{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T11:57:42Z","timestamp":1780401462286,"version":"3.54.1"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.jep.2022.115694","type":"journal-article","created":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T02:16:28Z","timestamp":1662776188000},"page":"115694","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Protease inhibitor from Libidibia ferrea seeds attenuates inflammatory and nociceptive responses in mice"],"prefix":"10.1016","volume":"300","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2211-9710","authenticated-orcid":false,"given":"Raquel","family":"Carvalho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iluska Senna","family":"Bonf\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9ssica","family":"de Ara\u00fajo Isa\u00edas Muller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana Cristina","family":"Pando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f4nica Cristina","family":"Toffoli-Kadri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2022.115694_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0259545","article-title":"Libidibia ferrea (juc\u00e1) anti-inflammatory action: a systematic review of in vivo and in vitro studies","volume":"16","author":"Almeida","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2022.115694_bib2","series-title":"As Plantas Que Curam","author":"Balbach","year":"1972"},{"key":"10.1016\/j.jep.2022.115694_bib3","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1590\/S0100-54052012000200004","article-title":"Purifica\u00e7\u00e3o parcial de inibidores de tripsina de sementes de Caesalpinia ferrea e Swartzia polyphylla e o efeito dos extratos prot\u00e9icos sobre fungos fitopatog\u00eanicos","volume":"38","author":"Bariani","year":"2012","journal-title":"Summa Phytopathol."},{"key":"10.1016\/j.jep.2022.115694_bib4","article-title":"Plantas do Nordeste, especialmente do Cear\u00e1","author":"Braga","year":"1976","journal-title":"Cole\u00e7\u00e3o Mossoroense"},{"key":"10.1016\/j.jep.2022.115694_bib5","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1055\/s-2006-939553","article-title":"Protease-activated receptors: how proteases signal to cells to cause inflammation and pain","volume":"32","author":"Bunnett","year":"2006","journal-title":"Semin. Thromb. Hemost."},{"key":"10.1016\/j.jep.2022.115694_bib6","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0378-8741(96)01441-9","article-title":"Preliminary studies of analgesic and anti-inflammatory properties of Caesalpinia ferrea crude extract","volume":"53","author":"Carvalho","year":"1996","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.115694_bib7","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.phytochem.2013.09.025","article-title":"Using a Caesalpinia echinata Lam. protease inhibitor as a tool for studying the roles of neutrophil elastase, cathepsin G and proteinase 3 in pulmonary edema","volume":"96","author":"Cruz-Silva","year":"2013","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2022.115694_bib8","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ddmod.2011.06.004","article-title":"Mast cell proteases and inflammation. Drug Discov","volume":"8","author":"Dai","year":"2011","journal-title":"Today Dis. Models"},{"key":"10.1016\/j.jep.2022.115694_bib9","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jep.2014.07.031","article-title":"Quantification of polyphenols and evaluation of antimicrobial, analgesic and anti-inflammatory activities of aqueous and acetone\u2013water extracts of Libidibia ferrea, Parapiptadenia rigida and Psidium guajava","volume":"156","author":"de Ara\u00fajo","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.115694_bib10","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.jep.2011.12.012","article-title":"Polysaccharide fractions of Caesalpinia ferrea pods: potential anti-inflammatory usage","volume":"139","author":"de Paulo Pereira","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.115694_bib11","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/BF01966691","article-title":"Blockade by antimacrophage serum of the migration of PMN neutrophils into the inflamed peritoneal cavity","volume":"17","author":"de Souza","year":"1985","journal-title":"Agents Actions"},{"key":"10.1016\/j.jep.2022.115694_bib12","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0014-2999(80)90377-5","article-title":"Release of prostaglandins E and F in an algogenic reaction and its inhibition","volume":"61","author":"Deraedt","year":"1980","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2022.115694_bib13","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.phrs.2016.01.021","article-title":"Medicinal plants in Brazil: pharmacological studies, drug discovery, challenges and perspectives","volume":"112","author":"Dutra","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2022.115694_bib14","article-title":"Libidibia ferrea fruit crude extract and fractions show anti-inflammatory, antioxidant, and antinociceptive effect in vivo and increase cell viability in vitro","volume":"1\u201314","author":"Falc\u00e3o","year":"2019","journal-title":"Evid.-based Complement. Altern. Med."},{"key":"10.1016\/j.jep.2022.115694_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/6064805","article-title":"Crude extract from Libidibia ferrea (Mart. ex. Tul.) LP Queiroz leaves decreased intra articular inflammation induced by zymosan in rats","volume":"19","author":"Falc\u00e3o","year":"2019","journal-title":"Evid.-based Complement. Altern. Med."},{"key":"10.1016\/j.jep.2022.115694_bib16","article-title":"Biological activities of Libidibia (Caesalpinia) ferrea var. parvifolia (Mart. ex Tul.) LP Queiroz pod preparations. Evid.-based Complement","volume":"1\u20137","author":"Freitas","year":"2012","journal-title":"Altern. Med."