome on cough expectorant","volume":"30","author":"Gao","year":"2010","journal-title":"J. Hunan Univ. Tradit. Chin. Med."},{"issue":"12","key":"10.1016\/j.jep.2022.115650_bib13","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1248\/bpb.17.1549","article-title":"Characterization of an acidic polysaccharide with immunological activities from the tuber of Pinellia ternata","volume":"17","author":"Gonda","year":"1994","journal-title":"Biol. Pharm. Bull."},{"issue":"1","key":"10.1016\/j.jep.2022.115650_bib14","first-page":"1","article-title":"Comparative study on the influence of different alcohol extracted crafts on the content of total alkaloid and acute toxicity of Rhizoma Pinelliae in mice","volume":"8","author":"Gong","year":"2011","journal-title":"Chin. J. Pharmacovigilance."},{"issue":"11\u201312","key":"10.1016\/j.jep.2022.115650_bib15","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1365\/s10337-006-0103-8","article-title":"Phytochemical study of the Rhizome of Pinellia ternata and quantification of phenylpropanoids in commercial Pinellia tuber by RP-LC","volume":"64","author":"Han","year":"2006","journal-title":"Chromatographia"},{"issue":"17","key":"10.1016\/j.jep.2022.115650_bib16","first-page":"1755","article-title":"Bioactive constituents inhibiting TNF-alpha production in fresh rhizome of Pinellia ternata","volume":"32","author":"Han","year":"2007","journal-title":"China J. Chin. Mater. Med."},{"issue":"4","key":"10.1016\/j.jep.2022.115650_bib17","first-page":"518","article-title":"Analysis on application law of dampness-removing traditional Chinese medicines in treatment of coronavirus disease 2019","volume":"13","author":"Hao","year":"2021","journal-title":"Chin. Herb. Med."},{"issue":"4","key":"10.1016\/j.jep.2022.115650_bib18","first-page":"414","article-title":"Determination of calcium oxalate in Pinellia ternata and the processed products from different habitats by UPLC. West China J","volume":"32","author":"He","year":"2017","journal-title":"Pharm. Sci."},{"issue":"5","key":"10.1016\/j.jep.2022.115650_bib19","first-page":"1024","article-title":"Research progress on potential application of gualou xiebai banxia decoction in prevention and treatment of COVID-19","volume":"35","author":"He","year":"2020","journal-title":"Drugs & Clinic"},{"issue":"9","key":"10.1016\/j.jep.2022.115650_bib20","first-page":"671","article-title":"Study on chemical constituents in rhizome of Pinellia ternata","volume":"30","author":"He","year":"2005","journal-title":"China J. Chin. Mater. Med."},{"issue":"11","key":"10.1016\/j.jep.2022.115650_bib21","first-page":"6","article-title":"Textual research on Pinelliae Rhizoma","author":"Hu","year":"1989","journal-title":"China J. Chin. Mater. Med."},{"issue":"10","key":"10.1016\/j.jep.2022.115650_bib22","first-page":"1773","article-title":"Research progress on pharmacological effects and toxicity of Pinellia ternata","volume":"32","author":"Huang","year":"2020","journal-title":"Nat. Prod. Res. Dev."},{"issue":"24","key":"10.1016\/j.jep.2022.115650_bib23","first-page":"103","article-title":"Preliminary studies on the in vitro antibacterial activities of Pinellia ternata extract by ethanol","volume":"27","author":"Huang","year":"2011","journal-title":"Chin. Agric. Sci. Bull."},{"issue":"6","key":"10.1016\/j.jep.2022.115650_bib24","first-page":"793","article-title":"Comparison of expectorant effect between pinellia rhizoma and processed Pinellia Rhizoma on rats with syndrome of cold-damp amassing in lung","volume":"39","author":"Huang","year":"2019","journal-title":"Jilin J. Tradit. Chin. Med."