{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T22:16:31Z","timestamp":1788041791571,"version":"build-2784847793"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T00:00:00Z","timestamp":1676419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81102868"],"award-info":[{"award-number":["81102868"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873067"],"award-info":[{"award-number":["81873067"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019971","name":"Luzhou Science and Technology Bureau","doi-asserted-by":"publisher","award":["2022-JYJ-124"],"award-info":[{"award-number":["2022-JYJ-124"]}],"id":[{"id":"10.13039\/501100019971","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ethnopharmacology"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.jep.2023.116266","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T11:33:12Z","timestamp":1676460792000},"page":"116266","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Optimal timing of free total rhubarb anthraquinones on immune regulation in rats with severe acute pancreatitis"],"prefix":"10.1016","volume":"308","author":[{"given":"Liqiang","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingjing","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yejiang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxia","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jep.2023.116266_bib1","doi-asserted-by":"crossref","first-page":"488","DOI":"10.2174\/18735592MTEwDNjQiz","article-title":"Physcion and physcion 8-O-beta-D-glucopyranoside: natural anthraquinones with potential anticancer activities","volume":"22","author":"Adnan","year":"2021","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.jep.2023.116266_bib2","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.talanta.2015.08.011","article-title":"Analysis of anthraquinones in rhubarb (Rheum palmatum and Rheum officinale) by supercritical fluid chromatography","volume":"144","author":"Aichner","year":"2015","journal-title":"Talanta"},{"key":"10.1016\/j.jep.2023.116266_bib3","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10495-018-1464-9","article-title":"Gastrointestinal microecology: a crucial and potential target in acute pancreatitis","volume":"23","author":"Cen","year":"2018","journal-title":"Apoptosis"},{"key":"10.1016\/j.jep.2023.116266_bib4","series-title":"Chinese Pharmacopoeia Commission","first-page":"24","author":"Chinese pharmacopoeia","year":"2020"},{"key":"10.1016\/j.jep.2023.116266_bib5","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.21873\/invivo.11583","article-title":"Apigenin exerts anti-inflammatory effects in an experimental model of acute pancreatitis by down-regulating TNF-alpha","volume":"33","author":"Charalabopoulos","year":"2019","journal-title":"Vivo"},{"key":"10.1016\/j.jep.2023.116266_bib6","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1001\/archsurg.1970.01340280036010","article-title":"Intestinal mucosal lesion in low-flow states. II. The protective effect of intraluminal glucose as energy substrate","volume":"101","author":"Chiu","year":"1970","journal-title":"Arch. Surg."},{"key":"10.1016\/j.jep.2023.116266_bib7","first-page":"425","article-title":"The pharmacology, toxicology and therapeutic potential of anthraquinone derivative emodin","volume":"18","author":"Cui","year":"2020","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.jep.2023.116266_bib8","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.intimp.2016.11.011","article-title":"Systematic investigation on the turning point of over-inflammation to immunosuppression in CLP mice model and their characteristics","volume":"42","author":"Deng","year":"2017","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.jep.2023.116266_bib9","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3389\/fcimb.2020.00128","article-title":"Circulating lymphocyte subsets induce secondary infection in acute pancreatitis","volume":"10","author":"Ding","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.jep.2023.116266_bib10","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/ptr.6532","article-title":"Aloe-emodin: a review of its pharmacology, toxicity, and pharmacokinetics","volume":"34","author":"Dong","year":"2020","journal-title":"Phytother Res."},{"key":"10.1016\/j.jep.2023.116266_bib11","series-title":"European Directorate for the Quality of Medicines","first-page":"1858","year":"2001"},{"key":"10.1016\/j.jep.2023.116266_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.106151","article-title":"Effects of sildenafil on inflammatory injury of the lung in sodium taurocholate-induced severe acute pancreatitis rats","volume":"80","author":"Fang","year":"2020","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.jep.2023.116266_bib13","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.2217\/imt.12.131","article-title":"Rhubarb attenuates the severity of acute necrotizing pancreatitis by inhibiting MAPKs in rats","volume":"4","author":"Feng","year":"2012","journal-title":"Immunotherapy"},{"key":"10.1016\/j.jep.2023.116266_bib14","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/ni904","article-title":"Foxp3 programs the development and function of CD4+CD25+ regulatory T cells","volume":"4","author":"Fontenot","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jep.2023.116266_bib15","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1097\/TA.0b013e318256e000","article-title":"Persistent inflammation and immunosuppression: a common syndrome and new horizon for surgical intensive care","volume":"72","author":"Gentile","year":"2012","journal-title":"J. Trauma. Acute. Care Surg."