{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T20:52:42Z","timestamp":1788382362914,"version":"build-2803163510"},"reference-count":89,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"publisher","award":["FRGS\/1\/2020\/STG02\/UM\/02\/1"],"award-info":[{"award-number":["FRGS\/1\/2020\/STG02\/UM\/02\/1"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.jep.2022.115957","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T19:46:23Z","timestamp":1670615183000},"page":"115957","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["In vivo anti-tumor activity of Lignosus rhinocerus TM02\u00ae using a MCF7-xenograft NCr nude mice model"],"prefix":"10.1016","volume":"304","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4756-0665","authenticated-orcid":false,"given":"Min Jia","family":"Ng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boon Hong","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kean Hooi","family":"Teoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeannie Hui-Yeng","family":"Yap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szu Ting","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chon Seng","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Fazril","family":"Mohamad Razif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9288-7328","authenticated-orcid":false,"given":"Shin Yee","family":"Fung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2022.115957_bib1","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.indcrop.2013.03.012","article-title":"Domestication of a wild medicinal sclerotial mushroom, Lignosus rhinocerotis (Cooke) Ryvarden","volume":"47","author":"Abdullah","year":"2013","journal-title":"Ind. Crop. Prod."},{"key":"10.1016\/j.jep.2022.115957_bib2","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/464238","article-title":"Evaluation of selected culinary-medicinal mushrooms for antioxidant and ACE inhibitory activities","volume":"2012","author":"Abdullah","year":"2012","journal-title":"Evid. Based Compl. Alt."},{"issue":"1","key":"10.1016\/j.jep.2022.115957_bib3","article-title":"Extracellular glucose is crucially involved in the fate decision of LPS-stimulated RAW264.7 murine macrophage cells","volume":"10","author":"Aki","year":"2020","journal-title":"Sci. Rep. Uk"},{"key":"10.1016\/j.jep.2022.115957_bib4","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.4236\/ajps.2018.96091","article-title":"Salvadora persica (miswak): antioxidant and promising antiangiogenic insights","volume":"9","author":"Al-Dabbagh","year":"2018","journal-title":"Am. J. Plant Sci."},{"issue":"13","key":"10.1016\/j.jep.2022.115957_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26133855","article-title":"Saffron and its major ingredients' effect on colon cancer cells with mismatch repair deficiency and microsatellite instability","volume":"26","author":"Amin","year":"2021","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.jep.2022.115957_bib6","article-title":"Spirulina protects against cadmium-induced hepatotoxicity in rats","volume":"1","author":"Amin","year":"2006","journal-title":"Am. J. Pharmacol. Toxicol."},{"issue":"9","key":"10.1016\/j.jep.2022.115957_bib7","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1007\/s11999-008-0346-9","article-title":"Statistics in brief: the importance of sample size in the planning and interpretation of medical research","volume":"466","author":"Biau","year":"2008","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.jep.2022.115957_bib8","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"issue":"2","key":"10.1016\/j.jep.2022.115957_bib9","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ccr.2009.01.009","article-title":"Inflammation and cancer: IL-6 and STAT3 complete the link","volume":"15","author":"Bromberg","year":"2009","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.jep.2022.115957_bib10","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s12931-015-0253-z","article-title":"Sulforaphane improves the bronchoprotective response in asthmatics through Nrf2-mediated gene pathways","volume":"16","author":"Brown","year":"2015","journal-title":"Respir. Res."