{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T23:48:10Z","timestamp":1769212090273,"version":"3.49.0"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009392","name":"Prince Sattam bin Abdulaziz University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011665","name":"Deanship of Scientific Research, King Saud University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.jep.2022.115752","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T13:23:10Z","timestamp":1664198590000},"page":"115752","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["In vivo investigation of the inhibitory effect of Peganum harmala L. and its major alkaloids on ethylene glycol-induced urolithiasis in rats"],"prefix":"10.1016","volume":"300","author":[{"given":"Summya","family":"Rashid","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Sameti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed H.","family":"Alqarni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0823-4015","authenticated-orcid":false,"given":"Fatma M.","family":"Abdel Bar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2022.115752_bib1","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.sajb.2022.03.044","article-title":"In vitro and in silico inhibition of COX-2 and 5-LOX by beta-carboline alkaloids from the seeds of Peganum harmala L","volume":"147","author":"Abdel Bar","year":"2022","journal-title":"South Afr. J. Bot."},{"key":"10.1016\/j.jep.2022.115752_bib2","doi-asserted-by":"crossref","DOI":"10.1155\/2009\/137072","article-title":"Mediators of inflammation in acute kidney injury","author":"Akcay","year":"2009","journal-title":"Mediators Inflamm. 2009"},{"issue":"6","key":"10.1016\/j.jep.2022.115752_bib3","first-page":"267","article-title":"Cytotoxic activity against a series of tumour cell lines of dimethyltin dichloride complexes with various donor ligands","volume":"138","author":"al-Allaf","year":"1999","journal-title":"Boll. Chim. Farm."},{"issue":"1","key":"10.1016\/j.jep.2022.115752_bib4","doi-asserted-by":"crossref","first-page":"126","DOI":"10.3109\/0886022X.2012.731999","article-title":"The biochemical and histopathological investigation of amlodipine in ethylene glycol-induced urolithiasis rat model","volume":"35","author":"Albayrak","year":"2013","journal-title":"Ren. Fail."},{"issue":"2","key":"10.1016\/j.jep.2022.115752_bib5","first-page":"470","article-title":"Enzymatic determination of total serum urea","volume":"20","author":"Allian","year":"1978","journal-title":"J. Clin. Chem."},{"key":"10.1016\/j.jep.2022.115752_bib6","first-page":"411","article-title":"Protective effects of the aqueous extract of Crocus sativus against ethylene glycol induced nephrolithiasis in rats","volume":"14","author":"Amin","year":"2015","journal-title":"EXCLI J"},{"key":"10.1016\/j.jep.2022.115752_bib7","first-page":"95","article-title":"A critical review on antiurolithiatic activity of bioactive phytoconstituents","author":"Anand","year":"2021","journal-title":"Res. J. Pharmacogn. Phytochem."},{"key":"10.1016\/j.jep.2022.115752_bib8","first-page":"1573","article-title":"Chemistry, pharmacology and medicinal properties of Peganum harmala L","volume":"6","author":"Asgarpanah","year":"2012","journal-title":"Afr. J. Pharm. Pharmacol."},{"key":"10.1016\/j.jep.2022.115752_bib9","first-page":"172","article-title":"The Hematoxylin and eosin","volume":"11","author":"Bancroft","year":"2013","journal-title":"Bancroft's Theor. Prac. Histological Tech."},{"issue":"2","key":"10.1016\/j.jep.2022.115752_bib10","first-page":"142","article-title":"Enzymatic colorimetric determination of uric acid","volume":"97","author":"Barham","year":"1972","journal-title":"J. Clin. Chem."},{"issue":"1","key":"10.1016\/j.jep.2022.115752_bib11","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jep.2008.12.004","article-title":"Antiurolithic effect of Bergenia ligulata rhizome: an explanation of the underlying mechanisms","volume":"122","author":"Bashir","year":"2009","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.jep.2022.115752_bib12","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.jaim.2018.12.003","article-title":"Anticalcifying effect of Daucus carota in experimental urolithiasis in Wistar rats","volume":"11","author":"Bawari","year":"2020","journal-title":"J. Ayurveda Integr. Med."