{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T12:55:52Z","timestamp":1793883352360,"version":"4.7.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T00:00:00Z","timestamp":1702857600000},"content-version":"vor","delay-in-days":292,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26\/010.001318\/2019"],"award-info":[{"award-number":["E-26\/010.001318\/2019"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26\/202.787\/2019"],"award-info":[{"award-number":["E-26\/202.787\/2019"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26\/210.068\/2021"],"award-info":[{"award-number":["E-26\/210.068\/2021"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.jep.2022.116043","type":"journal-article","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T11:20:01Z","timestamp":1671189601000},"page":"116043","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["New substances of Equisetum hyemale L. extracts and their in vivo antitumoral effect against oral squamous cell carcinoma"],"prefix":"10.1016","volume":"303","author":[{"given":"Lucas Nicolau","family":"de Queiroz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8366-3146","authenticated-orcid":false,"given":"Anna Carolina Carvalho","family":"Da Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme Freimann","family":"Wermelinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego Polo Dutra","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4234-4843","authenticated-orcid":false,"given":"Aislan Cristina Rheder Fagundes","family":"Pascoal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra Christine Helena Frankland","family":"Sawaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elan Cardozo Paes","family":"de Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno Sergio","family":"do Amaral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davyson","family":"de Lima Moreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3972-5530","authenticated-orcid":false,"given":"Bruno Kaufmann","family":"Robbs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2022.116043_bib1","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/j.1472-8206.2008.00622.x","article-title":"Dose\u2013response effect of ferulic acid against nicotine\u2010induced tissue damage and altered lipid levels in experimental rats: a pathohistological evaluation","volume":"22","author":"Adluri","year":"2008","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.jep.2022.116043_bib2","article-title":"Alkaloid extract of Equisetum arvense plant induce apoptosis in MCF7 cancer cell line","volume":"13","author":"Ahmed","year":"2020","journal-title":"Iraqi J. Cancer Med. Gene."},{"key":"10.1016\/j.jep.2022.116043_bib3","first-page":"1947","article-title":"Anticancer activity of EA1 extracted from Equisetum arvense","volume":"30","author":"Al Mohammed","year":"2017","journal-title":"Pak. J. Pharm. Sci."},{"key":"10.1016\/j.jep.2022.116043_bib4","first-page":"3139","article-title":"Investigation of pro-apoptotic activity of Equisetum arvense L. water extract on human leukemia U 937 cells","volume":"12","author":"Alexandru","year":"2007","journal-title":"Rom. Biotechnol. Lett."},{"key":"10.1016\/j.jep.2022.116043_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/S0140-6736(08)60728-X","article-title":"Head and neck cancer","volume":"371","author":"Argiris","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.jep.2022.116043_bib6","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ejphar.2010.03.054","article-title":"Chemopreventive potential of ferulic acid in 7, 12-dimethylbenz [a] anthracene-induced mammary carcinogenesis in Sprague\u2013Dawley rats","volume":"637","author":"Baskaran","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2022.116043_bib7","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0962-8924(00)88932-1","article-title":"The role of DNA fragmentation in apoptosis","volume":"5","author":"Bortner","year":"1995","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.jep.2022.116043_bib8","doi-asserted-by":"crossref","DOI":"10.1093\/aobpla\/plr009","article-title":"Equisetum species show uniform epicuticular wax structures but diverse composition patterns","author":"Brune","year":"2011","journal-title":"AoB Plants"},{"key":"10.1016\/j.jep.2022.116043_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.103984","article-title":"Molecular mechanism of action of new 1,4-naphthoquinones tethered to 1,2,3-1H-triazoles with cytotoxic and selective effect against oral squamous cell carcinoma","volume":"101","author":"Cavalcanti Chipoline","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.jep.2022.116043_bib10","doi-asserted-by":"crossref","DOI":"10.1038\/35070009","article-title":"Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I","volume":"3","author":"Coleman","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.jep.2022.116043_bib11","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2005.05.3348","article-title":"Chemotherapy