},{"issue":"11","key":"10.1016\/j.jep.2022.115650_bib25","first-page":"64","article-title":"Preliminary research on toxic substances foundation of Pinelliae Rhizoma","volume":"15","author":"Huang","year":"2013","journal-title":"J. Liaoning Univ. Tradit. Chin. Med."},{"issue":"2","key":"10.1016\/j.jep.2022.115650_bib26","doi-asserted-by":"crossref","first-page":"127","DOI":"10.5650\/jos.ess13092","article-title":"Chemical composition and major odor-active compounds of essential oil from Pinellia tuber (dried rhizome of Pinellia ternata) as crude drug","volume":"63","author":"Iwasa","year":"2014","journal-title":"J. Oleo Sci."},{"key":"10.1016\/j.jep.2022.115650_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fitote.2013.12.010","article-title":"The ethnobotanical, phytochemical and pharmacological profile of the genus Pinellia","volume":"93","author":"Ji","year":"2014","journal-title":"Fitoterapia"},{"issue":"7","key":"10.1016\/j.jep.2022.115650_bib28","first-page":"1717","article-title":"Toxic components and processing mechanism of Rhizoma Pinelliae","volume":"30","author":"Jin","year":"2019","journal-title":"Lishizhen Med. Mater. Med. Res."},{"issue":"39","key":"10.1016\/j.jep.2022.115650_bib29","first-page":"3652","article-title":"Sputum removing and cough relieving effects of 5 different solvent extracts of Pinellia ternata on mice","volume":"23","author":"Ke","year":"2012","journal-title":"China Pharm"},{"issue":"6","key":"10.1016\/j.jep.2022.115650_bib30","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1248\/bpb.29.1278","article-title":"Anti-obesity effect of Pinellia ternata extract in Zucker rats","volume":"29","author":"Kim","year":"2006","journal-title":"Biol. Pharm. Bull."},{"issue":"1","key":"10.1016\/j.jep.2022.115650_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-32852-x","article-title":"Antimicrobial genes from Allium sativum and Pinellia ternata revealed by a Bacillus subtilis expression system","volume":"8","author":"Kong","year":"2018","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.jep.2022.115650_bib32","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1055\/s-2006-957539","article-title":"Quantitative analysis of anti-emetic principle in the tubers of Pinellia ternata by enzyme immunoassay","volume":"64","author":"Kurata","year":"1998","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2022.115650_bib33","first-page":"1471164","article-title":"Comprehensive chemical profiling of Pinellia species tuber and processed Pinellia tuber by gas chromatography-mass spectrometry and liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry","author":"Lee","year":"2016","journal-title":"J. Chromatogr. A"},{"issue":"1","key":"10.1016\/j.jep.2022.115650_bib34","first-page":"47","article-title":"Research progress on Pinellia ternata","volume":"19","author":"Li","year":"2010","journal-title":"Chin. J. Ethomed. Ethnopharm."},{"key":"10.1016\/j.jep.2022.115650_bib35","series-title":"Development of Total Alkaloids in Pinellia Ternate (Thunb.) Breit., the Ninth Annual Conference of Chinese Medicine Chemistry Branch of China Association of Chinese Medicine","first-page":"5","author":"Li","year":"2014"},{"issue":"3","key":"10.1016\/j.jep.2022.115650_bib36","first-page":"59","article-title":"Preliminary study on germplasm evaluation of Pinellia ternata from different habitats in China","author":"Li","year":"2008","journal-title":"J. Chengdu Univ. Chin. Med."},{"key":"10.1016\/j.jep.2022.115650_bib37","article-title":"Traditional uses, phytochemistry, and pharmacology of toxicodendron vernicifluum (Stokes) F.A. Barkley-A review","volume":"267113476","author":"Li","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"11","key":"10.1016\/j.jep.2022.115650_bib38","first-page":"2546","article-title":"Effect of Pinelliae Rhizoma processed with lime and licorice on toxic lectin protein","volume":"45","author":"Li","year":"2020","journal-title":"China J. Chin. Mater. Med."