{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T13:19:22Z","timestamp":1782998362629,"version":"3.54.5"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.jep.2022.115799","type":"journal-article","created":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T21:38:02Z","timestamp":1665178682000},"page":"115799","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Systematic elucidation of the bioactive alkaloids and potential mechanism from Sophora flavescens for the treatment of eczema via network pharmacology"],"prefix":"10.1016","volume":"301","author":[{"given":"Yan","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-Jun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Long","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-Rui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Hui","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-De","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2022.115799_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.amsu.2021.102847","article-title":"Determinant factors of recurrence atopic dermatitis symptoms in children: a cross-sectional study","volume":"70","author":"Al-Adawiyah","year":"2021","journal-title":"Ann. Med. Surg."},{"issue":"12","key":"10.1016\/j.jep.2022.115799_bib2","doi-asserted-by":"crossref","DOI":"10.2340\/00015555-3511","article-title":"Counting the burden: atopic dermatitis and health-related quality of life","volume":"100","author":"Ali","year":"2020","journal-title":"Acta Derm. Venereol."},{"issue":"6","key":"10.1016\/j.jep.2022.115799_bib3","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1002\/JLB.2MR0120-510R","article-title":"Distinct modes of TNF signaling through its two receptors in health and disease","volume":"107","author":"Atretkhany","year":"2020","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jep.2022.115799_bib5","series-title":"Pharmacopoeia of the People's Republic of China, Part I","year":"2020"},{"issue":"9","key":"10.1016\/j.jep.2022.115799_bib6","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.3390\/plants9091166","article-title":"The active compounds and therapeutic mechanisms of pentaherbs formula for oral and topical treatment of atopic dermatitis based on network pharmacology","volume":"9","author":"Chu","year":"2020","journal-title":"Plants"},{"issue":"1","key":"10.1016\/j.jep.2022.115799_bib7","first-page":"91","article-title":"Update on atopic dermatitis: diagnosis, severity assessment, and treatment selection","volume":"8","author":"Fishbein","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"issue":"1","key":"10.1016\/j.jep.2022.115799_bib8","doi-asserted-by":"crossref","first-page":"e71","DOI":"10.1192\/j.eurpsy.2021.2249","article-title":"A systematic review on shared biological mechanisms of depression and anxiety in comorbidity with psoriasis, atopic dermatitis, and hidradenitis suppurativa","volume":"64","author":"Fabrazzo","year":"2021","journal-title":"Eur. Psychiatr."},{"issue":"2","key":"10.1016\/j.jep.2022.115799_bib9","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1007\/s10753-017-0716-0","article-title":"Oxymatrine sensitizes the HaCaT cells to the IFN-\u03b3 pathway and downregulates MDC, ICAM-1, and SOCS1 by activating p38, JNK, and akt","volume":"41","author":"Gao","year":"2018","journal-title":"Inflammation"},{"key":"10.1016\/j.jep.2022.115799_bib10","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jep.2015.06.010","article-title":"Sophora flavescens Ait.: traditional usage, phytochemistry and pharmacology of an important traditional Chinese medicine","volume":"172","author":"He","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.115799_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cytogfr.2016.05.001","article-title":"STAT3 signaling in immunity","volume":"31","author":"Hillmer","year":"2016","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.jep.2022.115799_bib12","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1248\/bpb.31.1964","article-title":"Lavandulyl flavanones from sophora flavescens protect mouse hippocampal cells against glutamate-induced neurotoxicity via the induction of heme oxygenase-1","volume":"31","author":"Jeong","year":"2008","journal-title":"Biol. Pharm. Bull."},{"issue":"1","key":"10.1016\/j.jep.2022.115799_bib13","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jep.2012.04.053","article-title":"Effect of Sophora flavescens Aiton extract on degranulation of mast cells and contact dermatitis induced by dinitrofluorobenzene in mice","volume":"142","author":"Kim","year":"2012","journal-title":"J. Ethnopharmacol."},{"issue":"4","key":"10.1016\/j.jep.2022.115799_bib14","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.3390\/nu13041349","article-title":"Gardenia jasminoides ameliorates antibiotic-associated aggravation of DNCB-induced atopic dermatitis by restoring the intestinal microbiome profile","volume":"13","author":"Kim","year":"2021","journal-title":"Nutrients"},{"issue":"11","key":"10.1016\/j.jep.2022.115799_bib15","first-page":"5232","article-title":"Matrine alleviates imiquimod-induced psoriasiform dermatitis in BALB\/c mice via dendritic cell regulation","volume":"11","author":"Li","year":"2018","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.jep.2022.115799_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2020.104556","article-title":"Phytochemistry and biological properties of isoprenoid flavonoids from Sophora flavescens Ait","volume":"143","author":"Li","year":"2020","journal-title":"Fitoterapia"},{"issue":"2","key":"10.1016\/j.jep.2022.115799_bib17","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3724\/SP.J.1009.2013.00110","article-title":"Traditional Chinese medicine network pharmacology: theory, methodology and application","volume":"11","author":"Li","year":"2013","journal-title":"Chin. J. Nat. Med."