},{"issue":"1","key":"10.1016\/j.jep.2022.115957_bib11","doi-asserted-by":"crossref","first-page":"F280","DOI":"10.1152\/ajprenal.00113.2010","article-title":"Bioimpedance spectroscopy for the estimation of body fluid volumes in mice","volume":"299","author":"Chapman","year":"2010","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"10","key":"10.1016\/j.jep.2022.115957_bib12","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1002\/iub.2101","article-title":"Cloning, overexpression, purification, and modeling of a lectin (Rhinocelectin) with antiproliferative activity from Tiger Milk Mushroom, Lignosus rhinocerus","volume":"71","author":"Cheong","year":"2019","journal-title":"IUBMB Life"},{"issue":"3","key":"10.1016\/j.jep.2022.115957_bib13","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.mce.2015.09.035","article-title":"Endocrine resistance in breast cancer--An overview and update","volume":"418","author":"Clarke","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"issue":"6117","key":"10.1016\/j.jep.2022.115957_bib14","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1126\/science.1232227","article-title":"Neutralizing tumor-promoting chronic inflammation: a magic bullet?","volume":"339","author":"Coussens","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.jep.2022.115957_bib15","first-page":"287","volume":"11","author":"Dai","year":"2009"},{"issue":"1","key":"10.1016\/j.jep.2022.115957_bib16","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.jff.2012.10.015","article-title":"Antioxidant capacities and total phenolic contents of 56 vegetables","volume":"5","author":"Deng","year":"2013","journal-title":"J. Funct.Foods"},{"issue":"4265","key":"10.1016\/j.jep.2022.115957_bib17","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/168167a0","article-title":"A colorimetric method for the determination of sugars","volume":"168","author":"Dubois","year":"1951","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.jep.2022.115957_bib18","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1007\/s00253-021-11225-x","article-title":"Functional evaluation of a recombinant fungal immunomodulatory protein from L. rhinocerus produced in P. pastoris and E. coli host expression systems","volume":"105","author":"Ejike","year":"2021","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"1","key":"10.1016\/j.jep.2022.115957_bib19","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1186\/s13104-020-05094-2","article-title":"Aescin and diosmin each alone or in low dose- combination ameliorate liver damage induced by carbon tetrachloride in rats","volume":"13","author":"El-Dakhly","year":"2020","journal-title":"BMC Res. Notes"},{"key":"10.1016\/j.jep.2022.115957_bib20","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3923\/rjphyto.2010.154.161","article-title":"Herbal medicine in africa-distribution, standardization and prospects","volume":"4","author":"Falodun","year":"2010","journal-title":"Res. J. Phytochem."},{"issue":"6","key":"10.1016\/j.jep.2022.115957_bib21","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/laban.254","article-title":"Estimation of rat mammary tumor volume using caliper and ultrasonography measurements","volume":"42","author":"Faustino-Rocha","year":"2013","journal-title":"Lab. Anim."},{"issue":"2","key":"10.1016\/j.jep.2022.115957_bib22","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.foodchem.2011.04.079","article-title":"Antioxidant capacities and total phenolic contents of 62 fruits","volume":"129","author":"Fu","year":"2011","journal-title":"Food Chem."},{"issue":"4","key":"10.1016\/j.jep.2022.115957_bib23","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.3390\/ijms12042112","article-title":"Total phenolic contents and antioxidant capacities of herbal and tea infusions","volume":"12","author":"Fu","year":"2011","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.jep.2022.115957_bib24","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1615\/IntJMedMushrooms.2022043505","article-title":"In vitro inhibition of melanin formation and enhancement of collagen production by a mushroom sclerotial water extract from the tiger milk mushroom, Lignosus rhinocerus (agaricomycetes), with No skin and eye irritation","volume":"24","author":"Fung","year":"2022","journal-title":"Int. J. Med. Mushrooms"},{"issue":"7\u20138","key":"10.1016\/j.jep.2022.115957_bib25","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1023\/B:DDAS.0000037792.04787.8a","article-title":"Oral broccoli sprouts for the treatment of Helicobacter pylori infection: a preliminary report","volume":"49","author":"Galan","year":"2004","journal-title":"Dig. Dis. Sci."