{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T16:45:11Z","timestamp":1772901911192,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.jep.2022.116047","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T16:20:44Z","timestamp":1671034844000},"page":"116047","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["The extract from Hyssopus cuspidatus Boriss. Prevents bronchial airway remodeling by inhibiting mouse bronchial wall thickening and hASMC proliferation and migration"],"prefix":"10.1016","volume":"303","author":[{"given":"Xiaocui","family":"Cai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7223-4645","authenticated-orcid":false,"given":"Yan","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haifang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhua","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingjun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jep.2022.116047_bib1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1097\/MCP.0000000000000441","article-title":"Airway remodeling in asthma: update on mechanisms and therapeutic approaches","volume":"24","author":"Boulet","year":"2018","journal-title":"Curr. Opin. Pulm. Med."},{"issue":"4","key":"10.1016\/j.jep.2022.116047_bib2","first-page":"848","article-title":"Chemical Constituents of the anti-asthmatic action parts from Hyssopus cuspidatus Boriss","volume":"44","author":"Cai","year":"2021","journal-title":"J. Chin. Med. Mater."},{"issue":"3","key":"10.1016\/j.jep.2022.116047_bib3","first-page":"353","article-title":"TNF-\u03b1 and IL-1\u03b2 upregulate bradykinin receptors and endothelin receptor in human bronchial smooth muscle cells via MAPK signaling pathways","volume":"33","author":"Cai","year":"2018","journal-title":"NW. Pharm. J."},{"issue":"4","key":"10.1016\/j.jep.2022.116047_bib4","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.immuni.2011.03.018","article-title":"Interleukin-10 signaling in regulatory T cells is required for Th17 cell-mediated inflammation","volume":"34","author":"Chaudhry","year":"2011","journal-title":"Immunity"},{"issue":"10","key":"10.1016\/j.jep.2022.116047_bib5","doi-asserted-by":"crossref","first-page":"10833","DOI":"10.1096\/fj.201900680R","article-title":"Effects of ATP-competitive and function-selective ERK inhibitors on airway smooth muscle cell proliferation","volume":"33","author":"Defnet","year":"2019","journal-title":"Faseb. J."},{"issue":"3","key":"10.1016\/j.jep.2022.116047_bib6","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s00441-016-2566-8","article-title":"Airway remodeling in asthma: what really matters","volume":"367","author":"Fehrenbach","year":"2017","journal-title":"Cell Tissue Res."},{"issue":"4","key":"10.1016\/j.jep.2022.116047_bib7","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/nri1589","article-title":"Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma","volume":"5","author":"Hawrylowicz","year":"2005","journal-title":"Nat. Rev. Immunol."},{"issue":"10100","key":"10.1016\/j.jep.2022.116047_bib8","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/S0140-6736(17)32130-X","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"390","author":"Hay","year":"2017","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.jep.2022.116047_bib9","first-page":"365","article-title":"Effect of Uygur medicine Hyssopus officinalis L. on serum IL-17 level and balance of Th1\/Th2 of asthma rats","volume":"20","author":"Hou","year":"2010","journal-title":"China J. Mod. Med."},{"issue":"19","key":"10.1016\/j.jep.2022.116047_bib10","first-page":"90","article-title":"Effects of Uigur herb Hyssopus officinaLis L. on serum eotaxin-2, eotaxin-3 and sP-selectin level of asthma rats","volume":"27","author":"Hou","year":"2009","journal-title":"Sci. Technol. Rev."},{"issue":"1","key":"10.1016\/j.jep.2022.116047_bib11","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1186\/s12906-019-2743-x","article-title":"Inhibition of airway remodeling and inflammatory response by Icariin in asthma","volume":"19","author":"Hu","year":"2019","journal-title":"BMC Compl. Alternative Med."