},{"issue":"5","key":"10.1016\/j.jep.2022.115650_bib39","first-page":"279","article-title":"Analysis of trace elements in processed products of Pinellia ternata (Thunb.) Breit","volume":"16","author":"Li","year":"1991","journal-title":"China J. Chin. Mater. Med."},{"issue":"10","key":"10.1016\/j.jep.2022.115650_bib40","first-page":"37","article-title":"Analysis of amino acids and inorganic elements in Pinelliae Rhizoma","author":"Li","year":"1990","journal-title":"China J. Chin. Mater. Med."},{"issue":"5","key":"10.1016\/j.jep.2022.115650_bib41","first-page":"1121","article-title":"The content of calcium oxalate crystal in different processed products of Pinellia ternata in comparison with the RP- HPLC method","volume":"26","author":"Liang","year":"2015","journal-title":"Lishizhen Med. Mat. Med. Res."},{"issue":"5","key":"10.1016\/j.jep.2022.115650_bib42","first-page":"54","article-title":"Research progress on chemical constituents and pharmacological activities of Pinellia ternata","volume":"42","author":"Luo","year":"2020","journal-title":"Special Wild Econ. Anim. Plant Res."},{"key":"10.1016\/j.jep.2022.115650_bib43","article-title":"Clinical data mining reveals Gancao-Banxia as a potential herbal pair against moderate COVID-19 by dual binding to IL-6\/STAT3","volume":"145105457","author":"Luo","year":"2022","journal-title":"Comput. Biol. Med."},{"issue":"4","key":"10.1016\/j.jep.2022.115650_bib44","first-page":"734","article-title":"Free organic acid in Rhizoma Pinelliae processed products","volume":"16","author":"Luo","year":"2014","journal-title":"Chin. J. Med. Guide."},{"issue":"5","key":"10.1016\/j.jep.2022.115650_bib45","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1055\/s-2006-962759","article-title":"An anti-emetic principle of Pinellia ternata tuber","volume":"53","author":"Maki","year":"1987","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2022.115650_bib46","article-title":"Pinellia ternata (Thunb.) Breit: a review of its germplasm resources, genetic diversity and active components","volume":"263113252","author":"Mao","year":"2020","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.jep.2022.115650_bib47","first-page":"81","article-title":"Active principles of Pinelliae tuber and new preparation of crude drug","volume":"14","author":"Maruno","year":"1997","journal-title":"Wa-Kan iyakugaku zasshi"},{"issue":"1","key":"10.1016\/j.jep.2022.115650_bib48","first-page":"145","article-title":"Amino acids analysis of Pinellia ternate in different growing areas","volume":"30","author":"Mo","year":"2010","journal-title":"Chin. J. Pharm. Anal."},{"issue":"1","key":"10.1016\/j.jep.2022.115650_bib49","doi-asserted-by":"crossref","DOI":"10.4238\/gmr.15017064","article-title":"Molecular identification of the traditional herbal medicines, Arisaematis Rhizoma and Pinelliae Tuber, and common adulterants via universal DNA barcode sequences","volume":"15","author":"Moon","year":"2016","journal-title":"Genet. Mol. Res."},{"issue":"9","key":"10.1016\/j.jep.2022.115650_bib50","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1248\/yakushi1947.85.9_832","article-title":"Studies on the water-soluble constituents of crude drugs. I. On the free amino acids isolated from tuber of Pinellia ternate Breitenbach and Arisaema ringens Schott","volume":"85","author":"Murakami","year":"1965","journal-title":"Yakugaku Zasshi"},{"issue":"8","key":"10.1016\/j.jep.2022.115650_bib51","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/S1567-5769(02)00086-3","article-title":"Pinellic acid from the tuber of Pinellia ternata Breitenbach as an effective oral adjuvant for nasal influenza vaccine","volume":"2","author":"Nagai","year":"2002","journal-title":"Int. Immunopharm."