{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T03:05:17Z","timestamp":1790305517284,"version":"4.1.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.jep.2022.116069","type":"journal-article","created":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T02:16:51Z","timestamp":1671848211000},"page":"116069","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Water extract from Herpetospermum pedunculosum attenuates oxidative stress and ferroptosis induced by acetaminophen via regulating Nrf2 and NF-\u03baB pathways"],"prefix":"10.1016","volume":"305","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9195-1121","authenticated-orcid":false,"given":"Jintao","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuxia","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meihao","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqing","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2022.116069_bib1","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/1534083","article-title":"Cruciferous vegetables and their bioactive metabolites: from prevention to novel therapies of colorectal cancer","author":"A\u011fag\u00fcnd\u00fcz","year":"2022","journal-title":"Evid Based Complement Alternat. Med."},{"key":"10.1016\/j.jep.2022.116069_bib2","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.chembiol.2020.03.011","article-title":"Breakdown of an ironclad defense system: the critical role of NRF2 in mediating ferroptosis","volume":"27","author":"Anandhan","year":"2020","journal-title":"Cell Chem Biol"},{"key":"10.1016\/j.jep.2022.116069_bib3","article-title":"Drug-induced liver injury","volume":"5","author":"Andrade","year":"2019","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.jep.2022.116069_bib4","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jep.2017.01.003","article-title":"Protective effects of petroleum ether extracts of Herpetospermum caudigerum against alpha-naphthylisothiocyanate-induced acute cholestasis of rats","volume":"198","author":"Cao","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.116069_bib5","doi-asserted-by":"crossref","first-page":"4611","DOI":"10.1073\/pnas.081082098","article-title":"An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen","volume":"98","author":"Chan","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jep.2022.116069_bib7","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.2147\/DDDT.S248823","article-title":"Sinomenine attenuates acetaminophen-induced acute liver injury by decreasing oxidative stress and inflammatory response via regulating TGF-\u03b2\/smad pathway in vitro and in vivo","volume":"14","author":"Chen","year":"2020","journal-title":"Drug Des. Dev. Ther."},{"issue":"4","key":"10.1016\/j.jep.2022.116069_bib9","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/s41573-018-0008-x","article-title":"Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases","volume":"18","author":"Cuadrado","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jep.2022.116069_bib10","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.1158\/0008-5472.CAN-18-3855","article-title":"Genetic ablation of the cystine transporter xCT in PDAC cells inhibits mTORC1, growth, survival, and tumor formation via nutrient and oxidative stresses","volume":"79","author":"Daher","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.jep.2022.116069_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114140","article-title":"Protection of Ficus pandurata Hance against acute alcohol-induced liver damage in mice via suppressing oxidative stress, inflammation, and apoptosis","volume":"275","author":"Dai","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.116069_bib12","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1002\/mc.23175","article-title":"CtBP1 transactivates RAD51 and confers cisplatin resistance to breast cancer cells","volume":"59","author":"Deng","year":"2020","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.jep.2022.116069_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154008","article-title":"Ethanolic extract of Tridax procumbens mitigates pulmonary inflammation via inhibition of NF-\u03baB\/p65\/ERK mediated signalling in an allergic asthma model","author":"Devi","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2022.116069_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101107","article-title":"NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis","volume":"23","author":"Dodson","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.jep.2022.116069_bib16","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1553-2712.2008.00296.x","article-title":"Hepatotoxicity despite early administration of intravenous N-acetylcysteine for acute acetaminophen overdose","volume":"16","author":"Doyon","year":"2009","journal-title":"Acad. Emerg. Med."