options for patients with metastatic or recurrent squamous cell carcinoma of the head and neck","volume":"24","author":"Colevas","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.jep.2022.116043_bib12","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1080\/14786410410001704714","article-title":"Phenolic constituents from Ephedra nebrodensis","volume":"19","author":"Cottiglia","year":"2005","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.jep.2022.116043_bib13","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.bbrc.2011.05.027","article-title":"Aliphatic acetogenin constituents of avocado fruits inhibit human oral cancer cell proliferation by targeting the EGFR\/RAS\/RAF\/MEK\/ERK1\/2 pathway","volume":"409","author":"D'Ambrosio","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jep.2022.116043_bib14","article-title":"Factors affecting professional delay in diagnosis and treatment of oral cancer in Iran","volume":"17","author":"Esmaelbeigi","year":"2014","journal-title":"Arch. Iran. Med."},{"key":"10.1016\/j.jep.2022.116043_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0047868","article-title":"NFAT1 C-terminal domains are necessary but not sufficient for inducing cell death","volume":"7","author":"Faget","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2022.116043_bib16","doi-asserted-by":"crossref","first-page":"6163","DOI":"10.1080\/14786419.2020.1831494","article-title":"Cytotoxic effect of pure compounds from Piper rivinoides Kunth against oral squamous cell carcinoma","volume":"35","author":"Fonseca","year":"2021","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.jep.2022.116043_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2012.11.072","article-title":"Identification of phenolic compounds in Equisetum giganteum by LC\u2013ESI-MS\/MS and a new approach to total flavonoid quantification","volume":"105","author":"Francescato","year":"2013","journal-title":"Talanta"},{"key":"10.1016\/j.jep.2022.116043_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/nprot.2006.339","article-title":"Clonogenic assay of cells in vitro","volume":"1","author":"Franken","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jep.2022.116043_bib19","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1515\/znb-1982-0419","article-title":"glucopyranosid)-8-\u00df-D-glucopyranosid, zwei neue Flavonolglykoside","author":"Geiger","year":"1982","journal-title":"Z. Naturforsch."},{"key":"10.1016\/j.jep.2022.116043_bib20","series-title":"Protocols for Screening Chemical Agents and Natural Products against Animal Tumors and Other Biological Systems","author":"Geran","year":"1972"},{"key":"10.1016\/j.jep.2022.116043_bib21","article-title":"Multidisciplinary approach to cancer treatment: focus on head and neck cancer","volume":"52","author":"Haddad","year":"2008","journal-title":"Dent. Clin."},{"key":"10.1016\/j.jep.2022.116043_bib22","first-page":"321","article-title":"Cytotoxicity induced by docetaxel in human oral squamous cell carcinoma cell lines","volume":"27","author":"Iida","year":"2013","journal-title":"In Vivo"},{"key":"10.1016\/j.jep.2022.116043_bib23","doi-asserted-by":"crossref","DOI":"10.1080\/14786419.2014.947491","article-title":"A new phenyl glycoside from the aerial parts of Equisetum hyemale","volume":"28","author":"Jin","year":"2014","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.jep.2022.116043_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/S0092-8674(02)00625-6","article-title":"Apoptosis","volume":"108","author":"Johnstone","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.jep.2022.116043_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2010.11.038","article-title":"Atractylenolide III, a sesquiterpenoid, induces apoptosis in human lung carcinoma A549 cells via mitochondria-mediated death pathway","volume":"49","author":"Kang","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jep.2022.116043_bib26","doi-asserted-by":"crossref","DOI":"10.1006\/excr.2000.4838","article-title":"Induction of apoptosis by cancer chemotherapy","volume":"256","author":"Kaufmann","year":"2000","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.jep.2022.116043_bib27","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.3892\/or.2013.2732","article-title":"Cytotoxic effects of mistletoe (Viscum album L.) in head and neck squamous cell carcinoma cell lines","volume":"30","author":"Klingbeil","year":"2013","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.jep.2022.116043_bib28","first-page":"201","article-title":"Inhibitory effects of the rhizome extract of Atractylodes japonica on the proliferation of human tumor cell lines","volume":"36","author":"Lee","year":"2005","journal-title":"Korean J. Pharmacogn."