{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:49:29Z","timestamp":1790704169919,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.jep.2022.115804","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T10:28:33Z","timestamp":1665397713000},"page":"115804","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Efficacy of curculigoside in protecting against ischemic brain injury through regulation of oxidative stress and NF-\u03baB and PI3K\/Akt expression"],"prefix":"10.1016","volume":"301","author":[{"given":"Yan","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aijun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinna","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanying","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjuan","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jep.2022.115804_bib1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1742-4658.2008.06766.x","article-title":"Post-ischemic brain damage: pathophysiology and role of inflammatory mediators","volume":"276","author":"Amantea","year":"2009","journal-title":"FEBS J."},{"issue":"4","key":"10.1016\/j.jep.2022.115804_bib2","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s13311-016-0483-x","article-title":"Inflammation and stroke: an overview","volume":"13","author":"Anrather","year":"2016","journal-title":"Neurotherapeutics"},{"issue":"9","key":"10.1016\/j.jep.2022.115804_bib3","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1097\/00004647-200109000-00009","article-title":"Recruitment of neutrophils across the blood-brain barrier: the role of E- and P-selectins","volume":"21","author":"Bernardes-Silva","year":"2001","journal-title":"J. Cerebr. Blood Flow Metabol."},{"issue":"8","key":"10.1016\/j.jep.2022.115804_bib4","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1248\/cpb.c12-01058","article-title":"Fingerprint analysis and simultaneous determination of phenolic compounds in extracts of Curculiginis Rhizoma by HPLC-diode array detector","volume":"61","author":"Bian","year":"2013","journal-title":"Chem. Pharm. Bull."},{"issue":"1","key":"10.1016\/j.jep.2022.115804_bib5","first-page":"7","article-title":"Oxidative stress as a mediator of apoptosis","volume":"15","author":"Buttke","year":"1994","journal-title":"ImmuTod"},{"issue":"2","key":"10.1016\/j.jep.2022.115804_bib6","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1161\/01.STR.0000200561.69611.f8","article-title":"The harms and benefits of inflammatory and immune responses in vascular disease","volume":"37","author":"Chamorro","year":"2006","journal-title":"Stroke"},{"issue":"30","key":"10.1016\/j.jep.2022.115804_bib7","article-title":"Effect of \"Tonifying Kidney and Invigorating Brain\" acupuncture in children with spastic cerebral palsy analyzed by multi-modality MRI combined with dynamic electroencephalogram","volume":"99","author":"Chen","year":"2020","journal-title":"Medicine (Baltim.)"},{"key":"10.1016\/j.jep.2022.115804_bib8","first-page":"240","article-title":"Effects of Bushen Tiaochong Recipe on the level of sex hormones and the expression of estrogen receptor \u03b1 and estrogen receptor \u03b2 mRNA in the hypothalamus in ovariectomized rats","volume":"28","author":"Du","year":"2011","journal-title":"Tianjin TCM"},{"issue":"2","key":"10.1016\/j.jep.2022.115804_bib9","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.taap.2015.10.001","article-title":"Totarol prevents neuronal injury in vitro and ameliorates brain ischemic stroke: potential roles of Akt activation and HO-1 induction","volume":"289","author":"Gao","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jep.2022.115804_bib10","first-page":"272","article-title":"Summary of \"China stroke prevention and treatment report 2019","volume":"17","year":"2020","journal-title":"Chi Jour Cere Dis"},{"key":"10.1016\/j.jep.2022.115804_bib11","doi-asserted-by":"crossref","first-page":"5235","DOI":"10.2147\/DDDT.S282112","article-title":"Prediction of targets of curculigoside A in osteoporosis and rheumatoid arthritis using network pharmacology and experimental verification","volume":"14","author":"Han","year":"2020","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.jep.2022.115804_bib12","series-title":"Protective Effect and Mechanism of Monosialoganglioside Sodium on Oxidative Damage of Vascular Endothelial Cells","author":"Hang","year":"2014"},{"issue":"2","key":"10.1016\/j.jep.2022.115804_bib13","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.ijcard.2011.05.013","article-title":"PI3K\/Akt signaling pathway involved in cardioprotection of preconditioning with high mobility group box 1 protein during myocardial ischemia and reperfusion","volume":"150","author":"Hu","year":"2011","journal-title":"Int. J. Cardiol."},{"issue":"10","key":"10.1016\/j.jep.2022.115804_bib14","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.3736\/jcim20121007","article-title":"[A theoretical and experimental study on the Fuzzy evaluation model of biological performance of Chinese materia medica with an either cold or hot herbal property]","volume":"10","author":"Jin","year":"2012","journal-title":"Zhong Xi Yi Jie He Xue Bao"},{"key":"10.1016\/j.jep.2022.115804_bib15","volume":"vol. 11","author":"Jiulue","year":"2011"},{"issue":"1","key":"10.1016\/j.jep.2022.115804_bib16","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/cne.20052","article-title":"Rat brain vascular distribution of interleukin-1 type-1 receptor immunoreactivity: relationship to patterns of inducible cyclooxygenase expression by peripheral inflammatory stimuli","volume":"472","author":"Konsman","year":"2004","journal-title":"J. Comp. Neurol."