{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T22:51:04Z","timestamp":1781304664047,"version":"3.54.1"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100020149","name":"Institute for Sustainable Malaria Control, University of Pretoria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020149","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.jep.2022.115659","type":"journal-article","created":{"date-parts":[[2022,8,28]],"date-time":"2022-08-28T07:24:30Z","timestamp":1661671470000},"page":"115659","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["In vitro antiplasmodial activity and cytotoxicity of extracts and chromatographic fractions of twigs from Pappea capensis EckI &amp; Zeyh. (Sapindaceae)"],"prefix":"10.1016","volume":"298","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8894-0889","authenticated-orcid":false,"given":"J. Mcebisi","family":"Mabuza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Kaiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Johanna","family":"Bapela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2022.115659_bib1","first-page":"93","article-title":"An investigation into the antimalarial effect of methanolic extract of Paullinia pinnata leaves in Plasmodium berghei infected mice and course of infection","volume":"43","author":"Adeyemo-Salami","year":"2014","journal-title":"Afr. J. Med. Med. Sci."},{"key":"10.1016\/j.jep.2022.115659_bib2","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0022-1759(94)90396-4","article-title":"A new rapid and simple non-radioactive assay to monitor and determine the proliferation of lymphocytes: an alternative to [3H]thymidine incorporation assay","volume":"170","author":"Ahmed","year":"1994","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.jep.2022.115659_bib3","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1080\/19452829.2014.985197","article-title":"Structural and institutional determinants of poverty in sub-Saharan African countries","volume":"16","author":"Akanbi","year":"2015","journal-title":"J. Human Develope. Capability."},{"key":"10.1016\/j.jep.2022.115659_bib5","first-page":"546","article-title":"Antimalarial medicinal plants used by Gumuz people of mandura woreda, benishangul-Gumuz regional state, Ethiopia","volume":"15","author":"Asnake","year":"2016","journal-title":"India J. Trad. Knowledge."},{"key":"10.1016\/j.jep.2022.115659_bib6","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.jep.2014.09.017","article-title":"In vitro antiplasmodial screening of ethnopharmacologically selected South African plant species used for the treatment of malaria","volume":"156","author":"Bapela","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.115659_bib7","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/s12936-020-03231-7","article-title":"The potential of anti-malarial compounds derived from African medicinal plants: a review of pharmacological evaluations from 2013 to 2019","volume":"19","author":"Bekono","year":"2020","journal-title":"Malar. J."},{"key":"10.1016\/j.jep.2022.115659_bib8","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.plipres.2007.10.002","article-title":"New advances in fatty acids as antimalarial, antimycobacterial, and antifungal agents","volume":"47","author":"Carballeira","year":"2008","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.jep.2022.115659_bib9","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4314\/ajtcam.v12i3.2","article-title":"Medicinal plant use of villagers in the Mopani district, Limpopo province, South Africa","volume":"12","author":"Chauke","year":"2015","journal-title":"Afr. J. Tradit., Complementary Altern. Med."},{"key":"10.1016\/j.jep.2022.115659_bib10","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.phytochem.2004.01.019","article-title":"Metabolic fingerprinting of wild type and transgenic tobacco plants by 1H NMR and multivariate analysis technique","volume":"65","author":"Choi","year":"2004","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2022.115659_bib11","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1002\/ptr.2838","article-title":"In vitro evaluation of the antiplasmodial activity of Dendropanax morbifera against chloroquine-sensitive strains of Plasmodium falciparum","volume":"23","author":"Chung","year":"2009","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2022.115659_bib13","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1128\/AAC.16.6.710","article-title":"Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique","volume":"16","author":"Desjardins","year":"1979","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jep.2022.115659_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.21010\/ajid.v14i1.1","article-title":"Callus induction of Sonchus arvensis L. and its antiplasmodial activity","volume":"14","author":"Dwi","year":"2020","journal-title":"Africa J. Infect Dis."