},{"issue":"10196","key":"10.1016\/j.jep.2022.116047_bib12","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0140-6736(19)31147-X","article-title":"Prevalence, risk factors, and management of asthma in China: a national cross-sectional study","volume":"394","author":"Huang","year":"2019","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.jep.2022.116047_bib13","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.3109\/02770903.2014.938353","article-title":"Serum levels of IL-l0, IL-17F and IL-33 in patients with asthma: a case-control study","volume":"51","author":"Jahromi","year":"2014","journal-title":"J. Asthma"},{"issue":"1","key":"10.1016\/j.jep.2022.116047_bib14","first-page":"187","article-title":"Anti-inflammatory mechanism extract from the aboveground parts of Hyssopus cuspidatus","volume":"45","author":"Kang","year":"2022","journal-title":"J. Chin. Med. Mater."},{"issue":"5","key":"10.1016\/j.jep.2022.116047_bib15","doi-asserted-by":"crossref","first-page":"L1019","DOI":"10.1152\/ajplung.2001.280.5.L1019","article-title":"ERK activation and mitogenesis in human airway smooth muscle cells","volume":"280","author":"Lee","year":"2001","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"issue":"3","key":"10.1016\/j.jep.2022.116047_bib16","first-page":"174","article-title":"Effect of transforming factor \u03b21 on the activity of extracellular signal-regulated kinase 1\/2 of airway smooth muscle cells in different periods of asthmatic rats","volume":"4","author":"Lin","year":"2010","journal-title":"Chin. J. Asthma"},{"key":"10.1016\/j.jep.2022.116047_bib17","article-title":"Network pharmacology-based analysis of the underlying mechanism of Hyssopus cuspidatus Boriss. For antiasthma: a characteristic medicinal material in Xinjiang","author":"Liu","year":"2021","journal-title":"Evid. Base. Compl. Alternat. Med."},{"key":"10.1016\/j.jep.2022.116047_bib18","series-title":"Pharmacography of Uighur (Upper)","author":"Liu","year":"1999"},{"key":"10.1016\/j.jep.2022.116047_bib19","series-title":"Clinical Research and Effect on Levels of IL-4, IL-5 and IL-10 of the Therapy of the United Chinese Traditional Medicine with Steroid-Resistant Asthma","author":"Liu","year":"2010"},{"key":"10.1016\/j.jep.2022.116047_bib20","series-title":"Effect of AMPK Activiation on Airway Inflammation and Remodeling and its Mechanism in Chronic Asthmatic Mice","author":"Ma","year":"2017"},{"issue":"25","key":"10.1016\/j.jep.2022.116047_bib21","first-page":"3532","article-title":"Component analysis of 40% ethanol eluate of polyamide resin column of Uighur medicine of Hyssopus cuspidatus and its improvement effect on inflammation in asthmatic mice","volume":"28","author":"Mao","year":"2017","journal-title":"J. China Pharm."},{"key":"10.1016\/j.jep.2022.116047_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114574","article-title":"Gekko gecko extract attenuates airway inflammation and mucus hypersecretion in a murine model of ovalbumin-induced asthma","volume":"282","author":"Nam","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.116047_bib26","series-title":"The Function of ORMDL3 in Adult Asthma and the Mechanism of Transcriptional Regulation of ORMDL3","author":"Qiu","year":"2013"},{"issue":"6","key":"10.1016\/j.jep.2022.116047_bib27","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1002\/1097-0215(200002)9999:9999<::AID-IJC1136>3.0.CO;2-J","article-title":"Mechanisms of platelet-derived growth factor-induced chemotaxis","volume":"91","author":"Ronnstrand","year":"2001","journal-title":"Int. J. Cancer"},{"issue":"3","key":"10.1016\/j.jep.2022.116047_bib28","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1093\/cvr\/cvt337","article-title":"Anthocyanidins, novel FAK inhibitors, attenuate PDGF-BB-induced aortic smooth muscle cell migration and neointima formation","volume":"101","author":"Son","year":"2014","journal-title":"Cardiovasc. Res."