},{"issue":"6","key":"10.1016\/j.jep.2022.115804_bib17","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1142\/S0192415X12500929","article-title":"Effect of Curculigo orchioides on reflux esophagitis by suppressing proinflammatory cytokines","volume":"40","author":"Ku","year":"2012","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jep.2022.115804_bib18","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/1479-5876-7-97","article-title":"Inflammatory mechanisms in ischemic stroke: therapeutic approaches","volume":"7","author":"Lakhan","year":"2009","journal-title":"J. Transl. Med."},{"issue":"27","key":"10.1016\/j.jep.2022.115804_bib19","doi-asserted-by":"crossref","first-page":"43709","DOI":"10.18632\/oncotarget.12574","article-title":"The protective effect of Epimedii Folium and Curculiginis Rhizoma on Alzheimer's disease by the inhibitions of NF-\u03baB\/MAPK pathway and NLRP3 inflammasome","volume":"8","author":"Lan","year":"2017","journal-title":"Oncotarget"},{"issue":"17","key":"10.1016\/j.jep.2022.115804_bib20","first-page":"1397","article-title":"[Modern biological basis of Chinese medical theory that \"kidney nourishes marrow and brain is sea of marrow\"]","volume":"31","author":"Li","year":"2006","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"10.1016\/j.jep.2022.115804_bib21","first-page":"1397","article-title":"Discussion on the modern biological basis of TCM \"kidney grows marrow, brain is marrow sea","volume":"17","author":"Lin","year":"2006","journal-title":"Chinese JTCM"},{"key":"10.1016\/j.jep.2022.115804_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114129","article-title":"Curculigoside attenuates oxidative stress and osteoclastogenesis via modulating Nrf2\/NF-\u03baB signaling pathway in RAW264.7 cells","volume":"275","author":"Liu","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.jep.2022.115804_bib23","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","article-title":"Reversible middle cerebral artery occlusion without craniectomy in rats","volume":"20","author":"Longa","year":"1989","journal-title":"Stroke"},{"issue":"3","key":"10.1016\/j.jep.2022.115804_bib24","first-page":"192","article-title":"[Determination of curculigoside in crude medicine Curculigo orchioides by HPLC]","volume":"27","author":"Lu","year":"2002","journal-title":"Zhongguo Zhongyao Zazhi"},{"issue":"6","key":"10.1016\/j.jep.2022.115804_bib25","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1468-1331.2004.00798.x","article-title":"Different cytokine levels in thrombolysis patients as predictors for clinical outcome","volume":"11","author":"Mazzotta","year":"2004","journal-title":"Eur. J. Neurol."},{"issue":"3","key":"10.1016\/j.jep.2022.115804_bib26","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.neuroscience.2008.08.019","article-title":"Systemic infection, inflammation and acute ischemic stroke","volume":"158","author":"McColl","year":"2009","journal-title":"Neuroscience"},{"issue":"4","key":"10.1016\/j.jep.2022.115804_bib27","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.jfda.2018.03.003","article-title":"Curculigoside and polyphenol-rich ethyl acetate fraction of Molineria latifolia rhizome improved glucose uptake via potential mTOR\/AKT activated GLUT4 translocation","volume":"26","author":"Ooi","year":"2018","journal-title":"J. Food Drug Anal."},{"issue":"5","key":"10.1016\/j.jep.2022.115804_bib28","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s12975-014-0345-y","article-title":"Novel humanized recombinant T cell receptor ligands protect the female brain after experimental stroke","volume":"5","author":"Pan","year":"2014","journal-title":"Transl Stroke Res"},{"key":"10.1016\/j.jep.2022.115804_bib29","first-page":"42","article-title":"Effects of Chinese herbal compound for invigorating the kidney, activating blood circulation and resolving phlegm on the central neurotransmitter and \u03b2-amyloid in D-galactose-induced aging model rats","author":"Ping","year":"2007","journal-title":"Chinese JEF"},{"issue":"1","key":"10.1016\/j.jep.2022.115804_bib30","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3736\/jcim20040120","article-title":"[Effects of kidney-tonifying Chinese herbal medicine on hypothalamic-pituitary gonadotrophic function]","volume":"2","author":"Shen","year":"2004","journal-title":"Zhong Xi Yi Jie He Xue Bao"},{"key":"10.1016\/j.jep.2022.115804_bib31","article-title":"Epimedii Folium and Curculiginis Rhizoma ameliorate lipopolysaccharides-induced cognitive impairment by regulating the TREM2 signaling pathway","volume":"284","author":"Shi","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.115804_bib32","first-page":"638+637","article-title":"Problems that should be paid attention to when copying animal models of human diseases","volume":"9","author":"Shiting","year":"2015","journal-title":"Disease surveillance and control"},{"key":"10.1016\/j.jep.2022.115804_bib33","first-page":"6","article-title":"Effect of kidney tonifying recipe on mRNA