},{"issue":"7","key":"10.1016\/j.jep.2022.115799_bib18","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1111\/bph.14572","article-title":"Salvation of the fallen angel: reactivating mutant p53","volume":"176","author":"Li","year":"2019","journal-title":"Br. J. Pharmacol."},{"issue":"11","key":"10.1016\/j.jep.2022.115799_bib19","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1007\/s40265-020-01335-7","article-title":"New and emerging systemic treatments for atopic dermatitis","volume":"80","author":"Newsom","year":"2020","journal-title":"Drugs"},{"issue":"11","key":"10.1016\/j.jep.2022.115799_bib20","article-title":"A systematic review and meta-analysis of risk factors associated with atopic dermatitis in Asia","volume":"13","author":"Ng","year":"2020","journal-title":"World. Allergy. Organ."},{"issue":"18","key":"10.1016\/j.jep.2022.115799_bib21","doi-asserted-by":"crossref","first-page":"6484","DOI":"10.3390\/ijms21186484","article-title":"Genetic and epigenetic aspects of atopic dermatitis","volume":"21","author":"Nedoszytko","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2022.115799_bib22","doi-asserted-by":"crossref","first-page":"688","DOI":"10.3390\/plants9060688","article-title":"Production of flavonoids in callus cultures of sophora flavescens aiton","volume":"9","author":"Park","year":"2020","journal-title":"Plants"},{"issue":"11","key":"10.1016\/j.jep.2022.115799_bib23","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1038\/s41401-020-0412-8","article-title":"Blockage of sphingosine-1-phosphate receptor 2 attenuates 2,4-dinitrochlorobenzene-induced atopic dermatitis in mice","volume":"41","author":"Park","year":"2020","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jep.2022.115799_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2022.867318","article-title":"Research advances on matrine","volume":"10","author":"Sun","year":"2022","journal-title":"Front. Chem."},{"issue":"8","key":"10.1016\/j.jep.2022.115799_bib25","doi-asserted-by":"crossref","first-page":"4130","DOI":"10.3390\/ijms22084130","article-title":"Molecular mechanisms of atopic dermatitis pathogenesis","volume":"22","author":"Sroka-Tomaszewska","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.jep.2022.115799_bib26","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1111\/bjd.17683","article-title":"Symptoms and diagnosis of anxiety and depression in atopic dermatitis in U.S. adults","volume":"181","author":"Silverberg","year":"2019","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jep.2022.115799_bib27","article-title":"Genome-wide mutational spectra analysis reveals significant cancer-specific heterogeneity","volume":"5","author":"Tan","year":"2015","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.jep.2022.115799_bib28","doi-asserted-by":"crossref","first-page":"7388","DOI":"10.1038\/s41598-021-86970-0","article-title":"Biosyntheses characterization of alkaloids and flavonoids in Sophora flavescens by combining metabolome and transcriptome","volume":"11","author":"Wei","year":"2021","journal-title":"Sci. Rep."},{"issue":"13","key":"10.1016\/j.jep.2022.115799_bib29","doi-asserted-by":"crossref","first-page":"7227","DOI":"10.3390\/ijms22137227","article-title":"The implications of pruritogens in the pathogenesis of atopic dermatitis","volume":"22","author":"Wong","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2022.115799_bib30","article-title":"The mechanism action of German chamomile (Matricaria recutita L.) in the treatment of eczema: based on dose-effect weight coefficient network pharmacology","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2022.115799_bib31","first-page":"1","article-title":"TCM network pharmacology: a new trend towards combining computational, experimental and clinical approaches","volume":"19","author":"Wang","year":"2021","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.jep.2022.115799_bib32","doi-asserted-by":"crossref","first-page":"365","DOI":"10.3389\/fcell.2020.00365","article-title":"The balance of TNF mediated pathways regulates inflammatory cell death signaling in healthy and diseased tissues","volume":"8","author":"Webster","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.jep.2022.115799_bib33","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/1646905","article-title":"Applications of network pharmacology in traditional Chinese medicine research","volume":"2020","author":"Zhou","year":"2020","journal-title":"Evid. Based. Complement. Alternat. Med."},{"key":"10.1016\/j.jep.2022.115799_bib34","doi-asserted-by":"crossref","first-page":"743","DOI":"10.3389\/fphar.2019.00743","article-title":"Systems pharmacology for investigation of the mechanisms of action of traditional Chinese medicine in drug Discovery","volume":"10","author":"Zhang","year":"2019","journal-title":"Front. Pharmacol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122008388?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122008388?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:31:30Z","timestamp":1759944690000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874122008388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":33,"alternative-id":["S0378874122008388"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2022.115799","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systematic elucidation of the bioactive alkaloids and potential mechanism from Sophora flavescens for the treatment of eczema via network pharmacology","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2022.115799","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115799"}}