{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T03:57:34Z","timestamp":1793419054063,"version":"4.5.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.jep.2022.115849","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T12:37:43Z","timestamp":1666701463000},"page":"115849","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"special_numbering":"PA","title":["Moringa oleifera L. leaf extract induces cell cycle arrest and mitochondrial apoptosis in Dalton's Lymphoma: An in vitro and in vivo study"],"prefix":"10.1016","volume":"302","author":[{"given":"Sandeep","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen Kumar","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alok","family":"Shukla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishi Kant","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand Kumar","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lokesh","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveen","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Kaushalendra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7621-9477","authenticated-orcid":false,"given":"Arbind","family":"Acharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2022.115849_bib1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0135814","article-title":"Moringa oleifera as an anti-cancer agent against breast and colorectal cancer cell lines","volume":"10","author":"Al-Asmari","year":"2015","journal-title":"PLoS One"},{"issue":"22","key":"10.1016\/j.jep.2022.115849_bib2","doi-asserted-by":"crossref","first-page":"5308","DOI":"10.3390\/molecules25225308","article-title":"Role of bcl-2 family proteins in photodynamic therapy mediated cell survival and regulation","volume":"25","author":"Aniogo","year":"2020","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.jep.2022.115849_bib3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/ptr.2023","article-title":"Moringa oleifera: a food plant with multiple medicinal uses","author":"Anwar","year":"2007","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2022.115849_bib4","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/S0140-6736(16)32407-2","article-title":"Non-hodgkin lymphoma","volume":"390","author":"Armitage","year":"2017","journal-title":"Lancet"},{"issue":"38","key":"10.1016\/j.jep.2022.115849_bib5","doi-asserted-by":"crossref","first-page":"118","DOI":"10.4103\/0973-1296.131022","article-title":"Leucas aspera inhibits the Dalton's ascitic lymphoma in Swiss albino mice: a preliminary study exploring possible mechanism of action","volume":"10","author":"Augustine","year":"2014","journal-title":"Phcog. Mag."},{"key":"10.1016\/j.jep.2022.115849_bib6","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/cdd.2008.148","article-title":"Tumour cell survival signalling by the ERK1\/2 pathway","volume":"16","author":"Balmanno","year":"2009","journal-title":"Cell Death Differ."},{"issue":"1","key":"10.1016\/j.jep.2022.115849_bib7","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1080\/07315724.2020.1735572","article-title":"Aqueous extract of Moringa oleifera exhibit potential anticancer activity and can be used as a possible cancer therapeutic agent: a study involving in vitro and in vivo approach","volume":"40","author":"Barhoi","year":"2021","journal-title":"J. Am. Coll. Nutr."},{"issue":"4","key":"10.1016\/j.jep.2022.115849_bib8","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00210-019-01742-y","article-title":"Investigations on acute oral toxicity studies of purpurin by application of OECD guideline 423 in rodents","volume":"393","author":"Bedi","year":"2020","journal-title":"N. Schmied. Arch. Pharmacol."},{"issue":"10","key":"10.1016\/j.jep.2022.115849_bib9","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.3390\/molecules26103030","article-title":"New cardenolides from biotransformation of Gitoxigenin by the endophytic fungus alternaria eureka 1E1BL1: characterization and cytotoxic activities","volume":"26","author":"Bedir","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2022.115849_bib10","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1158\/1078-0432.CCR-03-0362","article-title":"Characterization of p53 wild-type and null isogenic colorectal cancer cell lines resistant to 5-fluorouracil, oxaliplatin, and irinotecan","volume":"10","author":"Boyer","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jep.2022.115849_bib11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3389\/fphar.2016.00003","article-title":"Anticancer activity of Garcinia morella on T-cell murine lymphoma via apoptotic induction","volume":"7","author":"Choudhury","year":"2016","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.jep.2022.115849_bib12","first-page":"199","article-title":"VEGF expression in pancreatic cancer and other malignancies: a review of the literature","volume":"53","author":"Costache","year":"2015","journal-title":"Rom. J. Intern. Med."