},{"issue":"7","key":"10.1016\/j.jep.2022.115650_bib52","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1248\/cpb.26.2096","article-title":"Isolation of l-ephedrine from pinelliae tuber","volume":"26","author":"Oshio","year":"1978","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.jep.2022.115650_bib53","series-title":"Method for Evaluating Quality of Pinellia Ternata and Pinella Yaoluopingensis Based on Organic Acid","author":"Ou","year":"2021"},{"key":"10.1016\/j.jep.2022.115650_bib54","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1248\/yakushi1947.82.5_766","article-title":"Studies on the ingredients of Pinellia ternata Breitenbach. III. Steryl glucoside of Pinellia ternata Breitenbach","volume":"82","author":"OZEKI","year":"1962","journal-title":"Yakugaku Zasshi"},{"issue":"3","key":"10.1016\/j.jep.2022.115650_bib55","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1002\/jssc.201700901","article-title":"Rapid analysis of traditional Chinese medicine Pinellia ternata by microchip electrophoresis with electrochemical detection","volume":"41","author":"Shih","year":"2018","journal-title":"J. Separ. Sci."},{"issue":"5","key":"10.1016\/j.jep.2022.115650_bib56","first-page":"411","article-title":"Inhibitory effect of total alkaloids from Pinellia ternata on the proliferation of human breast cancer cells","volume":"26","author":"Sun","year":"2012","journal-title":"Mil. Med. J. South Chin."},{"issue":"8","key":"10.1016\/j.jep.2022.115650_bib57","first-page":"2047","article-title":"The molecular mechanism of treating COVID 19 with Huashi Baidu formula based on network pharmacology","volume":"43","author":"Sun","year":"2020","journal-title":"Chin. Med. Mat."},{"issue":"8","key":"10.1016\/j.jep.2022.115650_bib58","first-page":"1307","article-title":"Studies on the irritating substance of Pinellia ternata Breitenbach (Araceae)","volume":"19","author":"Suzuki","year":"1969","journal-title":"Arzneim. Forsch."},{"issue":"1","key":"10.1016\/j.jep.2022.115650_bib59","first-page":"77","article-title":"Isolation, crystallization, biological activities and some chemical characteristics of pinellin","author":"Tao","year":"1981","journal-title":"Acta Biochim. Biophys. Sin."},{"issue":"5","key":"10.1016\/j.jep.2022.115650_bib60","first-page":"289","article-title":"The theoretical basis and mechanism of Qingfei Paidu decoction in the treatment of COVID-19","volume":"22","author":"Tian","year":"2020","journal-title":"Chin. J. Med. Guide."},{"issue":"6","key":"10.1016\/j.jep.2022.115650_bib61","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1248\/bpb.17.859","article-title":"A glucan having reticuloendothelial system-potentiating and anti-complementary activities from the tuber of Pinellia ternata","volume":"17","author":"Tomoda","year":"1994","journal-title":"Biol. Pharm. Bull."},{"issue":"2","key":"10.1016\/j.jep.2022.115650_bib62","first-page":"15","article-title":"Determination of total acid in Pinellia ternata of various populations by potentiometric titration","volume":"1","author":"Wang","year":"2010","journal-title":"Pharm. Clin. Chin. Materia Medica"},{"issue":"11","key":"10.1016\/j.jep.2022.115650_bib63","first-page":"1588","article-title":"Study on antibacterial activities of Pinellia ternata against bacteria and fungi in vitro","volume":"18","author":"Wang","year":"2009","journal-title":"Proc. Clin. Med."