},{"issue":"6","key":"10.1016\/j.jep.2022.115752_bib13","doi-asserted-by":"crossref","first-page":"204","DOI":"10.21010\/ajtcam.v13i6.30","article-title":"Nephroprotective and diuretic effect of Nigella sativa L seeds oil on lithiasic Wistar rats","volume":"13","author":"Benhelima","year":"2016","journal-title":"Afr. J. Tradit., Complementary Altern. Med."},{"issue":"7","key":"10.1016\/j.jep.2022.115752_bib14","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1211\/jpp.58.7.0012","article-title":"Protective effects of Peganum harmala L. extract, harmine and harmaline against human low-density lipoprotein oxidation","volume":"58","author":"Berrougui","year":"2006","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jep.2022.115752_bib15","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.phrs.2006.04.001","article-title":"Vasorelaxant effects of harmine and harmaline extracted from Peganum harmala L. seeds in isolated rat aorta","volume":"54","author":"Berrougui","year":"2006","journal-title":"Pharmacol. Res."},{"issue":"6","key":"10.1016\/j.jep.2022.115752_bib80","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1159\/000167514","article-title":"Significance of tubulointerstitial changes in the renal cortex for the excretory function and concentration ability of the kidney: a morphometric contribution","volume":"7","author":"Bohle","year":"1987","journal-title":"Am. J. Nephrol."},{"issue":"1","key":"10.1016\/j.jep.2022.115752_bib81","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0344-0338(11)81021-6","article-title":"The consequences of tubulo-interstitial changes for renal function in glomerulopathies. A morphometric and cytological analysis","volume":"186","author":"Bohle","year":"1990","journal-title":"Pathol. Res. Pract."},{"issue":"2","key":"10.1016\/j.jep.2022.115752_bib16","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3109\/13813455.2015.1016974","article-title":"Hepatoprotective activity of Peganum harmala against ethanol-induced liver damages in rats","volume":"121","author":"Bourogaa","year":"2015","journal-title":"Arch. Physiol. Biochem."},{"issue":"10","key":"10.1016\/j.jep.2022.115752_bib17","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1055\/s-0029-1185719","article-title":"Herbal medicines in the management of urolithiasis: alternative or complementary?","volume":"75","author":"Butterweck","year":"2009","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2022.115752_bib18","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S0076-6879(85)13062-4","article-title":"Glutathione reductase","volume":"113","author":"Carlberg","year":"1985","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.jep.2022.115752_bib19","series-title":"CRC Handbook of Methods in Oxygen Radical Research","article-title":"Catalase activity","author":"Claiborne","year":"1985"},{"issue":"3\u20134","key":"10.1016\/j.jep.2022.115752_bib20","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.exppara.2004.04.002","article-title":"In vitro activity of the beta-carboline alkaloids harmane, harmine, and harmaline toward parasites of the species Leishmania infantum","volume":"106","author":"Di Giorgio","year":"2004","journal-title":"Exp. Parasitol."},{"issue":"4","key":"10.1016\/j.jep.2022.115752_bib21","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.fct.2010.01.011","article-title":"Protective effect of the hydro-alcoholic extract of Rubia cordifolia roots against ethylene glycol induced urolithiasis in rats","volume":"48","author":"Divakar","year":"2010","journal-title":"Food Chem. Toxicol."},{"issue":"7","key":"10.1016\/j.jep.2022.115752_bib22","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1080\/02772240903450736","article-title":"Antibacterial, antiviral and antioxidant activities of aerial part extracts of Peganum harmala L. grown in Tunisia","volume":"92","author":"Edziri","year":"2010","journal-title":"Toxicol. Environ. Chem."},{"issue":"4","key":"10.1016\/j.jep.2022.115752_bib82","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/ki.1990.266","article-title":"Chronic tubulo-interstitial nephritis: Correlation between structural and functional findings","volume":"38","author":"Eknoyan","year":"1990","journal-title":"Kidney Int."},{"key":"10.1016\/j.jep.2022.115752_bib23","first-page":"305","article-title":"Histo-functional effects of Peganum harmala on male rat's spermatogenesis and fertility","volume":"28","author":"El Dwairi","year":"2007","journal-title":"Neuroendocrinol. Lett."