},{"key":"10.1016\/j.jep.2022.115659_bib15","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.1021\/ac034173t","article-title":"A perfect smoother","volume":"75","author":"Eilers","year":"2003","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jep.2022.115659_bib16","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1007\/s00436-011-2763-z","article-title":"Antiplasmodial activity of flavonol quercetin and its analogues in Plasmodium falciparum: evidence from clinical isolates in Bangladesh and standardized parasite clones","volume":"110","author":"Ganesh","year":"2012","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.jep.2022.115659_bib17","series-title":"Traditional Medicine in Botswana: Traditional Medicinal Plants","author":"Hedberg","year":"1989"},{"key":"10.1016\/j.jep.2022.115659_bib18","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0001-706X(93)90083-N","article-title":"A comparison of three methods of estimating EC50 in studies of drug resistance of malaria parasites","volume":"55","author":"Huber","year":"1993","journal-title":"Acta Trop."},{"key":"10.1016\/j.jep.2022.115659_bib19","series-title":"Zulu Medicinal Plants: an Inventory","author":"Hutchings","year":"1996"},{"key":"10.1016\/j.jep.2022.115659_bib20","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3762\/bjoc.7.14","article-title":"Synthesis of Ru alkylidene complexes","volume":"7","author":"Kadyrov","year":"2011","journal-title":"Beilstein J. Org. Chem."},{"key":"10.1016\/j.jep.2022.115659_bib21","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3923\/pjn.2012.123.132","article-title":"Phytonutrient, mineral composition, and in vitro antioxidant activity of leaf and stem bark powders of Pappea capensis (L.)","volume":"11","author":"Karau","year":"2012","journal-title":"Pakistan J. Nutr."},{"key":"10.1016\/j.jep.2022.115659_bib22","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jep.2005.03.011","article-title":"Evaluation of plants used for antimalarial treatment by the Maasai of Kenya","volume":"101","author":"Koch","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.115659_bib23","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.3389\/fpls.2017.01302","article-title":"Metabolomics for plant improvement: status and prospects","volume":"8","author":"Kumar","year":"2017","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.jep.2022.115659_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105373","article-title":"Lupeol and its derivatives as anticancer and anti-inflammatory agents: molecular mechanisms and therapeutic efficacy","volume":"164","author":"Liu","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2022.115659_bib25","doi-asserted-by":"crossref","DOI":"10.1055\/s-0034-1394923","article-title":"Ethnobiological survey of Maasai traditional medicinal plants","volume":"80","author":"Makule","year":"2014","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2022.115659_bib26","doi-asserted-by":"crossref","first-page":"14319","DOI":"10.1016\/j.ijhydene.2022.02.175","article-title":"Green synthesis of DyBa2Fe3O7.988\/DyFeO3 nanocomposites using almond extract with dual eco-friendly applications: photocatalytic and antibacterial activities","volume":"47","author":"Mahdi","year":"2022","journal-title":"Int. J. Hydrogen Energy"},{"key":"10.1016\/j.jep.2022.115659_bib27","series-title":"Immunological Methods","first-page":"221","article-title":"Plasmodium falciparum malaria parasite cultures and their use in immunology","author":"Matile","year":"1990"},{"key":"10.1016\/j.jep.2022.115659_bib28","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1080\/01140670809510229","article-title":"Plant regeneration through somatic embryogenesis of jacket plum (Pappea capensis)","volume":"36","author":"Mng\u2019omba","year":"2008","journal-title":"N. Z. J. Crop Hortic. Sci."},{"key":"10.1016\/j.jep.2022.115659_bib29","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1055\/s-0033-1350691","article-title":"Antiprotozoal screening of 60 South African plants, and the identification of the antitrypanosomal germacranolides schkuhrin I and II","volume":"79","author":"Mokoka","year":"2013","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2022.115659_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2011\/171684","article-title":"Rapid determination of total thujone in absinthe using 1H NMR spectroscopy","volume":"2011","author":"Monakhova","year":"2011","journal-title":"Int. J. Spectrosc."