},{"key":"10.1016\/j.jep.2022.116069_bib17","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.redox.2016.10.001","article-title":"Oxidative stress during acetaminophen hepatotoxicity: sources, pathophysiological role and therapeutic potential","volume":"10","author":"Du","year":"2016","journal-title":"Redox Biol."},{"key":"10.1016\/j.jep.2022.116069_bib18","doi-asserted-by":"crossref","first-page":"7925","DOI":"10.1039\/D0FO00724B","article-title":"Kaempferol from Penthorum chinense Pursh suppresses HMGB1\/TLR4\/NF-kappaB signaling and NLRP3 inflammasome activation in acetaminophen-induced hepatotoxicity","volume":"11","author":"Du","year":"2020","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2022.116069_bib19","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1111\/jcmm.13568","article-title":"Hepatoprotective effect of Herpetospermum caudigerum Wall. on carbon tetrachloride-induced hepatic fibrosis in rats","volume":"22","author":"Feng","year":"2018","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.jep.2022.116069_bib20","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1503\/cmaj.1040752","article-title":"Liver enzyme alteration: a guide for clinicians","volume":"172","author":"Giannini","year":"2005","journal-title":"Can. Med. Assoc. J."},{"issue":"3","key":"10.1016\/j.jep.2022.116069_bib21","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3177\/jnsv.67.145","article-title":"Nicotinic acid against acetaminophen-induced hepatotoxicity via Sirt1\/Nrf2 antioxidative pathway in mice","volume":"67","author":"Hu","year":"2021","journal-title":"J nutr sci vit"},{"key":"10.1016\/j.jep.2022.116069_bib22","first-page":"432","article-title":"Protective effect and mechanism of total lignan from Tibetan medicine Melon seed on chronic alcoholic liver injury in rats","volume":"9","author":"Huang","year":"2018","journal-title":"Tradit. Chin. Med."},{"key":"10.1016\/j.jep.2022.116069_bib23","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/952943","article-title":"A review on protocatechuic Acid and its pharmacological potential","volume":"2014","author":"Kakkar","year":"2014","journal-title":"ISRN Pharmacol."},{"key":"10.1016\/j.jep.2022.116069_bib24","doi-asserted-by":"crossref","first-page":"T144","DOI":"10.1111\/j.1750-3841.2011.02243.x","article-title":"Free radical scavenging, cytotoxic, and hemolytic activities of an active antioxidant compound ethyl gallate from leaves of Acacia nilotica (L.) Wild. Ex. Delile subsp. indica (Benth.) Brenan","volume":"76","author":"Kalaivani","year":"2011","journal-title":"J. Food Sci."},{"key":"10.1016\/j.jep.2022.116069_bib25","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1089\/ars.2017.7176","article-title":"The roles of NRF2 in modulating cellular iron homeostasis","volume":"29","author":"Kerins","year":"2018","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.jep.2022.116069_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110774","article-title":"Pharmacological insights and prediction of lead bioactive isolates of Dita bark through experimental and computer-aided mechanism","volume":"131","author":"Khan","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2022.116069_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12876-017-0680-z","article-title":"Fast food diet-induced non-alcoholic fatty liver disease exerts early protective effect against acetaminophen intoxication in mice","volume":"17","author":"Kim","year":"2017","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.jep.2022.116069_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13071028","article-title":"Gancaonin N from Glycyrrhiza uralensis attenuates the inflammatory response by downregulating the NF-kappaB\/MAPK pathway on an acute pneumonia in vitro model","volume":"13","author":"Ko","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jep.2022.116069_bib29","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00204-014-1432-2","article-title":"Acetaminophen hepatotoxicity: an updated review","volume":"89","author":"Lancaster","year":"2015","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.jep.2022.116069_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jep.2018.09.033","article-title":"Hepatoprotection of Herpetospermum caudigerum Wall. against CCl4-induced liver fibrosis on rats","volume":"229","author":"Li","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.116069_bib31","doi-asserted-by":"crossref","first-page":"9433","DOI":"10.1073\/pnas.1821323116","article-title":"Cystine\/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance","volume":"116","author":"Lim","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jep.2022.116069_bib33","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1007\/s12253-015-9946-3","article-title":"Ferroptosis is involved in acetaminophen induced cell death","volume":"21","author":"L\u0151rincz","year":"2015","journal-title":"Pathol. Oncol. Res."