},{"issue":"11","key":"10.1016\/j.jep.2022.115650_bib64","first-page":"1545","article-title":"Effect of starch composition on dissolution of alkaloids in Aconiti Radix co-decocted with Pinelliae Rhizoma or Ampelopsis Radix","volume":"45","author":"Wang","year":"2014","journal-title":"Chin. Tradit. Herb. Drugs"},{"issue":"31","key":"10.1016\/j.jep.2022.115650_bib65","first-page":"108","article-title":"Study on toxic components and processing detoxification mechanism of Pinellia ternata","volume":"27","author":"Wang","year":"2019","journal-title":"Technol. Eco. Guide."},{"issue":"5","key":"10.1016\/j.jep.2022.115650_bib66","first-page":"844","article-title":"Purification and some properties of a trypsin inhibitor from Rhizoma pinelliae","volume":"21","author":"Wang","year":"2009","journal-title":"Nat. Prod. Res. Dev."},{"key":"10.1016\/j.jep.2022.115650_bib67","series-title":"Research on the \u201cDose-time-toxicity\u201d Relationship of Hepatotoxicity and Approach of the Toxicity Influential Factor of Pinellia","first-page":"142","author":"Wang","year":"2010"},{"issue":"2","key":"10.1016\/j.jep.2022.115650_bib68","first-page":"267","article-title":"Identification of Pinellia ternata and its counterfeits based on HPLC fingerprint analysis","volume":"36","author":"Wang","year":"2020","journal-title":"J. Nanjing Univ. Chin. Med."},{"issue":"21","key":"10.1016\/j.jep.2022.115650_bib69","first-page":"2676","article-title":"Research progress on chemical constituents, pharmacological action and toxicity of Pinellia ternata","volume":"31","author":"Wang","year":"2020","journal-title":"China Pharm"},{"key":"10.1016\/j.jep.2022.115650_bib70","series-title":"Method for Evaluating Quality of Rhizoma Pinelliae and Pinella Yaoluopingensis by Using Alkaloid","author":"Wang","year":"2021"},{"issue":"11","key":"10.1016\/j.jep.2022.115650_bib71","first-page":"828","article-title":"Survey of Pinellia ternata and its adulterants","volume":"26","author":"Wei","year":"2003","journal-title":"J. Chin. Med. Mater."},{"issue":"4","key":"10.1016\/j.jep.2022.115650_bib72","first-page":"503","article-title":"HPLC fingerprint of Pinellia ternata","volume":"31","author":"Wen","year":"2008","journal-title":"J. Chin. Med. Mater."},{"issue":"12","key":"10.1016\/j.jep.2022.115650_bib73","first-page":"725","article-title":"Studies on stimulating components of raw Pinellia ternata (Thunb.) (banxia)","volume":"24","author":"Wu","year":"1999","journal-title":"China J. Chin. Mater. Med."},{"issue":"4","key":"10.1016\/j.jep.2022.115650_bib74","first-page":"423","article-title":"The carbohydrate binding specificity of Pinellia lectin","author":"Wu","year":"1981","journal-title":"Acta Biochim. Biophys. Sin."},{"issue":"3","key":"10.1016\/j.jep.2022.115650_bib75","first-page":"267","article-title":"Isolation and characterization of a trypsin inhibitor from the rhizome of Pinellia ternata","author":"Wu","year":"1981","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1016\/j.jep.2022.115650_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.bse.2015.09.002","article-title":"Chemical constituents from the tubers of Pinellia ternata (Araceae) and their chemotaxonomic interest","volume":"62","author":"Wu","year":"2015","journal-title":"Biochem. Systemat. Ecol."},{"issue":"4","key":"10.1016\/j.jep.2022.115650_bib77","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1007\/s11011-022-00930-9","article-title":"Exploring the potential antidepressant mechanisms of Pinellia by using the network pharmacology and molecular docking","volume":"37","author":"Xiao","year":"2022","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.jep.2022.115650_bib78","first-page":"1","article-title":"Preparation of monoclonal antibody against Pinellia ternata lectin protein and establishment of double antibody sandwich ELISA method","author":"Xie","year":"2022","journal-title":"China J. Chin. Mater. Med."