{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:03:19Z","timestamp":1792008199384,"version":"4.4.0"},"reference-count":189,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.jep.2023.116156","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T02:10:06Z","timestamp":1675649406000},"page":"116156","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":71,"special_numbering":"C","title":["Herb\u2013drug interactions between Panax notoginseng or its biologically active compounds and therapeutic drugs: A comprehensive pharmacodynamic and pharmacokinetic review"],"prefix":"10.1016","volume":"307","author":[{"given":"Yujuan","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7578-4856","authenticated-orcid":false,"given":"Changhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2023.116156_bib1","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.2217\/fon-2018-0303","article-title":"Long noncoding RNAs as biotargets in cisplatin-based drug resistance","volume":"14","author":"Abu","year":"2018","journal-title":"Future Oncol."},{"key":"10.1016\/j.jep.2023.116156_bib2","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/s40266-017-0501-7","article-title":"Concurrent use of prescription drugs and herbal medicinal products in older adults: a systematic review","volume":"34","author":"Agbabiaka","year":"2017","journal-title":"Drugs Aging"},{"key":"10.1016\/j.jep.2023.116156_bib3","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1007\/s11239-017-1546-5","article-title":"Anti-coagulant activity of plants: mini review","volume":"44","author":"Akram","year":"2017","journal-title":"J. Thromb. Thrombolysis"},{"key":"10.1016\/j.jep.2023.116156_bib4","doi-asserted-by":"crossref","first-page":"5126","DOI":"10.1038\/s41598-021-84589-9","article-title":"Identification of geographical origins of Panax notoginseng based on HPLC multi-wavelength fusion profiling combined with average linear quantitative fingerprint method","volume":"11","author":"Bai","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2023.116156_bib5","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.1039\/D1FO00242B","article-title":"Ginsenoside Rh4 alleviates antibiotic-induced intestinal inflammation by regulating the TLR4-MyD88-MAPK pathway and gut microbiota composition","volume":"12","author":"Bai","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2023.116156_bib6","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1177\/1078155218799859","article-title":"Appropriateness of granulocyte colony-stimulating factor use in patients receiving chemotherapy by febrile neutropenia risk level","volume":"25","author":"Baig","year":"2018","journal-title":"J. Oncol. Pharm. Pract."},{"key":"10.1016\/j.jep.2023.116156_bib7","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ejps.2019.01.016","article-title":"Pharmacokinetic interaction of calcitriol with 20(S)-protopanaxadiol in mice: determined by LC\/MS analysis","volume":"130","author":"Ben-Eltriki","year":"2019","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.jep.2023.116156_bib8","doi-asserted-by":"crossref","first-page":"6015","DOI":"10.1038\/s41598-017-06471-x","article-title":"Combination of ginsenoside Rb1 and Rd protects the retina against bright light-induced degeneration","volume":"7","author":"Bian","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2023.116156_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9121906","article-title":"Antithrombotic therapy in the prevention of stroke","volume":"9","author":"Bir","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.jep.2023.116156_bib10","doi-asserted-by":"crossref","first-page":"536","DOI":"10.3390\/polym9100536","article-title":"A concise synthesis of three branches derived from polysaccharide RN1 and anti-pancreatic cancer activity study","volume":"9","author":"Cai","year":"2017","journal-title":"Polymers"},{"key":"10.1016\/j.jep.2023.116156_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.jfca.2020.103450","article-title":"Untargeted identification of adulterated Sanqi powder by near-infrared spectroscopy and one-class model","volume":"88","author":"Chen","year":"2020","journal-title":"J. Food Compos. Anal."},{"key":"10.1016\/j.jep.2023.116156_bib12","doi-asserted-by":"crossref","first-page":"4136","DOI":"10.3390\/ijms20174136","article-title":"New insights into mechanisms of cisplatin resistance: from tumor cell to microenvironment","volume":"20","author":"Chen","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2023.116156_bib13","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1038\/s41401-021-00751-z","article-title":"Ginsenoside 20(S)-Rh2 promotes cellular pharmacokinetics and intracellular antibacterial activity of levofloxacin against Staphylococcus aureus through drug efflux inhibition and subcellular stabilization","volume":"42","author":"Chen","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jep.2023.116156_bib14","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jgr.2016.03.006","article-title":"Effect of B-complex vitamins on the antifatigue activity and bioavailability of ginsenoside Re after oral administration","volume":"41","author":"Chen","year":"2017","journal-title":"J. Ginseng Res."},{"key":"10.1016\/j.jep.2023.116156_bib15","first-page":"3824","article-title":"Effect of Panax notoginseng saponins on liver drug metablic enzyme activity, mRNA and protein expressions in rats","volume":"39","author":"Chen","year":"2014","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"10.1016\/j.jep.2023.116156_bib16","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.chroma.2015.04.054","article-title":"A rapid and accurate method for the quantitative estimation of natural polysaccharides and their fractions using high performance size exclusion chromatography coupled with multi-angle laser light scattering and refractive index detector","volume":"1400","author":"Cheong","year":"2015","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jep.2023.116156_bib17","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.taap.2012.07.003","article-title":"A new herb-drug interaction of Polygonum cuspidatum, a resveratrol-rich nutraceutical, with carbamazepine in rats","volume":"263","author":"Chi","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jep.2023.116156_bib18","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1097\/CAD.0000000000000781","article-title":"Ginsenoside Rd reverses cisplatin resistance in non-small-cell lung cancer A549 cells by downregulating the nuclear factor erythroid 2-related factor 2 pathway","volume":"30","author":"Chian","year":"2019","journal-title":"Anti Cancer Drugs"},{"key":"10.1016\/j.jep.2023.116156_bib190","series-title":"Pharmacopoeia of the People\u2019s Republic of China","author":"Chinese Pharmacopoeia Commission","year":"2020"},{"key":"10.1016\/j.jep.2023.116156_bib19","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.3389\/fimmu.2017.01542","article-title":"Protective effect of panax notoginseng root water extract against influenza A virus infection by enhancing antiviral interferon-mediated immune responses and natural killer cell activity","volume":"8","author":"Choi","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2023.116156_bib20","doi-asserted-by":"crossref","first-page":"11","DOI":"10.11622\/smedj.2015004","article-title":"Interaction between warfarin and Chinese herbal medicines","volume":"56","author":"Chua","year":"2015","journal-title":"Singap. Med. J."