},{"key":"10.1016\/j.jep.2022.115694_bib17","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.toxicon.2009.08.009","article-title":"Contribution of mast cells to the oedema induced by Bothrops moojeni snake venom and a pharmacological assessment of the inflammatory mediators involved","volume":"55","author":"Galv\u00e3o-Nascimento","year":"2010","journal-title":"Toxicon"},{"key":"10.1016\/j.jep.2022.115694_bib18","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/sj.bjp.0704152","article-title":"Agonists of proteinase\u2010activated receptor 1 induce plasma extravasation by a neurogenic mechanism","volume":"133","author":"Garavilla","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jep.2022.115694_bib19","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1160\/TH09-12-0848","article-title":"The role of thrombin and protease-activated receptors in pain mechanisms","volume":"103","author":"Garc\u00eda","year":"2010","journal-title":"Thromb. Hemost."},{"key":"10.1016\/j.jep.2022.115694_bib75","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S1054-3589(08)61088-1","article-title":"Negative modulation of nitric oxide synthase by nitric oxide and nitroso compounds","volume":"34","author":"Griscavage","year":"1995","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.jep.2022.115694_bib20","first-page":"469","article-title":"Nitric oxide and superoxide in inflammation","volume":"54","author":"Guzik","year":"2003","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.jep.2022.115694_bib21","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0022-3565(24)35133-X","article-title":"Inhibitors of chymase as mast cell-stabilizing agents: contribution of chymase in the activation of human mast cells","volume":"291","author":"He","year":"1999","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.jep.2022.115694_bib22","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1016\/j.drudis.2019.05.026","article-title":"Peptide-based protease inhibitors from plants","volume":"24","author":"Hellinger","year":"2019","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.jep.2022.115694_bib23","first-page":"1","article-title":"Protease-activated receptors (PARs): mechanisms of action and potential therapeutic modulators in PAR-driven inflammatory diseases","volume":"17","author":"Heuberger","year":"2001","journal-title":"Thromb. J."},{"key":"10.1016\/j.jep.2022.115694_bib24","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1016\/j.molimm.2010.04.020","article-title":"Serine proteases of the human immune system in health and disease","volume":"47","author":"Heutinck","year":"2010","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.jep.2022.115694_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113501","article-title":"Polysaccaride-rich extract of Caesalpina ferrea stem barks attenuates mice acute inflammation induced by zymosan: oxidative stress modulation","volume":"267","author":"Holanda","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.115694_bib26","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0165-0270(85)90116-5","article-title":"Formalin test in mice, a useful technique for evaluating mild analgesics","volume":"14","author":"Hunskaar","year":"1985","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.jep.2022.115694_bib27","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1007\/BF02111441","article-title":"Protease inhibitors reduce the reverse passive Arthus reaction","volume":"8","author":"Hyman","year":"1978","journal-title":"Agents Actions"},{"key":"10.1016\/j.jep.2022.115694_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11101-012-9231-y","article-title":"Serine protease inhibitors in plants: nature's arsenal crafted for insect predators","volume":"12","author":"Jamal","year":"2013","journal-title":"Phytochemistry Rev."},{"key":"10.1016\/j.jep.2022.115694_bib29","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1172\/JCI10806","article-title":"The protease-activated receptor-2 agonist induces gastric mucus secretion and mucosal cytoprotection","volume":"107","author":"Kawabata","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jep.2022.115694_bib30","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1038\/sj.bjp.0702513","article-title":"Enhancement of vascular permeability by specific activation of protease\u2010activated receptor\u20101 in rat hindpaw: a protective role of endogenous and exogenous nitric oxide","volume":"126","author":"Kawabata","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jep.2022.115694_bib31","first-page":"863","article-title":"Antibody and inhibitor of chymase inhibit histamine release in immunoglobulin E-activated mast cells","volume":"10","author":"Kido","year":"1985","journal-title":"Biochem. Int."},{"key":"10.1016\/j.jep.2022.115694_bib32","first-page":"95","article-title":"Antibodies and inhibitor of chymase are incorporated into mast cell granules and inhibit histamine release","volume":"369","author":"Kido","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2022.115694_bib33","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1172\/JCI109662","article-title":"Evidence that proteases are involved in superoxide production by human polymorphonuclear leukocytes and monocytes","volume":"65","author":"Kitagawa","year":"1980","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jep.2022.115694_bib34","first-page":"418","article-title":"Acetic acid for analgesic screening. Fed","volume":"18","author":"Koster","year":"1959","journal-title":"SAVE Proc."},{"key":"10.1016\/j.jep.2022.115694_bib35","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.jep.2022.115694_bib36","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.4049\/jimmunol.138.9.3019","article-title":"CSF-1-induced resistance to viral infection in murine macrophages","volume":"138","author":"Lee","year":"1987","journal-title":"J. Immunol."