},{"issue":"7","key":"10.1016\/j.jep.2022.115752_bib24","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.arcmed.2016.12.010","article-title":"Protective effect of propolis in proteinuria, crystaluria, nephrotoxicity and hepatotoxicity induced by ethylene glycol ingestion","volume":"47","author":"El Menyiy","year":"2016","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.jep.2022.115752_bib25","first-page":"339","article-title":"Ibn-Sina's life and contributions to medicinal therapies of kidney calculi","volume":"65","author":"Faridi","year":"2012","journal-title":"Iran. J. Kidney Dis."},{"issue":"3","key":"10.1016\/j.jep.2022.115752_bib26","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.jep.2007.10.014","article-title":"Evaluation of the analgesic effect of alkaloid extract of Peganum harmala L.: possible mechanisms involved","volume":"115","author":"Farouk","year":"2008","journal-title":"J. Ethnopharmacol."},{"issue":"5","key":"10.1016\/j.jep.2022.115752_bib27","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.euroneuro.2005.08.005","article-title":"Antidepressant-like effect of harmane and other beta-carbolines in the mouse forced swim test","volume":"16","author":"Farzin","year":"2006","journal-title":"Eur. Neuropsychopharmacol"},{"issue":"9","key":"10.1016\/j.jep.2022.115752_bib28","first-page":"623","article-title":"Control of urinary risk factors of stone formation by Salvadora persica in experimental hyperoxaluria. Methods Find","volume":"32","author":"Geetha","year":"2010","journal-title":"Exp. Clin. Pharmacol."},{"issue":"6","key":"10.1016\/j.jep.2022.115752_bib29","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00240-014-0711-y","article-title":"Antilithiatic effects of crocin on ethylene glycol-induced lithiasis in rats","volume":"42","author":"Ghaeni","year":"2014","journal-title":"Urolithiasis"},{"issue":"19","key":"10.1016\/j.jep.2022.115752_bib30","doi-asserted-by":"crossref","first-page":"4569","DOI":"10.3390\/molecules25194569","article-title":"High reserve in \u03b4-tocopherol of Peganum harmala seeds oil and antifungal activity of oil against ten plant pathogenic fungi","volume":"25","author":"Hajji","year":"2020","journal-title":"Molecules (Basel, Switzerland)"},{"key":"10.1016\/j.jep.2022.115752_bib31","doi-asserted-by":"crossref","DOI":"10.15406\/icpjl.2016.02.00051","article-title":"Association of connective tissue fibers with estrogen expression in breast lesions among Sudanese females","volume":"2","author":"Hamad","year":"2016","journal-title":"Int. Clin. Pathol. J."},{"issue":"1","key":"10.1016\/j.jep.2022.115752_bib32","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1080\/01478885.2017.1396067","article-title":"Association of some carbohydrates with estrogen expression in breast lesions among Sudanese females","volume":"41","author":"Hamad","year":"2018","journal-title":"J. Histotechnol."},{"issue":"1","key":"10.1016\/j.jep.2022.115752_bib33","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3181\/00379727-74-17837","article-title":"Endogenous creatinine in serum and urine","volume":"74","author":"Hare","year":"1950","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.jep.2022.115752_bib34","doi-asserted-by":"crossref","first-page":"8199","DOI":"10.5897\/AJB10.564","article-title":"Biological activities of Peganum harmala leaves","volume":"9","author":"Hayet","year":"2010","journal-title":"Afr. J. Biotechnol."},{"issue":"6","key":"10.1016\/j.jep.2022.115752_bib35","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1515\/znb-1987-0626","article-title":"Synthesis and serotonin-receptor activity of substituted 1-Oxo-1,2,3,4-tetrahydro-\u03b2-carbolines","volume":"42","author":"Herdeis","year":"1987","journal-title":"Z. Naturforsch. B Chem. Sci."},{"issue":"3","key":"10.1016\/j.jep.2022.115752_bib36","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.fct.2009.12.019","article-title":"beta-Carboline alkaloids in Peganum harmala and inhibition of human monoamine oxidase (MAO)","volume":"48","author":"Herraiz","year":"2010","journal-title":"Food Chem. Toxicol."},{"issue":"4","key":"10.1016\/j.jep.2022.115752_bib37","first-page":"232","article-title":"Antiurolithiatic activity of Pinus eldarica medw: fruits aqueous extract in rats","volume":"7","author":"Hosseinzadeh","year":"2010","journal-title":"Urol. J."},{"issue":"38","key":"10.1016\/j.jep.2022.115752_bib38","first-page":"113","article-title":"Alkaloids from cultivated plant of Peganum harmala L","volume":"12","author":"Javzan","year":"2011","journal-title":"Mong. J. Chem."