},{"key":"10.1016\/j.jep.2022.115849_bib13","first-page":"1","article-title":"Vitamin contents of flowers and seeds of Moringa oleifera","volume":"21","author":"Dahot","year":"1988","journal-title":"Pak. J. Biochem."},{"key":"10.1016\/j.jep.2022.115849_bib14","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.biopha.2018.03.076","article-title":"Induction of apoptosis, anti-proliferation, tumor-angiogenic suppression and down-regulation of Dalton's Ascitic Lymphoma (DAL) induced tumorigenesis by poly-l-lysine: a mechanistic study","volume":"102","author":"Debnath","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2022.115849_bib15","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1076\/phbi.34.3.207.13211","article-title":"Antiinflammatory effects of Moringa oleifera root extract","volume":"34","author":"Ezeamuzie","year":"1996","journal-title":"Int. J. Pharmacogn."},{"key":"10.1016\/j.jep.2022.115849_bib16","series-title":"Global Cancer Observatory: Cancer Today","author":"Ferlay","year":"2020"},{"key":"10.1016\/j.jep.2022.115849_bib17","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.fshw.2016.04.001","article-title":"Moringa oleifera: a review on nutritive importance and its medicinal application","volume":"5","author":"Gopalakrishnan","year":"2016","journal-title":"Food Sci. Hum. Wellness"},{"key":"10.1016\/j.jep.2022.115849_bib18","doi-asserted-by":"crossref","first-page":"3668","DOI":"10.1073\/pnas.94.8.3668","article-title":"Cytosol-to-membrane redistribution of Bax and bcl-X(L) during apoptosis","volume":"94","author":"Hsu","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"12","key":"10.1016\/j.jep.2022.115849_bib19","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.apjtb.2017.10.016","article-title":"Plant-derived anticancer agents: a green anticancer approach","volume":"7","author":"Iqbal","year":"2017","journal-title":"Asian Pac. J. Trop. Biomed."},{"issue":"10","key":"10.1016\/j.jep.2022.115849_bib20","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1182\/blood-2013-09-527739","article-title":"MicroRNA-150 inhibits tumor invasion and metastasis by targeting the chemokine receptor CCR6, in advanced cutaneous T-cell lymphoma","volume":"123","author":"Ito","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.jep.2022.115849_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112256","article-title":"Ganoderma lucidum spore oil induces apoptosis of breast cancer cells in vitro and in vivo by activating caspase-3 and caspase-9","volume":"247","author":"Jiao","year":"2020","journal-title":"J. Ethnopharmacol."},{"issue":"10","key":"10.1016\/j.jep.2022.115849_bib22","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1158\/1078-0432.CCR-13-1081","article-title":"Molecular pathways: adaptive kinome reprogramming in response to targeted inhibition of the BRAF-MEK-ERK pathway in cancer","volume":"20","author":"Johnson","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jep.2022.115849_bib23","article-title":"The in vitro and in vivo anticancer properties of Moringa oleifera","volume":"14","author":"Khor","year":"2018","journal-title":"Evid Based Complement Alternat Med"},{"issue":"1","key":"10.1016\/j.jep.2022.115849_bib24","first-page":"1","article-title":"Dalton's lymphoma as a murine model for understanding the progression and development of T-cell lymphoma and its role in drug discovery","volume":"3","author":"Koiri","year":"2017","journal-title":"International Journal of Immunotherapy and Cancer Research"},{"issue":"3","key":"10.1016\/j.jep.2022.115849_bib25","doi-asserted-by":"crossref","first-page":"343","DOI":"10.3390\/nu10030343","article-title":"Nutraceutical or pharmacological potential of Moringa oleifera lam","volume":"10","author":"Kou","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.jep.2022.115849_bib26","series-title":"Apoptosis and Cancer","author":"Letai","year":"2017"},{"issue":"7","key":"10.1016\/j.jep.2022.115849_bib27","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/mc.20638","article-title":"Betulin induces mitochondrial cytochrome c release associated apoptosis in human cancer cells","volume":"49","author":"Li","year":"2010","journal-title":"Mol. Carcinog."