},{"issue":"5","key":"10.1016\/j.jep.2022.116047_bib29","first-page":"783","article-title":"Effect of Shegan Mahuang decoction on asthma mouse model of airway inflammation and serum IL-6 and IL-10 levels","volume":"26","author":"Sui","year":"2017","journal-title":"JETCM"},{"key":"10.1016\/j.jep.2022.116047_bib30","series-title":"Mechanisms of Traditional Korean Medicine MaHuangDingChuan Decoction in Improving Airway Remodeling by Regulating NF-\u03baB and MAPK Signaling Athway in Asthmatic Mice","author":"Sun","year":"2016"},{"issue":"1","key":"10.1016\/j.jep.2022.116047_bib32","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/jcp.26930","article-title":"MicroRNA-638 inhibits human airway smooth muscle cell proliferation and migration through targeting cyclin D1 and NOR1","volume":"234","author":"Wang","year":"2018","journal-title":"J. Cell. Physiol."},{"issue":"4","key":"10.1016\/j.jep.2022.116047_bib33","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s11302-018-9625-4","article-title":"P2X4R promotes airway remodeling by acting on the phenotype switching of bronchial smooth muscle cells in rats","volume":"14","author":"Wang","year":"2018","journal-title":"Purinergic Signal."},{"key":"10.1016\/j.jep.2022.116047_bib34","series-title":"Study on Airway Inflammatory Cell Invasion and IL-10 and IL-17 Levels in Allergic Asthma","author":"Wang","year":"2017"},{"issue":"2","key":"10.1016\/j.jep.2022.116047_bib35","first-page":"274","article-title":"Effects of montelukast on proliferation and apoptosis of airway smooth muscle cells in asthmatic rats by inhibiting TLR4\/NF-\u03baB signaling pathway","volume":"46","author":"Wang","year":"2020","journal-title":"J. Jilin Univ. - Med. Ed."},{"key":"10.1016\/j.jep.2022.116047_bib36","series-title":"Pharmacological Experimental Methodology","author":"Wei","year":"2010"},{"issue":"1","key":"10.1016\/j.jep.2022.116047_bib38","doi-asserted-by":"crossref","first-page":"L1","DOI":"10.1152\/ajplung.00034.2021","article-title":"Rho\/ROCK-MYOCD in regulating airway smooth muscle growth and remodeling","volume":"321","author":"Yang","year":"2021","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.jep.2022.116047_bib39","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.phymed.2018.12.043","article-title":"JAX2, an ethanol extract of Hyssopus cuspidatus Boriss., can prevent bronchial asthma by inhibiting MAPK\/NF-\u03baB inflammatory signaling","volume":"57","author":"Yuan","year":"2019","journal-title":"Phytomedicine"},{"issue":"13","key":"10.1016\/j.jep.2022.116047_bib40","first-page":"1790","article-title":"Effects of the different elutions of Hyssopus cuspidatus on smooth muscle contraction of isolated tracheal in Guinea pigs","volume":"28","author":"Yuan","year":"2017","journal-title":"J. China Pharm."},{"key":"10.1016\/j.jep.2022.116047_bib41","series-title":"Effect of \"Three-Acupoint and Five-Needling Method\" on the Expression of MEK\/ERK Pathway within Lung Tissue of Allergic Bronchial Asthmatic Rats","author":"Zhao","year":"2017"},{"key":"10.1016\/j.jep.2022.116047_bib42","series-title":"The Co-blockade of IL-13 and IL-25 Suppresses Airway Inflammation and Remodeling in a Mouse Model of Asthma","author":"Zhang","year":"2017"}],"updated-by":[{"DOI":"10.1016\/j.jep.2024.119280","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000}}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122010868?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122010868?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T14:07:27Z","timestamp":1740406047000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874122010868"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":37,"alternative-id":["S0378874122010868"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2022.116047","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.jep.2024.119280","asserted-by":"object"}]},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The extract from Hyssopus cuspidatus Boriss. Prevents bronchial airway remodeling by inhibiting mouse bronchial wall thickening and hASMC proliferation and migration","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2022.116047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116047"}}