},{"key":"10.1016\/j.jep.2023.116156_bib21","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jep.2012.04.027","article-title":"The effects of notoginsenoside R1 on the intestinal absorption of geniposide by the everted rat gut sac model","volume":"142","author":"Chula","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.116156_bib22","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.phymed.2017.01.010","article-title":"Pharmacokinetic herb-drug interaction of Xuesaitong dispersible tablet and aspirin after oral administration in blood stasis model rats","volume":"26","author":"Dai","year":"2017","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2023.116156_bib23","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/j.1365-2141.2008.07233.x","article-title":"Antiplatelet drugs","volume":"142","author":"De Meyer","year":"2008","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.jep.2023.116156_bib24","doi-asserted-by":"crossref","first-page":"25897","DOI":"10.18632\/oncotarget.13071","article-title":"Ginsenoside-Rb1 targets chemotherapy-resistant ovarian cancer stem cells via simultaneous inhibition of Wnt\/beta-catenin signaling and epithelial-to-mesenchymal transition","volume":"8","author":"Deng","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.jep.2023.116156_bib25","doi-asserted-by":"crossref","first-page":"5813","DOI":"10.1038\/s41598-017-05825-9","article-title":"Global deregulation of ginseng products may be a safety hazard to warfarin takers: solid evidence of ginseng-warfarin interaction","volume":"7","author":"Dong","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jep.2023.116156_bib26","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1159\/000315061","article-title":"Panax notogingseng saponins suppress RAGE\/MAPK signaling and NF-kappaB activation in apolipoprotein-E-deficient atherosclerosis-prone mice","volume":"29","author":"Dou","year":"2012","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.jep.2023.116156_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.658513","article-title":"Multiple molecular mechanisms to overcome multidrug resistance in cancer by natural secondary metabolites","volume":"12","author":"El-Readi","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2023.116156_bib28","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.taap.2012.12.019","article-title":"Structure-inhibition relationship of ginsenosides towards UDP-glucuronosyltransferases (UGTs)","volume":"267","author":"Fang","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jep.2023.116156_bib29","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1007\/s12272-010-1213-2","article-title":"Pharmacokinetics, tissue distribution, metabolism, and excretion of ginsenoside Rg1 in rats","volume":"33","author":"Feng","year":"2010","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.jep.2023.116156_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.prmcm.2021.100035","article-title":"Network pharmacology reveals the targets and mechanism for Panax notoginseng (Burk.) F. H. Chen against venous thromboembolism","volume":"2","author":"Feng","year":"2022","journal-title":"Pharmacol. Res. Mod. Chin. Med."},{"key":"10.1016\/j.jep.2023.116156_bib31","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/bph.12435","article-title":"Platelet P2Y12 receptors are involved in the haemostatic effect of notoginsenoside Ft1, a saponin isolated from Panax notoginseng","volume":"171","author":"Gao","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jep.2023.116156_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112255","article-title":"Protective effects of natural products against drug-induced nephrotoxicity: a review in recent years","volume":"153","author":"Gao","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jep.2023.116156_bib33","doi-asserted-by":"crossref","first-page":"937","DOI":"10.3390\/ijms21030937","article-title":"The pentose phosphate pathway and its involvement in cisplatin resistance","volume":"21","author":"Giacomini","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2023.116156_bib34","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1021\/acs.jafc.8b06073","article-title":"Study of the effects and mechanisms of ginsenoside compound K on myelosuppression","volume":"67","author":"Han","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jep.2023.116156_bib35","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.jgr.2018.07.009","article-title":"Studies of the effects and mechanisms of ginsenoside Re and Rk3 on myelosuppression induced by cyclophosphamide","volume":"43","author":"Han","year":"2019","journal-title":"J. Ginseng Res."},{"key":"10.1016\/j.jep.2023.116156_bib36","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.phymed.2010.10.004","article-title":"Radix\/Rhizoma Notoginseng extract (Sanchitongtshu) for ischemic stroke: a randomized controlled study","volume":"18","author":"He","year":"2011","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2023.116156_bib37","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.phymed.2008.06.008","article-title":"Synergism between natural products and antibiotics against infectious diseases","volume":"15","author":"Hemaiswarya","year":"2008","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2023.116156_bib38","doi-asserted-by":"crossref","first-page":"4437","DOI":"10.7150\/thno.34953","article-title":"Novel ginsenoside-based multifunctional liposomal delivery system for combination therapy of gastric cancer","volume":"9","author":"Hong","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.jep.2023.116156_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.113072","article-title":"Synergistic effects of curcumin and its analogs with other bioactive compounds: a comprehensive review","volume":"210","author":"Hosseini-Zare","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jep.2023.116156_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112637","article-title":"Astragalus propinquus Schischkin and Panax notoginseng (A&P) compound relieved cisplatin-induced acute kidney injury through inhibiting the mincle maintained macrophage inflammation","volume":"252","author":"Hui","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.116156_bib41","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1002\/ptr.5591","article-title":"A critical approach to evaluating clinical efficacy, adverse events and drug interactions of herbal remedies","volume":"30","author":"Izzo","year":"2016","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2023.116156_bib42","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1080\/14737140.2017.1356231","article-title":"Molecular approaches to potentiate cisplatin responsiveness in carcinoma therapeutics","volume":"17","author":"Jain","year":"2017","journal-title":"Expert Rev. Anticancer Ther."},{"key":"10.1016\/j.jep.2023.116156_bib43","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jep.2012.04.022","article-title":"Antibiotics attenuate anti-scratching behavioral effect of ginsenoside Re in mice","volume":"142","author":"Jang","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.116156_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.153936","article-title":"Combinatorial effect of thymoquinone with chemo agents for tumor therapy","volume":"98","author":"Jehan","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jep.2023.116156_bib45","doi-asserted-by":"crossref","first-page":"622","DOI":"10.3390\/molecules25030622","article-title":"Herb-drug interaction of red ginseng extract and ginsenoside rc with valsartan in rats","volume":"25","author":"Jeon","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2023.116156_bib46","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.jep.2010.08.033","article-title":"Panax notoginseng saponins decrease cholesterol ester via up-regulating ATP-binding cassette transporter A1 in foam cells","volume":"132","author":"Jia","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.116156_bib47","doi-asserted-by":"crossref","first-page":"430","DOI":"10.4103\/pm.pm_424_16","article-title":"Intervention effects of atorvastatin combined with panax notoginseng saponins on rats with atherosclerosis complicated with hepatic injury","volume":"13","author":"Jiang","year":"2017","journal-title":"Phcog. Mag."