},{"issue":"6","key":"10.1016\/j.jep.2022.115957_bib26","first-page":"2727","article-title":"Baicalin inhibits breast cancer development via inhibiting I\u0138B kinase activation in vitro and in vivo","volume":"53","author":"Gao","year":"2018","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.jep.2022.115957_bib27","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/1471-2407-13-63","article-title":"Rac3 induces a molecular pathway triggering breast cancer cell aggressiveness: differences in MDA-MB-231 and MCF-7 breast cancer cell lines","volume":"13","author":"Gest","year":"2013","journal-title":"BMC Cancer"},{"issue":"1","key":"10.1016\/j.jep.2022.115957_bib28","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ccr.2007.12.020","article-title":"Autocrine IL-6 signaling: a key event in tumorigenesis?","volume":"13","author":"Grivennikov","year":"2008","journal-title":"Cancer Cell"},{"issue":"Suppl. 2","key":"10.1016\/j.jep.2022.115957_bib29","doi-asserted-by":"crossref","first-page":"S174","DOI":"10.4103\/pm.pm_479_16","article-title":"Anti-inflammatory potential of petiveria alliacea on activated RAW264.7 murine macrophages","volume":"13","author":"Gutierrez","year":"2017","journal-title":"Phcog. Mag."},{"issue":"1","key":"10.1016\/j.jep.2022.115957_bib30","doi-asserted-by":"crossref","first-page":"9575","DOI":"10.1038\/s41598-018-27810-6","article-title":"Estrogen promotes progression of hormone-dependent breast cancer through CCL2-CCR2 axis by upregulation of Twist via PI3K\/AKT\/NF-\u03baB signaling","volume":"8","author":"Han","year":"2018","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.jep.2022.115957_bib31","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3390\/ijms19010181","article-title":"Halfway between 2D and animal models: are 3D cultures the ideal tool to study cancer-microenvironment interactions?","volume":"19","author":"Hoarau-V\u00e9chot","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2022.115957_bib32","first-page":"32","article-title":"Identification of the scientific name of hurulingzhi","volume":"6","author":"Huang","year":"1999","journal-title":"Acta Edulis Fungi"},{"key":"10.1016\/j.jep.2022.115957_bib33","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/B978-0-12-407190-2.00003-4","article-title":"Role of oxidative stress and the microenvironment in breast cancer development and progression","volume":"119","author":"Jezierska-Drutel","year":"2013","journal-title":"Adv. Cancer Res."},{"issue":"1","key":"10.1016\/j.jep.2022.115957_bib34","doi-asserted-by":"crossref","first-page":"4944","DOI":"10.1038\/ncomms5944","article-title":"TNFR1 mediates TNF-\u03b1-induced tumour lymphangiogenesis and metastasis by modulating VEGF-C-VEGFR3 signalling","volume":"5","author":"Ji","year":"2014","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.jep.2022.115957_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0249091","article-title":"Lignosus rhinocerotis Cooke Ryvarden ameliorates airway inflammation, mucus hypersecretion and airway hyperresponsiveness in a murine model of asthma","volume":"16","author":"Johnathan","year":"2021","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.jep.2022.115957_bib36","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1093\/carcin\/bgi370","article-title":"Genistein stimulates growth of human breast cancer cells in a novel, postmenopausal animal model, with low plasma estradiol concentrations","volume":"27","author":"Ju","year":"2006","journal-title":"Carcinogenesis"},{"issue":"1","key":"10.1016\/j.jep.2022.115957_bib37","article-title":"Identification