},{"issue":"22","key":"10.1016\/j.jep.2022.115650_bib79","first-page":"5912","article-title":"Effect of different parts of Pinelliae Rhizoma Decoction against airway inflammation and analysis of effective components","volume":"46","author":"Xue","year":"2021","journal-title":"China J. Chin. Mater. Med."},{"issue":"1","key":"10.1016\/j.jep.2022.115650_bib80","first-page":"102","article-title":"Study on toxicity of Pinellia ternata decoction","volume":"29","author":"Yan","year":"2012","journal-title":"Inf. Tradit. Chin. Med."},{"issue":"11","key":"10.1016\/j.jep.2022.115650_bib81","first-page":"1992","article-title":"Simultaneous determination of five representative components in Pinelliae Rhizoma by HPLC","volume":"39","author":"Yang","year":"2019","journal-title":"Chin. J. Pharm. Anal."},{"issue":"11","key":"10.1016\/j.jep.2022.115650_bib102","first-page":"955","article-title":"Research on the HPLC characteristic fingerprints of Rhizoma Pinelliae and processed products","volume":"49","author":"Yang","year":"2014","journal-title":"Chin. Phar. J."},{"issue":"17","key":"10.1016\/j.jep.2022.115650_bib82","first-page":"2586","article-title":"Methodological study on quality evaluation of crude and processed Pinelliae Rhizoma based on antitussive bioassay","volume":"46","author":"Yang","year":"2015","journal-title":"Chin. Herb. Med."},{"issue":"3","key":"10.1016\/j.jep.2022.115650_bib83","first-page":"33","article-title":"Toxic mechanism and clinical application of Pinellia ternate","volume":"12","author":"Yang","year":"2021","journal-title":"J. Fourth Mil. Med. Univ."},{"issue":"10","key":"10.1016\/j.jep.2022.115650_bib84","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1007\/s12272-015-0556-0","article-title":"The alum-processing mechanism attenuating toxicity of Araceae Pinellia ternata and Pinellia pedatisecta","volume":"38","author":"Yu","year":"2015","journal-title":"Arch Pharm. Res. (Seoul)"},{"issue":"5","key":"10.1016\/j.jep.2022.115650_bib85","first-page":"1037","article-title":"Study of toxic proteins on raphides from Pinellia ternata and Pinellia pedatisecta Schott","volume":"26","author":"Yu","year":"2011","journal-title":"Chin. J. Tradit. Chin. Med. Pharm."},{"issue":"9","key":"10.1016\/j.jep.2022.115650_bib86","first-page":"150","article-title":"Anti-inflammatory active components and mechanism of Banxia based on network pharmacology","volume":"38","author":"Yuan","year":"2020","journal-title":"Chin. Arch. Tradit. Chin. Med."},{"issue":"23","key":"10.1016\/j.jep.2022.115650_bib87","first-page":"4462","article-title":"Effects of processing on toxic components of Pinellia Rhizoma and its detoxification mechanism","volume":"41","author":"Yuan","year":"2016","journal-title":"China J. Chin. Mater. Med."},{"issue":"6","key":"10.1016\/j.jep.2022.115650_bib88","first-page":"452","article-title":"Ingredients-effect relationship study on antitussive and expectorant of Pinelliae Rhizoma","volume":"15","author":"Zeng","year":"2013","journal-title":"Modern Chin. Med."},{"issue":"7","key":"10.1016\/j.jep.2022.115650_bib89","first-page":"173","article-title":"Chemical components in Pinelliae Rhizoma by UPLC-Q-TOF-MS\/MS","volume":"25","author":"Zhai","year":"2019","journal-title":"Chin. J. Exp. Tradit. Med. Form."},{"issue":"7","key":"10.1016\/j.jep.2022.115650_bib90","first-page":"22","article-title":"Study on anti-tumor effect and mechanism of pinellia ternata polysaccharides in vivo","volume":"28","author":"Zhang","year":"2016","journal-title":"Strait Pharm. J."},{"issue":"6","key":"10.1016\/j.jep.2022.115650_bib91","first-page":"68","article-title":"Effect of different processing methods on the content of amino acid in Pinellia ternata","author":"Zhang","year":"2016","journal-title":"Hunan Agric. Sci."