},{"key":"10.1016\/j.jep.2023.116156_bib48","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1111\/bph.12971","article-title":"Molecular mechanisms governing different pharmacokinetics of ginsenosides and potential for ginsenoside-perpetrated herb\u2013drug interactions on OATP1B3","volume":"172","author":"Jiang","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jep.2023.116156_bib49","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.colsurfb.2018.11.067","article-title":"Novel breviscapine nanocrystals modified by panax notoginseng saponins for enhancing bioavailability and synergistic anti-platelet aggregation effect","volume":"175","author":"Jin","year":"2019","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.jep.2023.116156_bib50","first-page":"143","article-title":"Enhancement of oral bioavailability and immune response of Ginsenoside Rh2 by co-administration with piperine","volume":"16","author":"Jin","year":"2018","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.jep.2023.116156_bib51","doi-asserted-by":"crossref","first-page":"106","DOI":"10.5478\/MSL.2016.7.4.106","article-title":"Inhibitory effects of 12 ginsenosides on the activities of seven cytochromes P450 in human liver microsomes","volume":"7","author":"Jung Jae","year":"2016","journal-title":"Mass Spectrom. Lett."},{"key":"10.1016\/j.jep.2023.116156_bib52","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10735-012-9412-4","article-title":"Protective effect of Panax ginseng against serum biochemical changes and apoptosis in kidney of rats treated with gentamicin sulphate","volume":"43","author":"Kalkan","year":"2012","journal-title":"J. Mol. Histol."},{"key":"10.1016\/j.jep.2023.116156_bib53","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s11418-012-0713-4","article-title":"Increased effects of ginsenosides on the expression of cholesterol 7\u03b1-hydroxylase but not the bile salt export pump are involved in cholesterol metabolism","volume":"67","author":"Kawase","year":"2013","journal-title":"J. Nat. Med."},{"key":"10.1016\/j.jep.2023.116156_bib54","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s11418-013-0791-y","article-title":"Effects of ginsenosides on the expression of cytochrome P450s and transporters involved in cholesterol metabolism","volume":"68","author":"Kawase","year":"2014","journal-title":"J. Nat. Med."},{"key":"10.1016\/j.jep.2023.116156_bib55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5142\/jgr.2012.36.1.1","article-title":"Chemical diversity of panax ginseng, panax quinquifolium, and panax notoginseng","volume":"36","author":"Kim","year":"2012","journal-title":"J. Ginseng Res."},{"key":"10.1016\/j.jep.2023.116156_bib56","article-title":"Enhanced permeability and oral absorption of Panax notoginseng saponins by borneol","volume":"66","author":"Kim","year":"2021","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.jep.2023.116156_bib57","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/bdd.2246","article-title":"Characterization of red ginseng-drug interaction by CYP3A activity increased in high dose administration in mice","volume":"41","author":"Kim","year":"2020","journal-title":"Biopharm. Drug Dispos."},{"key":"10.1016\/j.jep.2023.116156_bib58","doi-asserted-by":"crossref","first-page":"8199","DOI":"10.3390\/ijms22158199","article-title":"Targeting DNA damage response and repair to enhance therapeutic index in cisplatin-based cancer treatment","volume":"22","author":"Kiss","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2023.116156_bib59","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1136\/bmj.39430.529549.BE","article-title":"Aspirin \"resistance\" and risk of cardiovascular morbidity: systematic review and meta-analysis","volume":"336","author":"Krasopoulos","year":"2008","journal-title":"BMJ"},{"key":"10.1016\/j.jep.2023.116156_bib60","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1016\/j.jfda.2018.03.002","article-title":"Organic solute carrier 22 (SLC22) family: potential for interactions with food, herbal\/dietary supplements, endogenous compounds, and drugs","volume":"26","author":"Lai","year":"2018","journal-title":"J. Food Drug Anal."},{"key":"10.1016\/j.jep.2023.116156_bib61","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13020-020-00356-4","article-title":"Herb-drug interactions between the medicinal mushrooms Lingzhi and Yunzhi and cytotoxic anticancer drugs: a systematic review","volume":"15","author":"Lam","year":"2020","journal-title":"Chin. Med."},{"key":"10.1016\/j.jep.2023.116156_bib62","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1055\/s-2002-35649","article-title":"Pananotin, a potent antifungal protein from roots of the traditional Chinese medicinal herb Panax notoginseng","volume":"68","author":"Lam","year":"2002","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2023.116156_bib63","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.jep.2009.07.038","article-title":"Antiplatelet and anticoagulant effects of Panax notoginseng: comparison of raw and steamed Panax notoginseng with Panax ginseng and Panax quinquefolium","volume":"125","author":"Lau","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.116156_bib64","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jgr.2016.12.013","article-title":"Protective effect of ginsenoside Rb1 against tacrolimus-induced apoptosis in renal proximal tubular LLC-PK1 cells","volume":"42","author":"Lee","year":"2018","journal-title":"J. Ginseng Res."},{"key":"10.1016\/j.jep.2023.116156_bib65","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.fct.2013.05.025","article-title":"Effects of Korean red ginseng extract on acute renal failure induced by gentamicin and pharmacokinetic changes by metformin in rats","volume":"59","author":"Lee","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jep.2023.116156_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112103","article-title":"Mechanisms and interactions in concomitant use of herbs and warfarin therapy: an updated review","volume":"143","author":"Leite","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2023.116156_bib67","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.2217\/nnm-2021-0329","article-title":"Doxorubicin nanomedicine based on ginsenoside Rg1 with alleviated cardiotoxicity and enhanced antitumor activity","volume":"16","author":"Li","year":"2021","journal-title":"Nanomedicine"},{"key":"10.1016\/j.jep.2023.116156_bib68","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/bmc.567","article-title":"High-performance liquid chromatographic assay for the active saponins from Panax notoginseng in rat tissues","volume":"20","author":"Li","year":"2006","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.jep.2023.116156_bib69","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1080\/10717544.2019.1600077","article-title":"Novel ultra-small micelles based on ginsenoside Rb1: a potential nanoplatform for ocular drug delivery","volume":"26","author":"Li","year":"2019","journal-title":"Drug Deliv."},{"key":"10.1016\/j.jep.2023.116156_bib70","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/2211-5463.12760","article-title":"Panax notoginseng saponins ameliorate cisplatin-induced mitochondrial injury via the HIF-1\u03b1\/mitochondria\/ROS pathway","volume":"10","author":"Li","year":"2020","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.jep.2023.116156_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111965","article-title":"Panax notoginseng saponins reduces the cisplatin-induced acute renal injury by increasing HIF-1\u03b1\/BNIP3 to inhibit mitochondrial apoptosis pathway","volume":"142","author":"Li","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2023.116156_bib72","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.chroma.2013.07.025","article-title":"A novel strategy with standardized reference extract qualification and single compound quantitative evaluation for quality control of Panax notoginseng used as a functional food","volume":"1313","author":"Li","year":"2013","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jep.2023.116156_bib73","first-page":"2056","volume":"24","author":"Li","year":"2019","journal-title":"J. BUON."