for antitumor effects of tramadol in a xenograft mouse model using orthotopic breast cancer cells","volume":"11","author":"Kim","year":"2021","journal-title":"Sci. Rep. Uk"},{"issue":"1","key":"10.1016\/j.jep.2022.115957_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/biology10010030","article-title":"Neuroprotective effects of extracts from tiger milk mushroom Lignosus rhinocerus against glutamate-induced toxicity in HT22 hippocampal neuronal cells and neurodegenerative diseases in Caenorhabditis elegans","volume":"10","author":"Kittimongkolsuk","year":"2021","journal-title":"Biology"},{"key":"10.1016\/j.jep.2022.115957_bib39","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3390\/ph14020093","article-title":"Extracts of the tiger milk mushroom (Lignosus rhinocerus) enhance stress resistance and extend lifespan in Caenorhabditis elegans via the DAF-16\/FoxO signaling pathway","volume":"14","author":"Kittimongkolsuk","year":"2021","journal-title":"Pharmaceuticals"},{"issue":"10","key":"10.1016\/j.jep.2022.115957_bib40","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1615\/IntJMedMushrooms.2021040120","article-title":"Longitudinal assessment of the tiger milk medicinal mushroom, Lignosus rhinocerus (agaricomycetes), sclerotium cultivar: uniformity of bioactive components","volume":"23","author":"Kong","year":"2021","journal-title":"Int. J. Med. Mushrooms"},{"key":"10.1016\/j.jep.2022.115957_bib41","doi-asserted-by":"crossref","first-page":"411","DOI":"10.2147\/IJWH.S7012","article-title":"Clinical trials and progress with paclitaxel in ovarian cancer","volume":"2","author":"Kumar","year":"2010","journal-title":"Int. J. Womens Health"},{"key":"10.1016\/j.jep.2022.115957_bib42","series-title":"Antitumor Effects of Polysaccharides Extracted from Mushroom Sclerotia: an in Vitro and in Vivo Study","author":"Lai","year":"2005"},{"key":"10.1016\/j.jep.2022.115957_bib43","first-page":"255","volume":"vol. 10","author":"Lai","year":"2008"},{"key":"10.1016\/j.jep.2022.115957_bib44","series-title":"Preliminary Study on the Potential of Polysaccharide from Indigenous Tiger's Milk Mushroom (Lignosus Rhinocerus) as Anti-lung Cancer Agent","author":"Lai","year":"2014"},{"issue":"1","key":"10.1016\/j.jep.2022.115957_bib45","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.jep.2013.08.034","article-title":"Chemical composition and cellular toxicity of ethnobotanical-based hot and cold aqueous preparations of the tiger's milk mushroom (Lignosus rhinocerotis)","volume":"150","author":"Lau","year":"2013","journal-title":"J. Ethnopharmacol."},{"issue":"7","key":"10.1016\/j.jep.2022.115957_bib46","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djv073","article-title":"MCF-7 cells\u2014changing the course of breast cancer research and Care for 45 years","volume":"107","author":"Lee","year":"2015","journal-title":"JNCI: J. Natl. Cancer Inst."},{"key":"10.1016\/j.jep.2022.115957_bib47","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2018.00461","article-title":"Airway relaxation effects of water-soluble sclerotial extract from Lignosus rhinocerotis","volume":"9","author":"Lee","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2022.115957_bib48","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/697603","article-title":"The Antiproliferative Activity of Sclerotia of Lignosus rhinocerus (Tiger Milk Mushroom)","author":"Lee","year":"2012","journal-title":"Evid. Based Compl. Alt."},{"issue":"30","key":"10.1016\/j.jep.2022.115957_bib49","doi-asserted-by":"crossref","first-page":"29637","DOI":"10.18632\/oncotarget.4936","article-title":"Cyclooxygenase-2 in tumor-associated macrophages promotes breast cancer cell survival by triggering a positive-feedback loop between macrophages and cancer cells","volume":"6","author":"Li","year":"2015","journal-title":"Oncotarget"},{"issue":"3","key":"10.1016\/j.jep.2022.115957_bib50","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph18031271","article-title":"Nutritional and 13-week subchronic toxicological evaluation of Lignosus rhinocerotis mycelium in sprague-dawley rats","volume":"18","author":"Li","year":"2021","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.jep.2022.115957_bib51","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.indcrop.2013.09.017","article-title":"Antioxidant capacities and total phenolic contents of infusions from 223 medicinal plants","volume":"51","author":"Li","year":"2013","journal-title":"Ind. Crop. Prod."