{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:53:00Z","timestamp":1793641980669,"version":"4.5.1"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007620","name":"Department of Education of Liaoning Province","doi-asserted-by":"publisher","award":["2020LJC15"],"award-info":[{"award-number":["2020LJC15"]}],"id":[{"id":"10.13039\/501100007620","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007620","name":"Department of Education of Liaoning Province","doi-asserted-by":"publisher","award":["LJKZ0911"],"award-info":[{"award-number":["LJKZ0911"]}],"id":[{"id":"10.13039\/501100007620","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007620","name":"Department of Education of Liaoning Province","doi-asserted-by":"publisher","award":["LJKZ0950"],"award-info":[{"award-number":["LJKZ0950"]}],"id":[{"id":"10.13039\/501100007620","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173961"],"award-info":[{"award-number":["82173961"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160825"],"award-info":[{"award-number":["82160825"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.jep.2022.115933","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T09:35:24Z","timestamp":1668764124000},"page":"115933","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":73,"special_numbering":"C","title":["A network pharmacology approach and experimental validation to investigate the anticancer mechanism and potential active targets of ethanol extract of Wei-Tong-Xin against colorectal cancer through induction of apoptosis via PI3K\/AKT signaling pathway"],"prefix":"10.1016","volume":"303","author":[{"given":"Fei","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanglin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xihan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengshi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiqi","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingxu","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2022.115933_bib1","series-title":"American Cancer Society-Facts and Figures- 2021","author":"Atlanta","year":"2021"},{"issue":"9","key":"10.1016\/j.jep.2022.115933_bib2","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1111\/cas.14532","article-title":"5-Fluorouracil resistance mechanisms in colorectal cancer: from classical pathways to promising processes","volume":"111","author":"Blondy","year":"2020","journal-title":"Cancer Sci."},{"issue":"4","key":"10.1016\/j.jep.2022.115933_bib3","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries (vol 68, pg 394, 2018)","volume":"70","author":"Bray","year":"2020","journal-title":"Ca-a Cancer J. Clinicians"},{"issue":"7","key":"10.1016\/j.jep.2022.115933_bib4","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1097\/CM9.0000000000001474","article-title":"Changing profiles of cancer burden worldwide and in China: a secondary analysis of the global cancer statistics 2020","volume":"134","author":"Cao","year":"2021","journal-title":"Chinese Med J"},{"issue":"7","key":"10.1016\/j.jep.2022.115933_bib5","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.bbalip.2016.04.006","article-title":"Deoxycholic acid mediates non-canonical EGFR-MAPK activation through the induction of calcium signaling in colon cancer cells","volume":"1861","author":"Centuori","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"issue":"4","key":"10.1016\/j.jep.2022.115933_bib6","first-page":"5465","article-title":"Expression of factors and key components associated with the PI3K signaling pathway in colon cancer","volume":"15","author":"Chen","year":"2018","journal-title":"Oncol. Lett."},{"issue":"2","key":"10.1016\/j.jep.2022.115933_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000863","article-title":"Cdk2 is required for p53-independent G(2)\/M checkpoint control","volume":"6","author":"Chung","year":"2010","journal-title":"PLoS Genet."},{"issue":"5","key":"10.1016\/j.jep.2022.115933_bib8","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.jep.2022.115933_bib9","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1002\/ptr.5299","article-title":"Inhibition of Wnt\/\u03b2-catenin pathway by dehydrocostus lactone and costunolide in colon cancer cells","volume":"29","author":"Dong","year":"2015","journal-title":"Phytother Res. : PTR"},{"key":"10.1016\/j.jep.2022.115933_bib10","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.fitote.2013.08.008","article-title":"Role of mitochondrial permeability transition in human hepatocellular carcinoma Hep-G2 cell death induced by rhein","volume":"91","author":"Du","year":"2013","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2022.115933_bib11","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.semcancer.2020.07.005","article-title":"Targeting p53 for the treatment of cancer","volume":"79","author":"Duffy","year":"2022","journal-title":"Semin. Cancer Biol."},{"issue":"7","key":"10.1016\/j.jep.2022.115933_bib12","doi-asserted-by":"crossref","first-page":"815","DOI":"10.7150\/ijbs.20052","article-title":"FOXO signaling pathways as therapeutic targets in cancer","volume":"13","author":"Farhan","year":"2017","journal-title":"Int. J. Biol. Sci."