},{"key":"10.1016\/j.jep.2023.116156_bib74","article-title":"A novel system for evaluating the inhibition effect of drugs on cytochrome P450 enzymes in vitro based on human-induced hepatocytes (hiHeps)","volume":"12","author":"Li","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2023.116156_bib75","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.5171","article-title":"Evaluation of the effects of notoginseng total saponins (NS), safflower total flavonoids (SF), and the combination of NS and SF (CNS) on the activities of cytochrome P450 enzymes using a cocktail method in rats","volume":"35","author":"Li","year":"2021","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.jep.2023.116156_bib76","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1039\/C3MB70507B","article-title":"A novel network pharmacology approach to analyse traditional herbal formulae: the Liu-Wei-Di-Huang pill as a case study","volume":"10","author":"Liang","year":"2014","journal-title":"Mol. Biosyst."},{"key":"10.1016\/j.jep.2023.116156_bib77","doi-asserted-by":"crossref","first-page":"102989","DOI":"10.18632\/oncotarget.19900","article-title":"Panax notoginseng saponins mitigate cisplatin induced nephrotoxicity by inducing mitophagy via HIF-1alpha","volume":"8","author":"Liang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.jep.2023.116156_bib78","doi-asserted-by":"crossref","first-page":"835","DOI":"10.2174\/138920011797470083","article-title":"Herb-drug interactions involving drug metabolizing enzymes and transporters","volume":"12","author":"Liu","year":"2011","journal-title":"Curr. Drug Metabol."},{"key":"10.1016\/j.jep.2023.116156_bib79","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jgr.2017.01.007","article-title":"Qualitative and quantitative analysis of the saponins in Panax notoginseng leaves using ultra-performance liquid chromatography coupled with time-of-flight tandem mass spectrometry and high performance liquid chromatography coupled with UV detector","volume":"42","author":"Liu","year":"2018","journal-title":"J. Ginseng Res."},{"key":"10.1016\/j.jep.2023.116156_bib80","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1124\/dmd.109.029819","article-title":"Absorption and disposition of ginsenosides after oral administration of panax notoginseng extract to rats","volume":"37","author":"Liu","year":"2009","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.jep.2023.116156_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105263","article-title":"Chemical constituents of Panax ginseng and Panax notoginseng explain why they differ in therapeutic efficacy","volume":"161","author":"Liu","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jep.2023.116156_bib82","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1111\/jcmm.12643","article-title":"Ginsenoside Rg1 improves bone marrow haematopoietic activity via extramedullary haematopoiesis of the spleen","volume":"19","author":"Liu","year":"2015","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.jep.2023.116156_bib83","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1517\/13543784.2014.892582","article-title":"Saponins of Panax notoginseng: chemistry, cellular targets and therapeutic opportunities in cardiovascular diseases","volume":"23","author":"Liu","year":"2014","journal-title":"Expet Opin. Invest. Drugs"},{"key":"10.1016\/j.jep.2023.116156_bib84","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1055\/s-2008-1034303","article-title":"Protective effect of saponins from Panax notoginseng against doxorubicin-induced cardiotoxicity in mice","volume":"74","author":"Liu","year":"2008","journal-title":"Planta Med."},{"key":"10.1016\/j.jep.2023.116156_bib85","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1080\/10717544.2020.1856222","article-title":"Preparation, optimization, and in vivo evaluation of an inhaled solution of total saponins of Panax notoginseng and its protective effect against idiopathic pulmonary fibrosis","volume":"27","author":"Liu","year":"2020","journal-title":"Drug Deliv."},{"key":"10.1016\/j.jep.2023.116156_bib86","first-page":"471","article-title":"A rapid method for chemical fingerprint analysis of Pan Panax notoginseng powders by ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry","volume":"13","author":"Liu","year":"2015","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.jep.2023.116156_bib87","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22945","article-title":"Ginsenoside RG1 augments doxorubicin-induced apoptotic cell death in MDA-MB-231 breast cancer cell lines","volume":"36","author":"Liu","year":"2022","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.jep.2023.116156_bib88","first-page":"8391","article-title":"Panax notoginseng saponins attenuates cisplatin-induced nephrotoxicity via inhibiting the mitochondrial pathway of apoptosis","volume":"7","author":"Liu","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.jep.2023.116156_bib89","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3109\/15376516.2015.1006492","article-title":"Possible mechanism of PNS protection against cisplatin-induced nephrotoxicity in rat models","volume":"25","author":"Liu","year":"2015","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.jep.2023.116156_bib90","article-title":"Structural characterization of polysaccharides isolated from panax notoginseng medicinal residue and its protective effect on myelosuppression induced by cyclophosphamide","volume":"19","author":"Liu","year":"2022","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.jep.2023.116156_bib91","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12885-020-07742-z","article-title":"Neutral polysaccharide from Panax notoginseng enhanced cyclophosphamide antitumor efficacy in hepatoma H22-bearing mice","volume":"21","author":"Liu","year":"2021","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jep.2023.116156_bib92","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1111\/jphp.13057","article-title":"Phospholipase C\u03b32 signalling contributes to the haemostatic effect of Notoginsenoside Ft1","volume":"71","author":"Liu","year":"2018","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jep.2023.116156_bib93","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1007\/s10637-020-01027-9","article-title":"Notoginsenoside R1 counteracts mesenchymal stem cell-evoked oncogenesis and doxorubicin resistance in osteosarcoma cells by blocking IL-6 secretion-induced JAK2\/STAT3 signaling","volume":"39","author":"Lu","year":"2021","journal-title":"Invest. N. Drugs"},{"key":"10.1016\/j.jep.2023.116156_bib94","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6528\/abe1f0","article-title":"One step assembly of ginsenoside Rb1-based nanovehicles with fast cellular transport in photothermal-chemical combined cancer therapy","volume":"32","author":"Luo","year":"2021","journal-title":"Nanotechnology"},{"key":"10.1016\/j.jep.2023.116156_bib95","doi-asserted-by":"crossref","first-page":"602","DOI":"10.25135\/rnp.54.18.01.203","article-title":"The protective effect and MoA of Panax notoginseng saponins combined with aminoguanidine on kidney in diabetic nephropathy rats","volume":"12","author":"Lv","year":"2018","journal-title":"Record Nat. Prod."