},{"issue":"6","key":"10.1016\/j.jep.2022.115650_bib92","first-page":"1089","article-title":"Research progresses of pharmacological actions in antimicrobial, anti-inflammation and antitumor of extract from Pinelliae Rhizoma","volume":"14","author":"Zhang","year":"2017","journal-title":"Anti-Infect. Pharm."},{"issue":"5","key":"10.1016\/j.jep.2022.115650_bib93","first-page":"466","article-title":"Effects of alkaloids of Pinellia ternata on 5-HT3 receptor and NK1 receptor in isolated Guinea-pig Ileum","volume":"41","author":"Zhang","year":"2017","journal-title":"J. Shandong Univ. Tradit. Chin. Med."},{"issue":"10","key":"10.1016\/j.jep.2022.115650_bib94","first-page":"1620","article-title":"Isolation and structure elucidation of chemical constituents from Pinellia ternata","volume":"36","author":"Zhang","year":"2013","journal-title":"J. Chin. Med. Mater."},{"issue":"1","key":"10.1016\/j.jep.2022.115650_bib95","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jep.2013.06.039","article-title":"General toxicity of Pinellia ternata (Thunb.) Berit. in rat: a metabonomic method for profiling of serum metabolic changes","volume":"149","author":"Zhang","year":"2013","journal-title":"J. Ethnopharmacol."},{"issue":"20","key":"10.1016\/j.jep.2022.115650_bib96","first-page":"1706","article-title":"Study on irritation of calcium oxalate crystal in raw Pinellia ternata","volume":"31","author":"Zhong","year":"2006","journal-title":"China J. Chin. Mater. Med."},{"issue":"1","key":"10.1016\/j.jep.2022.115650_bib97","first-page":"38","article-title":"Proliferation inhibition of total alkaloids from Pinellia ternata in human lung cancer cells","volume":"31","author":"Zhou","year":"2013","journal-title":"J. Pharm. Pract."},{"issue":"3","key":"10.1016\/j.jep.2022.115650_bib98","first-page":"102","article-title":"Study on alkaloids in rhizome of Pinellia ternata","volume":"32","author":"Zhou","year":"2006","journal-title":"Chin. J. Inf. Tradit. Chin. Med."},{"issue":"2","key":"10.1016\/j.jep.2022.115650_bib99","first-page":"86","article-title":"Anti-inflammatory effect of total alkaloids part of rhizoma Pinellia ternata Praeparata","author":"Zhou","year":"2006","journal-title":"J. Nanjing Univ. Chin. Med."},{"issue":"7","key":"10.1016\/j.jep.2022.115650_bib100","first-page":"1007","article-title":"Correlation of Pinellia ternata agglutinin and Pinellia ternata raphides' toxicity","volume":"37","author":"Zhu","year":"2012","journal-title":"China J. Chin. Mater. Med."},{"issue":"1","key":"10.1016\/j.jep.2022.115650_bib101","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/2193-1801-1-13","article-title":"Purification and characterization of a novel plant lectin from Pinellia ternata with antineoplastic activity","volume":"1","author":"Zuo","year":"2012","journal-title":"SpringerPlus"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122006894?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122006894?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:30:54Z","timestamp":1759944654000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874122006894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":102,"alternative-id":["S0378874122006894"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2022.115650","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A comprehensive review on ethnopharmacological, phytochemical, pharmacological and toxicological evaluation, and quality control of Pinellia ternata (Thunb.) Breit.","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2022.115650","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115650"}}