},{"issue":"2","key":"10.1016\/j.jep.2022.115933_bib13","first-page":"193","article-title":"Socioeconomic inequalities in colorectal cancer incidence in Canada: trends over two decades","volume":"33","author":"Hajizadeh","year":"2022","journal-title":"Cancer Causes Control"},{"issue":"6","key":"10.1016\/j.jep.2022.115933_bib14","doi-asserted-by":"crossref","first-page":"876","DOI":"10.5858\/134.6.876","article-title":"Colorectal dysplasia in chronic inflammatory bowel disease pathology, clinical implications, and pathogenesis","volume":"134","author":"Harpaz","year":"2010","journal-title":"Arch. Pathol. Lab Med."},{"key":"10.1016\/j.jep.2022.115933_bib15","article-title":"Treatment of acute Lymphoblastic Leukemia from traditional Chinese medicine","volume":"2014","author":"Hsiao","year":"2014","journal-title":"Evid. base Compl. Alternative Med."},{"key":"10.1016\/j.jep.2022.115933_bib16","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.gene.2018.08.048","article-title":"Activation of p53 by costunolide blocks glutaminolysis and inhibits proliferation in human colorectal cancer cells","volume":"678","author":"Hu","year":"2018","journal-title":"Gene"},{"issue":"13","key":"10.1016\/j.jep.2022.115933_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/cells11132040","article-title":"Ferroptosis and its role in chronic diseases","volume":"11","author":"Hu","year":"2022","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.jep.2022.115933_bib18","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s13045-021-01137-8","article-title":"Targeting Akt in cancer for precision therapy","volume":"14","author":"Hua","year":"2021","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.jep.2022.115933_bib19","series-title":"Basic Studies on Wei-Tong-Xin","author":"Jia","year":"2002"},{"issue":"3","key":"10.1016\/j.jep.2022.115933_bib20","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.drup.2008.03.001","article-title":"Role of mTOR in anticancer drug resistance: perspectives for improved drug treatment","volume":"11","author":"Jiang","year":"2008","journal-title":"Drug Resist. Updates"},{"issue":"6","key":"10.1016\/j.jep.2022.115933_bib21","doi-asserted-by":"crossref","first-page":"4587","DOI":"10.1007\/s11033-020-05435-1","article-title":"Role of PI3K\/AKT pathway in cancer: the framework of malignant behavior","volume":"47","author":"Jiang","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.jep.2022.115933_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113363","article-title":"Effect of weimaining on apoptosis and Caspase-3 expression in a breast cancer mouse model","volume":"264","author":"Ke","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"8","key":"10.1016\/j.jep.2022.115933_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/nu10081021","article-title":"Anti-cancer natural products and their bioactive compounds inducing ER Stress-mediated apoptosis: a review","volume":"10","author":"Kim","year":"2018","journal-title":"Nutrients"},{"issue":"6","key":"10.1016\/j.jep.2022.115933_bib24","doi-asserted-by":"crossref","first-page":"424","DOI":"10.3341\/kjo.2015.29.6.424","article-title":"Effects of Bevacizumab on Bcl-2 expression and apoptosis in retinal pigment epithelial cells under oxidative Stress","volume":"29","author":"Kim","year":"2015","journal-title":"Kor. J. Ophthalmol. : Kor. J. Ophthalmol."},{"issue":"7","key":"10.1016\/j.jep.2022.115933_bib25","doi-asserted-by":"crossref","first-page":"8471","DOI":"10.1007\/s13277-016-5035-9","article-title":"Major apoptotic mechanisms and genes involved in apoptosis","volume":"37","author":"Kiraz","year":"2016","journal-title":"Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine"},{"key":"10.1016\/j.jep.2022.115933_bib26","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/978-1-60761-987-1_18","article-title":"Cytoscape: software for visualization and analysis of biological networks","volume":"696","author":"Kohl","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jep.2022.115933_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2018.00160","article-title":"Phosphoinositide 3-kinase\/Akt signaling and redox metabolism in cancer","volume":"8","author":"Koundouros","year":"2018","journal-title":"Front. Oncol."},{"issue":"18","key":"10.1016\/j.jep.2022.115933_bib28","doi-asserted-by":"crossref","first-page":"4542","DOI":"10.12998\/wjcc.v9.i18.4542","article-title":"Tetramethylpyrazine inhibits proliferation of colon cancer cells in vitro","volume":"9","author":"Li","year":"2021","journal-title":"World J. Clin. Cases"},{"issue":"2","key":"10.1016\/j.jep.2022.115933_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18020367","article-title":"Role of autophagy and apoptosis in non-Small-cell lung cancer","volume":"18","author":"Liu","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2022.115933_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115282","article-title":"Uncovering the pharmacological mechanism of Wei-Tong-Xin against gastric ulcer based on network pharmacology combined with in vivo experiment validation","volume":"293","author":"Liu","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"12","key":"10.1016\/j.jep.2022.115933_bib31","first-page":"2196","article-title":"Effect of PI3K\/Akt signaling pathway on PRAS40Thr246 phosphorylation in gastric cancer cells","volume":"48","author":"Lu","year":"2019","journal-title":"Iran. J. Public Health"},{"key":"10.1016\/j.jep.2022.115933_bib32","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mam.2019.06.005","article-title":"Lifestyle and dietary environmental factors in colorectal cancer susceptibility","volume":"69","author":"Murphy","year":"2019","journal-title":"Mol. Aspect. Med."