},{"key":"10.1016\/j.jep.2023.116156_bib96","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/5651989","article-title":"The herb-drug interaction of clopidogrel and Xuesaitong dispersible tablet by modulation of the pharmacodynamics and liver carboxylesterase 1A metabolism","volume":"2018","author":"Ma","year":"2018","journal-title":"Evid.-based Complement Altern. Med."},{"key":"10.1016\/j.jep.2023.116156_bib98","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jgr.2019.09.002","article-title":"Ginsenoside Rg3 reduces the adhesion, invasion, and intracellular survival of Salmonella enterica serovar Typhimurium","volume":"45","author":"Mechesso","year":"2021","journal-title":"J. Ginseng Res."},{"key":"10.1016\/j.jep.2023.116156_bib99","doi-asserted-by":"crossref","first-page":"9487","DOI":"10.1002\/jcp.29756","article-title":"Effect of Rooibos (Aspalathus linearis) extract on atorvastatin-induced toxicity in C3A liver cells","volume":"235","author":"Millar","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.jep.2023.116156_bib100","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.vph.2011.12.006","article-title":"Panax notoginseng and its components decreased hypertension via stimulation of endothelial-dependent vessel dilatation","volume":"56","author":"Pan","year":"2012","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.jep.2023.116156_bib101","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12906-021-03499-5","article-title":"Panax notoginseng saponins reverse P-gp-mediated steroid resistance in lupus: involvement in the suppression of the SIRT1\/FoxO1\/MDR1 signalling pathway in lymphocytes","volume":"22","author":"Pan","year":"2022","journal-title":"BMC Complement. Med. Ther."},{"key":"10.1016\/j.jep.2023.116156_bib102","first-page":"53","article-title":"Effect of ginsenoside rc on the pharmacokinetics of mycophenolic acid, a ugt1a9 substrate, and its glucuronide metabolite in rats","volume":"12","author":"Park","year":"2021","journal-title":"Mass Spectrom. Lett."},{"key":"10.1016\/j.jep.2023.116156_bib103","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1038\/s41401-019-0273-1","article-title":"Intravenous formulation of Panax notoginseng root extract: human pharmacokinetics of ginsenosides and potential for perpetrating drug interactions","volume":"40","author":"Pintusophon","year":"2019","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jep.2023.116156_bib104","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1080\/01635580903407171","article-title":"Increased ubiquitination of multidrug resistance 1 by ginsenoside rd","volume":"62","author":"Pokharel","year":"2010","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.jep.2023.116156_bib105","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s13318-022-00753-0","article-title":"Effects and mechanism of action of panax notoginseng saponins on the pharmacokinetics of warfarin","volume":"47","author":"Qian","year":"2022","journal-title":"Eur. J. Drug Metabol. Pharmacokinet."},{"key":"10.1016\/j.jep.2023.116156_bib106","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s13659-018-0176-8","article-title":"Research of panax spp. in kunming institute of botany, CAS","volume":"8","author":"Qiao","year":"2018","journal-title":"Nat. Product. Bioprospecting."},{"key":"10.1016\/j.jep.2023.116156_bib107","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s13020-020-00349-3","article-title":"Multiple circulating alkaloids and saponins from intravenous Kang-Ai injection inhibit human cytochrome P450 and UDP-glucuronosyltransferase isozymes: potential drug\u2013drug interactions","volume":"15","author":"Qin","year":"2020","journal-title":"Chin. Med."},{"key":"10.1016\/j.jep.2023.116156_bib108","doi-asserted-by":"crossref","first-page":"9128","DOI":"10.1039\/D1FO02081A","article-title":"Hepatoprotective effects of ginsenoside Rk3 in acetaminophen-induced liver injury in mice by activation of autophagy","volume":"12","author":"Qu","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2023.116156_bib109","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1111\/bcp.13862","article-title":"Pharmacokinetic herb-drug interaction between ginger and crizotinib","volume":"86","author":"Revol","year":"2020","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.jep.2023.116156_bib110","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1177\/1534735409356981","article-title":"Can the therapeutic gain of radiotherapy Be increased by concurrent administration of asian botanicals?","volume":"9","author":"Sagar","year":"2009","journal-title":"Integr. Cancer Ther."},{"key":"10.1016\/j.jep.2023.116156_bib111","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3390\/ph13120455","article-title":"Exploring herbal medicine use during palliative cancer care: the integrative physician as a facilitator of pharmacist-patient-oncologist communication","volume":"13","author":"Samuels","year":"2020","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.jep.2023.116156_bib112","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.3390\/molecules23081904","article-title":"Permeability of ciprofloxacin-loaded polymeric micelles including ginsenoside as P-glycoprotein inhibitor through a caco-2 cells monolayer as an intestinal absorption model","volume":"23","author":"Sharif Makhmal Zadeh","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2023.116156_bib113","first-page":"1705","article-title":"Interaction between four herb compounds and a western drug by CYP3A4 enzyme metabolism in vitro","volume":"34","author":"Shen","year":"2009","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"10.1016\/j.jep.2023.116156_bib114","doi-asserted-by":"crossref","DOI":"10.1016\/j.lwt.2021.112446","article-title":"Structures, physicochemical and bioactive properties of polysaccharides extracted from Panax notoginseng using ultrasonic\/microwave-assisted extraction","volume":"154","author":"Shen","year":"2022","journal-title":"LWT--Food Sci. Technol."},{"key":"10.1016\/j.jep.2023.116156_bib115","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1038\/aps.2013.69","article-title":"Pharmacokinetic interactions between 20(S)-ginsenoside Rh2 and the HIV protease inhibitor ritonavir in vitro and in vivo","volume":"34","author":"Shi","year":"2013","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jep.2023.116156_bib116","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1142\/S0192415X11009366","article-title":"Effects of panax notoginseng saponins on proliferation and differentiation of rat hippocampal neural stem cells","volume":"39","author":"Si","year":"2011","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jep.2023.116156_bib117","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1016\/j.jchromb.2010.10.007","article-title":"Simultaneous determination of three Panax notoginseng saponins at sub-nanograms by LC\u2013MS\/MS in dog plasma for pharmacokinetics of compound Danshen tablets","volume":"878","author":"Song","year":"2010","journal-title":"J. Chromatogr., B: Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jep.2023.116156_bib118","doi-asserted-by":"crossref","first-page":"261","DOI":"10.5582\/ddt.2011.v5.6.261","article-title":"Standardization of traditional Chinese medicine and evaluation of evidence from its clinical practice","volume":"5","author":"Song","year":"2011","journal-title":"Drug Discov. Ther."