},{"issue":"3","key":"10.1016\/j.jep.2022.115752_bib39","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000136485","article-title":"Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite","volume":"11","author":"Jollow","year":"1974","journal-title":"Pharmacology"},{"key":"10.1016\/j.jep.2022.115752_bib40","series-title":"Clinical Chemistry","author":"Kanter","year":"1975"},{"issue":"1\u20132","key":"10.1016\/j.jep.2022.115752_bib41","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.jep.2005.11.004","article-title":"Effect of Moringa oleifera Lam. root-wood on ethylene glycol induced urolithiasis in rats","volume":"105","author":"Karadi","year":"2006","journal-title":"J. Ethnopharmacol."},{"issue":"5","key":"10.1016\/j.jep.2022.115752_bib42","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s00240-005-0492-4","article-title":"Hyperoxaluria-induced oxidative stress and antioxidants for renal protection","volume":"33","author":"Khan","year":"2005","journal-title":"Urol. Res."},{"issue":"3","key":"10.1016\/j.jep.2022.115752_bib43","first-page":"256","article-title":"Reactive oxygen species, inflammation and calcium oxalate nephrolithiasis","volume":"3","author":"Khan","year":"2014","journal-title":"Transl. Androl. Urol."},{"issue":"8","key":"10.1016\/j.jep.2022.115752_bib44","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1089\/end.2008.0020","article-title":"Ayurvedic medicine and renal calculi","volume":"22","author":"Kieley","year":"2008","journal-title":"J. Endourol."},{"key":"10.1016\/j.jep.2022.115752_bib45","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/7389864","article-title":"Evaluation of antidiabetic and antihyperlipidemic effects of Peganum harmala seeds in diabetic rats","volume":"2016","author":"Komeili","year":"2016","journal-title":"Cholesterol"},{"key":"10.1016\/j.jep.2022.115752_bib46","article-title":"Phytochemical screening and evaluation of analgesic, anti-inflammatory activities of Peganum harmala Linn., seeds in rodents","volume":"5","author":"Kumar","year":"2015","journal-title":"J. Appl. Pharm. Sci."},{"issue":"5","key":"10.1016\/j.jep.2022.115752_bib47","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1007\/s11164-012-0752-1","article-title":"Quantitative structure\u2013activity relationship of antitumor and neurotoxic \u03b2-carbolines alkaloids: nine harmine derivatives","volume":"39","author":"Lamchouri","year":"2013","journal-title":"Res. Chem. Intermed."},{"key":"10.1016\/j.jep.2022.115752_bib48","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jep.2017.03.049","article-title":"A review on traditional uses, phytochemistry, pharmacology, pharmacokinetics and toxicology of the genus Peganum","volume":"203","author":"Li","year":"2017","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.jep.2022.115752_bib49","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.bbrc.2017.05.126","article-title":"Harmine is an inflammatory inhibitor through the suppression of NF-\u03baB signaling","volume":"489","author":"Liu","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.jep.2022.115752_bib50","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.jep.2022.115752_bib51","doi-asserted-by":"crossref","first-page":"78","DOI":"10.4103\/0253-7613.174564","article-title":"Antiurolithiatic effect of lithocare against ethylene glycol-induced urolithiasis in Wistar rats","volume":"48","author":"Lulat","year":"2016","journal-title":"Indian J. Pharmacol."},{"issue":"26","key":"10.1016\/j.jep.2022.115752_bib52","first-page":"432","article-title":"Cytotoxicity of Peganum harmala L. seeds extract and its relationship with contents of \u00df-carboline alkaloids","volume":"8","author":"Mahmoudian","year":"2002","journal-title":"RJMS"},{"issue":"1","key":"10.1016\/j.jep.2022.115752_bib53","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S0254-6272(15)30016-9","article-title":"Medicinal properties of Peganum harmala L. in traditional Iranian medicine and modern phytotherapy: a review","volume":"35","author":"Mina","year":"2015","journal-title":"J. Tradit. Chin. Med."},{"issue":"4","key":"10.1016\/j.jep.2022.115752_bib54","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3347\/kjp.2007.45.4.267","article-title":"Treatment of natural tropical theileriosis with the extract of the plant Peganum harmala","volume":"45","author":"Mirzaei","year":"2007","journal-title":"Kor. J. Parasitol."