},{"key":"10.1016\/j.jep.2023.116266_bib16","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1159\/000506830","article-title":"Management of severe acute pancreatitis: an update","volume":"102","author":"Gliem","year":"2021","journal-title":"Digestion"},{"key":"10.1016\/j.jep.2023.116266_bib17","doi-asserted-by":"crossref","first-page":"891","DOI":"10.3389\/fimmu.2019.00891","article-title":"Challenge to the intestinal mucosa during sepsis","volume":"10","author":"Haussner","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2023.116266_bib18","first-page":"954","article-title":"Progresses of immunomodulatory therapy in sever acute pancreatitis","volume":"29","author":"He","year":"2017","journal-title":"Zhonghua Wei Zhong Bing Ji Jiu Yi Xue"},{"key":"10.1016\/j.jep.2023.116266_bib19","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1097\/MOG.0000000000000456","article-title":"Management of acute pancreatitis in the first 72 hours","volume":"34","author":"James","year":"2018","journal-title":"Curr. Opin. Gastroenterol."},{"key":"10.1016\/j.jep.2023.116266_bib20","series-title":"Pharmaceutical and Food Safety Bureau, Ministry of Health","first-page":"1344","author":"Japanese Pharmacopoeia","year":"2006"},{"key":"10.1016\/j.jep.2023.116266_bib21","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/3909468","article-title":"Da-cheng-qi decoction alleviates intestinal injury in rats with severe acute pancreatitis by inhibiting the JAK2-STAT3 signaling pathway","author":"Jin","year":"2019","journal-title":"Evid Based Complement Alternat Med."},{"key":"10.1016\/j.jep.2023.116266_bib22","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1097\/MCG.0000000000001117","article-title":"Early enteral nutrition prevent acute pancreatitis from deteriorating in obese patients","volume":"54","author":"Jin","year":"2020","journal-title":"J. Clin. Gastroenterol."},{"key":"10.1016\/j.jep.2023.116266_bib23","article-title":"The clinical course of acute pancreatitis and the inflammatory mediators that drive it","author":"Kyl\u00e4np\u00e4\u00e4","year":"2012","journal-title":"Int. J. Inflamm."},{"key":"10.1016\/j.jep.2023.116266_bib24","article-title":"Update on pharmacological activities, security, and pharmacokinetics of rhein","volume":"2021","author":"Li","year":"2021","journal-title":"Evid Based Complement Alternat Med."},{"key":"10.1016\/j.jep.2023.116266_bib25","article-title":"The effects of secretory IgA in the mucosal immune system","volume":"2020","author":"Li","year":"2020","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.jep.2023.116266_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cytogfr.2019.11.001","article-title":"The role of interleukin-18 in pancreatitis and pancreatic cancer","volume":"50","author":"Li","year":"2019","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.jep.2023.116266_bib27","first-page":"292","article-title":"Clinical applications of urinary organic acids. Part 2. Dysbiosis markers","volume":"13","author":"Lord","year":"2008","journal-title":"Alternative Med. Rev."},{"key":"10.1016\/j.jep.2023.116266_bib28","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jep.2018.08.033","article-title":"Rhubarb Peony Decoction ameliorates ulcerative colitis in mice by regulating gut microbiota to restoring Th17\/Treg balance","volume":"231","author":"Luo","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.116266_bib29","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s10620-020-06225-2","article-title":"Inhibition of ferroptosis attenuates acute kidney injury in rats with severe acute pancreatitis","volume":"66","author":"Ma","year":"2021","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.jep.2023.116266_bib30","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/j.cgh.2019.11.017","article-title":"Worldwide variations in demographics, management, and outcomes of acute pancreatitis","volume":"18","author":"Matta","year":"2020","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jep.2023.116266_bib31","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.imlet.2019.11.002","article-title":"Advances in immunomodulatory therapy for severe acute pancreatitis","volume":"217","author":"Munir","year":"2020","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.jep.2023.116266_bib32","doi-asserted-by":"crossref","first-page":"763","DOI":"10.3389\/fimmu.2018.00763","article-title":"Unique action of interleukin-18 on T cells and other immune cells","volume":"9","author":"Nakanishi","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jep.2023.116266_bib33","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1159\/000486155","article-title":"Dachengqi