},{"key":"10.1016\/j.jep.2023.116156_bib119","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2020.610070","article-title":"Novel opportunity to reverse antibiotic resistance: to explore traditional Chinese medicine with potential activity against antibiotics-resistance bacteria","volume":"11","author":"Su","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jep.2023.116156_bib120","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13046-015-0274-y","article-title":"Additive antiangiogenesis effect of ginsenoside Rg3 with low-dose metronomic temozolomide on rat glioma cells both in vivo and in vitro","volume":"35","author":"Sun","year":"2016","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.jep.2023.116156_bib121","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1080\/10717544.2020.1756985","article-title":"PLGA microsphere-based composite hydrogel for dual delivery of ciprofloxacin and ginsenoside Rh2 to treat Staphylococcus aureus-induced skin infections","volume":"27","author":"Sun","year":"2020","journal-title":"Drug Deliv."},{"key":"10.1016\/j.jep.2023.116156_bib122","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.foodchem.2009.04.122","article-title":"Effects of steaming the root of Panax notoginseng on chemical composition and anticancer activities","volume":"118","author":"Sun","year":"2010","journal-title":"Food Chem."},{"key":"10.1016\/j.jep.2023.116156_bib123","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2020.106098","article-title":"Synergism of sophoraflavanone G with norfloxacin against effluxing antibiotic-resistant Staphylococcus aureus","volume":"56","author":"Sun","year":"2020","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.jep.2023.116156_bib124","article-title":"Comparative analysis of compatibility influence on invigorating blood circulation for combined use of panax notoginseng saponins and aspirin using metabolomics approach","volume":"12","author":"Sun","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2023.116156_bib125","doi-asserted-by":"crossref","first-page":"3144","DOI":"10.3390\/ijms19103144","article-title":"Effects of panax notoginseng saponins on esterases responsible for aspirin hydrolysis in vitro","volume":"19","author":"Sun","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2023.116156_bib126","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3390\/molecules23020455","article-title":"Inhibitory influence of panax notoginseng saponins on aspirin hydrolysis in human intestinal caco-2 cells","volume":"23","author":"Sun","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.jep.2023.116156_bib127","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112432","article-title":"Herb-drug interactions and toxicity: underscoring potential mechanisms and forecasting clinically relevant interactions induced by common phytoconstituents via data mining and computational approaches","volume":"156","author":"Suroowan","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jep.2023.116156_bib128","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/bcp.14404","article-title":"Warfarin and food, herbal or dietary supplement interactions: a systematic review","volume":"87","author":"Tan","year":"2021","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.jep.2023.116156_bib129","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.fct.2013.07.069","article-title":"Red ginseng protects against gentamicin-induced balance dysfunction and hearing loss in rats through antiapoptotic functions of ginsenoside Rb1","volume":"60","author":"Tian","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jep.2023.116156_bib130","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jchromb.2016.12.007","article-title":"Effect of Panax notoginseng saponins on the pharmacokinetics of aspirin in rats","volume":"1040","author":"Tian","year":"2017","journal-title":"J. Chromatogr., B"},{"key":"10.1016\/j.jep.2023.116156_bib131","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jchromb.2017.12.033","article-title":"Effect of aspirin on the pharmacokinetics and absorption of panax notoginseng saponins","volume":"1074\u20131075","author":"Tian","year":"2018","journal-title":"J. Chromatogr., B"},{"key":"10.1016\/j.jep.2023.116156_bib132","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1089\/jmf.2021.K.0003","article-title":"Phytochemical and over-the-counter drug interactions: involvement of phase I and II drug-metabolizing enzymes and phase III transporters","volume":"24","author":"Truong","year":"2021","journal-title":"J. Med. Food"},{"key":"10.1016\/j.jep.2023.116156_bib133","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/404761","article-title":"Panax notoginseng attenuates bleomycin-induced pulmonary fibrosis in mice","volume":"2011","author":"Tsai","year":"2011","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jep.2023.116156_bib134","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.ijbiomac.2020.02.034","article-title":"A novel acidic polysaccharide from the residue of Panax notoginseng and its hepatoprotective effect on alcoholic liver damage in mice","volume":"149","author":"Wang","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jep.2023.116156_bib135","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s00280-006-0350-2","article-title":"Notoginseng enhances anti-cancer effect of 5-fluorouracil on human colorectal cancer cells","volume":"60","author":"Wang","year":"2007","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.jep.2023.116156_bib136","first-page":"1149","article-title":"Chemopreventive effects of Panax notoginseng and its major constituents on SW480 human colorectal cancer cells","volume":"31","author":"Wang","year":"2007","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.jep.2023.116156_bib137","article-title":"Systematic review and meta-analysis on randomized controlled trials on efficacy and safety of panax notoginseng saponins in treatment of acute ischemic stroke","volume":"2021","author":"Wang","year":"2021","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jep.2023.116156_bib138","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1002\/ptr.6605","article-title":"Antimicrobial activities of Asian ginseng, American ginseng, and notoginseng","volume":"34","author":"Wang","year":"2020","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2023.116156_bib139","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.thromres.2016.03.022","article-title":"Panax notoginseng saponin is superior to aspirin in inhibiting platelet adhesion to injured endothelial cells through COX pathway in vitro","volume":"141","author":"Wang","year":"2016","journal-title":"Thromb. Res."},{"key":"10.1016\/j.jep.2023.116156_bib140","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/706723","article-title":"Effects of borneol on pharmacokinetics and tissue distribution of notoginsenoside R1 and ginsenosides Rg1 and Re in panax notoginseng in rabbits","volume":"2013","author":"Wang","year":"2013","journal-title":"J. Anal. Methods. Chem."},{"key":"10.1016\/j.jep.2023.116156_bib141","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1111\/liv.12329","article-title":"Panaxatriol saponin ameliorated liver injury by acetaminophen via restoring thioredoxin-1 and pro-caspase-12","volume":"34","author":"Wang","year":"2014","journal-title":"Liver Int."},{"key":"10.1016\/j.jep.2023.116156_bib142","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jep.2016.05.005","article-title":"Traditional uses, botany, phytochemistry, pharmacology and toxicology of Panax notoginseng (Burk.) F.H. Chen: a review","volume":"188","author":"Wang","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.116156_bib143","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/sj.bjc.6604227","article-title":"20(S)-25-methoxyl-dammarane-3\u03b2, 12\u03b2, 20-triol, a novel natural product for prostate cancer therapy: activity in vitro and in vivo and mechanisms of action","volume":"98","author":"Wang","year":"2008","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.jep.2023.116156_bib144","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.111165","article-title":"Combination of Panax notoginseng saponins and aspirin potentiates platelet inhibition with alleviated gastric injury via modulating arachidonic acid metabolism","volume":"134","author":"Wang","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2023.116156_bib145","article-title":"Traditional Chinese medicine for refractory nephrotic syndrome: strategies and promising treatments","volume":"2018","author":"Wang","year":"2018","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jep.2023.116156_bib146","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1248\/yakushi.131.993","article-title":"Induction of differentiation by panaxydol in human hepatocarcinoma SMMC-7721 cells via cAMP and MAP kinase dependent mechanism","volume":"131","author":"Wang","year":"2011","journal-title":"Yakugaku Zasshi-J. Pharm. Soc. Jpn."