},{"issue":"13","key":"10.1016\/j.jep.2022.115933_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13133210","article-title":"Epigenetic deregulation of apoptosis in cancers","volume":"13","author":"Ozyerli-Goknar","year":"2021","journal-title":"Cancers"},{"issue":"7","key":"10.1016\/j.jep.2022.115933_bib34","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s00210-014-0985-1","article-title":"Review article: the role of oxidative stress in pathogenesis and treatment of inflammatory bowel diseases","volume":"387","author":"Piechota-Polanczyk","year":"2014","journal-title":"N. Schmied. Arch. Pharmacol."},{"key":"10.1016\/j.jep.2022.115933_bib35","doi-asserted-by":"crossref","DOI":"10.1038\/srep39534","article-title":"Compound to Extract to Formulation: a knowledge-transmitting approach for metabolites identification of Gegen-Qinlian Decoction, a traditional Chinese medicine formula","volume":"6","author":"Qiao","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2022.115933_bib36","doi-asserted-by":"crossref","DOI":"10.1186\/1758-2946-6-13","article-title":"TCMSP: a database of systems pharmacology for drug discovery from herbal medicines","volume":"6","author":"Ru","year":"2014","journal-title":"J. Cheminf."},{"issue":"21","key":"10.1016\/j.jep.2022.115933_bib37","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1200\/JCO.2013.53.2473","volume":"32","author":"Schwartzberg","year":"2014","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.jep.2022.115933_bib38","doi-asserted-by":"crossref","DOI":"10.1186\/1758-2946-4-31","article-title":"Drug-likeness analysis of traditional Chinese medicines: 1. property distributions of drug-like compounds, non-drug-like compounds and natural compounds from traditional Chinese medicines","volume":"4","author":"Shen","year":"2012","journal-title":"J. Cheminf."},{"issue":"8","key":"10.1016\/j.jep.2022.115933_bib39","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1007\/s10620-019-05972-1","article-title":"Upper gastrointestinal disease influences the occurrence of inflammatory bowel disease","volume":"65","author":"Sonnenberg","year":"2020","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.jep.2022.115933_bib40","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-015-0321-5","article-title":"Apoptosis, autophagy, necroptosis, and cancer metastasis","volume":"14","author":"Su","year":"2015","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.jep.2022.115933_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2017.00916","article-title":"Phytochemicals and PI3K inhibitors in cancer-an insight","volume":"8","author":"Suvarna","year":"2017","journal-title":"Front. Pharmacol."},{"issue":"D1","key":"10.1016\/j.jep.2022.115933_bib42","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.jep.2022.115933_bib43","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.bbamcr.2010.09.005","article-title":"ZBP-89 enhances Bak expression and causes apoptosis in hepatocellular carcinoma cells","volume":"1813","author":"To","year":"2011","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"issue":"16","key":"10.1016\/j.jep.2022.115933_bib44","doi-asserted-by":"crossref","first-page":"14040","DOI":"10.1074\/jbc.M108975200","article-title":"The phosphatidylinositol 3-kinase (PI3K)-Akt pathway suppresses Bax translocation to mitochondria","volume":"277","author":"Tsuruta","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jep.2022.115933_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2019.107447","article-title":"5-fluorouracil and other fluoropyrimidines in colorectal cancer: past, present and future","volume":"206","author":"Vodenkova","year":"2020","journal-title":"Pharmacol. Therapeut."},{"issue":"2","key":"10.1016\/j.jep.2022.115933_bib46","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/00001574-200203000-00002","article-title":"New advances in the molecular and cellular biology of the small intestine","volume":"18","author":"Walters","year":"2002","journal-title":"Curr. Opin. Gastroenterol."},{"key":"10.1016\/j.jep.2022.115933_bib47","article-title":"Emodin induced necroptosis and inhibited glycolysis in the renal cancer cells by enhancing ROS","volume":"2021","author":"Wang","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"5","key":"10.1016\/j.jep.2022.115933_bib48","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1142\/S0192415X18500507","article-title":"Application of traditional Chinese medicines as personalized therapy in human cancers","volume":"46","author":"Wang","year":"2018","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jep.2022.115933_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112600","article-title":"Protective effect of ShaoYao decoction on colitis-associated colorectal cancer by inducing Nrf2 signaling pathway","volume":"252","author":"Wang","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.115933_bib50","article-title":"Isoalantolactone enhances the antitumor activity of doxorubicin by inducing reactive oxygen Species and DNA damage","volume":"12","author":"Wu","year":"2022","journal-title":"Front. Oncol."