},{"key":"10.1016\/j.jep.2022.115957_bib52","series-title":"Compendium of Materia Medica : Bencao Gangmu","author":"Li","year":"2003"},{"issue":"3","key":"10.1016\/j.jep.2022.115957_bib53","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1080\/09735070.2012.11886432","article-title":"Traditional medicinal plants used by the Kensiu tribe of lubuk ulu legong, Kedah, Malaysia","volume":"6","author":"Mohammad","year":"2012","journal-title":"Stud. Ethno-Med."},{"issue":"5","key":"10.1016\/j.jep.2022.115957_bib54","first-page":"3867","article-title":"Intranasal administration of Lignosus rhinocerotis (Cooke) Ryvarden (Tiger Milk mushroom) extract attenuates airway inflammation in murine model of allergic asthma","volume":"17","author":"Muhamad","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.jep.2022.115957_bib55","first-page":"1","article-title":"Lipid-rich fraction of the sclerotium of Tiger Milk Mushroom Lignosus rhinocerotis (Agaricomycetes) attenuates LPS-induced inflammation in BV2 cells via Nrf2 pathway","volume":"56","author":"Nallathamby","year":"2021","journal-title":"Braz. J. Pharmaceut. Sci."},{"issue":"10","key":"10.1016\/j.jep.2022.115957_bib56","first-page":"1485","article-title":"Identification and in vitro evaluation of lipids from sclerotia of Lignosus rhinocerotis for antioxidant and anti-neuroinflammatory activities","volume":"11","author":"Nallathamby","year":"2016","journal-title":"Nat. Prod. Commun."},{"key":"10.1016\/j.jep.2022.115957_bib57","article-title":"Can breast tumors affect the oxidative status of the surrounding environment? A comparative analysis among cancerous breast, mammary adjacent tissue, and plasma","volume":"2015","author":"Panis","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jep.2022.115957_bib58","article-title":"Characterisation of a new fungal immunomodulatory protein from tiger milk mushroom, Lignosus Rhinocerotis","volume":"6","author":"Pushparajah","year":"2016","journal-title":"Sci. Rep. Uk"},{"issue":"4","key":"10.1016\/j.jep.2022.115957_bib59","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1007\/s13197-013-1238-x","article-title":"Evaluation of antioxidant activities of bioactive compounds and various extracts obtained from saffron (Crocus sativus L.): a review","volume":"52","author":"Rahaiee","year":"2015","journal-title":"J. Food Sci. Technol."},{"issue":"8","key":"10.1016\/j.jep.2022.115957_bib60","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1517\/14656566.5.8.1771","article-title":"Paclitaxel for non-small cell lung cancer","volume":"5","author":"Ramalingam","year":"2004","journal-title":"Expet Opin. Pharmacother."},{"issue":"1","key":"10.1016\/j.jep.2022.115957_bib61","first-page":"31","article-title":"The status of antioxidants, malondialdehyde and some trace elements in serum of patients with breast cancer","volume":"7","author":"Sadati Zarrini","year":"2016","journal-title":"Caspian J. Intern. Med."},{"issue":"1","key":"10.1016\/j.jep.2022.115957_bib62","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s12957-015-0529-2","article-title":"Interleukin-6 and pro inflammatory status in the breast tumor microenvironment","volume":"13","author":"Sanguinetti","year":"2015","journal-title":"World J. Surg. Oncol."},{"issue":"7","key":"10.1016\/j.jep.2022.115957_bib63","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"issue":"14","key":"10.1016\/j.jep.2022.115957_bib64","doi-asserted-by":"crossref","first-page":"7948","DOI":"10.3390\/su13147948","article-title":"Current knowledge of medicinal mushrooms related to anti-oxidant properties","volume":"13","author":"Shaffique","year":"2021","journal-title":"Sustainability"},{"issue":"3","key":"10.1016\/j.jep.2022.115957_bib65","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1002\/cam4.174","article-title":"Association between adjuvant regional radiotherapy and cognitive function in breast cancer patients treated with conservation therapy","volume":"3","author":"Shibayama","year":"2014","journal-title":"Cancer Med."