},{"key":"10.1016\/j.jep.2023.116156_bib147","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1039\/C8FO00368H","article-title":"Anti-anemia effects of ginsenoside Rk3 and ginsenoside Rh4 on mice with ribavirin-induced anemia","volume":"9","author":"Wei","year":"2018","journal-title":"Food Funct."},{"key":"10.1016\/j.jep.2023.116156_bib148","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jchromb.2015.11.024","article-title":"Transporter modulation by Chinese herbal medicines and its mediated pharmacokinetic herb-drug interactions","volume":"1026","author":"Wu","year":"2016","journal-title":"J. Chromatogr., B: Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jep.2023.116156_bib149","doi-asserted-by":"crossref","DOI":"10.1016\/j.jstrokecerebrovasdis.2022.106597","article-title":"Panax notoginseng saponins combined with dual antiplatelet drugs potentiates anti-thrombotic effect with alleviated gastric injury in A carotid artery thrombosis rat model","volume":"31","author":"Wu","year":"2022","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"10.1016\/j.jep.2023.116156_bib150","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.indcrop.2017.04.045","article-title":"Accumulation of saponins in Panax notoginseng during its growing seasons","volume":"104","author":"Xia","year":"2017","journal-title":"Ind. Crop. Prod."},{"key":"10.1016\/j.jep.2023.116156_bib151","article-title":"Screening of drug metabolizing enzymes for the ginsenoside compound K in vitro: an efficient anti-cancer substance originating from Panax Ginseng","volume":"11","author":"Xiao","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2023.116156_bib152","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1007\/s11418-014-0831-2","article-title":"Effects of ginsenoside Re on rat jejunal contractility","volume":"68","author":"Xiong","year":"2014","journal-title":"J. Nat. Med."},{"key":"10.1016\/j.jep.2023.116156_bib153","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.jep.2014.10.054","article-title":"Effects of broad-spectrum antibiotics on the metabolism and pharmacokinetics of ginsenoside Rb1: a study on rats\u05f3 gut microflora influenced by lincomycin","volume":"158","author":"Xu","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.116156_bib154","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ejphar.2012.07.050","article-title":"Improvement of ginsenoside Rg1 on hematopoietic function in cyclophosphamide-induced myelosuppression mice","volume":"695","author":"Xu","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2023.116156_bib155","doi-asserted-by":"crossref","first-page":"3658","DOI":"10.3390\/ijms19113658","article-title":"Ginsenoside Rg1 prevents doxorubicin-induced cardiotoxicity through the inhibition of autophagy and endoplasmic reticulum stress in mice","volume":"19","author":"Xu","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jep.2023.116156_bib156","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13020-021-00424-3","article-title":"Anti-platelet aggregation of Panax notoginseng triol saponins by regulating GP1BA for ischemic stroke therapy","volume":"16","author":"Xu","year":"2021","journal-title":"Chin. Med."},{"key":"10.1016\/j.jep.2023.116156_bib157","doi-asserted-by":"crossref","first-page":"10939","DOI":"10.1039\/C6RA27542G","article-title":"Antifungal activity and mechanism of heat-transformed ginsenosides from notoginseng against Epidermophyton floccosum, Trichophyton rubrum, and Trichophyton mentagrophytes","volume":"7","author":"Xue","year":"2017","journal-title":"RSC Adv."},{"key":"10.1016\/j.jep.2023.116156_bib158","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1007\/s12355-020-00811-4","article-title":"New value-added sugar and Brown sugar products from sugarcane: a commercial approach","volume":"22","author":"Yang","year":"2020","journal-title":"Sugar Tech"},{"key":"10.1016\/j.jep.2023.116156_bib159","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/bdd.1806","article-title":"Enhanced oral bioavailability and anti-tumour effect of paclitaxel by 20(s)-ginsenoside Rg3 in vivo","volume":"33","author":"Yang","year":"2012","journal-title":"Biopharm. Drug Dispos."},{"key":"10.1016\/j.jep.2023.116156_bib160","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.phytochem.2014.07.012","article-title":"Saponins in the genus Panax L. (Araliaceae): a systematic review of their chemical diversity","volume":"106","author":"Yang","year":"2014","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jep.2023.116156_bib161","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.fitote.2013.10.010","article-title":"Synergy effects of herb extracts: pharmacokinetics and pharmacodynamic basis","volume":"92","author":"Yang","year":"2014","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2023.116156_bib162","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jgr.2019.12.009","article-title":"Phytochemical analysis of Panax species: a review","volume":"45","author":"Yang","year":"2021","journal-title":"J. Ginseng Res."},{"key":"10.1016\/j.jep.2023.116156_bib163","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.2174\/1871520620999201110191459","article-title":"Panax notoginseng saponins promote cell death and chemosensitivity in pancreatic cancer through the apoptosis and autophagy pathways","volume":"21","author":"Yao","year":"2021","journal-title":"Anti Cancer Agents Med. Chem."},{"key":"10.1016\/j.jep.2023.116156_bib164","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2022.112464","article-title":"Platelet membrane-cloaked selenium\/ginsenoside Rb1 nanosystem as biomimetic reactor for atherosclerosis therapy","volume":"214","author":"Yin","year":"2022","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.jep.2023.116156_bib165","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3109\/13880209.2015.1029051","article-title":"Effects of notoginsenoside R1 on CYP1A2, CYP2C11, CYP2D1, and CYP3A1\/2 activities in rats by cocktail probe drugs","volume":"54","author":"Yin","year":"2016","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jep.2023.116156_bib166","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1248\/bpb.30.2196","article-title":"Anti-diabetic effects of compound K versus metformin versus compound K-metformin combination therapy in diabetic db\/db mice","volume":"30","author":"Yoon","year":"2007","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jep.2023.116156_bib167","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s11655-016-2472-7","article-title":"Exploring mechanisms of Panax notoginseng saponins in treating coronary heart disease by integrating gene interaction network and functional enrichment analysis","volume":"22","author":"Yu","year":"2016","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.jep.2023.116156_bib168","doi-asserted-by":"crossref","first-page":"577","DOI":"10.2174\/1389200211209050577","article-title":"Absorption, disposition, and pharmacokinetics of saponins from Chinese medicinal herbs: what do we know and what do we need to know more?","volume":"13","author":"Yu","year":"2012","journal-title":"Curr. Drug Metabol."