},{"key":"10.1016\/j.jep.2022.115659_bib31","first-page":"726","article-title":"Antiprotozoal activity and cytotoxicity of metabolites from leaves of Teclea trichocarpa","volume":"4","author":"Mwangi","year":"2010","journal-title":"J. Med. Plants Res."},{"key":"10.1016\/j.jep.2022.115659_bib32","series-title":"Chemistry WebBook","year":"2011"},{"key":"10.1016\/j.jep.2022.115659_bib33","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jep.2006.10.036","article-title":"In vitro antiprotozoal activities and cytotoxicity of some selected Cameroonian medicinal plants","volume":"111","author":"Ndjakou","year":"2007","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.115659_bib34","series-title":"Trees of Southern Africa: Covering All Known Indigenous Species in the Republic of South Africa, South-West Africa, Botswana, Lesotho & Swaziland","author":"Palmer","year":"1972"},{"key":"10.1016\/j.jep.2022.115659_bib35","first-page":"50","article-title":"Chloriquine sensitivity of isolates of Plasmodium falciparum adapted to in vitro culture","volume":"33","author":"Ponnudurai","year":"1981","journal-title":"TGM (Trop. Geogr. Med.)"},{"key":"10.1016\/j.jep.2022.115659_bib36","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.sajb.2010.10.011","article-title":"Gender expression and inflorescence structure of Pappea capensis Eckl. And Zeyh. (Sapindaceae)","volume":"77","author":"Robbertse","year":"2011","journal-title":"South Afr. J. Bot."},{"key":"10.1016\/j.jep.2022.115659_bib37","doi-asserted-by":"crossref","first-page":"3875","DOI":"10.3390\/molecules26133875","article-title":"Antiplasmodial and cytotoxic flavonoids from Pappea capensis (Eckl. & Zeyh.) leaves","volume":"26","author":"Tajuddeen","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2022.115659_bib38","first-page":"1","article-title":"Alkaloids from plants with antimalarial activity: a review of recent studies","volume":"2020","author":"Uzor","year":"2020","journal-title":"Evid. base Compl. Alternative Med."},{"key":"10.1016\/j.jep.2022.115659_bib39","series-title":"Making the Most of Indigenous Trees","author":"Venter","year":"1996"},{"key":"10.1016\/j.jep.2022.115659_bib40","series-title":"People's Plants: a Guide to Useful Plants of Southern Africa","author":"Van Wyk","year":"2000"},{"key":"10.1016\/j.jep.2022.115659_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0254804","article-title":"Growth, secondary metabolite production, and in vitro antiplasmodial activity of Sonchus arvensis L. callus under dolomite [CaMg(CO3)2] treatment","volume":"16","author":"Wahyuni","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2022.115659_bib42","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.jep.2011.06.038","article-title":"Medicinal plants used in the management of chronic joint pains in Machakos and Makueni counties, Kenya","volume":"137","author":"Wambugu","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.115659_bib44","series-title":"The Medicinal and Poisonous Plants of Southern and Eastern Africa Being an Account for Their Medicinal and Other Uses, Chemical Composition, Pharmacological Effects, and Toxicology in Man and Animal","author":"Watt","year":"1962"},{"key":"10.1016\/j.jep.2022.115659_bib45","series-title":"World Malaria Report 2021","author":"WHO","year":"2021"},{"key":"10.1016\/j.jep.2022.115659_bib46","series-title":"Malaria","author":"WHO","year":"2020"},{"key":"10.1016\/j.jep.2022.115659_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2021.116405","article-title":"Synthesis, characterization and application of Co\/Co3O4 nanocomposites as an effective photocatalyst for discoloration of organic dye contaminants in wastewater and antibacterial properties","volume":"337","author":"Yousefi","year":"2021","journal-title":"J. Mol. Liq."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122006985?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122006985?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:37:08Z","timestamp":1759945028000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874122006985"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":44,"alternative-id":["S0378874122006985"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2022.115659","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vitro antiplasmodial activity and cytotoxicity of extracts and chromatographic fractions of twigs from Pappea capensis EckI & Zeyh. (Sapindaceae)","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2022.115659","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115659"}}