},{"issue":"2","key":"10.1016\/j.jep.2022.115752_bib55","doi-asserted-by":"crossref","first-page":"153","DOI":"10.4102\/ojvr.v73i2.162","article-title":"Treatment of natural ovine malignant theileriosis with a chloroform extract of the plant Peganum harmala","volume":"73","author":"Mirzaiedehaghi","year":"2006","journal-title":"Onderstepoort J. Vet. Res."},{"key":"10.1016\/j.jep.2022.115752_bib56","first-page":"5086","article-title":"Differential distribution of glutathione and glutathione related enzymes in rabbit kidney","volume":"44","author":"Mohandas","year":"1984","journal-title":"Cancer Res."},{"issue":"14","key":"10.1016\/j.jep.2022.115752_bib57","doi-asserted-by":"crossref","first-page":"199","DOI":"10.4103\/0973-7847.120524","article-title":"Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids","volume":"7","author":"Moloudizargari","year":"2013","journal-title":"Pharmacogn. Rev."},{"issue":"1","key":"10.1016\/j.jep.2022.115752_bib58","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1021\/jo00001a066","article-title":"Carboxyl-mediated Pictet-Spengler reaction. Direct synthesis of 1,2,3,4-tetrahydro-.beta.-carbolines from tryptamine-2-carboxylic acids","volume":"56","author":"Narayanan","year":"1991","journal-title":"J. Org. Chem."},{"issue":"7","key":"10.1016\/j.jep.2022.115752_bib59","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.fitote.2010.04.004","article-title":"Antibacterial and antifungal activities of (beta)-carboline alkaloids of Peganum harmala (L) seeds and their combination effects","volume":"81","author":"Nenaah","year":"2010","journal-title":"Fitoterapia"},{"issue":"3","key":"10.1016\/j.jep.2022.115752_bib60","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.jaim.2019.09.007","article-title":"Efficacy of Herbmed Plus in urolithic rats: an experimental study","volume":"11","author":"Patankar","year":"2020","journal-title":"J. Ayurveda Integr. Med."},{"issue":"1","key":"10.1016\/j.jep.2022.115752_bib61","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jep.2012.08.043","article-title":"Antiurolithiatic activity of saponin rich fraction from the fruits of Solanum xanthocarpum Schrad. & Wendl. (Solanaceae) against ethylene glycol induced urolithiasis in rats","volume":"144","author":"Patel","year":"2012","journal-title":"J. Ethnopharmacol."},{"issue":"6","key":"10.1016\/j.jep.2022.115752_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2020.e04253","article-title":"Effect of Macrotyloma uniflorum in ethylene glycol induced urolithiasis in rats","volume":"6","author":"Patel","year":"2020","journal-title":"Heliyon"},{"issue":"4","key":"10.1016\/j.jep.2022.115752_bib63","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/S0367-326X(99)00065-9","article-title":"Antibacterial activity of Peganum harmala","volume":"70","author":"Prashanth","year":"1999","journal-title":"Fitoterapia"},{"issue":"8","key":"10.1016\/j.jep.2022.115752_bib64","first-page":"1032","article-title":"In vitro and in vivo activities of Peganum harmala extract against Leishmania major","volume":"16","author":"Rahimi-Moghaddam","year":"2011","journal-title":"J. Res. Med. Sci."},{"key":"10.1016\/j.jep.2022.115752_bib65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.abb.2016.07.004","article-title":"Inhibition of precancerous lesions development in kidneys by chrysin via regulating hyperproliferation, inflammation and apoptosis at pre clinical stage","volume":"606","author":"Rashid","year":"2016","journal-title":"Arch. Biochem. Biophys."},{"issue":"2","key":"10.1016\/j.jep.2022.115752_bib66","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jep.2012.01.003","article-title":"Anti-urolithiatic effects of Punica granatum in male rats","volume":"140","author":"Rathod","year":"2012","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2022.115752_bib67","first-page":"275","article-title":"Peganum harmala L. Extract reduces oxidative stress and improves symptoms in 6-hydroxydopamine-induced Parkinson's disease in rats","volume":"15","author":"Rezaei","year":"2016","journal-title":"Iran. J. Pharm. Res."