},{"key":"10.1016\/j.jep.2023.116156_bib169","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1248\/bpb.b110535","article-title":"Panax notoginseng saponins enhances the cytotoxicity of cisplatin via increasing gap junction intercellular communication","volume":"35","author":"Yu","year":"2012","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jep.2023.116156_bib170","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1248\/bpb.b16-00046","article-title":"Protective effect of ginsenoside Rg1 on bleomycin-induced pulmonary fibrosis in rats: involvement of caveolin-1 and TGF-\u03b21 signal pathway","volume":"39","author":"Zhan","year":"2016","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jep.2023.116156_bib171","doi-asserted-by":"crossref","first-page":"897","DOI":"10.3892\/mmr.2013.1597","article-title":"Components of Panax notoginseng saponins enhance the cytotoxicity of cisplatin via their effects on gap junctions","volume":"8","author":"Zhang","year":"2013","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jep.2023.116156_bib172","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.ejphar.2014.07.020","article-title":"Non-antibiotic agent ginsenoside 20(S)-Rh2 enhanced the antibacterial effects of ciprofloxacin in vitro and in vivo as a potential NorA inhibitor","volume":"740","author":"Zhang","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jep.2023.116156_bib173","article-title":"Stereoselective regulations of P-glycoprotein by ginsenoside Rh2 epimers and the potential mechanisms from the view of pharmacokinetics","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jep.2023.116156_bib174","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1124\/dmd.110.034793","article-title":"20(S)-ginsenoside Rh2 noncompetitively inhibits P-glycoprotein in vitro and in vivo: a case for herb-drug interactions","volume":"38","author":"Zhang","year":"2010","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.jep.2023.116156_bib175","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.113792","article-title":"Network pharmacology reveals pharmacological effect and mechanism of Panax notoginseng (Burk.) F. H. Chen on reproductive and genetic toxicity in male mice","volume":"270","author":"Zhang","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.116156_bib176","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.etap.2009.01.001","article-title":"Reduction of cyclophosphamide-induced DNA damage and apoptosis effects of ginsenoside Rb1 on mouse bone marrow cells and peripheral blood leukocytes","volume":"27","author":"Zhang","year":"2009","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.jep.2023.116156_bib177","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.bbrc.2006.02.044","article-title":"Antiangiogenic effect of low-dose cyclophosphamide combined with ginsenoside Rg3 on Lewis lung carcinoma","volume":"342","author":"Zhang","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jep.2023.116156_bib178","doi-asserted-by":"crossref","first-page":"10352","DOI":"10.3390\/molecules180910352","article-title":"Bioactive protopanaxatriol type saponins isolated from the roots of Panax notoginseng (Burk.) F","volume":"18","author":"Zhang","year":"2013","journal-title":"H. Chen. Molecules."},{"key":"10.1016\/j.jep.2023.116156_bib179","doi-asserted-by":"crossref","first-page":"202","DOI":"10.4062\/biomolther.2016.066","article-title":"Ginsenoside Rb1 inhibits doxorubicin-triggered H9C2 cell apoptosis via aryl hydrocarbon receptor","volume":"25","author":"Zhang","year":"2017","journal-title":"Biomol. Ther."},{"key":"10.1016\/j.jep.2023.116156_bib180","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.3389\/fphar.2019.01578","article-title":"Steamed panax notoginseng attenuates anemia in mice with blood deficiency syndrome via regulating hematopoietic factors and JAK-STAT pathway","volume":"10","author":"Zhang","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2023.116156_bib181","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40360-019-0378-7","article-title":"The impact of cytochrome 450 and Paraoxonase polymorphisms on clopidogrel resistance and major adverse cardiac events in coronary heart disease patients after percutaneous coronary intervention","volume":"21","author":"Zhang","year":"2020","journal-title":"BMC Pharmacol. Toxicol."},{"key":"10.1016\/j.jep.2023.116156_bib182","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.biopha.2018.11.021","article-title":"Herb-drug interaction: a case study of effects and involved mechanisms of cisplatin on the pharmacokinetics of ginsenoside Rb1 in tumor-bearing mice","volume":"110","author":"Zhou","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2023.116156_bib183","article-title":"Combination of Xuesaitong and aspirin based on the antiplatelet effect and gastrointestinal injury: study protocol for a randomized controlled noninferiority trial","volume":"2021","author":"Zhu","year":"2021","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jep.2023.116156_bib184","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.biopha.2018.04.054","article-title":"Network pharmacology-based identification of protective mechanism of Panax Notoginseng Saponins on aspirin induced gastrointestinal injury","volume":"105","author":"Zhu","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2023.116156_bib185","doi-asserted-by":"crossref","first-page":"83792","DOI":"10.18632\/oncotarget.19698","article-title":"Oral administration of Ginsenoside Rg1 prevents cardiac toxicity induced by doxorubicin in mice through anti-apoptosis","volume":"8","author":"Zhu","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.jep.2023.116156_bib186","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.21037\/apm-20-1681","article-title":"Xuesaitong injection (lyophilized) combined with aspirin and clopidogrel protect against focal cerebral ischemic\/reperfusion injury in rats by suppressing oxidative stress and inflammation and regulating the NOX2\/IL-6\/STAT3 pathway","volume":"10","author":"Zhu","year":"2020","journal-title":"Ann. Palliat. Med."},{"key":"10.1016\/j.jep.2023.116156_bib187","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3390\/nu9020166","article-title":"S\u2010Allylmercaptocysteine attenuates cisplatin\u2010induced nephrotoxicity through suppression of apoptosis, oxidative stress, and inflammation","volume":"9","author":"Zhu","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.jep.2023.116156_bib188","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.jconrel.2020.12.036","article-title":"Multifunctional ginsenoside Rg3-based liposomes for glioma targeting therapy","volume":"330","author":"Zhu","year":"2021","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.jep.2023.116156_bib189","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13578-019-0279-x","article-title":"PNS-R1 inhibits Dex-induced bronchial epithelial cells apoptosis in asthma through mitochondrial apoptotic pathway","volume":"9","author":"Zou","year":"2019","journal-title":"Cell Biosci."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123000247?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123000247?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:53:33Z","timestamp":1736384013000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874123000247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":189,"alternative-id":["S0378874123000247"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2023.116156","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Herb\u2013drug interactions between Panax notoginseng or its biologically active compounds and therapeutic drugs: A comprehensive pharmacodynamic and pharmacokinetic review","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2023.116156","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116156"}}