expression of apoptosis-related gene Bax and bcl-2 in hippocampal CA1 area of naturally aging rats","volume":"27","author":"Shujuan","year":"2011","journal-title":"Phar CCM"},{"key":"10.1016\/j.jep.2022.115804_bib34","first-page":"57","article-title":"The effect of \"tonifying the kidney and activating blood\" acupuncture method on the learning and memory ability and AChE activity of brain tissue in SAMP8 mice of Alzheimer's disease model","volume":"29","author":"Sisi","year":"2010","journal-title":"Shanghai JA"},{"key":"10.1016\/j.jep.2022.115804_bib35","first-page":"12","article-title":"Increase in surface expression of ICAM-1, VCAM-1 and E-selectin in human cerebromicrovascular endothelial cells subjected to ischemia-like insults","volume":"70","author":"Stanimirovic","year":"1997","journal-title":"Acta Neurochir. Suppl."},{"key":"10.1016\/j.jep.2022.115804_bib36","first-page":"92","article-title":"The effect of \"tonifying the kidney and promoting blood circulation\" on the metabolism of acetylcholine in the brain of aged rats","author":"Tian Qing","year":"2004","journal-title":"Journal of HUST (Natural Science Edition)"},{"key":"10.1016\/j.jep.2022.115804_bib37","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.fitote.2017.01.009","article-title":"Metabolites of curculigoside in rats and their antiosteoporotic activities in osteoblastic MC3T3-E1 cells","volume":"117","author":"Wang","year":"2017","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2022.115804_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118356","article-title":"Curculigoside inhibits ferroptosis in ulcerative colitis through the induction of GPX4","volume":"259","author":"Wang","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.jep.2022.115804_bib39","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1749-8546-2-13","article-title":"The effects of rhizoma Curculiginis and rhizoma drynariae extracts on bones","volume":"2","author":"Wong","year":"2007","journal-title":"Chin. Med."},{"key":"10.1016\/j.jep.2022.115804_bib40","series-title":"Study on the Effect of Recombinant Ganoderma Lucidum Immunomodulatory Protein on Focal Cerebral Ischemia in Rats","author":"Xiuna","year":"2014"},{"issue":"6","key":"10.1016\/j.jep.2022.115804_bib41","first-page":"902","article-title":"Brain neural effects of the 'tonifying kidney and benefiting marrow' method in the treatment of osteoporosis","volume":"39","author":"Xu","year":"2019","journal-title":"J. Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2022.115804_bib42","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/9281481","article-title":"Curculigoside protects against excess-iron-induced bone loss by attenuating akt-FoxO1-dependent oxidative damage to mice and osteoblastic MC3T3-E1 cells","volume":"2019","author":"Zhang","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"7","key":"10.1016\/j.jep.2022.115804_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0133289","article-title":"Effects of curculigoside on memory impairment and bone loss via anti-oxidative character in APP\/PS1 mutated transgenic mice","volume":"10","author":"Zhao","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2022.115804_bib44","first-page":"208","article-title":"Regulative effect of Zuogui Wan on 8-hydroxydeoxyguanylic acid in the cerebral cortex of aged rats","author":"Zhao Gang","year":"2002","journal-title":"Journal of FDU (Medical Edition)"},{"issue":"12","key":"10.1016\/j.jep.2022.115804_bib45","first-page":"2565","article-title":"Effect of bushen Yizhi decoction on central neurotransmitter in Alzheimer's model rats","volume":"27","author":"Zhilong","year":"2009","journal-title":"Chinese JTCM"},{"issue":"1\u20133","key":"10.1016\/j.jep.2022.115804_bib46","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.ejphar.2008.02.057","article-title":"Cardioprotective effect of fluvastatin on isoproterenol-induced myocardial infarction in rat","volume":"586","author":"Zhou","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2022.115804_bib47","first-page":"23","article-title":"Effect of bushen Yizhi recipe on the ability of learning and memory in rats with dementia","author":"Zhou Lequan","year":"2001","journal-title":"Chi Med Res"},{"issue":"11","key":"10.1016\/j.jep.2022.115804_bib48","first-page":"756","article-title":"Effects of the recipe for nourishing kidney and activating blood and replenishing qi and activating blood on C\u00e3(2+) and C\u00e3(2+)-ATPase in aged rats with cerebral ischemia","author":"Zhou Qingan","year":"2004","journal-title":"Chi Med Eme"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122008431?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122008431?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:30:58Z","timestamp":1759944658000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874122008431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":48,"alternative-id":["S0378874122008431"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2022.115804","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of curculigoside in protecting against ischemic brain injury through regulation of oxidative stress and NF-\u03baB and PI3K\/Akt expression","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2022.115804","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115804"}}