},{"key":"10.1016\/j.jep.2022.116043_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2012.09.015","article-title":"Cell cycle arrest and cell apoptosis induced by Equisetum hyemale extract in murine leukemia L1210 cells","volume":"144","author":"Li","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.116043_bib30","article-title":"Biofunctional activities of Equisetum ramosissimum extract: protective effects against oxidation, melanoma, and melanogenesis","volume":"1\u20139","author":"Li","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jep.2022.116043_bib31","first-page":"543","article-title":"In vitro anticancer activity and cytotoxicity screening of phytochemical extracts from selected traditional Chinese medicinal plants","volume":"22","author":"Liang","year":"2017","journal-title":"J. BUON"},{"key":"10.1016\/j.jep.2022.116043_bib32","first-page":"544","article-title":"In vitro anticancer activity and cytotoxicity screening of phytochemical extracts from selected traditional Chinese medicinal plants","volume":"22","author":"Liang","year":"2017","journal-title":"J. BUON"},{"key":"10.1016\/j.jep.2022.116043_bib33","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jtice.2009.05.014","article-title":"Apoptosis effect of Sinularia leptoclados, S. depressan and S. inflate extracts in human oral squamous cell carcinomas","volume":"41","author":"Liang","year":"2010","journal-title":"J. Taiwan Inst. Chem. Eng."},{"key":"10.1016\/j.jep.2022.116043_bib34","article-title":"Critical evaluation of diagnostic aids for the detection of oral cancer","volume":"44","author":"Lingen","year":"2008","journal-title":"Oral Oncol."},{"key":"10.1016\/j.jep.2022.116043_bib35","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2020.10926","article-title":"Isoferulic acid inhibits human leukemia cell growth through induction of G2\/M-phase arrest and inhibition of Akt\/mTOR signaling","author":"Long","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jep.2022.116043_bib36","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.1016\/j.foodchem.2012.07.073","article-title":"Secondary metabolites from the unripe pulp of Persea americana and their antimycobacterial activities","volume":"135","author":"Lu","year":"2012","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2022.116043_bib37","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1128\/MCB.00501-15","article-title":"NFAT2 Isoforms differentially regulate gene expression, cell death, and transformation through alternative N-terminal domains","volume":"36","author":"Lucena","year":"2016","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.jep.2022.116043_bib38","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.biopha.2018.11.129","article-title":"Cytotoxicity and selectiveness of Brazilian Piper species towards oral carcinoma cells","volume":"110","author":"Macedo","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2022.116043_bib39","first-page":"1","article-title":"Apoptotic effect of \u03b2-pinene on oral squamous cell carcinoma as one of the major compounds from essential oil of medicinal plant Piper rivinoides Kunth","author":"Machado","year":"2021","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.jep.2022.116043_bib40","article-title":"Cytotoxic activity of Thai medicinal plants against human cholangiocarcinoma, laryngeal and hepatocarcinoma cells in vitro","volume":"10","author":"Mahavorasirikul","year":"2010","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.jep.2022.116043_bib41","first-page":"258","article-title":"Etnobot\u00e2nica na comunidade de Santa B\u00e1rbara, Ascurra, Santa Catarina, Brasil","volume":"10","author":"Meyer","year":"2012","journal-title":"Rev. Brasileira Bioci\u00eancias"},{"key":"10.1016\/j.jep.2022.116043_bib42","first-page":"3775","article-title":"Chemopreventive effects of ferulic acid on oral and rice germ on large bowel carcinogenesis","volume":"19","author":"Mori","year":"1999","journal-title":"Anticancer Res."},{"key":"10.1016\/j.jep.2022.116043_bib43","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0304-3835(91)90121-W","article-title":"Inhibitory effects of Ixora javanica extract on skin chemical carcinogenesis in mice and its antitumour activity","volume":"60","author":"Nair","year":"1991","journal-title":"Cancer Lett."},{"key":"10.1016\/j.jep.2022.116043_bib44","doi-asserted-by":"crossref","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural products as sources of new drugs over the nearly four decades from 01\/1981 to 09\/2019","volume":"83","author":"Newman","year":"2020","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.jep.2022.116043_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.indcrop.2014.07.036","article-title":"Extraction methods for the determination of phenolic compounds from Equisetum arvense L. herb","volume":"61","author":"Oniszczuk","year":"2014","journal-title":"Ind. Crop. Prod."