},{"issue":"10","key":"10.1016\/j.jep.2022.115933_bib51","article-title":"Global colorectal cancer burden in 2020 and projections to 2040","volume":"14","author":"Xi","year":"2021","journal-title":"Translational Oncol."},{"issue":"5","key":"10.1016\/j.jep.2022.115933_bib52","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1002\/cam4.2108","article-title":"Traditional Chinese medicine as a cancer treatment: modern perspectives of ancient but advanced science","volume":"8","author":"Xiang","year":"2019","journal-title":"Cancer Med."},{"issue":"7","key":"10.1016\/j.jep.2022.115933_bib53","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/hr.2013.18","article-title":"Chinese herbal formulas for treating hypertension in traditional Chinese medicine: perspective of modern science","volume":"36","author":"Xiong","year":"2013","journal-title":"Hypertens. Res."},{"issue":"1","key":"10.1016\/j.jep.2022.115933_bib54","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/cbdd.13860","article-title":"Caspase-3: a primary target for natural and synthetic compounds for cancer therapy","volume":"98","author":"Yadav","year":"2021","journal-title":"Chem. Biol. Drug Des."},{"issue":"5","key":"10.1016\/j.jep.2022.115933_bib55","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1007\/s12094-017-1774-3","article-title":"Ki67 targeted strategies for cancer therapy","volume":"20","author":"Yang","year":"2018","journal-title":"Clin. Transl. Oncol."},{"issue":"3","key":"10.1016\/j.jep.2022.115933_bib56","first-page":"903","article-title":"Mechanism of cell death induced by silica nanoparticles in hepatocyte cells is by apoptosis","volume":"44","author":"Yang","year":"2019","journal-title":"Int. J. Mol. Med."},{"issue":"6","key":"10.1016\/j.jep.2022.115933_bib57","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1248\/bpb.b14-00647","article-title":"In vivo anti-tumor effects of the ethanol extract of Gleditsia sinensis thorns and its active constituent","volume":"38","author":"Yi","year":"2015","journal-title":"Cytochalasin H. Biol. Pharm. Bulletin"},{"issue":"1","key":"10.1016\/j.jep.2022.115933_bib58","article-title":"Systems pharmacology to reveal multi-scale mechanisms of traditional Chinese medicine for gastric cancer","volume":"11","author":"Zhang","year":"2021","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.jep.2022.115933_bib59","first-page":"2474","article-title":"The exosome-mediated PI3k\/Akt\/mTOR signaling pathway in cervical cancer","volume":"12","author":"Zhang","year":"2019","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.jep.2022.115933_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154180","article-title":"Wei-Tong-Xin ameliorates functional dyspepsia via inactivating TLR4\/MyD88 by regulating gut microbial structure and metabolites","volume":"102","author":"Zhang","year":"2022","journal-title":"Phytomedicine"},{"issue":"4","key":"10.1016\/j.jep.2022.115933_bib61","doi-asserted-by":"crossref","first-page":"763","DOI":"10.3892\/ol.2012.822","article-title":"The expression and clinical significance of PI3K, pAkt and VEGF in colon cancer","volume":"4","author":"Zhang","year":"2012","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.jep.2022.115933_bib62","article-title":"Molecular classification based on prognostic and cell cycle-associated genes in patients with colon cancer","volume":"11","author":"Zhang","year":"2021","journal-title":"Front. Oncol."},{"issue":"4","key":"10.1016\/j.jep.2022.115933_bib63","first-page":"3547","article-title":"PI3K\/Akt and HIF-1 signaling pathway in hypoxia-ischemia","volume":"18","author":"Zhang","year":"2018","journal-title":"Mol. Med. Rep."},{"issue":"3","key":"10.1016\/j.jep.2022.115933_bib64","doi-asserted-by":"crossref","first-page":"3980","DOI":"10.18632\/oncotarget.14012","article-title":"Mechanisms of resistance to anti-EGFR therapy in colorectal cancer","volume":"8","author":"Zhao","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.jep.2022.115933_bib65","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jep.2022.115933_bib66","doi-asserted-by":"crossref","DOI":"10.1177\/1534735418822120","article-title":"A purified resin glycoside fraction from pharbitidis semen induces paraptosis by activating chloride intracellular channel-1 in human colon cancer cells","volume":"18","author":"Zhu","year":"2019","journal-title":"Integr. Cancer Ther."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122009722?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122009722?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:43:44Z","timestamp":1777571024000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874122009722"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":66,"alternative-id":["S0378874122009722"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2022.115933","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A network pharmacology approach and experimental validation to investigate the anticancer mechanism and potential active targets of ethanol extract of Wei-Tong-Xin against colorectal cancer through induction of apoptosis via PI3K\/AKT signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2022.115933","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115933"}}