},{"key":"10.1016\/j.jep.2022.115694_bib37","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1590\/S0102-695X2011005000197","article-title":"Anti-inflammatory and analgesic potential of Caesalpinia ferrea","volume":"22","author":"Lima","year":"2012","journal-title":"Rev. Bras. Farmacogn."},{"key":"10.1016\/j.jep.2022.115694_bib39","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.sajb.2019.12.013","article-title":"Bioprospection of Libidibia ferrea var. ferrea: phytochemical properties and antibacterial activity","volume":"130","author":"Luna","year":"2020","journal-title":"South Afr. J. Bot."},{"key":"10.1016\/j.jep.2022.115694_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/molecules25173831","article-title":"Caesalpinia ferrea C. Mart. (Fabaceae) phytochemistry, ethnobotany, and bioactivities: a review","volume":"25","author":"Mac\u00eado","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2022.115694_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0063571","article-title":"Characterization and pharmacological properties of a novel multifunctional Kunitz inhibitor from Erythrina velutina seeds","volume":"8","author":"Machado","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2022.115694_bib42","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.jep.2019.03.032","article-title":"Medicinal plants of the Caatinga, northeastern Brazil: ethnopharmacopeia (1980-1990) of the late professor Francisco Jos\u00e9 de Abreu Matos","volume":"237","author":"Magalh\u00e3es","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.115694_bib43","first-page":"29","article-title":"Ethnobotany and ethnopharmacology of medicinal plants used in communities of the soure marine extractive reserve, Par\u00e1 State, Brazil","volume":"19","author":"Magno-Silva","year":"2020","journal-title":"Bol. Latinoam. Caribe Plantas Med. Aromat."},{"key":"10.1016\/j.jep.2022.115694_bib44","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0014-5793(01)03077-0","article-title":"The serine protease inhibitor antithrombin III inhibits LPS\u2010mediated NF\u2010\u03baB activation by TLR\u20104","volume":"508","author":"Mansell","year":"2001","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jep.2022.115694_bib45","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.coph.2017.05.007","article-title":"Inflammation as target in cancer therapy","volume":"35","author":"Marelli","year":"2017","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.jep.2022.115694_bib46","first-page":"115","article-title":"Carrageenan-induced paw edema in the rat and mouse","volume":"225","author":"Morris","year":"2003","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jep.2022.115694_bib47","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.jep.2022.115694_bib48","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0002-9440(10)64971-1","article-title":"Anti-inflammatory effects of mutant forms of secretory leukocyte protease inhibitor","volume":"156","author":"Mulligan","year":"2000","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.jep.2022.115694_bib49","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.jpain.2020.12.006","article-title":"A role for protease activated receptor type 3 (PAR3) in nociception demonstrated through development of a novel peptide agonist","volume":"22","author":"Mwirigi","year":"2021","journal-title":"J. Pain"},{"key":"10.1016\/j.jep.2022.115694_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/antiox9040290","article-title":"Oxidative stress and inflammation as targets for novel preventive and therapeutic approaches in non communicable diseases","volume":"9","author":"Nediani","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.jep.2022.115694_bib51","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/ni.3790","article-title":"A guiding map for inflammation","volume":"18","author":"Netea","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jep.2022.115694_bib52","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0167-4838(99)00285-X","article-title":"Leucaena leucocephala serine proteinase inhibitor: primary structure and action on blood coagulation, kinin release and rat paw edema","volume":"1477","author":"Oliva","year":"2000","journal-title":"BBA - Protein Structure."},{"key":"10.1016\/j.jep.2022.115694_bib53","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1111\/j.1476-5381.2010.00924.x","article-title":"Effect of plant neutrophil elastase inhibitor on leucocyte migration, adhesion and cytokine release in inflammatory conditions","volume":"161","author":"Oliveira","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jep.2022.115694_bib54","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S1043-4682(05)80007-8","article-title":"Neutrophil proteinases and matrix degradation. The cell biology of pericellular proteolysis","volume":"6","author":"Owen","year":"1995","journal-title":"Semin. Cell Biol."},{"key":"10.1016\/j.jep.2022.115694_bib55","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.exppara.2010.06.030","article-title":"Trypanosoma cruzi: effect of the absence of 5-lipoxygenase (5-LO)-derived leukotrienes on levels of cytokines, nitric oxide and iNOS expression in cardiac tissue in the acute phase of infection in mice","volume":"127","author":"Panis","year":"2011","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.jep.2022.115694_bib56","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nri1841","article-title":"Neutrophil serine proteases: specific regulators of inflammation","volume":"6","author":"Pham","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jep.2022.115694_bib57","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0022-1759(80)90340-3","article-title":"A simple colorimetric method for the measurement of hydrogen peroxide produced by cells in