decoction attenuates intestinal vascular endothelial injury in severe acute pancreatitis in vitro and in vivo","volume":"44","author":"Pan","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.jep.2023.116266_bib34","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.smim.2016.03.012","article-title":"Dendritic cell development-History, advances, and open questions","volume":"27","author":"Puhr","year":"2015","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.jep.2023.116266_bib35","first-page":"1482","article-title":"Intervention effect of modified dachengqi decoction on intestinal mucosal barrier of severe acute pancreatitis model rats","volume":"35","author":"Qin","year":"2015","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"10.1016\/j.jep.2023.116266_bib36","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1097\/MPA.0000000000001006","article-title":"TH1 and TH2 cytokine profiles as predictors of severity in acute pancreatitis","volume":"47","author":"Rodriguez-Nicolas","year":"2018","journal-title":"Pancreas"},{"key":"10.1016\/j.jep.2023.116266_bib37","first-page":"CD012010","article-title":"Serum amylase and lipase and urinary trypsinogen and amylase for diagnosis of acute pancreatitis","volume":"4","author":"Rompianesi","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.jep.2023.116266_bib38","first-page":"138","article-title":"Intestinal permeability and systemic endotoxemia in patients with acute pancreatitis","volume":"87","author":"Schietroma","year":"2016","journal-title":"Ann. Ital. Chir."},{"key":"10.1016\/j.jep.2023.116266_bib39","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1097\/00000658-199201000-00007","article-title":"A better model of acute pancreatitis for evaluating therapy","volume":"215","author":"Schmidt","year":"1992","journal-title":"Ann. Surg."},{"key":"10.1016\/j.jep.2023.116266_bib40","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1053\/j.gastro.2017.10.018","article-title":"Cathepsin B-mediated activation of trypsinogen in endocytosing macrophages increases severity of pancreatitis in mice","volume":"154","author":"Sendler","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jep.2023.116266_bib41","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.mehy.2008.09.007","article-title":"Trypsin is the culprit of multiple organ injury with severe acute pancreatitis","volume":"72","author":"Sha","year":"2009","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.jep.2023.116266_bib42","doi-asserted-by":"crossref","first-page":"4147","DOI":"10.1111\/bph.15158","article-title":"Artesunate interacts with the vitamin D receptor to reverse sepsis-induced immunosuppression in a mouse model via enhancing autophagy","volume":"177","author":"Shang","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jep.2023.116266_bib43","doi-asserted-by":"crossref","first-page":"3468","DOI":"10.1007\/s10620-017-4813-6","article-title":"Association of systemic inflammatory and anti-inflammatory responses with adverse outcomes in acute pancreatitis: preliminary results of an ongoing study","volume":"62","author":"Sharma","year":"2017","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.jep.2023.116266_bib44","first-page":"14","article-title":"Interaction between the gut microbiome and mucosal immune system","volume":"4","author":"Shi","year":"2017","journal-title":"Mil Med Res"},{"key":"10.1016\/j.jep.2023.116266_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113685","article-title":"Medicinal plants from the 14th edition of the Russian Pharmacopoeia, recent updates","volume":"268","author":"Shikov","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.jep.2023.116266_bib46","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s12664-016-0647-y","article-title":"Pathophysiological mechanisms in acute pancreatitis: current understanding","volume":"35","author":"Singh","year":"2016","journal-title":"Indian J. Gastroenterol."},{"key":"10.1016\/j.jep.2023.116266_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110002","article-title":"The pharmacological properties of chrysophanol, the recent advances","volume":"125","author":"Su","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jep.2023.116266_bib48","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.cca.2020.08.029","article-title":"The diagnostic value of serum C-reactive protein, procalcitonin, interleukin-6 and lactate dehydrogenase in patients with severe acute pancreatitis","volume":"510","author":"Tian","year":"2020","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.jep.2023.116266_bib49","first-page":"1234","article-title":"Effects of Rhubarb combined with ulinastatin on T-cell subsets in sepsis rats","volume":"8","author":"Tian","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.jep.2023.116266_bib50","doi-asserted-by":"crossref","first-page":"5511","DOI":"10.4238\/2015.May.25.2","article-title":"Ulinastatin promotes T lymphocyte apoptosis in rats with severe acute pancreatitis via mitochondrial pathways","volume":"14","author":"Wang","year":"2015","journal-title":"Genet. Mol. Res."