},{"issue":"25","key":"10.1016\/j.jep.2022.115849_bib28","doi-asserted-by":"crossref","first-page":"4008","DOI":"10.1039\/C9TB00569B","article-title":"Intracellular Fenton reaction based on mitochondria-targeted copper (ii)\u2013peptide complex for induced apoptosis","volume":"7","author":"Li","year":"2019","journal-title":"J. Mater. Chem. B"},{"issue":"11","key":"10.1016\/j.jep.2022.115849_bib29","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.3390\/ijms19113533","article-title":"Anticancer activity of natural compounds from plant and marine environment","volume":"19","author":"Lichota","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2022.115849_bib30","doi-asserted-by":"crossref","first-page":"841","DOI":"10.4081\/jphia.2018.841","article-title":"Investigation of medicinal plants traditionally used as dietary supplements: a review on Moringa oleifera","volume":"9","author":"Matic","year":"2018","journal-title":"J. Publ. Health Afr."},{"key":"10.1016\/j.jep.2022.115849_bib31","first-page":"612","article-title":"Evaluation of hematological and hepatorenal functions of methanolic extract of Moringa oleifera Lam. Root treated mice","volume":"37","author":"Mazumder","year":"1999","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.jep.2022.115849_bib32","first-page":"152","article-title":"Chemical investigation of aerial parts of gmelina asiatica linn by GC-MS","volume":"1","author":"Merlin","year":"2009","journal-title":"Pharmacogn. Res."},{"issue":"2","key":"10.1016\/j.jep.2022.115849_bib33","doi-asserted-by":"crossref","first-page":"318","DOI":"10.3390\/plants10020318","article-title":"Health benefits of uses and applications of Moringa oleifera in bakery products","volume":"10","author":"Milla","year":"2021","journal-title":"Plants"},{"issue":"10","key":"10.1016\/j.jep.2022.115849_bib34","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.1039\/D0DT03873C","article-title":"Influence of anchoring moieties on new benzimidazole-based Schiff base copper (II) complexes towards estrogen dependent breast cancer cells","volume":"50","author":"Paul","year":"2021","journal-title":"Dalton Trans."},{"issue":"19","key":"10.1016\/j.jep.2022.115849_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221910516","article-title":"Incomptine A induces apoptosis, ros production and a differential protein expression on non-hodgkin\u2019s lymphoma cells","volume":"22","author":"Pina-Jim\u00e9nez","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.jep.2022.115849_bib36","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1111\/j.1476-5381.1995.tb16670.x","article-title":"Inhibition of angiogenesis, tumour growth and metastasis by the NO-releasing vasodilators, isosorbide mononitrate and dinitrate","volume":"116","author":"Pipili-Synetos","year":"1995","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.jep.2022.115849_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40659-019-0221-z","article-title":"CoCl2 simulated hypoxia induce cell proliferation and alter the expression pattern of hypoxia associated genes involved in angiogenesis and apoptosis","volume":"52","author":"Rana","year":"2019","journal-title":"Biol. Res."},{"key":"10.1016\/j.jep.2022.115849_bib38","first-page":"12","article-title":"Anti in\ufb02ammatory and antihepatotoxic activities of the rats of Morringa pterygosperma Geaertn","volume":"60","author":"Rao","year":"1998","journal-title":"Indian J. Pharmaceut. Sci."},{"key":"10.1016\/j.jep.2022.115849_bib39","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.indcrop.2015.01.002","article-title":"Optimization of extraction method to obtain a phenolic compounds-rich extract from Moringa oleifera Lam Leaves","volume":"66","author":"Rodr\u00edguez-P\u00e9rez","year":"2015","journal-title":"Ind. Crop. Prod."},{"key":"10.1016\/j.jep.2022.115849_bib40","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.phrs.2012.04.005","article-title":"ERK1\/2 MAP kinases: structure, function, and regulation","volume":"66","author":"Roskoski","year":"2012","journal-title":"Pharmacol. Res."},{"issue":"2","key":"10.1016\/j.jep.2022.115849_bib41","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.canlet.2009.04.033","article-title":"Lupeol, a novel anti-inflammatory and anti-cancer dietary triterpene","volume":"285","author":"Saleem","year":"2009","journal-title":"Cancer Lett."