},{"issue":"43","key":"10.1016\/j.jep.2022.115957_bib66","doi-asserted-by":"crossref","first-page":"15550","DOI":"10.1073\/pnas.1416940111","article-title":"Sulforaphane treatment of autism spectrum disorder (ASD)","volume":"111","author":"Singh","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.jep.2022.115957_bib67","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.arr.2012.10.004","article-title":"Oxidative stress and cancer: an overview","volume":"12","author":"Sosa","year":"2013","journal-title":"Ageing Res. Rev."},{"issue":"3","key":"10.1016\/j.jep.2022.115957_bib68","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA A Cancer J. Clin."},{"key":"10.1016\/j.jep.2022.115957_bib69","series-title":"Setting-up Pilot-Plant for Up-Scaling Production of \u2018Tiger-Milk\u2019mushroom as Dietary Functional Food","author":"Tan","year":"2009"},{"key":"10.1016\/j.jep.2022.115957_bib70","doi-asserted-by":"crossref","first-page":"161","DOI":"10.17660\/ActaHortic.2010.859.19","article-title":"Genetic markers for identification of a Malaysian medicinal mushroom Lignosus rhinoceros (Cendawan susu rimau)","volume":"859","author":"Tan","year":"2010","journal-title":"Acta Hortic."},{"issue":"21","key":"10.1016\/j.jep.2022.115957_bib71","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.18632\/oncotarget.26699","article-title":"HIGH expression of OSM and IL-6 are associated with decreased breast cancer survival: synergistic induction of IL-6 secretion by OSM and IL-1\u03b2","volume":"10","author":"Tawara","year":"2019","journal-title":"Oncotarget"},{"issue":"3a","key":"10.1016\/j.jep.2022.115957_bib72","first-page":"2037","article-title":"Changes in cytokine profile during local IL-2 therapy in cancer patients","volume":"26","author":"Tomova","year":"2006","journal-title":"Anticancer Res."},{"key":"10.1016\/j.jep.2022.115957_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114024","article-title":"Restitution of epithelial cells during intestinal mucosal wound healing: the effect of a polysaccharide from the sclerotium of Lignosus rhinocerotis (Cooke) Ryvarden","volume":"274","author":"Veeraperumal","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"1462","key":"10.1016\/j.jep.2022.115957_bib74","article-title":"The metabolic signature of macrophage responses","volume":"10","author":"Viola","year":"2019","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.jep.2022.115957_bib75","doi-asserted-by":"crossref","first-page":"495","DOI":"10.2217\/WHE.10.42","article-title":"Nab-Paclitaxel: a novel formulation of taxane for treatment of breast cancer","volume":"6","author":"Vishnu","year":"2010","journal-title":"Women's Health"},{"key":"10.1016\/j.jep.2022.115957_bib76","first-page":"53","article-title":"Safety and efficacy of nab-paclitaxel in the treatment of patients with breast cancer","volume":"5","author":"Vishnu","year":"2011","journal-title":"Breast Cancer"},{"issue":"2","key":"10.1016\/j.jep.2022.115957_bib77","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.foodhyd.2010.04.008","article-title":"Immunomodulatory activities of mushroom sclerotial polysaccharides","volume":"25","author":"Wong","year":"2011","journal-title":"Food Hydrocolloids"},{"key":"10.1016\/j.jep.2022.115957_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2022.101944","article-title":"Anti-oxidative effects of functional food, Lignosus rhinocerus sclerotia (TM02\u00ae cultivar) using a type 2 diabetes mellitus rodent model","volume":"49","author":"Yap","year":"2022","journal-title":"Food Biosci."},{"issue":"8","key":"10.1016\/j.jep.2022.115957_bib79","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1615\/IntJMedMushrooms.2020035658","article-title":"The immunomodulating properties of tiger milk medicinal mushroom, Lignosus rhinocerus TM02 cultivar (agaricomycetes) and its associated carbohydrate composition","volume":"22","author":"Yap","year":"2020","journal-title":"Int. J. Med. Mushrooms"},{"key":"10.1016\/j.jep.2022.115957_bib80","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2164-15-635","article-title":"The genome of the Tiger Milk mushroom, Lignosus rhinocerotis, provides insights into the genetic basis of its medicinal properties","volume":"15","author":"Yap","year":"2014","journal-title":"BMC Genom."