},{"key":"10.1016\/j.jep.2023.116266_bib51","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s13020-020-00370-6","article-title":"What we already know about rhubarb: a comprehensive review","volume":"15","author":"Xiang","year":"2020","journal-title":"Chin. Med."},{"key":"10.1016\/j.jep.2023.116266_bib52","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S2468-1253(16)30004-8","article-title":"Global incidence and mortality of pancreatic diseases: a systematic review, meta-analysis, and meta-regression of population-based cohort studies","volume":"1","author":"Xiao","year":"2016","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"10.1016\/j.jep.2023.116266_bib53","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/8784905","article-title":"Exploration of the curative effect of early enteral nutrition nursing on patients with severe acute pancreatitis and the improvement of patients' mental Health and inflammation level","volume":"2021","author":"Xiao","year":"2021","journal-title":"J. Healthc. Eng."},{"key":"10.1016\/j.jep.2023.116266_bib54","doi-asserted-by":"crossref","first-page":"710","DOI":"10.5152\/tjg.2022.21307","article-title":"Butyrate ameliorates intestinal epithelial barrier injury via enhancing Foxp3+ regulatory T-cell function in severe acute pancreatitis model","volume":"33","author":"Xiao","year":"2022","journal-title":"Turk. J. Gastroenterol."},{"key":"10.1016\/j.jep.2023.116266_bib55","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3389\/fphar.2018.00075","article-title":"Free total rhubarb anthraquinones protect intestinal injury via regulation of the intestinal immune response in a rat model of severe acute pancreatitis","volume":"9","author":"Xiong","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jep.2023.116266_bib56","first-page":"9300","article-title":"Association between glucose-regulated protein and neutrophil apoptosis in severe acute pancreatitis","volume":"8","author":"Xu","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.jep.2023.116266_bib57","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/2549486","article-title":"Protective role of somatostatin in sepsis-induced intestinal barrier dysfunction through inhibiting the activation of NF-kappaB pathway","volume":"2020","author":"Xu","year":"2020","journal-title":"Gastroenterol. Res. Pract."},{"key":"10.1016\/j.jep.2023.116266_bib58","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1007\/s10620-008-0668-1","article-title":"Infectious complications in patients with severe acute pancreatitis","volume":"54","author":"Xue","year":"2009","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.jep.2023.116266_bib59","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.apjtm.2016.09.001","article-title":"Clinical significance of dynamic detection for serum levels of MCP-1, TNF-alpha and IL-8 in patients with acute pancreatitis","volume":"9","author":"Yang","year":"2016","journal-title":"Asian. Pac. J. Trop. Med."},{"key":"10.1016\/j.jep.2023.116266_bib60","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.fitote.2015.05.018","article-title":"The pharmacokinetic study on the mechanism of toxicity attenuation of rhubarb total free anthraquinone oral colon-specific drug delivery system","volume":"104","author":"Zhang","year":"2015","journal-title":"Fitoterapia"},{"key":"10.1016\/j.jep.2023.116266_bib61","first-page":"753","article-title":"Expression and clinical significance of rhubarb on serum amylase and TNF-alpha of rat model of acute pancreatitis","volume":"31","author":"Zhang","year":"2017","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"10.1016\/j.jep.2023.116266_bib62","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1053\/j.gastro.2012.12.042","article-title":"Role of immune cells and immune-based therapies in pancreatitis and pancreatic ductal adenocarcinoma","volume":"144","author":"Zheng","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jep.2023.116266_bib63","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.876168","article-title":"Dynamic monitoring of immunoinflammatory response identifies immunoswitching characteristics of severe acute pancreatitis in rats","volume":"13","author":"Zhuang","year":"2022","journal-title":"Front. Immunol."}],"container-title":["Journal of Ethnopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123001344?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378874123001344?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:37:07Z","timestamp":1759945027000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378874123001344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":63,"alternative-id":["S0378874123001344"],"URL":"https:\/\/doi.org\/10.1016\/j.jep.2023.116266","relation":{},"ISSN":["0378-8741"],"issn-type":[{"value":"0378-8741","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Optimal timing of free total rhubarb anthraquinones on immune regulation in rats with severe acute pancreatitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Ethnopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jep.2023.116266","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"116266"}}