},{"key":"10.1016\/j.jep.2022.116043_bib46","series-title":"Medicinal Plants in the Republic of Korea: Information on 150 Commonly Used Medicinal Plants","author":"Organization","year":"1998"},{"key":"10.1016\/j.jep.2022.116043_bib47","first-page":"1623","article-title":"Analysis of phenolic compounds composition by HPLC and assessment of antioxidant capacity in Equisetum arvense L. extracts","volume":"67","author":"Pallag","year":"2016","journal-title":"Rev. Chem."},{"key":"10.1016\/j.jep.2022.116043_bib48","article-title":"Toxicological screening","volume":"2","author":"Parasuraman","year":"2011","journal-title":"J. Pharmacol. Pharmacother."},{"key":"10.1016\/j.jep.2022.116043_bib49","article-title":"Toxicological screening","volume":"2","author":"Parasuraman","year":"2011","journal-title":"J. Pharmacol. Pharmacother."},{"key":"10.1016\/j.jep.2022.116043_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2021.131296","article-title":"Molecular docking and dynamic simulations of Cefixime, Etoposide and Nebrodenside A against the pathogenic proteins of SARS-CoV-2","volume":"1247","author":"Rashid","year":"2022","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.jep.2022.116043_bib51","doi-asserted-by":"crossref","DOI":"10.1007\/s10495-005-6075-6","article-title":"Morphological criteria to distinguish cell death induced by apoptotic and necrotic treatments","volume":"10","author":"Rello","year":"2005","journal-title":"Apoptosis"},{"key":"10.1016\/j.jep.2022.116043_bib52","doi-asserted-by":"crossref","DOI":"10.17219\/acem\/116753","article-title":"Oral cancer: the first symptoms and reasons for delaying correct diagnosis and appropriate treatment","volume":"29","author":"Rutkowska","year":"2020","journal-title":"Adv. Clin. Exp. Med."},{"key":"10.1016\/j.jep.2022.116043_bib53","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12090","article-title":"Anti-proliferative and apoptotic activities of constituents of chloroform extract of Juglans regia leaves","volume":"47","author":"Salimi","year":"2014","journal-title":"Cell Prolif"},{"key":"10.1016\/j.jep.2022.116043_bib54","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.tcb.2015.08.003","article-title":"An apoptotic \u2018eat me\u2019 signal: phosphatidylserine exposure","volume":"25","author":"Segawa","year":"2015","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.jep.2022.116043_bib55","article-title":"Cancer statistics, 2021","volume":"71","author":"Siegel","year":"2021","journal-title":"CA A Cancer J. Clin."},{"key":"10.1016\/j.jep.2022.116043_bib56","doi-asserted-by":"crossref","DOI":"10.1080\/10799893.2018.1468780","article-title":"Antiproliferative and apoptosis-induction studies of 5-hydroxy 3\u2032,4\u2032,7-trimethoxyflavone in human breast cancer cells MCF-7: an in vitro and in silico approach","volume":"38","author":"Sudha","year":"2018","journal-title":"J. Recept. Signal Transduction"},{"key":"10.1016\/j.jep.2022.116043_bib57","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA A Cancer J. Clin."},{"key":"10.1016\/j.jep.2022.116043_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/S0367-326X(00)00234-3","article-title":"Turkish folk medicinal plants, part III: \u015eile (Istanbul)","volume":"71","author":"Tuzlac\u0131","year":"2000","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2022.116043_bib59","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1093\/carcin\/21.6.1149","article-title":"Efficacy of potential chemopreventive agents on rat colon aberrant crypt formation and progression","volume":"21","author":"Wargovich","year":"2000","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jep.2022.116043_bib60","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.4155\/fmc-2017-0205","article-title":"Potential cytotoxic and selective effect of new benzo[ b ]xanthenes against oral squamous cell carcinoma","volume":"10","author":"Zorzanelli","year":"2018","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.jep.2022.116043_bib61","doi-asserted-by":"crossref","first-page":"5148","DOI":"10.3390\/molecules27165148","article-title":"Pro-apoptotic antitumoral effect of novel acridine-core naphthoquinone compounds against oral squamous cell carcinoma","volume":"27","author":"Zorzanelli","year":"2022","journal-title":"Molecules"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122010820?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122010820?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T14:27:35Z","timestamp":1778509655000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874122010820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":61,"alternative-id":["S0378874122010820"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2022.116043","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"New substances of Equisetum hyemale L. extracts and their in vivo antitumoral effect against oral squamous cell carcinoma","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2022.116043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"116043"}}