culture","volume":"38","author":"Pick","year":"1981","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.jep.2022.115694_bib58","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.biopha.2018.12.053","article-title":"Serine protease inhibitors rich Coccinia grandis (L.) Voigt leaf extract induces protective immune responses in murine visceral leishmaniasis","volume":"111","author":"Pramanik","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2022.115694_bib59","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/nrg1111","article-title":"Human and mouse proteases: a comparative genomic approach","volume":"4","author":"Puente","year":"2003","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.jep.2022.115694_bib60","article-title":"Investigation of antimicrobial and anticoagulant effects of trypsin inhibitor from Caesalpinia ferrea var. cearenses. Brazil","volume":"4","author":"Rosenegger","year":"2017","journal-title":"J. Med. Biol. Res."},{"key":"10.1016\/j.jep.2022.115694_bib61","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.yexmp.2012.09.014","article-title":"Role of serine proteases in inflammation: Bowman\u2013Birk protease inhibitor (BBI) as a potential therapy for autoimmune diseases","volume":"93","author":"Safavi","year":"2012","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.jep.2022.115694_bib62","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1385\/NMM:7:1-2:079","article-title":"Protease-activated receptors","volume":"7","author":"Saito","year":"2005","journal-title":"Neuromol Med."},{"key":"10.1016\/j.jep.2022.115694_bib63","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.76231","article-title":"Viruses: what triggers inflammation in COVID-19?","volume":"11","author":"Sawa","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.jep.2022.115694_bib64","article-title":"Libidibia ferrea mature seeds promote antinociceptive effect by peripheral and central pathway: possible involvement of opioid and cholinergic receptors","volume":"1\u201310","author":"Sawada","year":"2014","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.jep.2022.115694_bib65","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1080\/19390211.2017.1407383","article-title":"Trypsin inhibitors from Cajanus cajan and Phaseolus limensis possess antioxidant, anti-inflammatory, and antibacterial activity","volume":"15","author":"Shamsi","year":"2018","journal-title":"J. Diet. Suppl."},{"key":"10.1016\/j.jep.2022.115694_bib66","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.ijbiomac.2016.02.069","article-title":"Characterization, biomedical and agricultural applications of protease inhibitors: a review","volume":"91","author":"Shamsi","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2022.115694_bib67","series-title":"Environmental Concerns and Sustainable Development","article-title":"Biodiversity and therapeutic potential of medicinal plants","author":"Sharma","year":"2020"},{"key":"10.1016\/j.jep.2022.115694_bib68","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/72247","article-title":"Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism","volume":"6","author":"Steinhoff","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.jep.2022.115694_bib69","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1177\/1753425909353641","article-title":"ONO 3403, a synthetic serine protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-\u03b1 and nitric oxide production and protects mice from lethal endotoxic shock","volume":"17","author":"Tumurkhuu","year":"2011","journal-title":"Innate Immun."},{"key":"10.1016\/j.jep.2022.115694_bib70","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1097\/01.CCM.0000060005.48885.2B","article-title":"Gabexate mesilate, a synthetic anticoagulant, inhibits the expression of endothelial leukocyte adhesion molecules in vitro","volume":"31","author":"Uchiba","year":"2003","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.jep.2022.115694_bib71","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.4049\/jimmunol.169.3.1467","article-title":"Characterization of thrombin-induced leukocyte rolling and adherence: a potential proinflammatory role for proteinase-activated receptor-4","volume":"169","author":"Vergnolle","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.jep.2022.115694_bib72","doi-asserted-by":"crossref","first-page":"5064","DOI":"10.4049\/jimmunol.163.9.5064","article-title":"Proteinase-activated receptor-2-activating peptides induce leukocyte rolling, adhesion, and extravasation in vivo","volume":"163","author":"Vergnolle","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.jep.2022.115694_bib73","first-page":"246","article-title":"The use of changes in capillary permeability in mice to distinguish between narcotic and nonnarcotic analgesics","volume":"22","author":"Whittle","year":"1964","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jep.2022.115694_bib74","doi-asserted-by":"crossref","first-page":"544","DOI":"10.3181\/00379727-111-27849","article-title":"Carrageenin-induced edema in hind paw of the rat as an assay for antiinflammatory drugs","volume":"111","author":"Winter","year":"1962","journal-title":"Proc. Soc. Exp. Biol. Med."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122007334?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122007334?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:26:58Z","timestamp":1759944418000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874122007334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":74,"alternative-id":["S0378874122007334"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2022.115694","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protease inhibitor from Libidibia ferrea seeds attenuates inflammatory and nociceptive responses in mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2022.115694","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115694"}}