},{"key":"10.1016\/j.jep.2022.116069_bib34","first-page":"6639","article-title":"Artesunate suppresses oxidative and inflammatory processes by activating Nrf2 and ROSdependent p38 MAPK and protects against cerebral ischemiareperfusion injury","volume":"17","author":"Lu","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jep.2022.116069_bib35","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/736837","article-title":"Glutathione homeostasis and functions: potential targets for medical interventions","volume":"2012","author":"Lushchak","year":"2012","journal-title":"J. Amino Acids"},{"key":"10.1016\/j.jep.2022.116069_bib36","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev-pharmtox-011112-140320","article-title":"Role of nrf2 in oxidative stress and toxicity","volume":"53","author":"Ma","year":"2013","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.jep.2022.116069_bib37","series-title":"Yue-wang-yao-zhen","author":"Mao","year":"2012"},{"key":"10.1016\/j.jep.2022.116069_bib38","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.taap.2012.08.015","article-title":"Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity","volume":"264","author":"McGill","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jep.2022.116069_bib39","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/j.jep.2011.07.068","article-title":"Ethyl gallate isolated from Pistacia integerrima Linn. inhibits cell adhesion molecules by blocking AP-1 transcription factor","volume":"137","author":"Mehla","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.116069_bib40","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1002\/cpt1974164676","article-title":"Acetaminophen\u2010induced hepatic injury: protective role of glutathione in man and rationale for therapy","volume":"16","author":"Mitchell","year":"1974","journal-title":"Clin. Pharmacol. Therapeut."},{"key":"10.1016\/j.jep.2022.116069_bib41","article-title":"Protective effects of liposomal N-acetylcysteine against paraquat-induced cytotoxicity and gene expression","volume":"14","author":"Mitsopoulos","year":"2011","journal-title":"J. Toxicol."},{"key":"10.1016\/j.jep.2022.116069_bib42","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.bbrc.2005.10.185","article-title":"Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity","volume":"339","author":"Okawa","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jep.2022.116069_bib43","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.abb.2006.08.005","article-title":"Nrf2 regulates an adaptive response protecting against oxidative damage following diquat-mediated formation of superoxide anion","volume":"454","author":"Osburn","year":"2006","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.jep.2022.116069_bib44","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1021\/tx00034a019","article-title":"Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics","volume":"4","author":"Patten","year":"1993","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.jep.2022.116069_bib45","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1002\/hep.23937","article-title":"Drug\u2010induced acute liver failure: results of a US multicenter, prospective study","volume":"52","author":"Reuben","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.jep.2022.116069_bib46","doi-asserted-by":"crossref","first-page":"281","DOI":"10.14218\/JCTH.2016.00049","article-title":"Limited knowledge of acetaminophen in patients with liver disease","volume":"4","author":"Saab","year":"2016","journal-title":"J. Clin. Transl. Hepatol."},{"issue":"5","key":"10.1016\/j.jep.2022.116069_bib47","doi-asserted-by":"crossref","first-page":"752","DOI":"10.7150\/ijbs.40612","article-title":"Hepatoprotective effect of Citrus aurantium L. Against APAP-induced liver injury by regulating liver lipid metabolism and apoptosis","volume":"16","author":"Shu","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.jep.2022.116069_bib48","first-page":"210","article-title":"The role and place of medicinal plants in the strategies for disease prevention","volume":"5","author":"Sofowora","year":"2013","journal-title":"Afr. J. Tradit., Complementary Altern. Med."},{"key":"10.1016\/j.jep.2022.116069_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-019-1564-7","article-title":"Ferritinophagy is required for the induction of ferroptosis by the bromodomain protein BRD4 inhibitor (+)-JQ1 in cancer cells","volume":"10","author":"Sui","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jep.2022.116069_bib50","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1172\/JCI11830","article-title":"NF-\u03baB: a key role in inflammatory diseases","volume":"107","author":"Tak","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jep.2022.116069_bib51","series-title":"Shel-Gong-Shel-Phreng","author":"Temal","year":"1840"},{"key":"10.1016\/j.jep.2022.116069_bib52","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1177\/1535370214549520","article-title":"Comparative evaluation of N-acetylcysteine and N-acetylcysteineamide in acetaminophen-induced hepatotoxicity in human hepatoma