},{"key":"10.1016\/j.jep.2022.115849_bib42","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.bbamcr.2006.10.005","article-title":"The MEK\/ERK cascade: from signaling specificity to diverse functions","volume":"1773","author":"Shaul","year":"2007","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.jep.2022.115849_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114060","article-title":"Achyranthes aspera L. leaf extract induced anticancer effects on Dalton's Lymphoma via regulation of PKC\u03b1 signaling pathway and mitochondrial apoptosis","volume":"274","author":"Singh","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"7","key":"10.1016\/j.jep.2022.115849_bib44","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1039\/C9TB02628B","article-title":"Studies on interaction potency model based on drug synergy and therapeutic potential of triple stimuli-responsive delivery of doxorubicin and 5-fluoro-2-deoxyuridine against lymphoma using disulfide-bridged cysteine over mesoporous silica nanoparticles","volume":"8","author":"Srivastava","year":"2020","journal-title":"J. Mater. Chem. B"},{"issue":"3","key":"10.1016\/j.jep.2022.115849_bib45","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA A Cancer J. Clin."},{"key":"10.1016\/j.jep.2022.115849_bib46","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1089\/jmf.2015.0113","article-title":"The antiproliferative effect of Moringa oleifera crude aqueous leaf extract on human esophageal cancer cells","volume":"19","author":"Tiloke","year":"2016","journal-title":"J. Med. Food"},{"key":"10.1016\/j.jep.2022.115849_bib47","first-page":"3","article-title":"Anticancer molecular mechanisms of resveratrol","volume":"12","author":"Varoni","year":"2016","journal-title":"Front. Nutr."},{"issue":"4","key":"10.1016\/j.jep.2022.115849_bib48","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3390\/antiox6040091","article-title":"Bioactive components in Moringa oleifera leaves protect against chronic disease","volume":"6","author":"Vergara-Jimenez","year":"2017","journal-title":"Antioxidants"},{"issue":"1","key":"10.1016\/j.jep.2022.115849_bib49","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s40199-022-00439-7","article-title":"Cobalt (III) complex exerts anti-cancer effects on T cell lymphoma through induction of cell cycle arrest and promotion of apoptosis","volume":"30","author":"Verma","year":"2022","journal-title":"Daru"},{"issue":"2","key":"10.1016\/j.jep.2022.115849_bib50","first-page":"553","article-title":"Type II cGMP-dependent protein kinase inhibits EGF-triggered signal transduction of the MAPK\/ERK-mediated pathway in gastric cancer cells","volume":"27","author":"Wu","year":"2012","journal-title":"Oncol. Rep."},{"issue":"11","key":"10.1016\/j.jep.2022.115849_bib51","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.7150\/jca.32071","article-title":"Cordycepin induces apoptosis and G2\/M phase Arrest through the ERK pathways in esophageal cancer cells","volume":"10","author":"Xu","year":"2019","journal-title":"J. Cancer"},{"issue":"1","key":"10.1016\/j.jep.2022.115849_bib52","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.565","article-title":"The role of hypoxia-inducible factor-2 in digestive system cancers","volume":"6","author":"Zhao","year":"2015","journal-title":"Cell Death Dis."},{"issue":"11","key":"10.1016\/j.jep.2022.115849_bib53","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.2147\/CMAR.S191681","article-title":"KIF15 promotes bladder cancer proliferation via the MEK-ERK signaling pathway","volume":"26","author":"Zhao","year":"2019","journal-title":"Cancer Manag. Res."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122008881?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122008881?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:29:03Z","timestamp":1759944543000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874122008881"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":53,"alternative-id":["S0378874122008881"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2022.115849","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Moringa oleifera L. leaf extract induces cell cycle arrest and mitochondrial apoptosis in Dalton's Lymphoma: An in vitro and in vivo study","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2022.115849","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115849"}}