},{"issue":"1","key":"10.1016\/j.jep.2022.115752_bib68","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1006\/phrs.2000.0745","article-title":"Effect of A. lanata leaf extract and Vediuppu chunnam on the urinary risk factors of calcium oxalate urolithiasis during experimental hyperoxaluria","volume":"43","author":"Selvam","year":"2001","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2022.115752_bib69","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s40816-021-00255-7","article-title":"Improving health benefits with considering traditional and modern health benefits of Peganum harmala","volume":"7","author":"Shahrajabian","year":"2021","journal-title":"Clin. Phytoscience"},{"issue":"4","key":"10.1016\/j.jep.2022.115752_bib70","doi-asserted-by":"crossref","DOI":"10.34172\/jnp.2020.40","article-title":"Comparison efficacy of oral Peganum harmala seed versus tamsulosin on pain relief and expulsion of renal and ureteral stones; a randomized clinical trial","volume":"9","author":"Shakeri","year":"2020","journal-title":"J. Nephropathol."},{"key":"10.1016\/j.jep.2022.115752_bib71","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/1969525","article-title":"Antiurolithiasis activity of bioactivity guided fraction of Bergenia ligulata against ethylene glycol induced renal calculi in rat","volume":"2017","author":"Sharma","year":"2017","journal-title":"BioMed Res. Int."},{"issue":"4","key":"10.1016\/j.jep.2022.115752_bib72","first-page":"279","article-title":"A phylogenetic analysis of Zygophyllaceae R.Br. based on morphological, anatomical and rbcL DNA sequence data","volume":"122","author":"Sheahan","year":"2008","journal-title":"Bot. J. Linn. Soc."},{"issue":"2","key":"10.1016\/j.jep.2022.115752_bib73","doi-asserted-by":"crossref","first-page":"127","DOI":"10.15171\/jrip.2017.25","article-title":"Impact of oral capsule of Peganum harmala on alleviating urinary symptoms in men with benign prostatic hyperplasia; a randomized clinical trial","volume":"6","author":"Shirani-Boroujeni","year":"2017","journal-title":"J. Ren. Inj. Prev."},{"issue":"6","key":"10.1016\/j.jep.2022.115752_bib74","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.3987\/COM-88-4490","article-title":"Studies in the chemical constituents of the seeds of Peganum harmala: isolation and structure elucidation of two 8-carboline lactams - harmalanine and harmalacidine","volume":"27","author":"Siddiqui","year":"1988","journal-title":"Heterocycles"},{"issue":"4","key":"10.1016\/j.jep.2022.115752_bib75","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s12291-008-0086-3","article-title":"Preliminary studies on the hypoglycemic effect of Peganum harmala L. Seeds ethanol extract on normal and streptozotocin induced diabetic rats","volume":"23","author":"Singh","year":"2008","journal-title":"Indian J. Clin. Biochem."},{"issue":"2","key":"10.1016\/j.jep.2022.115752_bib76","article-title":"Characteristics of the new comprehensive herbal medicine for the treatment and prevention of urolithiasis","volume":"7","author":"Smyslova","year":"2015","journal-title":"Biol. Med."},{"issue":"4","key":"10.1016\/j.jep.2022.115752_bib77","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S1995-7645(13)60058-9","article-title":"Efficacy evaluation of the protein isolated from Peganum harmala seeds as an antioxidant in liver of rats","volume":"6","author":"Soliman","year":"2013","journal-title":"Asian Pac. J. Trop. Med."},{"issue":"7","key":"10.1016\/j.jep.2022.115752_bib78","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1002\/cbdv.201500384","article-title":"Cytotoxic constituents and mechanism from Peganum harmala","volume":"13","author":"Wang","year":"2016","journal-title":"Chem. Biodivers."},{"issue":"2","key":"10.1016\/j.jep.2022.115752_bib79","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/0003-9861(81)90095-3","article-title":"Cytosolic factors which affect microsomal lipid peroxidation in lung and liver","volume":"206","author":"Wright","year":"1981","journal-title":"Arch. Biochem. Biophys."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122007917?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122007917?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:33:13Z","timestamp":1759944793000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874122007917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":82,"alternative-id":["S0378874122007917"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2022.115752","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vivo investigation of the inhibitory effect of Peganum harmala L. and its major alkaloids on ethylene glycol-induced urolithiasis in rats","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2022.115752","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115752"}}