HepaRG cells","volume":"240","author":"Tobwala","year":"2015","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.jep.2022.116069_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114182","article-title":"Central and peripheral pain intervention by Ophiorrhiza rugosa leaves: potential underlying mechanisms and insight into the role of pain modulators","volume":"276","author":"Uddin Chy","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2022.116069_bib54","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/s41419-020-02961-5","article-title":"(+)-Clausenamide protects against drug-induced liver injury by inhibiting hepatocyte ferroptosis","volume":"11","author":"Wang","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jep.2022.116069_bib55","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.bbrc.2020.07.032","article-title":"NEDD4L-mediated LTF protein degradation limits ferroptosis","volume":"4","author":"Wang","year":"2020","journal-title":"Biochem bioph res co"},{"key":"10.1016\/j.jep.2022.116069_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153257","article-title":"Ethyl acetate extract of herpetospermum pedunculosum alleviates alpha-naphthylisothiocyanate-induced cholestasis by activating the farnesoid x receptor and suppressing oxidative stress and inflammation in rats","volume":"76","author":"Wei","year":"2020","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2022.116069_bib57","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.jhep.2016.11.017","article-title":"Role of the inflammasome in acetaminophen-induced liver injury and acute liver failure","volume":"66","author":"Woolbright","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jep.2022.116069_bib58","doi-asserted-by":"crossref","first-page":"71","DOI":"10.15586\/aei.v50i4.639","article-title":"6'-O-galloylpaeoniflorin alleviates inflammation and oxidative stress in pediatric pneumonia through activating Nrf2 activation","volume":"50","author":"Xu","year":"2022","journal-title":"Allergol. Immunopathol."},{"key":"10.1016\/j.jep.2022.116069_bib59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-020-2334-2","article-title":"Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure","volume":"11","author":"Yamada","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jep.2022.116069_bib60","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.redox.2018.04.019","article-title":"Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions","volume":"17","author":"Yan","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.jep.2022.116069_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153211","article-title":"Limonin ameliorates acetaminophen-induced hepatotoxicity by activating Nrf2 antioxidative pathway and inhibiting NF-kappaB inflammatory response via upregulating Sirt1","volume":"69","author":"Yang","year":"2020","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2022.116069_bib62","first-page":"131","article-title":"Acetaminophen-induced hepatotoxicity: a comprehensive update","volume":"4","author":"Yoon","year":"2016","journal-title":"J. clin. transl. hepatol."},{"key":"10.1016\/j.jep.2022.116069_bib63","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1248\/cpb.54.1592","article-title":"Hepatitis B virus inhibiting constituents from Herpetospermum caudigerum","volume":"54","author":"Yuan","year":"2006","journal-title":"Chem. Pharmaceut. Bull."},{"key":"10.1016\/j.jep.2022.116069_bib64","unstructured":"Yuthok, Y., The 8th century. The four med."},{"key":"10.1016\/j.jep.2022.116069_bib65","doi-asserted-by":"crossref","first-page":"5429","DOI":"10.2147\/OTT.S254995","article-title":"The role of erastin in ferroptosis and its prospects in cancer therapy","volume":"13","author":"Zhao","year":"2020","journal-title":"OncoTargets Ther."},{"key":"10.1016\/j.jep.2022.116069_bib66","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.apsb.2020.06.016","article-title":"SIRT6 as a key event linking P53 and NRF2 counteracts APAP-induced hepatotoxicity through inhibiting oxidative stress and promoting hepatocyte proliferation","volume":"11","author":"Zhou","year":"2021","journal-title":"Acta Pharm. Sin. B"}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122011084?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874122011084?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:35:43Z","timestamp":1759944943000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874122011084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":62,"alternative-id":["S0378874122011084"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2022.116069","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Water extract from Herpetospermum pedunculosum attenuates oxidative stress and ferroptosis induced by acetaminophen via regulating Nrf2 and NF-\u03baB pathways","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2022.116069","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116069"}}