},{"issue":"1","key":"10.1016\/j.jep.2022.115957_bib81","doi-asserted-by":"crossref","first-page":"23","DOI":"10.7150\/ijms.10019","article-title":"Genome-based proteomic analysis of Lignosus rhinocerotis (Cooke) ryvarden sclerotium","volume":"12","author":"Yap","year":"2015","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.jep.2022.115957_bib82","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.jep.2015.08.042","article-title":"Shotgun proteomic analysis of tiger milk mushroom (Lignosus rhinocerotis) and the isolation of a cytotoxic fungal serine protease from its sclerotium","volume":"174","author":"Yap","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.115957_bib83","doi-asserted-by":"crossref","DOI":"10.1186\/s12934-017-0713-x","article-title":"Heterologous expression of cytotoxic sesquiterpenoids from the medicinal mushroom Lignosus rhinocerotis in yeast","volume":"16","author":"Yap","year":"2017","journal-title":"Microb. Cell Factories"},{"issue":"12","key":"10.1016\/j.jep.2022.115957_bib84","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1002\/jsfa.6121","article-title":"Nutrient composition, antioxidant properties, and anti-proliferative activity of Lignosus rhinocerus Cooke sclerotium","volume":"93","author":"Yap","year":"2013","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.jep.2022.115957_bib85","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2018.00103","article-title":"Inhibition of protein glycation by tiger milk mushroom [Lignosus rhinocerus (Cooke) ryvarden] and search for potential anti-diabetic activity-related metabolic pathways by genomic and transcriptomic data mining","volume":"9","author":"Yap","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2022.115957_bib86","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.4940","article-title":"Molecular attributes and apoptosis-inducing activities of a putative serine protease isolated from Tiger Milk mushroom (Lignosus rhinocerus) sclerotium against breast cancer cells in vitro","volume":"6","author":"Yap","year":"2018","journal-title":"PeerJ"},{"key":"10.1016\/j.jep.2022.115957_bib87","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/3126376","article-title":"Human embryonic stem cell-derived neural lineages as in vitro models for screening the neuroprotective properties of Lignosus rhinocerus (Cooke) ryvarden","volume":"2019","author":"Yeo","year":"2019","journal-title":"BioMed Res. Int."},{"issue":"1","key":"10.1016\/j.jep.2022.115957_bib88","first-page":"18","article-title":"Antioxidant activity and the polyphenolic and flavonoid contents of five high altitude medicinal plants used in Bhutanese sowa rigpa medicine","volume":"7","author":"Yeshi","year":"2017","journal-title":"J. Biol. Active Prod. Nat."},{"issue":"1","key":"10.1016\/j.jep.2022.115957_bib89","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/s41392-021-00658-5","article-title":"Inflammation and tumor progression: signaling pathways and targeted intervention","volume":"6","author":"Zhao","year":"2021","journal-title":"Signal Transduct. Targeted Ther."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122009965?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122009965?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T23:58:36Z","timestamp":1778543916000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874122009965"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":89,"alternative-id":["S0378874122009965"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2022.115957","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vivo anti-tumor activity of Lignosus rhinocerus TM02\u00ae using a MCF7-xenograft NCr nude mice model","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2022.115957","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115957"}}